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The map label for this gene is uppS [H]

Identifier: 213158372

GI number: 213158372

Start: 2403037

End: 2403789

Strand: Reverse

Name: uppS [H]

Synonym: AB57_2318

Alternate gene names: 213158372

Gene position: 2403789-2403037 (Counterclockwise)

Preceding gene: 213158373

Following gene: 213158371

Centisome position: 59.35

GC content: 40.5

Gene sequence:

>753_bases
ATGACCGATTCAGAAGAGTATCATCTTCCTCAGCATGTTGCCATCATCATGGATGGCAACAATCGCTTTGCAAAGAAAAA
TCAAATGCAAAAAGGCGATGGGCACAGAGAGGGTAAAAATGTTCTTGACCCTATTGTTGAACATTGTGTTAAAACTGGCG
TTCGTGCTTTAACTGTTTTTGCATTTTCGAGTGAAAATTGGAATCGACCACAATATGAAGTCGATCTGCTTATGAAACTT
CTTGAAGAAACGATTCATGAGCAAATACCTCGCATGAAGAAATTCAATATTGCTTTGCGCTTTATAGGGGATCGTTCCCG
ATTACCTTCACATTTAGTTGCCTTAATGGAAGATGCAGAGCAACAAACAGCACATCATGAGGCCATGACATTAACTATTG
CAGTAAGCTATGGTGGTATGTGGGATATTGCAAATGCAGCTAAGCAGGTTGCTCAAGCAGTTTCCCGTGGCGAAATTGAC
GCTGATCAAATAAATGTTGATTTGTTCGCAAAATATGTCAGTCTAAACGATCTGCCAGCTGTGGACTTGTTGATCCGTAC
AGGTGGCGATTTCCGTATATCTAACTTCTTATTATGGCAAGCGGCTTATGCGGAGCTGTATTTTACGGATACTTTGTGGC
CGGAATTTACAGTGGAAGAATTCGACCATGCATTGAATGTTTTTTCAGGGCGTGAACGTCGTTTCGGTAAAACATCTGAA
CAAATTCAGCAAGAGAAAATCGAGAAATTATAA

Upstream 100 bases:

>100_bases
GTGCAGGCGATGATATCCAAAAAATCACTGATAAATATGTTGCAGAAGTAGACAAACGTCTAGCAGCGAAAGAAGCAGAA
TTGATGAAGGTCTAATTTTT

Downstream 100 bases:

>100_bases
TGTTAGAGCGGATTGTTACCGCATTGGTACTTGTTGCAGTTGTTTTGGGCTGTATGTTTGCTACGCAATCACATTATCCA
ATGTTGGTACTTATGATTGT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTDSEEYHLPQHVAIIMDGNNRFAKKNQMQKGDGHREGKNVLDPIVEHCVKTGVRALTVFAFSSENWNRPQYEVDLLMKL
LEETIHEQIPRMKKFNIALRFIGDRSRLPSHLVALMEDAEQQTAHHEAMTLTIAVSYGGMWDIANAAKQVAQAVSRGEID
ADQINVDLFAKYVSLNDLPAVDLLIRTGGDFRISNFLLWQAAYAELYFTDTLWPEFTVEEFDHALNVFSGRERRFGKTSE
QIQQEKIEKL

Sequences:

>Translated_250_residues
MTDSEEYHLPQHVAIIMDGNNRFAKKNQMQKGDGHREGKNVLDPIVEHCVKTGVRALTVFAFSSENWNRPQYEVDLLMKL
LEETIHEQIPRMKKFNIALRFIGDRSRLPSHLVALMEDAEQQTAHHEAMTLTIAVSYGGMWDIANAAKQVAQAVSRGEID
ADQINVDLFAKYVSLNDLPAVDLLIRTGGDFRISNFLLWQAAYAELYFTDTLWPEFTVEEFDHALNVFSGRERRFGKTSE
QIQQEKIEKL
>Mature_249_residues
TDSEEYHLPQHVAIIMDGNNRFAKKNQMQKGDGHREGKNVLDPIVEHCVKTGVRALTVFAFSSENWNRPQYEVDLLMKLL
EETIHEQIPRMKKFNIALRFIGDRSRLPSHLVALMEDAEQQTAHHEAMTLTIAVSYGGMWDIANAAKQVAQAVSRGEIDA
DQINVDLFAKYVSLNDLPAVDLLIRTGGDFRISNFLLWQAAYAELYFTDTLWPEFTVEEFDHALNVFSGRERRFGKTSEQ
IQQEKIEKL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=37.7358490566038, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=37.7358490566038, Blast_Score=161, Evalue=6e-40,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=48.0519480519481, Blast_Score=232, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=38.4976525821596, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=37.8504672897196, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=33.1797235023041, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI18857969, Length=217, Percent_Identity=33.6405529953917, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28654; Mature: 28523

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSEEYHLPQHVAIIMDGNNRFAKKNQMQKGDGHREGKNVLDPIVEHCVKTGVRALTVF
CCCCCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEE
AFSSENWNRPQYEVDLLMKLLEETIHEQIPRMKKFNIALRFIGDRSRLPSHLVALMEDAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCHHCCHHHHHHHHHHHH
QQTAHHEAMTLTIAVSYGGMWDIANAAKQVAQAVSRGEIDADQINVDLFAKYVSLNDLPA
HHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCH
VDLLIRTGGDFRISNFLLWQAAYAELYFTDTLWPEFTVEEFDHALNVFSGRERRFGKTSE
HHEEEECCCCEEHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCHHCCCCHH
QIQQEKIEKL
HHHHHHHHCC
>Mature Secondary Structure 
TDSEEYHLPQHVAIIMDGNNRFAKKNQMQKGDGHREGKNVLDPIVEHCVKTGVRALTVF
CCCCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEE
AFSSENWNRPQYEVDLLMKLLEETIHEQIPRMKKFNIALRFIGDRSRLPSHLVALMEDAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCHHCCHHHHHHHHHHHH
QQTAHHEAMTLTIAVSYGGMWDIANAAKQVAQAVSRGEIDADQINVDLFAKYVSLNDLPA
HHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCH
VDLLIRTGGDFRISNFLLWQAAYAELYFTDTLWPEFTVEEFDHALNVFSGRERRFGKTSE
HHEEEECCCCEEHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCHHCCCCHH
QIQQEKIEKL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA