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The map label for this gene is yngE [H]

Identifier: 213157965

GI number: 213157965

Start: 3568944

End: 3570557

Strand: Reverse

Name: yngE [H]

Synonym: AB57_3459

Alternate gene names: 213157965

Gene position: 3570557-3568944 (Counterclockwise)

Preceding gene: 213157966

Following gene: 213157964

Centisome position: 88.15

GC content: 44.36

Gene sequence:

>1614_bases
ATGACCATTCTTCAATCCGAAATTACTGTTGGTAGTGAACAGTATCAAAAGAATAAAGAGGCACTACTTGCTCAACTGAA
TGAAGTCCGTGCAATTCAGCAAAAAAGTATTGATAAATCGTATGCTGCTAAACCGAAATTCGATAAAAAGGGCAAGATTC
TGCCGCATGAGCGTGTACGGTTATTGCTCGATGCCGATTCGCCTTTTGTCGAGCTTTGTGGCTTGGTTGGCTACAACATG
CATGATGACAAGGATGGCTCCGAAGCTGGTGGTGGTGTAATTGCTGGCATTGGTTTTGTCAGTGGTGTGCGTTGTCTGGT
CTCTGCAAGTAATAGCGCGATTAAAGGCGGGACCATGTCACCTATGGGTGTACAGAAAACTTTGCGTTTGCAAAAAATTG
CCTTAGAACAAAAACTCCCGCTGATTACGCTGACCGAAAGTGGCGGTGCTAACTTAAATTATGCAGCTGAAGTATTTACC
TATGGTGGTATGACTTTTGCCAATCAGGCACGTTTGTCTGCAGCAGGTATTCCTCAGCTTGCAGTGGTACATGGGAATGC
AACGGCAGGAGGAGCTTATCAACCAGGTCTTTCGGATTATGTCATTGTAGTACGCAAACAAACAGAGATGCTTCTTGCAG
GTCCACCTTTACTTCTGGCTGCCACGGGTGAAGTCGCCACAGTGGAGGAATTGGGTGGGGCGGAAATGCATGCGCAGGTT
GCTGGAACAGCAGAATACTTAGCAGAAAATGATGCCGATGGAATTCGGCTTGCACGTGAAATTTTTGAACACCTCAACTG
GAAAGAGCAAATCAAACCAGTTGATGTGACTTATAAAGAGCCTCGTTACGATACCGAGGAACTGTTGGGTGTTATTCCAA
GTGATCCTAAACAACCATTTGATATGAAAGAAGTGGTTGCCCGCATTATTGACGATTCAGATTTTCTAGAATTTAAGCAG
GAATATGATGATTTAACGGTATGTGGCTGGGCAAAAATTGGTGGTTTGCATATCGGTATTATTACCAATAATGGTCCGAT
TACCCCTCAAGGAGCAGTGAAAGCAGCGCAGTTTATTCACTTATGTGAACAGACTAACCGCCCGTTATTATTCTTACATA
ACACTACTGGCTTTATGGTGGGAACCGATGCCGAGCAAAATGGCATTATTAAGCATGGCTCAAAACTGATTCAAGCGGTT
GCCAATTGTACTGTACCTAAAATTTCAATCGTTGTGGCAGGGTCATATGGTGCTGGTAACTACGCAATGTGTGGTCGGAG
TTTATCGCCAGATTTTATTTTTGCTTGGCCGAACTCGCATGTTGCTGTAATGGGGGCTGCACAGGCCGGAAAGGTACTAC
GTATTGTTGCTGAAGGGAAACAAAAAGCTTCCGGGCAGGAACCGAATCCGCAAATGCTCGATTTTCTTGAGCAAAGTACG
GCCATGAAATTAGAGCAGCAATCTACCGCGCTTTTCAATACGGCCATGCTACATGATGACGGCATTATTGACCCGCGAGA
TACCCGAAAATTACTTATTTTCCTTTTAGAAACTATTTATGAAGCACAGCAACGCGATCTAAATCCGACCCGTTTTGGTG
TGTCTCGTTTTTAA

Upstream 100 bases:

>100_bases
AATGGTTTCCATCGCGCGTTTATTCCTGAAATTTTTAAAAAAGATAAGACTGCGAAAGTCGAGCAAAGCAATAATTCAGG
CTCGGAGTGAGGAATAAAAA

Downstream 100 bases:

