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The map label for this gene is fadA [H]

Identifier: 213157868

GI number: 213157868

Start: 3460818

End: 3462023

Strand: Direct

Name: fadA [H]

Synonym: AB57_3356

Alternate gene names: 213157868

Gene position: 3460818-3462023 (Clockwise)

Preceding gene: 213157867

Following gene: 213157869

Centisome position: 85.44

GC content: 43.12

Gene sequence:

>1206_bases
ATGAGCGAGGCTTATATTATTGATGCCATTCGCACCCCACGCGGAAAAGGAAAAAAAGATGGCTCTCTTTACGAAGTAAA
ACCAATTACATTACTGACGACCTTATTAAATGAATTACAGCAGCGCCATCAACTCGATACCTCTAAAGTTGACGATATTG
TTTTGGGCTGCGTAACACCAATTGGCGATCAAGGTGGTGACATTGCCAAAACAGCAGCGATTGCAGCAGGTTGGAATGAT
GATGTTGCTGGGGTACAAATCAATCGCTTTTGTGCATCAGGTTTAGAAGCAGTTAACATGGCAGCCATGAAAGTCCGCTC
TGGTTGGGAAGATTTAGTGGTTGCTGGTGGCGTTGAATCAATGTCACGCATTCCAATGGGTTCTGATGGTGGGCCGTGGG
CTTTAGATCCAGAAACAAATCTTAAGTCATCATTTGTTCCACAAGGTATTGGGGCCGACCTCATTGCAACCTTAGATGGC
TATAGCCGTGAAGATGTTGATAATTTCGCTGTGAAATCACAACAAAAAGCTGCGGCAGCTCAATCAAATGGTTATTTCGA
CCAATCAGTTGTGCCGGTAAAAGATCACGCAGGTGTGGTAATTTTAGAGAAAGATGAATTTATTAAAGGCAATACCACAC
TCGAAGGACTAACGAAGCTCAACCCAAGTTTTGAAATGATGGGCCAAATGGGCTTTGATGCAGTCGCTTTACAAAAATAT
CCAGAAGCACAAAAAATAAATCATGTTCATCACGCAGGTAACTCATCAGGTATTGTCGATGGAGCAGCTGTAGTTTTATT
AGCTTCTGAAAAAGCTGTCAAAGAACAAAATTTAAAACCACGCGCTAAAGTTTTGGCGACTGCACTGGTTGGTACCGACC
CAACCATCATGCTGACTGGTCCTGCCCCTGCTGCACGCAAAGCCTTGGAAAAAGCTGGTTTAACAATTGATGATATTGAC
CTATTTGAAGTTAACGAAGCATTTGCAGCTGTCGTGATGCGTTTTATAAATGAACTTAATGTACCTGCTGAAAAAGTCAA
CGTAAATGGCGGTGCGATTGCTTTAGGTCATCCCTTAGGGGCAACCGGTGCCATGATTTTGGGTACATTACTTGATGAGC
TTGAACGTCAAAATAAAAAACGCGGTTTAGCAACGCTCTGTGTCGGCGGTGGTATGGGTATTGCCACCATTATTGAACGT
GTATAA

Upstream 100 bases:

>100_bases
AAATCATCACCTGACTGGTGCGCTTATCGTCATTGCGTTGCCTTTTAAAACCAGTACACTCAAAACACAACAAAGTTTAA
GTAATAAAAAAGGAACTGTT

Downstream 100 bases:

>100_bases
AAATTTAGGGATATATAAAGATGAGTGCAATTCAATACGAAAAAAATGCCGACAATATTGTCATTTTAACGCTTGACTCA
ACTGGTCAGTCTGCAAATAC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTSKVDDIVLGCVTPIGDQGGDIAKTAAIAAGWND
DVAGVQINRFCASGLEAVNMAAMKVRSGWEDLVVAGGVESMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDG
YSREDVDNFAVKSQQKAAAAQSNGYFDQSVVPVKDHAGVVILEKDEFIKGNTTLEGLTKLNPSFEMMGQMGFDAVALQKY
PEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQNLKPRAKVLATALVGTDPTIMLTGPAPAARKALEKAGLTIDDID
LFEVNEAFAAVVMRFINELNVPAEKVNVNGGAIALGHPLGATGAMILGTLLDELERQNKKRGLATLCVGGGMGIATIIER
V

Sequences:

>Translated_401_residues
MSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTSKVDDIVLGCVTPIGDQGGDIAKTAAIAAGWND
DVAGVQINRFCASGLEAVNMAAMKVRSGWEDLVVAGGVESMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDG
YSREDVDNFAVKSQQKAAAAQSNGYFDQSVVPVKDHAGVVILEKDEFIKGNTTLEGLTKLNPSFEMMGQMGFDAVALQKY
PEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQNLKPRAKVLATALVGTDPTIMLTGPAPAARKALEKAGLTIDDID
LFEVNEAFAAVVMRFINELNVPAEKVNVNGGAIALGHPLGATGAMILGTLLDELERQNKKRGLATLCVGGGMGIATIIER
V
>Mature_400_residues
SEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTSKVDDIVLGCVTPIGDQGGDIAKTAAIAAGWNDD
VAGVQINRFCASGLEAVNMAAMKVRSGWEDLVVAGGVESMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDGY
SREDVDNFAVKSQQKAAAAQSNGYFDQSVVPVKDHAGVVILEKDEFIKGNTTLEGLTKLNPSFEMMGQMGFDAVALQKYP
EAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQNLKPRAKVLATALVGTDPTIMLTGPAPAARKALEKAGLTIDDIDL
FEVNEAFAAVVMRFINELNVPAEKVNVNGGAIALGHPLGATGAMILGTLLDELERQNKKRGLATLCVGGGMGIATIIERV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=408, Percent_Identity=37.0098039215686, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=38.659793814433, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI167614485, Length=419, Percent_Identity=34.6062052505967, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=31.0843373493976, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4504327, Length=448, Percent_Identity=29.6875, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI194353979, Length=114, Percent_Identity=47.3684210526316, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=41.8439716312057, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=39.9509803921569, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI87082165, Length=414, Percent_Identity=36.7149758454106, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788554, Length=417, Percent_Identity=38.3693045563549, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788683, Length=439, Percent_Identity=27.5626423690205, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI133906874, Length=371, Percent_Identity=38.544474393531, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI25147385, Length=412, Percent_Identity=33.0097087378641, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17535921, Length=411, Percent_Identity=30.4136253041363, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=403, Percent_Identity=29.2803970223325, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17551802, Length=446, Percent_Identity=26.457399103139, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=36.318407960199, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6325229, Length=416, Percent_Identity=33.8942307692308, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=38.7951807228916, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17648125, Length=415, Percent_Identity=35.6626506024096, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24640423, Length=421, Percent_Identity=31.353919239905, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=29.6380090497738, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42282; Mature: 42151

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTSKVDDIVLGCVTP
CCCCEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHHHHEEHHHCCC
IGDQGGDIAKTAAIAAGWNDDVAGVQINRFCASGLEAVNMAAMKVRSGWEDLVVAGGVES
CCCCCCCHHHHHHEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCHHH
MSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDGYSREDVDNFAVKSQQKAAAA
HHCCCCCCCCCCEEECCCCCCCHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QSNGYFDQSVVPVKDHAGVVILEKDEFIKGNTTLEGLTKLNPSFEMMGQMGFDAVALQKY
HCCCCCCCCEEEECCCCCEEEEECCCEECCCCCHHHHHHCCCCHHHHHHCCCCHHHHHHC
PEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQNLKPRAKVLATALVGTDPTIMLTG
CCHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCEEEEEC
PAPAARKALEKAGLTIDDIDLFEVNEAFAAVVMRFINELNVPAEKVNVNGGAIALGHPLG
CCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCEEEECCCCC
ATGAMILGTLLDELERQNKKRGLATLCVGGGMGIATIIERV
CHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTSKVDDIVLGCVTP
CCCEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHHHHEEHHHCCC
IGDQGGDIAKTAAIAAGWNDDVAGVQINRFCASGLEAVNMAAMKVRSGWEDLVVAGGVES
CCCCCCCHHHHHHEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCHHH
MSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDGYSREDVDNFAVKSQQKAAAA
HHCCCCCCCCCCEEECCCCCCCHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QSNGYFDQSVVPVKDHAGVVILEKDEFIKGNTTLEGLTKLNPSFEMMGQMGFDAVALQKY
HCCCCCCCCEEEECCCCCEEEEECCCEECCCCCHHHHHHCCCCHHHHHHCCCCHHHHHHC
PEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQNLKPRAKVLATALVGTDPTIMLTG
CCHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCEEEEEC
PAPAARKALEKAGLTIDDIDLFEVNEAFAAVVMRFINELNVPAEKVNVNGGAIALGHPLG
CCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCEEEECCCCC
ATGAMILGTLLDELERQNKKRGLATLCVGGGMGIATIIERV
CHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]