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The map label for this gene is lysP [H]

Identifier: 213157854

GI number: 213157854

Start: 3444536

End: 3445996

Strand: Direct

Name: lysP [H]

Synonym: AB57_3341

Alternate gene names: 213157854

Gene position: 3444536-3445996 (Clockwise)

Preceding gene: 213157853

Following gene: 213157855

Centisome position: 85.04

GC content: 40.66

Gene sequence:

>1461_bases
ATGAGCGAAACACATGCTCCTGAAAAACTCCAGCGTAAGCTTGGGGCTCGTCATCTGAATATGATCGCCATTGGTGGTTC
CATTGGTACAGGTCTTTTCCTTGCTTCTGGGTCAACCATTGCAAATGCAGGTCCAGGTGGGGCGTTACTCGCCTACTCCC
TCATTGGTATTATGATTTACTTCTTAATGACCAGTTTAGGTGAACTTGCGACACACACACCAACATCCGGTGCTTTCTTT
ACCTATGGAAGTCGCTATGTCGAAGAGGGTTTTGGTTTCGCTCTAGGCTGGAACTACTGGTACAACTGGGCAATTACGGT
TGCGTTTGAACTCGTTGCCGTACAGTTTATTATGAAATTCTGGTTCCCAGATGTTCCCGGATTCTATTGGAGCGCCCTCT
TTCTCGTCATTATCTTTATGATTAATGCGATGACCGTAAAAGGATTTGGTGAAAGTGAATTCTGGTTCTCCATGGTTAAA
GTAATTGCCATTGTTGCCTTTATTATTATTGGTATCGCCATGATTATTAAGATTATGTTGACACCAGGAGTAGCAACTTT
TGGCAACTGGACTTATAAAGAGGCACCATTCGTAGGTGGTTTACAAGCCATGATTGGGGTAGCCATGATTGCTGGGTTCT
CATTTCAGGGAACCGAGATGGTGGGTGTAGCAGCGGGTGAATCAAAAGATCCGAAGAAGACGATTCCGCTTGCAATTAAA
CAGATTTTCTGGCGAATTTTATTATTCTATATCTTGTGTATTTTCATTATCGGCACCCTAATTGCCTATGATGATCCAAA
CTTATTACAAGCAGCCGCAACAGAAAATATTGCTCTTTCTCCTTTCACCTTACTTTATGAAAAAGTAGGTTTTGCTTTTG
CTGCAAGCTTAATGAATGCAGTTATTTTGACTGCTATTTTGTCGGCAGGTAACTCGGGCATGTACTCTTCTACCCGTATG
TTATTTGATATGGCGCAACAAGGCCGTGCACCAAAATGGTTTGCAAAACTCGATAGTCGTGGTGTTCCAATGAATGCATT
ATATGCAACTACATTCATTGCGGCATTCTGCTTCTTAACGACTTTTATCGGTGAAAAGCAAGTCTTTAACTGGCTCCTCA
ATATGTCAGGAATGTGTGGTTTCATTGTCTGGTTAGGTATTGCAATTTCGCATTATCGTTTCCGTAAAGGTTATATTGCT
CAAGGTTATAAATTAGAAGATCTTGCATACCGCGCTAAGTTTTTCCCATTCGCACCTTGGTTTGCCTTTATCCTCTGTTC
TGTCATTATTTTAGGACAAAACTACCAAGCGGTTTTAGGCGGTAAAATTGACTGGATTGGCTTACTTTCTACTTATATCA
GCTTGCCTTTATTTTTAGTAATCTGGCTTGGATATAAATGGAAAAATAAAACTAAATTAATTCCTTACGATCAAATGGAT
GTAAAACCAGAGCAAGATTAA

Upstream 100 bases:

>100_bases
CTTAATTGAGAAGCACTTTGGTCAGTGTGAGATTAAAACTGATCTTCAAGGCTTTAAGGTGTTATATGCCTGTGCATAAC
AAACTATGTAAGGAATCTCC

Downstream 100 bases:

>100_bases
TACTGAGTTCAAGTAATTAATCAGCGCTTATTAAGGGTCAAAAAACTTGATCTTTAGTTAAAAACAGGTAAAATGCCGTT
CAGATTTTCAACGGCACTTT

Product: amino-acid transport protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSETHAPEKLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYSLIGIMIYFLMTSLGELATHTPTSGAFF
TYGSRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKFWFPDVPGFYWSALFLVIIFMINAMTVKGFGESEFWFSMVK
VIAIVAFIIIGIAMIIKIMLTPGVATFGNWTYKEAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKKTIPLAIK
QIFWRILLFYILCIFIIGTLIAYDDPNLLQAAATENIALSPFTLLYEKVGFAFAASLMNAVILTAILSAGNSGMYSSTRM
LFDMAQQGRAPKWFAKLDSRGVPMNALYATTFIAAFCFLTTFIGEKQVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIA
QGYKLEDLAYRAKFFPFAPWFAFILCSVIILGQNYQAVLGGKIDWIGLLSTYISLPLFLVIWLGYKWKNKTKLIPYDQMD
VKPEQD

Sequences:

>Translated_486_residues
MSETHAPEKLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYSLIGIMIYFLMTSLGELATHTPTSGAFF
TYGSRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKFWFPDVPGFYWSALFLVIIFMINAMTVKGFGESEFWFSMVK
VIAIVAFIIIGIAMIIKIMLTPGVATFGNWTYKEAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKKTIPLAIK
QIFWRILLFYILCIFIIGTLIAYDDPNLLQAAATENIALSPFTLLYEKVGFAFAASLMNAVILTAILSAGNSGMYSSTRM
LFDMAQQGRAPKWFAKLDSRGVPMNALYATTFIAAFCFLTTFIGEKQVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIA
QGYKLEDLAYRAKFFPFAPWFAFILCSVIILGQNYQAVLGGKIDWIGLLSTYISLPLFLVIWLGYKWKNKTKLIPYDQMD
VKPEQD
>Mature_485_residues
SETHAPEKLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYSLIGIMIYFLMTSLGELATHTPTSGAFFT
YGSRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKFWFPDVPGFYWSALFLVIIFMINAMTVKGFGESEFWFSMVKV
IAIVAFIIIGIAMIIKIMLTPGVATFGNWTYKEAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKKTIPLAIKQ
IFWRILLFYILCIFIIGTLIAYDDPNLLQAAATENIALSPFTLLYEKVGFAFAASLMNAVILTAILSAGNSGMYSSTRML
FDMAQQGRAPKWFAKLDSRGVPMNALYATTFIAAFCFLTTFIGEKQVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIAQ
GYKLEDLAYRAKFFPFAPWFAFILCSVIILGQNYQAVLGGKIDWIGLLSTYISLPLFLVIWLGYKWKNKTKLIPYDQMDV
KPEQD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=488, Percent_Identity=61.8852459016393, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI87081708, Length=439, Percent_Identity=38.2687927107062, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1786302, Length=477, Percent_Identity=34.8008385744235, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1786789, Length=430, Percent_Identity=34.4186046511628, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=34.8837209302326, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=34.4519015659955, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87081915, Length=416, Percent_Identity=35.0961538461538, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=31.25, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786602, Length=397, Percent_Identity=36.5239294710327, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI87082250, Length=236, Percent_Identity=25.4237288135593, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87081869, Length=300, Percent_Identity=25, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=392, Percent_Identity=23.7244897959184, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=37.1717171717172, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324061, Length=498, Percent_Identity=35.3413654618474, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322892, Length=488, Percent_Identity=37.9098360655738, Blast_Score=309, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6321629, Length=484, Percent_Identity=32.8512396694215, Blast_Score=296, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6324990, Length=486, Percent_Identity=34.156378600823, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6324059, Length=498, Percent_Identity=34.7389558232932, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6324553, Length=432, Percent_Identity=35.1851851851852, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324924, Length=493, Percent_Identity=32.4543610547667, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319824, Length=493, Percent_Identity=30.0202839756592, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=497, Percent_Identity=28.9738430583501, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6321053, Length=455, Percent_Identity=31.6483516483516, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6320251, Length=488, Percent_Identity=27.8688524590164, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6319542, Length=488, Percent_Identity=29.3032786885246, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6319543, Length=492, Percent_Identity=29.0650406504065, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6322967, Length=481, Percent_Identity=31.6008316008316, Blast_Score=236, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6324981, Length=472, Percent_Identity=32.4152542372881, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=478, Percent_Identity=28.4518828451883, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=555, Percent_Identity=26.6666666666667, Blast_Score=173, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53954; Mature: 53823

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETHAPEKLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYSLIGIMIY
CCCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHH
FLMTSLGELATHTPTSGAFFTYGSRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKF
HHHHHHHHHHCCCCCCCCEECCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
WFPDVPGFYWSALFLVIIFMINAMTVKGFGESEFWFSMVKVIAIVAFIIIGIAMIIKIML
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPGVATFGNWTYKEAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKKTIPLAIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
QIFWRILLFYILCIFIIGTLIAYDDPNLLQAAATENIALSPFTLLYEKVGFAFAASLMNA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VILTAILSAGNSGMYSSTRMLFDMAQQGRAPKWFAKLDSRGVPMNALYATTFIAAFCFLT
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TFIGEKQVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIAQGYKLEDLAYRAKFFPFAPW
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCCHHH
FAFILCSVIILGQNYQAVLGGKIDWIGLLSTYISLPLFLVIWLGYKWKNKTKLIPYDQMD
HHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCC
VKPEQD
CCCCCC
>Mature Secondary Structure 
SETHAPEKLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYSLIGIMIY
CCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHH
FLMTSLGELATHTPTSGAFFTYGSRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKF
HHHHHHHHHHCCCCCCCCEECCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
WFPDVPGFYWSALFLVIIFMINAMTVKGFGESEFWFSMVKVIAIVAFIIIGIAMIIKIML
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPGVATFGNWTYKEAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKKTIPLAIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
QIFWRILLFYILCIFIIGTLIAYDDPNLLQAAATENIALSPFTLLYEKVGFAFAASLMNA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VILTAILSAGNSGMYSSTRMLFDMAQQGRAPKWFAKLDSRGVPMNALYATTFIAAFCFLT
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TFIGEKQVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIAQGYKLEDLAYRAKFFPFAPW
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCCHHH
FAFILCSVIILGQNYQAVLGGKIDWIGLLSTYISLPLFLVIWLGYKWKNKTKLIPYDQMD
HHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCC
VKPEQD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]