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The map label for this gene is mutL [H]

Identifier: 213158497

GI number: 213158497

Start: 2535131

End: 2537083

Strand: Reverse

Name: mutL [H]

Synonym: AB57_2448

Alternate gene names: 213158497

Gene position: 2537083-2535131 (Counterclockwise)

Preceding gene: 213158498

Following gene: 213158496

Centisome position: 62.64

GC content: 39.68

Gene sequence:

>1953_bases
ATGACTGATGAAAAGCTAACACAACGTCGTATTCATACATTAGACGCCGCGTTAGCGAACCAGATTGCTGCCGGTGAGGT
GATTGAACGTCCTTCATCGGTCGTAAAAGAATTATTAGAAAACTCAATTGATGCAGGTGCAACCGAATTAATTGTGCGGA
TTGCACAAGGCGGCTCAACATTAATCGAGATTATTGACAATGGACATGGGATTCATCCTGATGATTTACCATTGGCAGTG
ATGCGCCATGCAACCAGTAAAATTAAAACAGCAGAAGATTTACACGCGATTGTTAGCTTAGGTTTCCGTGGTGAAGCACT
TGCTTCTATTGCAGCAGTTTCACGATTGACTTTAACCAGTAGCCAAGATGAAAGCGGAATTGGTCATCAGGTTGAGGTGA
ATGGTACCGCCTTTGATCATCAACAAGTCCAAGCTGTTGCTGCACAAAAGGGCACCCATATTCGAGTTCAGGACTTGTTT
TTTAATGTGCCCGCTCGCCGTAAATTTTTAAAAAAACCAACCACTGAATTTGGGCATATTGAAGAAATTGTACGCCGTTT
AGCTTTAACGCATTTTGATATACGTTTTGTACTTGAGCATAACGATAATATTCGAATTAATTTACCAATAGCAGATAGCG
GTGAATTAAGATTTCAGCGTGTACAGCAATTATTGGGTCAACAGTTTGTTCAAAATGCTTACTGGATCGATGCCGAAAGT
ATTAACATGCGTTTGTCAGGTTGGCTAGGGCATCCTTCAGATGCACGTGCCCAAGCAGACTTACAATATGTGTATGTAAA
TGGCCGAATTGTGAAAGATAAAACCATTTCACATGCTTTAAGAATGGCATATGACGGTATTTTACATGGCCATCAGCATT
CATCTTATTTACTTTTCTTAGAAGTTGATCCTGAAAATATTGATGTTAACGTTCACCCGACGAAACATGAGATTCGTTTT
CTAAATCAACGTGAAGTACATGAGTTTGTAAGACATTATGCTAAAGAAACGTTAGCACAATTTCAGACAGCTAGTGCTGA
TTTAGCACAAGCTATGAAAGCGGACGATACTCAGGCTTCATTTGTACAGTCTCAGCCTAAATATCAAGAACAATTCACAT
TGCATCGCACAGACCAAGCTGTTGATACAACACTAGATAAGTCTAGTAGTTATCAGCCCTCTACTGAACTTTTAACTGAT
TTTAATAATAGTCGTCCCCAAGCTGTTCATTATGCGGAACAAACTCCAAAATATAATGGTTCTGCGCAGTTAAATAATGC
ATTAAAGACTTACTTGGCTCCATTACGTGATCAACCTACAAATTTTTCAGTTGATGAAAATATTGAGTCTGTCGCTAAGG
TAGATGAATTTCCATTAGGTATCGCAATTGCCCAGCTTCATGGAATTTATATTTTGGCGCAAAATACTGAAGGCCTGATT
ATTGTTGATATGCATGCAGCACATGAGCGTATTTTGCTGCAACAAATGAAAAATGCTTGGGATAAACCTGAGTTTTGGAC
ATCTCAACAGTTGCTTATCCCTAAAGTGATCTCAATTAGCCGTATGCAAGCTATTCGTGTTGAGGATTTAAAACCTCAGC
TTGAACGCTTAGGGTTAGAGATTGATTTATATGGCGATGAGCAAGTCATTGTGCGTGGTGTGCCGGCTATTTTGCAAAAA
GCGGATTTTGAAAATCTTATTCCCGAACTTCTCAATGATTTAGATCCAAATGATGAAGCACAAGGTTTATTGCAAAAGCG
TGATGAACTGTTAGCAGGTATGGCGTGTCATGGTGCAGTACGTGCTCATCGACAACTTAGTCTCTCAGAAATGAATGCTT
TACTTCGCCAAATGGAACAAACCGAATTTGCAAGCCAATGTAACCATGGTCGCCCAACTTGGCGTGCATTTCCATTATCT
CAACTAGATAAATTATTTGCTCGAGGAGAGTAG

Upstream 100 bases:

>100_bases
ATCATCATTGATATTCAAAAATCAGATGATGAACTCAATCGTTTCGTCACCTTAACTTTACCAACAGAGCATTTGTACCA
GACTTTGCAGGAACAGCTTC

Downstream 100 bases:

>100_bases
TTTTACATGTCAAACCAATTGCCCGTCATCAATTTAATGGGACCGACTGCAAGCGGAAAAACCGCTTTGGCATGTGAACT
CTATGAACGTGGAAATTTTG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MTDEKLTQRRIHTLDAALANQIAAGEVIERPSSVVKELLENSIDAGATELIVRIAQGGSTLIEIIDNGHGIHPDDLPLAV
MRHATSKIKTAEDLHAIVSLGFRGEALASIAAVSRLTLTSSQDESGIGHQVEVNGTAFDHQQVQAVAAQKGTHIRVQDLF
FNVPARRKFLKKPTTEFGHIEEIVRRLALTHFDIRFVLEHNDNIRINLPIADSGELRFQRVQQLLGQQFVQNAYWIDAES
INMRLSGWLGHPSDARAQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQHSSYLLFLEVDPENIDVNVHPTKHEIRF
LNQREVHEFVRHYAKETLAQFQTASADLAQAMKADDTQASFVQSQPKYQEQFTLHRTDQAVDTTLDKSSSYQPSTELLTD
FNNSRPQAVHYAEQTPKYNGSAQLNNALKTYLAPLRDQPTNFSVDENIESVAKVDEFPLGIAIAQLHGIYILAQNTEGLI
IVDMHAAHERILLQQMKNAWDKPEFWTSQQLLIPKVISISRMQAIRVEDLKPQLERLGLEIDLYGDEQVIVRGVPAILQK
ADFENLIPELLNDLDPNDEAQGLLQKRDELLAGMACHGAVRAHRQLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLS
QLDKLFARGE

Sequences:

>Translated_650_residues
MTDEKLTQRRIHTLDAALANQIAAGEVIERPSSVVKELLENSIDAGATELIVRIAQGGSTLIEIIDNGHGIHPDDLPLAV
MRHATSKIKTAEDLHAIVSLGFRGEALASIAAVSRLTLTSSQDESGIGHQVEVNGTAFDHQQVQAVAAQKGTHIRVQDLF
FNVPARRKFLKKPTTEFGHIEEIVRRLALTHFDIRFVLEHNDNIRINLPIADSGELRFQRVQQLLGQQFVQNAYWIDAES
INMRLSGWLGHPSDARAQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQHSSYLLFLEVDPENIDVNVHPTKHEIRF
LNQREVHEFVRHYAKETLAQFQTASADLAQAMKADDTQASFVQSQPKYQEQFTLHRTDQAVDTTLDKSSSYQPSTELLTD
FNNSRPQAVHYAEQTPKYNGSAQLNNALKTYLAPLRDQPTNFSVDENIESVAKVDEFPLGIAIAQLHGIYILAQNTEGLI
IVDMHAAHERILLQQMKNAWDKPEFWTSQQLLIPKVISISRMQAIRVEDLKPQLERLGLEIDLYGDEQVIVRGVPAILQK
ADFENLIPELLNDLDPNDEAQGLLQKRDELLAGMACHGAVRAHRQLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLS
QLDKLFARGE
>Mature_649_residues
TDEKLTQRRIHTLDAALANQIAAGEVIERPSSVVKELLENSIDAGATELIVRIAQGGSTLIEIIDNGHGIHPDDLPLAVM
RHATSKIKTAEDLHAIVSLGFRGEALASIAAVSRLTLTSSQDESGIGHQVEVNGTAFDHQQVQAVAAQKGTHIRVQDLFF
NVPARRKFLKKPTTEFGHIEEIVRRLALTHFDIRFVLEHNDNIRINLPIADSGELRFQRVQQLLGQQFVQNAYWIDAESI
NMRLSGWLGHPSDARAQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQHSSYLLFLEVDPENIDVNVHPTKHEIRFL
NQREVHEFVRHYAKETLAQFQTASADLAQAMKADDTQASFVQSQPKYQEQFTLHRTDQAVDTTLDKSSSYQPSTELLTDF
NNSRPQAVHYAEQTPKYNGSAQLNNALKTYLAPLRDQPTNFSVDENIESVAKVDEFPLGIAIAQLHGIYILAQNTEGLII
VDMHAAHERILLQQMKNAWDKPEFWTSQQLLIPKVISISRMQAIRVEDLKPQLERLGLEIDLYGDEQVIVRGVPAILQKA
DFENLIPELLNDLDPNDEAQGLLQKRDELLAGMACHGAVRAHRQLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLSQ
LDKLFARGE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=334, Percent_Identity=33.5329341317365, Blast_Score=202, Evalue=8e-52,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=29.8780487804878, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=29.8780487804878, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI4505913, Length=337, Percent_Identity=27.5964391691395, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI310128478, Length=337, Percent_Identity=27.5964391691395, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI189458896, Length=326, Percent_Identity=28.5276073619632, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=27.9166666666667, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI91992160, Length=263, Percent_Identity=29.6577946768061, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI91992162, Length=263, Percent_Identity=29.6577946768061, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI310128480, Length=288, Percent_Identity=25.6944444444444, Blast_Score=93, Evalue=8e-19,
Organism=Escherichia coli, GI1790612, Length=568, Percent_Identity=37.6760563380282, Blast_Score=322, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71991825, Length=345, Percent_Identity=32.463768115942, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=361, Percent_Identity=27.7008310249307, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=355, Percent_Identity=32.6760563380282, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=375, Percent_Identity=26.9333333333333, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=337, Percent_Identity=24.6290801186944, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136968, Length=335, Percent_Identity=34.0298507462687, Blast_Score=186, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17136970, Length=364, Percent_Identity=25, Blast_Score=100, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73147; Mature: 73015

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEKLTQRRIHTLDAALANQIAAGEVIERPSSVVKELLENSIDAGATELIVRIAQGGST
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCE
LIEIIDNGHGIHPDDLPLAVMRHATSKIKTAEDLHAIVSLGFRGEALASIAAVSRLTLTS
EEHEECCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEC
SQDESGIGHQVEVNGTAFDHQQVQAVAAQKGTHIRVQDLFFNVPARRKFLKKPTTEFGHI
CCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHCCCCCHHHH
EEIVRRLALTHFDIRFVLEHNDNIRINLPIADSGELRFQRVQQLLGQQFVQNAYWIDAES
HHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEECCC
INMRLSGWLGHPSDARAQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQHSSYLLFL
CCEEEEECCCCCCCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEE
EVDPENIDVNVHPTKHEIRFLNQREVHEFVRHYAKETLAQFQTASADLAQAMKADDTQAS
EECCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FVQSQPKYQEQFTLHRTDQAVDTTLDKSSSYQPSTELLTDFNNSRPQAVHYAEQTPKYNG
HHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEEHHHCCCCCC
SAQLNNALKTYLAPLRDQPTNFSVDENIESVAKVDEFPLGIAIAQLHGIYILAQNTEGLI
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCCCEE
IVDMHAAHERILLQQMKNAWDKPEFWTSQQLLIPKVISISRMQAIRVEDLKPQLERLGLE
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IDLYGDEQVIVRGVPAILQKADFENLIPELLNDLDPNDEAQGLLQKRDELLAGMACHGAV
EEEECCCEEEECCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAHRQLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLSQLDKLFARGE
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHCCC
>Mature Secondary Structure 
TDEKLTQRRIHTLDAALANQIAAGEVIERPSSVVKELLENSIDAGATELIVRIAQGGST
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCE
LIEIIDNGHGIHPDDLPLAVMRHATSKIKTAEDLHAIVSLGFRGEALASIAAVSRLTLTS
EEHEECCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEC
SQDESGIGHQVEVNGTAFDHQQVQAVAAQKGTHIRVQDLFFNVPARRKFLKKPTTEFGHI
CCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHCCCCCHHHH
EEIVRRLALTHFDIRFVLEHNDNIRINLPIADSGELRFQRVQQLLGQQFVQNAYWIDAES
HHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEECCC
INMRLSGWLGHPSDARAQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQHSSYLLFL
CCEEEEECCCCCCCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEE
EVDPENIDVNVHPTKHEIRFLNQREVHEFVRHYAKETLAQFQTASADLAQAMKADDTQAS
EECCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FVQSQPKYQEQFTLHRTDQAVDTTLDKSSSYQPSTELLTDFNNSRPQAVHYAEQTPKYNG
HHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEEHHHCCCCCC
SAQLNNALKTYLAPLRDQPTNFSVDENIESVAKVDEFPLGIAIAQLHGIYILAQNTEGLI
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCCCEE
IVDMHAAHERILLQQMKNAWDKPEFWTSQQLLIPKVISISRMQAIRVEDLKPQLERLGLE
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IDLYGDEQVIVRGVPAILQKADFENLIPELLNDLDPNDEAQGLLQKRDELLAGMACHGAV
EEEECCCEEEECCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAHRQLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLSQLDKLFARGE
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA