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The map label for this gene is bvgS [H]

Identifier: 213157919

GI number: 213157919

Start: 3520358

End: 3521626

Strand: Reverse

Name: bvgS [H]

Synonym: AB57_3411

Alternate gene names: 213157919

Gene position: 3521626-3520358 (Counterclockwise)

Preceding gene: 213157927

Following gene: 213157918

Centisome position: 86.94

GC content: 37.83

Gene sequence:

>1269_bases
ATGACACAGCGATTAGAACTACATCAGGTAGAGCAGTTAACAGCTTGTAAAATATCACTATTACTTGGATTAAATGCCGA
GCAGAATTATATTGAGCAATTTTTCCGGTTTAGTCTTCGCCTGTTGAAGTGTCAAAAAGCTTTGCTTACTTTTAATCAGG
AACCTTATTTTTGGCATCATTGCCCGGATGGCATGACTGCAATTTCCTTTAAACCTTCAAGACACCTAAAACAATGTTTT
GCTAAACAACAGGTGATTCATCACAATCATCCTTCTTATCAAAATTTAATCAACTATTTAAAAGAGCTAAATATTGAATG
TGGGCGTGCCTTAGCTGTCCATTTGGTGCAGCCTGACCAGACATCTATGGGATTTGCAGTTTTCTTCGATGACGATGAAA
ATTGTTTTGAAGATGATCAAATTCAGTTGCTTCTCGATTACTGTTCTAGTTTTATGCAACAAGTCGAGTTGAAGTTTAAT
TATGAAGAATTAAATGAACTCTATGAGCAGCAAGTCGCGCTGAACTCGAGTAAAACAAAGTTCTTTTCTATTATTTCGCA
TGACTTGCGGGCGCCGTTTCATGGCTTATTAGGTTTCTCCGAAGTGTTAGCTAAAGAACGTGAAACACTGGATGAGTCGA
GTATTCAAAACATTGCTGATTATTTATACGACACTTCTCAATCGACCTATAACTTACTTGAAAGTTTGCTGACATGGGCA
ATGGCCGAAGGTGGTCGCTTTGTTTATCACCCAATTAATTTTAAACTTAGACAAGTGAGCAATATTGTTTGTGATGTGCT
GCATACATTGGCTTTAAAGAAAAATATTGAATTGGTAAATGCGGTTTCCGAAGATTTAAAAATCTATGCCGATATCAATA
TGATGACTTCCGTGATCCAAAACTTGGTGTCAAATGCATTGAAATTTACCGATGTTGATGGTTCTGGAAAAGTGTTTATT
GAAGCGAAGCAGGTGGGTACAAATGTCGAAATCACTGTGCGTGATACAGGGCTTGGCATGACTGAACAGCAAATGGCAAA
TTTATTCCATCCGCGTATTACAGCAAGCTTTAAAGGCACCGCTGGGGAAAAAGGTGCGGGTTTAGGTTTGAGCTTATGTA
AGCGTTTTGTCGAGATTAATCAGGGGAAAATTAGTGTAACCTCCCAAAAAGGAGTGGGAACGTCATTTAAAGTTTTATTA
CCTTCTGCTCAAGAAGTCCCTGAACATCATGTAGAACAACAAAATACATCTGAAGCAAAATTGGTTTAA

Upstream 100 bases:

>100_bases
TAATGTACTGTGTTAAAGTTTGTAGTAGATCATAATGATTATAAGTACATTCTTCAAAAGAGCGGTTCCGACCAACAATG
ACAAAATCTGTGAGGCGGGC

Downstream 100 bases:

>100_bases
TCCCTTTTCCTACTACTACTTGAACTGCTATAACTAAAAAGAGAGTCTGAGGAAAAGAGCTTTTTTATATGAATGCGGAG
CAGTTACAAAAAACATTACG

Product: two-component system histidine kinase sensor component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTQRLELHQVEQLTACKISLLLGLNAEQNYIEQFFRFSLRLLKCQKALLTFNQEPYFWHHCPDGMTAISFKPSRHLKQCF
AKQQVIHHNHPSYQNLINYLKELNIECGRALAVHLVQPDQTSMGFAVFFDDDENCFEDDQIQLLLDYCSSFMQQVELKFN
YEELNELYEQQVALNSSKTKFFSIISHDLRAPFHGLLGFSEVLAKERETLDESSIQNIADYLYDTSQSTYNLLESLLTWA
MAEGGRFVYHPINFKLRQVSNIVCDVLHTLALKKNIELVNAVSEDLKIYADINMMTSVIQNLVSNALKFTDVDGSGKVFI
EAKQVGTNVEITVRDTGLGMTEQQMANLFHPRITASFKGTAGEKGAGLGLSLCKRFVEINQGKISVTSQKGVGTSFKVLL
PSAQEVPEHHVEQQNTSEAKLV

