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The map label for this gene is folE [H]

Identifier: 213158083

GI number: 213158083

Start: 2872585

End: 2873139

Strand: Direct

Name: folE [H]

Synonym: AB57_2795

Alternate gene names: 213158083

Gene position: 2872585-2873139 (Clockwise)

Preceding gene: 213158079

Following gene: 213158084

Centisome position: 70.92

GC content: 41.8

Gene sequence:

>555_bases
ATGTCAATGCAGCAATCGTACGCAAATATTCTGACTGCCGTCGGTGAAGACCTTAATCGTCCCGGCCTTAAAGATACGCC
TGTGCGTGCGGCTAAAGCTTTTTCATATTTAACTTCTGGCTATAGTAAAACTTTAGAAGAAGTCACCAATAATGCTGTTT
TCCCATCAGATAACCATGAAATGGTATTGGTGAAGAATATTGAATTTTATTCGCTCTGCGAACATCATCTTCTCCCATTC
TATGGCCGTGTTCATGTTGCCTATTTACCAGAAGGCAAAGTTCTTGGCTTATCTAAATTTGCACGTATTACCGAGATGTT
TGCTCGTCGTTTGCAAATTCAGGAAAACCTGACTCAGCAAATCGCTGAAGCTGTTGCAGAAGTCACTGATGCTCGCGGTG
TCGCTGTAGTTATCGATTCAGCACATATGTGTATGATGATGCGTGGTGTAGGTAAACAAGAATCTACCACTCGTACAGTT
TCATTTGTCGGAGATTTTAAAACCGATAAAGAAGCGCGCCGTGAATTCTTAAGTGCAGTACCAGAAAGCTACTAA

Upstream 100 bases:

>100_bases
CGGAAAAACCAAAATAAATATAGTGCGAGGATTTATGAACATCAGGTCATGTTTCTGATACAATGCCGAGCTTGTCTAAT
AGAGTAAATTTATACGTCTT

Downstream 100 bases:

>100_bases
TATAGTTTTTACTGCCTAAATAAAAGCCCGACAATGTTGGGCTTTTTTTATAGCTGAACGCGATAAACTTCGACCAATTC
TATAAAATATAACAATTAAA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSMQQSYANILTAVGEDLNRPGLKDTPVRAAKAFSYLTSGYSKTLEEVTNNAVFPSDNHEMVLVKNIEFYSLCEHHLLPF
YGRVHVAYLPEGKVLGLSKFARITEMFARRLQIQENLTQQIAEAVAEVTDARGVAVVIDSAHMCMMMRGVGKQESTTRTV
SFVGDFKTDKEARREFLSAVPESY

Sequences:

>Translated_184_residues
MSMQQSYANILTAVGEDLNRPGLKDTPVRAAKAFSYLTSGYSKTLEEVTNNAVFPSDNHEMVLVKNIEFYSLCEHHLLPF
YGRVHVAYLPEGKVLGLSKFARITEMFARRLQIQENLTQQIAEAVAEVTDARGVAVVIDSAHMCMMMRGVGKQESTTRTV
SFVGDFKTDKEARREFLSAVPESY
>Mature_183_residues
SMQQSYANILTAVGEDLNRPGLKDTPVRAAKAFSYLTSGYSKTLEEVTNNAVFPSDNHEMVLVKNIEFYSLCEHHLLPFY
GRVHVAYLPEGKVLGLSKFARITEMFARRLQIQENLTQQIAEAVAEVTDARGVAVVIDSAHMCMMMRGVGKQESTTRTVS
FVGDFKTDKEARREFLSAVPESY

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=175, Percent_Identity=50.8571428571429, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI4503949, Length=175, Percent_Identity=50.8571428571429, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI66932972, Length=139, Percent_Identity=50.3597122302158, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI66932970, Length=149, Percent_Identity=47.6510067114094, Blast_Score=160, Evalue=6e-40,
Organism=Escherichia coli, GI1788476, Length=176, Percent_Identity=39.2045454545455, Blast_Score=105, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560486, Length=179, Percent_Identity=55.3072625698324, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6321706, Length=170, Percent_Identity=54.7058823529412, Blast_Score=198, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24656782, Length=178, Percent_Identity=55.0561797752809, Blast_Score=193, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24656796, Length=179, Percent_Identity=54.7486033519553, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24656791, Length=178, Percent_Identity=55.0561797752809, Blast_Score=192, Evalue=9e-50,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20604; Mature: 20473

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMQQSYANILTAVGEDLNRPGLKDTPVRAAKAFSYLTSGYSKTLEEVTNNAVFPSDNHE
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MVLVKNIEFYSLCEHHLLPFYGRVHVAYLPEGKVLGLSKFARITEMFARRLQIQENLTQQ
EEEEECCHHHHHHHHHCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHH
IAEAVAEVTDARGVAVVIDSAHMCMMMRGVGKQESTTRTVSFVGDFKTDKEARREFLSAV
HHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
PESY
CCCC
>Mature Secondary Structure 
SMQQSYANILTAVGEDLNRPGLKDTPVRAAKAFSYLTSGYSKTLEEVTNNAVFPSDNHE
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MVLVKNIEFYSLCEHHLLPFYGRVHVAYLPEGKVLGLSKFARITEMFARRLQIQENLTQQ
EEEEECCHHHHHHHHHCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHH
IAEAVAEVTDARGVAVVIDSAHMCMMMRGVGKQESTTRTVSFVGDFKTDKEARREFLSAV
HHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
PESY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA