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The map label for this gene is fadJ [H]

Identifier: 213157869

GI number: 213157869

Start: 3462044

End: 3464179

Strand: Direct

Name: fadJ [H]

Synonym: AB57_3357

Alternate gene names: 213157869

Gene position: 3462044-3464179 (Clockwise)

Preceding gene: 213157868

Following gene: 213157870

Centisome position: 85.47

GC content: 42.09

Gene sequence:

>2136_bases
ATGAGTGCAATTCAATACGAAAAAAATGCCGACAATATTGTCATTTTAACGCTTGACTCAACTGGTCAGTCTGCAAATAC
CATGAATGCAGAATTTCGTGACTCGCTTGATGAGGTCACCCAGAAACTTAAAGCAGTAACAGAACTTTCAGGTGTTATTT
TTCGCTCAGCAAAAAAAACTTTCTTTGCTGGTGGTGATTTAGATGAACTGATTCAAGTTCAACCTGAGCATGCAACTGAC
TTTTTCAATATGGTTGAGAAGTTAAAAGGTCATCTAAGAACGATTGAAACACTAGGAGTTCCAGTTGTTGCAGCATTAAA
TGGCACGGCACTGGGCGGAGGATGGGAAATCGCATTAAGTTGCCATCACCGTATTGCAATCAATGACCCGAAAAGCAAAT
TTGGCCTACCAGAAGTTACCTTAGGTTTACTACCGGGCGGCGGTGGTATTGTACGTATGGTCCGTCTGCTTGGTCTTCAA
AATGCATTTCCATTTTTAATGGAAGGTAAGCAGTTCGGTGTCGATAAAGCAAAATCTTTAGGCTTAATTCATGACACAGC
TGAAAATGAACAAGAACTTTTAGATAAAGCGATTGCTTGGATCAAAGCCAATCCAAAATCTCAACAGCCTTTTGATGTGA
AGGGTTATAAAATTCCGGGTGGCGATCCAAAAACTCCGGCAGTTGCACAAGTTCTTGCCATTGCGCCAGCCATGTTAAAA
GACAAAACCAAGGGCTGCTATCCTGCTCCTGAAGCGATTATGGCTGCCGCAGTTGAAGGTGCTCAAGTTGATGTCGATAC
CGCCTTGCGCATCGAGTCTCGCTACTTTACTCAACTAGCAACAGGCCAAATTTCTAAAAATATGATTGGCACTTTCTGGC
ATGGTCTAAATGCAATTAAGTCGGGTGCTAGCCGTCCTGCCGATATTGCAAAATGGCAAGCCACTAAAGTGGGCGTGTTG
GGTGCGGGCATGATGGGTGCCGGTATTGCCTACGCCACTGCAATTAAAGGCATTCCTGTTATCCTTAAAGATGTATCTGT
TGAAAATGCTGAAAAAGGCAAAGCTTATTCTCAGAAATTGCTAGATAAACGTGTTTCACAAGGCCGCATGACGGCAGAAA
AACGTGATCAGATTTTATCGCTCATTACGGCTACAGCTTCTGCTGAAGACTTACAAGGTTGTGACCTGATTATTGAAGCC
GTATTTGAAAACCAAGAACTTAAAGCGAAAGTCACTCAAGAAGCTGAACAATACTTAGCGCCTAATGGTGTAATGGCATC
AAATACATCAACTCTACCGATTACAGGTTTAGCGCAAGCAAGCAAGAATGATAAAGCATTTATTGGCCTGCATTTCTTTA
GCCCTGTCGACAAAATGCAATTGGTTGAGATTATTAAAGGTAAAAACACCTCCGCAGAGACACTTGCCAAAGCTTACGAC
TTTGTACAACAAATTGGAAAAACACCGATTGTTGTTAATGATAGCCGTGGTTTCTTTACCAGTCGTGTGTTTGGTACTTT
TATTCAAGAAGGTATGCGCTTACTTGCAGAAGGCGTCCATCCAGCGCGTATTGAAATGGCAGCACTGAAAGCTGGCATGC
CGGTGGGACCACTTGCGATTCAAGATGAAGTGTCTTTAACTTTAACGGAGCATGTTGCAAGTGAAACACGTAAAGCGCTA
CAAGCCGAAGGCAAAGAGCTACCGAAAACACCAGTAGATGAAGTGATTCATACCATGATTCATGAATTAAACCGTAAAGG
TAAAGCTGCTGGCGCAGGTTTCTATGACTATCCTGAAAATGGTAAAAAACACTTATGGGAAGGCTTAAACCGTTGGCAAA
AAGATCATGATATTTCTGAGCAAGATATGATTGACCGTATTTTGTTTGTACAAGCCTTAGATACCTTACGTTGTTATGAA
GAAGGGGTATTAGAGTCAGTGATTGATGCCAATGTCGGTTCTATTTTTGGAATTGGTTATGCTCCGTGGACGGGAGGAGC
AATTCAATTCTTAAATCAATATGGGATTGATAAAGCACAAAAACGTGCCGAAGAGTTGGCTGCCAAATATGGTGAGCGCT
TCACGCCCCCAACGTTACTAAAAACTAAAGCTGAGCAGAAGCAAAATATTCAATAA

Upstream 100 bases:

>100_bases
GTCAAAATAAAAAACGCGGTTTAGCAACGCTCTGTGTCGGCGGTGGTATGGGTATTGCCACCATTATTGAACGTGTATAA
AAATTTAGGGATATATAAAG

Downstream 100 bases:

>100_bases
GTTAGAGCTCTTGAATATTTAAGAATTGCATAAACCTTACCCATATAAATATATTTTATTTATATGGGTTTTTCTTTATG
TCCTTTAAGATTTCAGCCTT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MSAIQYEKNADNIVILTLDSTGQSANTMNAEFRDSLDEVTQKLKAVTELSGVIFRSAKKTFFAGGDLDELIQVQPEHATD
FFNMVEKLKGHLRTIETLGVPVVAALNGTALGGGWEIALSCHHRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQ
NAFPFLMEGKQFGVDKAKSLGLIHDTAENEQELLDKAIAWIKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAMLK
DKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLATGQISKNMIGTFWHGLNAIKSGASRPADIAKWQATKVGVL
GAGMMGAGIAYATAIKGIPVILKDVSVENAEKGKAYSQKLLDKRVSQGRMTAEKRDQILSLITATASAEDLQGCDLIIEA
VFENQELKAKVTQEAEQYLAPNGVMASNTSTLPITGLAQASKNDKAFIGLHFFSPVDKMQLVEIIKGKNTSAETLAKAYD
FVQQIGKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPARIEMAALKAGMPVGPLAIQDEVSLTLTEHVASETRKAL
QAEGKELPKTPVDEVIHTMIHELNRKGKAAGAGFYDYPENGKKHLWEGLNRWQKDHDISEQDMIDRILFVQALDTLRCYE
EGVLESVIDANVGSIFGIGYAPWTGGAIQFLNQYGIDKAQKRAEELAAKYGERFTPPTLLKTKAEQKQNIQ

Sequences:

>Translated_711_residues
MSAIQYEKNADNIVILTLDSTGQSANTMNAEFRDSLDEVTQKLKAVTELSGVIFRSAKKTFFAGGDLDELIQVQPEHATD
FFNMVEKLKGHLRTIETLGVPVVAALNGTALGGGWEIALSCHHRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQ
NAFPFLMEGKQFGVDKAKSLGLIHDTAENEQELLDKAIAWIKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAMLK
DKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLATGQISKNMIGTFWHGLNAIKSGASRPADIAKWQATKVGVL
GAGMMGAGIAYATAIKGIPVILKDVSVENAEKGKAYSQKLLDKRVSQGRMTAEKRDQILSLITATASAEDLQGCDLIIEA
VFENQELKAKVTQEAEQYLAPNGVMASNTSTLPITGLAQASKNDKAFIGLHFFSPVDKMQLVEIIKGKNTSAETLAKAYD
FVQQIGKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPARIEMAALKAGMPVGPLAIQDEVSLTLTEHVASETRKAL
QAEGKELPKTPVDEVIHTMIHELNRKGKAAGAGFYDYPENGKKHLWEGLNRWQKDHDISEQDMIDRILFVQALDTLRCYE
EGVLESVIDANVGSIFGIGYAPWTGGAIQFLNQYGIDKAQKRAEELAAKYGERFTPPTLLKTKAEQKQNIQ
>Mature_710_residues
SAIQYEKNADNIVILTLDSTGQSANTMNAEFRDSLDEVTQKLKAVTELSGVIFRSAKKTFFAGGDLDELIQVQPEHATDF
FNMVEKLKGHLRTIETLGVPVVAALNGTALGGGWEIALSCHHRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQN
AFPFLMEGKQFGVDKAKSLGLIHDTAENEQELLDKAIAWIKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAMLKD
KTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLATGQISKNMIGTFWHGLNAIKSGASRPADIAKWQATKVGVLG
AGMMGAGIAYATAIKGIPVILKDVSVENAEKGKAYSQKLLDKRVSQGRMTAEKRDQILSLITATASAEDLQGCDLIIEAV
FENQELKAKVTQEAEQYLAPNGVMASNTSTLPITGLAQASKNDKAFIGLHFFSPVDKMQLVEIIKGKNTSAETLAKAYDF
VQQIGKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPARIEMAALKAGMPVGPLAIQDEVSLTLTEHVASETRKALQ
AEGKELPKTPVDEVIHTMIHELNRKGKAAGAGFYDYPENGKKHLWEGLNRWQKDHDISEQDMIDRILFVQALDTLRCYEE
GVLESVIDANVGSIFGIGYAPWTGGAIQFLNQYGIDKAQKRAEELAAKYGERFTPPTLLKTKAEQKQNIQ

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=724, Percent_Identity=32.1823204419889, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI68989263, Length=601, Percent_Identity=29.2845257903494, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI261878539, Length=592, Percent_Identity=28.7162162162162, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=33.448275862069, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=32.0261437908497, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI194097323, Length=176, Percent_Identity=30.1136363636364, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI157694516, Length=203, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI213417737, Length=203, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI4502327, Length=189, Percent_Identity=31.7460317460317, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115430219, Length=217, Percent_Identity=27.6497695852535, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788682, Length=703, Percent_Identity=35.2773826458037, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1790281, Length=718, Percent_Identity=31.7548746518106, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=32.5088339222615, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1787659, Length=176, Percent_Identity=30.1136363636364, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI221142681, Length=191, Percent_Identity=30.3664921465969, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=740, Percent_Identity=32.1621621621622, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17508951, Length=743, Percent_Identity=34.7240915208614, Blast_Score=335, Evalue=6e-92,
Organism=Caenorhabditis elegans, GI17508953, Length=739, Percent_Identity=34.3707713125846, Blast_Score=334, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25144276, Length=631, Percent_Identity=35.6576862123613, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71985923, Length=386, Percent_Identity=26.6839378238342, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=380, Percent_Identity=25.5263157894737, Blast_Score=152, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17549919, Length=307, Percent_Identity=28.9902280130293, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=298, Percent_Identity=30.2013422818792, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17563036, Length=312, Percent_Identity=27.8846153846154, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=270, Percent_Identity=27.4074074074074, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=179, Percent_Identity=30.1675977653631, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=172, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921000, Length=735, Percent_Identity=32.108843537415, Blast_Score=322, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24583077, Length=735, Percent_Identity=32.108843537415, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24583079, Length=735, Percent_Identity=32.108843537415, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24653139, Length=169, Percent_Identity=37.2781065088757, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129971, Length=193, Percent_Identity=29.0155440414508, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653477, Length=193, Percent_Identity=29.0155440414508, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45549573, Length=210, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583165, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 77161; Mature: 77030

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIQYEKNADNIVILTLDSTGQSANTMNAEFRDSLDEVTQKLKAVTELSGVIFRSAKKT
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFAGGDLDELIQVQPEHATDFFNMVEKLKGHLRTIETLGVPVVAALNGTALGGGWEIALS
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCEEEEEE
CHHRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDKAKSL
ECCEEEECCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHC
GLIHDTAENEQELLDKAIAWIKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAMLK
CCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHH
DKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLATGQISKNMIGTFWHGLNAIK
HCCCCCCCCHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGASRPADIAKWQATKVGVLGAGMMGAGIAYATAIKGIPVILKDVSVENAEKGKAYSQKL
CCCCCCCHHHHHHHHEECEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHH
LDKRVSQGRMTAEKRDQILSLITATASAEDLQGCDLIIEAVFENQELKAKVTQEAEQYLA
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PNGVMASNTSTLPITGLAQASKNDKAFIGLHFFSPVDKMQLVEIIKGKNTSAETLAKAYD
CCCEEECCCCCCCEEHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHH
FVQQIGKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPARIEMAALKAGMPVGPLAI
HHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE
QDEVSLTLTEHVASETRKALQAEGKELPKTPVDEVIHTMIHELNRKGKAAGAGFYDYPEN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GKKHLWEGLNRWQKDHDISEQDMIDRILFVQALDTLRCYEEGVLESVIDANVGSIFGIGY
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
APWTGGAIQFLNQYGIDKAQKRAEELAAKYGERFTPPTLLKTKAEQKQNIQ
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAIQYEKNADNIVILTLDSTGQSANTMNAEFRDSLDEVTQKLKAVTELSGVIFRSAKKT
CCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFAGGDLDELIQVQPEHATDFFNMVEKLKGHLRTIETLGVPVVAALNGTALGGGWEIALS
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCEEEEEE
CHHRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDKAKSL
ECCEEEECCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHC
GLIHDTAENEQELLDKAIAWIKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAMLK
CCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHH
DKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLATGQISKNMIGTFWHGLNAIK
HCCCCCCCCHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGASRPADIAKWQATKVGVLGAGMMGAGIAYATAIKGIPVILKDVSVENAEKGKAYSQKL
CCCCCCCHHHHHHHHEECEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHH
LDKRVSQGRMTAEKRDQILSLITATASAEDLQGCDLIIEAVFENQELKAKVTQEAEQYLA
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PNGVMASNTSTLPITGLAQASKNDKAFIGLHFFSPVDKMQLVEIIKGKNTSAETLAKAYD
CCCEEECCCCCCCEEHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHH
FVQQIGKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPARIEMAALKAGMPVGPLAI
HHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE
QDEVSLTLTEHVASETRKALQAEGKELPKTPVDEVIHTMIHELNRKGKAAGAGFYDYPEN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GKKHLWEGLNRWQKDHDISEQDMIDRILFVQALDTLRCYEEGVLESVIDANVGSIFGIGY
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
APWTGGAIQFLNQYGIDKAQKRAEELAAKYGERFTPPTLLKTKAEQKQNIQ
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA