Click here to switch to the map view.

The map label for this gene is cyoE

Identifier: 213158555

GI number: 213158555

Start: 2603270

End: 2604148

Strand: Direct

Name: cyoE

Synonym: AB57_2508

Alternate gene names: 213158555

Gene position: 2603270-2604148 (Clockwise)

Preceding gene: 213158554

Following gene: 213158556

Centisome position: 64.27

GC content: 37.2

Gene sequence:

>879_bases
ATGTTGAAAAAGTATTTATTCCTGACTAAACCAGGAATTCTCTTCGGTAATTTCATTACCACCTTGGGCGGCTTCTTCTT
AGCCGCCCAAGGCTCTATAGACATCTTATTATTATTGCTCACTCTCATTGGAACAACATTAGTTGTTGCTTCAGGTTGTG
TGGTTAATAATGTTATAGATCAAGATATTGATACAAAGATGCAGCGCACTCAAAACCGTGCACTTGTTAAAAAAACCATC
TCTCCTACTGTTGCGCTTGTATATGCTTTCGTACTCGGAGTAATGGGTTTTAGCATTTTGTGGTTTGGTGTAAATGGTTA
CGCATTTTTGTTTGCAATGATTGGTTTTATTGTCTATGTCGGTTTTTATAGTTTGTGGACTAAACGTACCTCAATCCACC
AAACCGTCATTGGTAGTATCTCCGGAGCGAGCCCTCCTGTTATTGGTTATACAGCAGTAACTCATCAATTTGATGTGGCA
GCCTTGCTTTTGTTTTTAGCATACGCTTTATGGCAAATGCCTCACTCTTGGGCAATTGCAATTTATCGTTTTGATGATTA
CAAAAATGCGGGAATTCCTATCTTGCCTGTAGCACGTTCCATTTATCGCACGAAAATTGAATGTGTAATCTATATCCTGT
TGTTTGCAGCTGTTTTGAATGGGTTATATTGTTTTGGCTACACCAATGTATTTTTCTTGATTACCTTTAATGCTTTGACC
GCATACTGGTTTTATTTATCAATTATTGGATTTAAAGCCGAAAACGACCAACTTTGGGCTAAACGCTTTTTCCTTTACTC
AGTAATCTTAATTACTTTGCTAAGTTTAAGTTTTAGCTTTACCTATCAATCTCCTGCTCCAAATCTTCCTCTCTTTTAA

Upstream 100 bases:

>100_bases
GCATTTATCTACACAATCCTATGTATCGCTGTACTTTTAATCGGTTCTGTGTGGATTATGAATTACCTTCACTACAATAT
GATGATCTAAACTGATTGTC

Downstream 100 bases:

>100_bases
TTAAGGGAGGATTTCCTCCTCTCTCAAATAACTTTTATATTTCTCATCAAAAGATTTGTTTTTAGTCTAATTTTTACCTA
TAATTCAGCCTTCGCATTTT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLKKYLFLTKPGILFGNFITTLGGFFLAAQGSIDILLLLLTLIGTTLVVASGCVVNNVIDQDIDTKMQRTQNRALVKKTI
SPTVALVYAFVLGVMGFSILWFGVNGYAFLFAMIGFIVYVGFYSLWTKRTSIHQTVIGSISGASPPVIGYTAVTHQFDVA
ALLLFLAYALWQMPHSWAIAIYRFDDYKNAGIPILPVARSIYRTKIECVIYILLFAAVLNGLYCFGYTNVFFLITFNALT
AYWFYLSIIGFKAENDQLWAKRFFLYSVILITLLSLSFSFTYQSPAPNLPLF

Sequences:

>Translated_292_residues
MLKKYLFLTKPGILFGNFITTLGGFFLAAQGSIDILLLLLTLIGTTLVVASGCVVNNVIDQDIDTKMQRTQNRALVKKTI
SPTVALVYAFVLGVMGFSILWFGVNGYAFLFAMIGFIVYVGFYSLWTKRTSIHQTVIGSISGASPPVIGYTAVTHQFDVA
ALLLFLAYALWQMPHSWAIAIYRFDDYKNAGIPILPVARSIYRTKIECVIYILLFAAVLNGLYCFGYTNVFFLITFNALT
AYWFYLSIIGFKAENDQLWAKRFFLYSVILITLLSLSFSFTYQSPAPNLPLF
>Mature_292_residues
MLKKYLFLTKPGILFGNFITTLGGFFLAAQGSIDILLLLLTLIGTTLVVASGCVVNNVIDQDIDTKMQRTQNRALVKKTI
SPTVALVYAFVLGVMGFSILWFGVNGYAFLFAMIGFIVYVGFYSLWTKRTSIHQTVIGSISGASPPVIGYTAVTHQFDVA
ALLLFLAYALWQMPHSWAIAIYRFDDYKNAGIPILPVARSIYRTKIECVIYILLFAAVLNGLYCFGYTNVFFLITFNALT
AYWFYLSIIGFKAENDQLWAKRFFLYSVILITLLSLSFSFTYQSPAPNLPLF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=172, Percent_Identity=37.2093023255814, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786631, Length=285, Percent_Identity=51.5789473684211, Blast_Score=301, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71998235, Length=235, Percent_Identity=30.2127659574468, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=243, Percent_Identity=28.8065843621399, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921064, Length=262, Percent_Identity=30.9160305343511, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_ACIB3 (B7H0K1)

Other databases:

- EMBL:   CP001172
- RefSeq:   YP_002325197.1
- GeneID:   7059490
- GenomeReviews:   CP001172_GR
- KEGG:   abb:ABBFA_001294
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32719; Mature: 32719

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x209a25b0)-; HASH(0x21eff444)-; HASH(0x21ef2f30)-; HASH(0x223f20ac)-; HASH(0x21e4d890)-; HASH(0x21f6be00)-; HASH(0x2191bb18)-; HASH(0x21e88280)-; HASH(0x20de3a3c)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKYLFLTKPGILFGNFITTLGGFFLAAQGSIDILLLLLTLIGTTLVVASGCVVNNVID
CCCCEEEEECCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QDIDTKMQRTQNRALVKKTISPTVALVYAFVLGVMGFSILWFGVNGYAFLFAMIGFIVYV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GFYSLWTKRTSIHQTVIGSISGASPPVIGYTAVTHQFDVAALLLFLAYALWQMPHSWAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IYRFDDYKNAGIPILPVARSIYRTKIECVIYILLFAAVLNGLYCFGYTNVFFLITFNALT
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AYWFYLSIIGFKAENDQLWAKRFFLYSVILITLLSLSFSFTYQSPAPNLPLF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCH
>Mature Secondary Structure
MLKKYLFLTKPGILFGNFITTLGGFFLAAQGSIDILLLLLTLIGTTLVVASGCVVNNVID
CCCCEEEEECCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QDIDTKMQRTQNRALVKKTISPTVALVYAFVLGVMGFSILWFGVNGYAFLFAMIGFIVYV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GFYSLWTKRTSIHQTVIGSISGASPPVIGYTAVTHQFDVAALLLFLAYALWQMPHSWAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IYRFDDYKNAGIPILPVARSIYRTKIECVIYILLFAAVLNGLYCFGYTNVFFLITFNALT
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AYWFYLSIIGFKAENDQLWAKRFFLYSVILITLLSLSFSFTYQSPAPNLPLF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA