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The map label for this gene is fumC [H]

Identifier: 213158386

GI number: 213158386

Start: 2416976

End: 2418370

Strand: Reverse

Name: fumC [H]

Synonym: AB57_2334

Alternate gene names: 213158386

Gene position: 2418370-2416976 (Counterclockwise)

Preceding gene: 213158387

Following gene: 213158384

Centisome position: 59.71

GC content: 42.8

Gene sequence:

>1395_bases
ATGCAAACACGAATTGAACATGACACAATGGGTGAGATTGAAGTTCCGAATGAAGCGCTGTGGGGTGCACAAACCCAACG
TAGCTTACAGAACTTTAAAATCGGGCAGGAGCGTTTACCCCGTGCCATGATTCGAGCGATGGGCTTGGTAAAAAAAGCAG
CGGCAATAACCAATGCAGAGTTAGGCCAGTTACCACAAGATTTGAGCCAATATATTGTGGGGGCAGCTGAGGAAGTGATT
GCAGGGAAATGGGACTCTCAGTTTCCACTCGTGGTTTGGCAAACAGGTTCAGGTACGCAAAGTAACATGAACTGTAATGA
AGTGATTGCAAATATTGCAAATCAAAAGCTAGGCCAAGCGCTCGGAGCACAAAAGCCGGTACATCCGAACGATCATGTTA
ACCGCGCACAATCTACTAATGACTCATTCCCAACGGCTATTCATGTTGCGGCAAGTTTGCAAATTAATGAATTACTGATT
CCAGCCGTAGAACAGCTTAAAGCGACTTTGCAAAAAAAGTCGGACGAATTTCAAGATATTGTTAAAATTGGCCGTACCCA
TTTACAAGACGCGACGCCACTGACACTTGGCCAAGAGTTTAGCGGTTATGTTTCTCAGCTCGAGCATGGTTTAGTACGTT
TACAGCAAGCTTTAAGTGGTCTGTATGAGTTACCATTAGGTGGCACAGCGGTAGGAACTGGGTTAAATGCTCATCCTGAC
TATGCTGTTAAGGCAGCAGCTCAGCTTGCAGCTTTAACGGGTTTGCCATTTGTTACCGCTCCTAATAAATTTGAAGCACT
TGCAGGACGTGATGCTGCTGTTTTTGCATCAGGCGCATTAAAAACTCTAGCGGTAAGCTTGAACAAGATTGCCAATGATA
TTCGTTGGTTAGCAAGTGGCCCACGTTGTGGCTTCGGCGAAATCCGTATTCCTGAAAATGAACCTGGTTCAAGTATTATG
CCAGGTAAAGTGAACCCGACTCAAAGTGAAGCAATGACCATGGTTGTTGCTCAAGTGCTTGGCAACGATACCACTATTAA
TGTCGCTGGTGCTTCGGGTAATTTCGAGCTCAATGTATTTATGCCAGTGATTGCTTATAACTTACTGCAATCTATTCAGT
TGCTTGGTGATGCATGTAATAGTTTTAATGATCACTGTGCAGTAGGGATTGAGCCGAATCGTGAGAAAATTGATCATTTC
TTGCATAATTCTCTTATGTTAGTTACGGCATTAAATCCGGTTATTGGTTATGAAAACTCTGCAAAAGTGGCGAAAACTGC
TTATAAAGAGAATAAAACTTTAAAACAAGTTGCTGTAGAGCTAGGACTTGTTACAGCAGAGCAATTTGATGAAGTGGTTA
AACCTGAAAAAATGGTTTCGCCAAATAGTAAATAA

Upstream 100 bases:

>100_bases
TTTACAATAATGGAATGCTTGAGTACGATACTAAAATTAACTAGCCAAAGCATAAATTGCTTCAGCCCGTGAGTTCTTTA
ACCAGATAACCGAGGTTTCT

Downstream 100 bases:

>100_bases
GCGATTTAACAATAGCCATCAGCAGTATATTTTGTAGCGATTTTACAAACTCTTAACTACTGATGGCTATTATGCTTAAG
ATGTTAAAGTTAGGGCCATT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MQTRIEHDTMGEIEVPNEALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAELGQLPQDLSQYIVGAAEEVI
AGKWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGQALGAQKPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLI
PAVEQLKATLQKKSDEFQDIVKIGRTHLQDATPLTLGQEFSGYVSQLEHGLVRLQQALSGLYELPLGGTAVGTGLNAHPD
YAVKAAAQLAALTGLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASGPRCGFGEIRIPENEPGSSIM
PGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVFMPVIAYNLLQSIQLLGDACNSFNDHCAVGIEPNREKIDHF
LHNSLMLVTALNPVIGYENSAKVAKTAYKENKTLKQVAVELGLVTAEQFDEVVKPEKMVSPNSK

Sequences:

>Translated_464_residues
MQTRIEHDTMGEIEVPNEALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAELGQLPQDLSQYIVGAAEEVI
AGKWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGQALGAQKPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLI
PAVEQLKATLQKKSDEFQDIVKIGRTHLQDATPLTLGQEFSGYVSQLEHGLVRLQQALSGLYELPLGGTAVGTGLNAHPD
YAVKAAAQLAALTGLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASGPRCGFGEIRIPENEPGSSIM
PGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVFMPVIAYNLLQSIQLLGDACNSFNDHCAVGIEPNREKIDHF
LHNSLMLVTALNPVIGYENSAKVAKTAYKENKTLKQVAVELGLVTAEQFDEVVKPEKMVSPNSK
>Mature_464_residues
MQTRIEHDTMGEIEVPNEALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAELGQLPQDLSQYIVGAAEEVI
AGKWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGQALGAQKPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLI
PAVEQLKATLQKKSDEFQDIVKIGRTHLQDATPLTLGQEFSGYVSQLEHGLVRLQQALSGLYELPLGGTAVGTGLNAHPD
YAVKAAAQLAALTGLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASGPRCGFGEIRIPENEPGSSIM
PGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVFMPVIAYNLLQSIQLLGDACNSFNDHCAVGIEPNREKIDHF
LHNSLMLVTALNPVIGYENSAKVAKTAYKENKTLKQVAVELGLVTAEQFDEVVKPEKMVSPNSK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=60.2173913043478, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=48.0519480519481, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=62.0614035087719, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=42.0258620689655, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790398, Length=211, Percent_Identity=31.7535545023697, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=59.95670995671, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=60.4294478527607, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=60.4347826086956, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=58.5683297180043, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=58.5683297180043, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.7922077922078, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24662684, Length=466, Percent_Identity=58.7982832618026, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.267818574514, Blast_Score=494, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49884; Mature: 49884

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRIEHDTMGEIEVPNEALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAE
CCCCCCCCCCCCEECCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
LGQLPQDLSQYIVGAAEEVIAGKWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGQA
HHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGAQKPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLIPAVEQLKATLQKKSDEFQDI
HCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLEHGLVRLQQALSGLYELPLGGTAVGTGLNAHPD
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
YAVKAAAQLAALTGLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASG
HHHHHHHHHHHHHCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGFGEIRIPENEPGSSIMPGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEH
MPVIAYNLLQSIQLLGDACNSFNDHCAVGIEPNREKIDHFLHNSLMLVTALNPVIGYENS
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCEEEEEHHHHHHCCCCC
AKVAKTAYKENKTLKQVAVELGLVTAEQFDEVVKPEKMVSPNSK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure
MQTRIEHDTMGEIEVPNEALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAE
CCCCCCCCCCCCEECCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
LGQLPQDLSQYIVGAAEEVIAGKWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGQA
HHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGAQKPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLIPAVEQLKATLQKKSDEFQDI
HCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLEHGLVRLQQALSGLYELPLGGTAVGTGLNAHPD
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
YAVKAAAQLAALTGLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASG
HHHHHHHHHHHHHCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGFGEIRIPENEPGSSIMPGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEH
MPVIAYNLLQSIQLLGDACNSFNDHCAVGIEPNREKIDHFLHNSLMLVTALNPVIGYENS
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCEEEEEHHHHHHCCCCC
AKVAKTAYKENKTLKQVAVELGLVTAEQFDEVVKPEKMVSPNSK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]