>100_bases
TCAATCTTTACCGTAATTAAAAAAATTAATAGGAACAACACCATGAAATTTACTGCCGAACATGAAGCATTACGTCGCAC
AGCGCGTCAATTTGTTGAAA

Product: methylcrotonoyl-CoA carboxylase beta chain

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTILQSEITVGSEQYQKNKEALLAQLNEVRAIQQKSIDKSYAAKPKFDKKGKILPHERVRLLLDADSPFVELCGLVGYNM
HDDKDGSEAGGGVIAGIGFVSGVRCLVSASNSAIKGGTMSPMGVQKTLRLQKIALEQKLPLITLTESGGANLNYAAEVFT
YGGMTFANQARLSAAGIPQLAVVHGNATAGGAYQPGLSDYVIVVRKQTEMLLAGPPLLLAATGEVATVEELGGAEMHAQV
AGTAEYLAENDADGIRLAREIFEHLNWKEQIKPVDVTYKEPRYDTEELLGVIPSDPKQPFDMKEVVARIIDDSDFLEFKQ
EYDDLTVCGWAKIGGLHIGIITNNGPITPQGAVKAAQFIHLCEQTNRPLLFLHNTTGFMVGTDAEQNGIIKHGSKLIQAV
ANCTVPKISIVVAGSYGAGNYAMCGRSLSPDFIFAWPNSHVAVMGAAQAGKVLRIVAEGKQKASGQEPNPQMLDFLEQST
AMKLEQQSTALFNTAMLHDDGIIDPRDTRKLLIFLLETIYEAQQRDLNPTRFGVSRF

Sequences:

>Translated_537_residues
MTILQSEITVGSEQYQKNKEALLAQLNEVRAIQQKSIDKSYAAKPKFDKKGKILPHERVRLLLDADSPFVELCGLVGYNM
HDDKDGSEAGGGVIAGIGFVSGVRCLVSASNSAIKGGTMSPMGVQKTLRLQKIALEQKLPLITLTESGGANLNYAAEVFT
YGGMTFANQARLSAAGIPQLAVVHGNATAGGAYQPGLSDYVIVVRKQTEMLLAGPPLLLAATGEVATVEELGGAEMHAQV
AGTAEYLAENDADGIRLAREIFEHLNWKEQIKPVDVTYKEPRYDTEELLGVIPSDPKQPFDMKEVVARIIDDSDFLEFKQ
EYDDLTVCGWAKIGGLHIGIITNNGPITPQGAVKAAQFIHLCEQTNRPLLFLHNTTGFMVGTDAEQNGIIKHGSKLIQAV
ANCTVPKISIVVAGSYGAGNYAMCGRSLSPDFIFAWPNSHVAVMGAAQAGKVLRIVAEGKQKASGQEPNPQMLDFLEQST
AMKLEQQSTALFNTAMLHDDGIIDPRDTRKLLIFLLETIYEAQQRDLNPTRFGVSRF
>Mature_536_residues
TILQSEITVGSEQYQKNKEALLAQLNEVRAIQQKSIDKSYAAKPKFDKKGKILPHERVRLLLDADSPFVELCGLVGYNMH
DDKDGSEAGGGVIAGIGFVSGVRCLVSASNSAIKGGTMSPMGVQKTLRLQKIALEQKLPLITLTESGGANLNYAAEVFTY
GGMTFANQARLSAAGIPQLAVVHGNATAGGAYQPGLSDYVIVVRKQTEMLLAGPPLLLAATGEVATVEELGGAEMHAQVA
GTAEYLAENDADGIRLAREIFEHLNWKEQIKPVDVTYKEPRYDTEELLGVIPSDPKQPFDMKEVVARIIDDSDFLEFKQE
YDDLTVCGWAKIGGLHIGIITNNGPITPQGAVKAAQFIHLCEQTNRPLLFLHNTTGFMVGTDAEQNGIIKHGSKLIQAVA
NCTVPKISIVVAGSYGAGNYAMCGRSLSPDFIFAWPNSHVAVMGAAQAGKVLRIVAEGKQKASGQEPNPQMLDFLEQSTA
MKLEQQSTALFNTAMLHDDGIIDPRDTRKLLIFLLETIYEAQQRDLNPTRFGVSRF

