Click here to switch to the map view.

The map label for this gene is hdc

Identifier: 213158096

GI number: 213158096

Start: 2886945

End: 2888096

Strand: Reverse

Name: hdc

Synonym: AB57_2808

Alternate gene names: 213158096

Gene position: 2888096-2886945 (Counterclockwise)

Preceding gene: 213158097

Following gene: 213158095

Centisome position: 71.3

GC content: 38.8

Gene sequence:

>1152_bases
ATGATTTTATCGCCTGCTGATCAAGAGAGAATAGAGACATTCTGGAATTACTGTTTAAAACATCAATACTTCAATATTGG
ATATCCTGAATCTGCAGATTTTGATTATTCAGCTTTATTCCGTTTTTTCAAATTCTCTATTAATAATTGTGGTGATTGGA
AAGACTATAGCAATTACGCATTGAATTCTTTTGACTTTGAAAAAGATGTGATGGCGTATTTTGCTGAAATTTTTCAAATT
CCCTTTGAAGAAAGCTGGGGATATGTGACCAATGGTGGTACAGAGGGTAATATGTTTGGCTGCTATCTGGCGCGTGAGCT
ATTTTCTGATTCCACATTATATTACTCAAAAGATACGCATTATTCGGTGGGAAAAATCGCCAAATTATTGCAGATGAAAT
CTTGTGTGATCGAATCATTGGATAATGGTGAAATCGACTATGATGATTTAATCCATAAAATAAAAACCAATAAAGAAAGT
CACCCCATTATTTTTGCAAATATTGGTACGACCATGACCGGTGCAATTGATGATATTGAAATGATTCAAGAGCGCTTAGC
GCAAATCGGAATCATGCGCCGAGATTATTATATTCATGCCGATGCTGCCTTAAGTGGCATGATTTTACCTTTTGTTGATC
ATCCTCAAGCGTTTTCCTTTGCTCATGGTATCGACTCAATCTGTGTGTCTGGTCATAAAATGATTGGCTCACCGATTCCG
TGTGGCATTGTTGTGGCCAAACGCCAAAATGTAGAGCGTATATCAGTAGATGTTGACTATATCTCTACACGTGATCAAAC
CATTAGCGGTTCTCGTAATGGTCATACCGTCTTGCTGATGTGGGCGGCAATACGTAGCCAAACTAATTTACAAAGACGAC
AGAGAATTCAGCATTGCCTAAAAATGGCCCAGTACGCGGTTGATCGCTTTCAGGCAGTGGGCATTCCTGCTTGGCGAAAT
CCGAATTCAATTACTGTGGTATTTCCGTGTCCTTCTGAGCACATCTGGAAAAAGCATTATCTGGCAACCTCTGGAAATAT
GGCTCATTTAATTACTACGGCACATCACCGAGATACACGTCAGATTGATAGCTTAATTGACGACGTTATTTTTGATTTAC
AAGGTGCTTCTAAACGTACAGTTGGCTTTTAG

Upstream 100 bases:

>100_bases
GCATACGACAAATCCTGGTCGCTAAATTTATACATAAAATTTATATCTTTGATAGCGACTCCTTAGACGACTTGTAATCG
TCATATTAACGGAGCAAAAA

Downstream 100 bases:

>100_bases
TCATATCAACCAAGATGATTTAGACAAATCCATATTAATTTTTACAGTCTAGAAAATGATCTAAAAATATTTTGATAGGG
TGGTTAGGAAGTTTTTGATG

Product: histidine decarboxylase

Products: NA

Alternate protein names: HDC

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYALNSFDFEKDVMAYFAEIFQI
PFEESWGYVTNGGTEGNMFGCYLARELFSDSTLYYSKDTHYSVGKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKES
HPIIFANIGTTMTGAIDDIEMIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIP
CGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCLKMAQYAVDRFQAVGIPAWRN
PNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTRQIDSLIDDVIFDLQGASKRTVGF

Sequences:

>Translated_383_residues
MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYALNSFDFEKDVMAYFAEIFQI
PFEESWGYVTNGGTEGNMFGCYLARELFSDSTLYYSKDTHYSVGKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKES
HPIIFANIGTTMTGAIDDIEMIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIP
CGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCLKMAQYAVDRFQAVGIPAWRN
PNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTRQIDSLIDDVIFDLQGASKRTVGF
>Mature_383_residues
MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYALNSFDFEKDVMAYFAEIFQI
PFEESWGYVTNGGTEGNMFGCYLARELFSDSTLYYSKDTHYSVGKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKES
HPIIFANIGTTMTGAIDDIEMIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIP
CGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCLKMAQYAVDRFQAVGIPAWRN
PNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTRQIDSLIDDVIFDLQGASKRTVGF

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCHS_ACIB3 (B7GZJ8)

Other databases:

- EMBL:   CP001172
- RefSeq:   YP_002324975.1
- ProteinModelPortal:   B7GZJ8
- GeneID:   7057775
- GenomeReviews:   CP001172_GR
- KEGG:   abb:ABBFA_001064
- HOGENOM:   HBG320100
- OMA:   EFVRRWQ
- ProtClustDB:   PRK02769
- HAMAP:   MF_00609
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR021115
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11999

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.22

Molecular weight: Translated: 43737; Mature: 43737

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
LNSFDFEKDVMAYFAEIFQIPFEESWGYVTNGGTEGNMFGCYLARELFSDSTLYYSKDTH
CCCCCCHHHHHHHHHHHHHCCCHHCCCEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCC
YSVGKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKESHPIIFANIGTTMTGAIDDIE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
MIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIP
HHHHHHHHHCCHHCCEEEEECHHHCCEEEECCCCCCHHHHHHCHHHHHHCCCHHCCCCCC
CGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCL
CCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
KMAQYAVDRFQAVGIPAWRNPNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTR
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHEECCCCEEEEEEECCCCHHH
QIDSLIDDVIFDLQGASKRTVGF
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
LNSFDFEKDVMAYFAEIFQIPFEESWGYVTNGGTEGNMFGCYLARELFSDSTLYYSKDTH
CCCCCCHHHHHHHHHHHHHCCCHHCCCEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCC
YSVGKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKESHPIIFANIGTTMTGAIDDIE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
MIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIP
HHHHHHHHHCCHHCCEEEEECHHHCCEEEECCCCCCHHHHHHCHHHHHHCCCHHCCCCCC
CGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCL
CCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
KMAQYAVDRFQAVGIPAWRNPNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTR
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHEECCCCEEEEEEECCCCHHH
QIDSLIDDVIFDLQGASKRTVGF
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA