Click here to switch to the map view.

The map label for this gene is phrB [H]

Identifier: 213158208

GI number: 213158208

Start: 3023215

End: 3023625

Strand: Direct

Name: phrB [H]

Synonym: AB57_2927

Alternate gene names: 213158208

Gene position: 3023215-3023625 (Clockwise)

Preceding gene: 213158207

Following gene: 213158209

Centisome position: 74.64

GC content: 37.47

Gene sequence:

>411_bases
ATGCGACAACTTTTACAAACAGGCTGGATGCATAATCGAGTACGTATGATTACGGCCATGTTTTTATGTAAAAATCTTTT
GATTGATTGGCGCATTGGTGAACAATGGTTTATGCAACATTTAATTGATGGTGACCTCGCCGCAAATAATGGCGGTTGGC
AATGGTGTGCCTCAACAGGAACAGATGCCGTACCTTATTTTCGGATTTTCAACCCAATTGCTCAATCAAAGAAGTTTGAT
CCGGAGGGTGAATATATTCGCCAATGGATAAAAGAATTGGCTCATTTGGACAATAAAACGATTCATGAACCCTACTCAAG
CAAAAGCGATCTTGGTTTAAATTATTCAAAACCCATAGTAGATTTAAAAGAAACACGCCTTAAAGCAATTGAAACTTTCA
AGAATATTTAG

Upstream 100 bases:

>100_bases
ATTTAAAAAAGATAGTCAGAAGATTAAATGGAACCATAATCCAGAACATTTAACCGCATGGCAAACGGGTCAAACCGGTA
TTCCTATTGTTGATGCCGGG

Downstream 100 bases:

>100_bases
ATAACAATTGAGTCTGCTCTGTTTATTTTTGATGAAAAATTAATAACAAGGTTTGACTATACAGTGGCTTTAATCTACAA
ATAAACATAATAGATACCTA

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MRQLLQTGWMHNRVRMITAMFLCKNLLIDWRIGEQWFMQHLIDGDLAANNGGWQWCASTGTDAVPYFRIFNPIAQSKKFD
PEGEYIRQWIKELAHLDNKTIHEPYSSKSDLGLNYSKPIVDLKETRLKAIETFKNI

Sequences:

>Translated_136_residues
MRQLLQTGWMHNRVRMITAMFLCKNLLIDWRIGEQWFMQHLIDGDLAANNGGWQWCASTGTDAVPYFRIFNPIAQSKKFD
PEGEYIRQWIKELAHLDNKTIHEPYSSKSDLGLNYSKPIVDLKETRLKAIETFKNI
>Mature_136_residues
MRQLLQTGWMHNRVRMITAMFLCKNLLIDWRIGEQWFMQHLIDGDLAANNGGWQWCASTGTDAVPYFRIFNPIAQSKKFD
PEGEYIRQWIKELAHLDNKTIHEPYSSKSDLGLNYSKPIVDLKETRLKAIETFKNI

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536103, Length=145, Percent_Identity=31.7241379310345, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI188536100, Length=145, Percent_Identity=31.7241379310345, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI4758072, Length=145, Percent_Identity=33.1034482758621, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1786926, Length=136, Percent_Identity=62.5, Blast_Score=187, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324962, Length=135, Percent_Identity=53.3333333333333, Blast_Score=154, Evalue=4e-39,
Organism=Drosophila melanogaster, GI17137248, Length=108, Percent_Identity=40.7407407407407, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585455, Length=108, Percent_Identity=40.7407407407407, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648152, Length=148, Percent_Identity=30.4054054054054, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 15959; Mature: 15959

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQLLQTGWMHNRVRMITAMFLCKNLLIDWRIGEQWFMQHLIDGDLAANNGGWQWCASTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCC
TDAVPYFRIFNPIAQSKKFDPEGEYIRQWIKELAHLDNKTIHEPYSSKSDLGLNYSKPIV
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
DLKETRLKAIETFKNI
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQLLQTGWMHNRVRMITAMFLCKNLLIDWRIGEQWFMQHLIDGDLAANNGGWQWCASTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCC
TDAVPYFRIFNPIAQSKKFDPEGEYIRQWIKELAHLDNKTIHEPYSSKSDLGLNYSKPIV
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
DLKETRLKAIETFKNI
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6325460; 8905232; 9278503; 2200511; 7604260 [H]