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=40.5959031657356, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=28.9628180039139, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=28.060263653484, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI310133460, Length=145, Percent_Identity=35.8620689655172, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17552936, Length=491, Percent_Identity=45.8248472505092, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI25147359, Length=429, Percent_Identity=31.4685314685315, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI25147362, Length=429, Percent_Identity=31.4685314685315, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586065, Length=556, Percent_Identity=41.726618705036, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58131; Mature: 58000

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILQSEITVGSEQYQKNKEALLAQLNEVRAIQQKSIDKSYAAKPKFDKKGKILPHERVR
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEE
LLLDADSPFVELCGLVGYNMHDDKDGSEAGGGVIAGIGFVSGVRCLVSASNSAIKGGTMS
EEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHEEECCCCCCCCCCCC
PMGVQKTLRLQKIALEQKLPLITLTESGGANLNYAAEVFTYGGMTFANQARLSAAGIPQL
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHEEEECCEEECCCCHHHHCCCCEE
AVVHGNATAGGAYQPGLSDYVIVVRKQTEMLLAGPPLLLAATGEVATVEELGGAEMHAQV
EEEECCCCCCCCCCCCCCCEEEEEEECCCEEEECCCEEEEECCCEEEHHHCCCCCEEHHH
AGTAEYLAENDADGIRLAREIFEHLNWKEQIKPVDVTYKEPRYDTEELLGVIPSDPKQPF
HHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCCEEECCCCCCHHHHHCCCCCCCCCCC
DMKEVVARIIDDSDFLEFKQEYDDLTVCGWAKIGGLHIGIITNNGPITPQGAVKAAQFIH
CHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEECCEEEEEEECCCCCCCCHHHHHHHHHH
LCEQTNRPLLFLHNTTGFMVGTDAEQNGIIKHGSKLIQAVANCTVPKISIVVAGSYGAGN
HHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
YAMCGRSLSPDFIFAWPNSHVAVMGAAQAGKVLRIVAEGKQKASGQEPNPQMLDFLEQST
HHCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEECCHHHCCCCCCCHHHHHHHHHHH
AMKLEQQSTALFNTAMLHDDGIIDPRDTRKLLIFLLETIYEAQQRDLNPTRFGVSRF
HHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC
>Mature Secondary Structure 
TILQSEITVGSEQYQKNKEALLAQLNEVRAIQQKSIDKSYAAKPKFDKKGKILPHERVR
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEE
LLLDADSPFVELCGLVGYNMHDDKDGSEAGGGVIAGIGFVSGVRCLVSASNSAIKGGTMS
EEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHEEECCCCCCCCCCCC
PMGVQKTLRLQKIALEQKLPLITLTESGGANLNYAAEVFTYGGMTFANQARLSAAGIPQL
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHEEEECCEEECCCCHHHHCCCCEE
AVVHGNATAGGAYQPGLSDYVIVVRKQTEMLLAGPPLLLAATGEVATVEELGGAEMHAQV
EEEECCCCCCCCCCCCCCCEEEEEEECCCEEEECCCEEEEECCCEEEHHHCCCCCEEHHH
AGTAEYLAENDADGIRLAREIFEHLNWKEQIKPVDVTYKEPRYDTEELLGVIPSDPKQPF
HHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCCEEECCCCCCHHHHHCCCCCCCCCCC
DMKEVVARIIDDSDFLEFKQEYDDLTVCGWAKIGGLHIGIITNNGPITPQGAVKAAQFIH
CHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEECCEEEEEEECCCCCCCCHHHHHHHHHH
LCEQTNRPLLFLHNTTGFMVGTDAEQNGIIKHGSKLIQAVANCTVPKISIVVAGSYGAGN
HHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
YAMCGRSLSPDFIFAWPNSHVAVMGAAQAGKVLRIVAEGKQKASGQEPNPQMLDFLEQST
HHCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEECCHHHCCCCCCCHHHHHHHHHHH
AMKLEQQSTALFNTAMLHDDGIIDPRDTRKLLIFLLETIYEAQQRDLNPTRFGVSRF
HHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]