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The map label for this gene is coaBC [H]

Identifier: 213157927

GI number: 213157927

Start: 3530033

End: 3531286

Strand: Reverse

Name: coaBC [H]

Synonym: AB57_3419

Alternate gene names: 213157927

Gene position: 3531286-3530033 (Counterclockwise)

Preceding gene: 213157930

Following gene: 213157919

Centisome position: 87.18

GC content: 43.7

Gene sequence:

>1254_bases
GTGAGCTTTGATTTAAGTGTTATTCCTCATAAAAACATTGTTTTAGCTGTTACAGGTGGGATTGCTGCCTATAAGAGTGC
CATTTTGGTCCGTCGTCTTAAAGATTATGGTTTTGACGTTCGGGTTGTGATGACACACGGGGCTCAAGCATTTATTACAC
CTCTAACTTTTCAGGCTCTTTCAGGAAATCCTGTACATACCGAGCTTTTAGACCCTGAGGCTGAAGCTGGAATGGGCCAT
ATTGAATTGGCTCGCTGGGCTGATTTATTACTGGTTGCTCCAGCAAGTTGTGACACATTAGCTAAGTTTGCTAATGGTTT
GGCAGATGACTTACTCAGTACTTTATTTTTAGCAACTAAAGCGCCTGTGTGGGTCGCTCCTGCGATGAACCAGCAAATGT
GGGCTGCAAAAGCAACTCAGCGTAATTTGCAAACTCTGGTTGAAGATGGCGTGCATGTGATTATGCCAGATGCAGGGGAG
CAGGCGTGTGGTGATGTAGGCTTAGGCCGTATGCCGGAACCAGAAGAAATTGCAAGGCAAGTGGCGGGTTATTTCCATCA
AGCCCAACGTGCAATTGCTGAAAAATTTGGGTTGTTGGCAGGTAAGCGAGTTGTAATTACTGCTGGACCAACCCGTGAAG
CGATTGACCCTGTTCGTTATATCTCAAATCATAGTACTGGAAAAATGGGCTTTGCTTTAGCTGCGGCATGTTATGCAGCA
GGCGCAAAAGTTACGTTAATTGCTGGTCCCGTAAGTTTAGATACTCCAAACGGTGTTCAACGTGTAAATGTTGCTTCGGC
TCGACAAATGTTAGATGTCAGTATGGAGTCGCTTGAGACTGGCTGTGACATCTTTATTGCGACAGCGGCTGTAGCTGATT
ATCGCGTTGCCGAAGTGGCAGAGCATAAAATTAAGAAAGCAGGGGATGAGCTGAATGTTTCCCTTGTAAAAAATCCGGAT
ATTGTGGCAACGATTGCAGCTCAGGAAAAACGTCCATTTATGGTAGGCTTTGCTGCCGAAACGCAGAATGTTGAAGAATA
TGCAGCAGGGAAACTCGTTGCTAAAAAGCTAGATATGATTGCATGTAACGATGTTTCTCGTGCTGATATTGGCTTTGCTT
CTGATGAAAATGCGATGACAGTATTTTTTGCTGAAAGTTACCATATGAAAAAACGTGAGTTAGAAAAAGCATCTAAGCAA
GAAATTTCTCAACAATTGGTTGAAGCTATTTCGGATGCATTACGCCGTAAATAA

Upstream 100 bases:

>100_bases
TATTCTGCTTAAAAATTTATTTTGTTTGCCCAATCAATCTTGGGTCTGCGCGTATTTAATGCTATTGTGAGCGCCACTGC
AACAGAAAGGTATCCTGTTC

Downstream 100 bases:

>100_bases
TTTTTGAACCAAATAAAAAAAACCGCGAATAAATCGCGGTTTTTTTTATAGTCTCATTTAGACAATCAAGGGATTTCATC
TTCAAATTCAGGTTTGACCT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSFDLSVIPHKNIVLAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQALSGNPVHTELLDPEAEAGMGH
IELARWADLLLVAPASCDTLAKFANGLADDLLSTLFLATKAPVWVAPAMNQQMWAAKATQRNLQTLVEDGVHVIMPDAGE
QACGDVGLGRMPEPEEIARQVAGYFHQAQRAIAEKFGLLAGKRVVITAGPTREAIDPVRYISNHSTGKMGFALAAACYAA
GAKVTLIAGPVSLDTPNGVQRVNVASARQMLDVSMESLETGCDIFIATAAVADYRVAEVAEHKIKKAGDELNVSLVKNPD
IVATIAAQEKRPFMVGFAAETQNVEEYAAGKLVAKKLDMIACNDVSRADIGFASDENAMTVFFAESYHMKKRELEKASKQ
EISQQLVEAISDALRRK