Sequences:

>Translated_422_residues
MTQRLELHQVEQLTACKISLLLGLNAEQNYIEQFFRFSLRLLKCQKALLTFNQEPYFWHHCPDGMTAISFKPSRHLKQCF
AKQQVIHHNHPSYQNLINYLKELNIECGRALAVHLVQPDQTSMGFAVFFDDDENCFEDDQIQLLLDYCSSFMQQVELKFN
YEELNELYEQQVALNSSKTKFFSIISHDLRAPFHGLLGFSEVLAKERETLDESSIQNIADYLYDTSQSTYNLLESLLTWA
MAEGGRFVYHPINFKLRQVSNIVCDVLHTLALKKNIELVNAVSEDLKIYADINMMTSVIQNLVSNALKFTDVDGSGKVFI
EAKQVGTNVEITVRDTGLGMTEQQMANLFHPRITASFKGTAGEKGAGLGLSLCKRFVEINQGKISVTSQKGVGTSFKVLL
PSAQEVPEHHVEQQNTSEAKLV
>Mature_421_residues
TQRLELHQVEQLTACKISLLLGLNAEQNYIEQFFRFSLRLLKCQKALLTFNQEPYFWHHCPDGMTAISFKPSRHLKQCFA
KQQVIHHNHPSYQNLINYLKELNIECGRALAVHLVQPDQTSMGFAVFFDDDENCFEDDQIQLLLDYCSSFMQQVELKFNY
EELNELYEQQVALNSSKTKFFSIISHDLRAPFHGLLGFSEVLAKERETLDESSIQNIADYLYDTSQSTYNLLESLLTWAM
AEGGRFVYHPINFKLRQVSNIVCDVLHTLALKKNIELVNAVSEDLKIYADINMMTSVIQNLVSNALKFTDVDGSGKVFIE
AKQVGTNVEITVRDTGLGMTEQQMANLFHPRITASFKGTAGEKGAGLGLSLCKRFVEINQGKISVTSQKGVGTSFKVLLP
SAQEVPEHHVEQQNTSEAKLV

Specific function: Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=26.9662921348315, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=29.5154185022026, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=28.2608695652174, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=28.6324786324786, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=24.5833333333333, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082128, Length=255, Percent_Identity=24.3137254901961, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=24.7787610619469, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=25.8928571428571, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=259, Percent_Identity=24.7104247104247, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790300, Length=255, Percent_Identity=25.0980392156863, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=23.6607142857143, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00989 PAS; PF00072 Response_reg; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47877; Mature: 47746

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRLELHQVEQLTACKISLLLGLNAEQNYIEQFFRFSLRLLKCQKALLTFNQEPYFWHH
CCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CPDGMTAISFKPSRHLKQCFAKQQVIHHNHPSYQNLINYLKELNIECGRALAVHLVQPDQ
CCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCC
TSMGFAVFFDDDENCFEDDQIQLLLDYCSSFMQQVELKFNYEELNELYEQQVALNSSKTK
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
FFSIISHDLRAPFHGLLGFSEVLAKERETLDESSIQNIADYLYDTSQSTYNLLESLLTWA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MAEGGRFVYHPINFKLRQVSNIVCDVLHTLALKKNIELVNAVSEDLKIYADINMMTSVIQ
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEECHHHHHHHHH
NLVSNALKFTDVDGSGKVFIEAKQVGTNVEITVRDTGLGMTEQQMANLFHPRITASFKGT
HHHHHHHEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCEEEECCCC
AGEKGAGLGLSLCKRFVEINQGKISVTSQKGVGTSFKVLLPSAQEVPEHHVEQQNTSEAK
CCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
LV
CC
>Mature Secondary Structure 
TQRLELHQVEQLTACKISLLLGLNAEQNYIEQFFRFSLRLLKCQKALLTFNQEPYFWHH
CCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CPDGMTAISFKPSRHLKQCFAKQQVIHHNHPSYQNLINYLKELNIECGRALAVHLVQPDQ
CCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCC
TSMGFAVFFDDDENCFEDDQIQLLLDYCSSFMQQVELKFNYEELNELYEQQVALNSSKTK
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
FFSIISHDLRAPFHGLLGFSEVLAKERETLDESSIQNIADYLYDTSQSTYNLLESLLTWA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MAEGGRFVYHPINFKLRQVSNIVCDVLHTLALKKNIELVNAVSEDLKIYADINMMTSVIQ
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEECHHHHHHHHH
NLVSNALKFTDVDGSGKVFIEAKQVGTNVEITVRDTGLGMTEQQMANLFHPRITASFKGT
HHHHHHHEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCEEEECCCC
AGEKGAGLGLSLCKRFVEINQGKISVTSQKGVGTSFKVLLPSAQEVPEHHVEQQNTSEAK
CCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1791760; 12910271 [H]