Sequences:

>Translated_417_residues
MSFDLSVIPHKNIVLAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQALSGNPVHTELLDPEAEAGMGH
IELARWADLLLVAPASCDTLAKFANGLADDLLSTLFLATKAPVWVAPAMNQQMWAAKATQRNLQTLVEDGVHVIMPDAGE
QACGDVGLGRMPEPEEIARQVAGYFHQAQRAIAEKFGLLAGKRVVITAGPTREAIDPVRYISNHSTGKMGFALAAACYAA
GAKVTLIAGPVSLDTPNGVQRVNVASARQMLDVSMESLETGCDIFIATAAVADYRVAEVAEHKIKKAGDELNVSLVKNPD
IVATIAAQEKRPFMVGFAAETQNVEEYAAGKLVAKKLDMIACNDVSRADIGFASDENAMTVFFAESYHMKKRELEKASKQ
EISQQLVEAISDALRRK
>Mature_416_residues
SFDLSVIPHKNIVLAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQALSGNPVHTELLDPEAEAGMGHI
ELARWADLLLVAPASCDTLAKFANGLADDLLSTLFLATKAPVWVAPAMNQQMWAAKATQRNLQTLVEDGVHVIMPDAGEQ
ACGDVGLGRMPEPEEIARQVAGYFHQAQRAIAEKFGLLAGKRVVITAGPTREAIDPVRYISNHSTGKMGFALAAACYAAG
AKVTLIAGPVSLDTPNGVQRVNVASARQMLDVSMESLETGCDIFIATAAVADYRVAEVAEHKIKKAGDELNVSLVKNPDI
VATIAAQEKRPFMVGFAAETQNVEEYAAGKLVAKKLDMIACNDVSRADIGFASDENAMTVFFAESYHMKKRELEKASKQE
ISQQLVEAISDALRRK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=36.1111111111111, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI87082301, Length=410, Percent_Identity=53.1707317073171, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17560194, Length=188, Percent_Identity=33.5106382978723, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=208, Percent_Identity=30.2884615384615, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322925, Length=114, Percent_Identity=37.719298245614, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324629, Length=114, Percent_Identity=35.0877192982456, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=30.6878306878307, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44838; Mature: 44707

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLSVIPHKNIVLAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQAL
CCCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECHHEEEEC
SGNPVHTELLDPEAEAGMGHIELARWADLLLVAPASCDTLAKFANGLADDLLSTLFLATK
CCCCCEECCCCCHHHCCCCCEEHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
APVWVAPAMNQQMWAAKATQRNLQTLVEDGVHVIMPDAGEQACGDVGLGRMPEPEEIARQ
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCCHHHHHHH
VAGYFHQAQRAIAEKFGLLAGKRVVITAGPTREAIDPVRYISNHSTGKMGFALAAACYAA
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GAKVTLIAGPVSLDTPNGVQRVNVASARQMLDVSMESLETGCDIFIATAAVADYRVAEVA
CCEEEEEECCEECCCCCCCCEECHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
EHKIKKAGDELNVSLVKNPDIVATIAAQEKRPFMVGFAAETQNVEEYAAGKLVAKKLDMI
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCEE
ACNDVSRADIGFASDENAMTVFFAESYHMKKRELEKASKQEISQQLVEAISDALRRK
EECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFDLSVIPHKNIVLAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQAL
CCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECHHEEEEC
SGNPVHTELLDPEAEAGMGHIELARWADLLLVAPASCDTLAKFANGLADDLLSTLFLATK
CCCCCEECCCCCHHHCCCCCEEHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
APVWVAPAMNQQMWAAKATQRNLQTLVEDGVHVIMPDAGEQACGDVGLGRMPEPEEIARQ
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCCHHHHHHH
VAGYFHQAQRAIAEKFGLLAGKRVVITAGPTREAIDPVRYISNHSTGKMGFALAAACYAA
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GAKVTLIAGPVSLDTPNGVQRVNVASARQMLDVSMESLETGCDIFIATAAVADYRVAEVA
CCEEEEEECCEECCCCCCCCEECHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
EHKIKKAGDELNVSLVKNPDIVATIAAQEKRPFMVGFAAETQNVEEYAAGKLVAKKLDMI
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCEE
ACNDVSRADIGFASDENAMTVFFAESYHMKKRELEKASKQEISQQLVEAISDALRRK
EECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]