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The map label for this gene is ispA [H]

Identifier: 213157703

GI number: 213157703

Start: 3307710

End: 3308621

Strand: Reverse

Name: ispA [H]

Synonym: AB57_3182

Alternate gene names: 213157703

Gene position: 3308621-3307710 (Counterclockwise)

Preceding gene: 213157704

Following gene: 213157702

Centisome position: 81.68

GC content: 42.11

Gene sequence:

>912_bases
GTGTCATCACTCTCTCAAGTTAATGCGGATGTTTTAAAACAAGCTCAACAACGTATTCAACAAGATTTATTGACGACACT
GGCTGCATTCTCAATTCCCGAACCTTTAAAAAGCGCTGTACACCATGCAGTTATGCTCGGTGGAAAACGTGTGCGTCCGG
CTTTGTGTTACGCTACAGCTTCTTTACAAGATAATCCAAATTTTGCGGCTGCTCGCCGTGCTGCGGTTGCTGTTGAACTC
ATCCATTGTTATTCCTTAGCACATGATGACCTGCCTTGTATGGACAATGATTTGCTTCGCCGTGGTCAGCCAACGTGTCA
TGTTGCATTTGGTGAAGATACCGCGTTACTTGCGGGTGACATTTTACAATCGATGGCATTTGAAGTTTTAGGTAGTCGTT
TGTTTGATGAGCAAGGGCAGGGAACGGATGCTGCAATTGTCTTAAAGCAAATTCAAATTTTAGCTACAGCTAGTTCTAAA
ATGGTTTGTGGACAGGTCTTAGACTTACAAGCCGAAGCTAAGCAAATTTCTCAAGACGAACTAGAAAATATCCACCGTAA
TAAAACGGGTGCGCTTATTCAGGCTGCCATTATGATGGGGGCAGTGACAATTTTCTCGGGTACAGATCAGGCAATTCCAA
AACTACGTCAATATGGTCAAGCGATTGGACTGGCTTTTCAGGTCCAAGATGATATTTTGGATATTACGTCGAGCACTGAA
ACTTTAGGCAAAACCGCTGGTAAAGACGAACAAGTACAAAAATCGACTTATCCTGCTCTAATGGGACTAGAGCAAGCACA
GATTTATGCTAAAGAATTGCATGATCAAGCTTTCGAAGCTTTAGCGCATTTCGGTGAAAATGCAAAAGAATTAGTTGAGA
TTTCACAATTCCTGTTAGCTCGTACTAATTAA

Upstream 100 bases:

>100_bases
TAACTCATCACGCACTTTTTACAGTGAATCGTGTATGATGTAGCACATGAATGTTTCATCACATTCAATAAAATTTCTCT
ACTGATTTTACGAGGCGACT

Downstream 100 bases:

>100_bases
TAAAAACATAAATCAATCTTCCTACTTCTATTCAGACTTAATGAATACAGGAGAAAAGAATGAATGGTGAACAGCTTCAT
CAACTCGCAATAGAGGCGGC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSSLSQVNADVLKQAQQRIQQDLLTTLAAFSIPEPLKSAVHHAVMLGGKRVRPALCYATASLQDNPNFAAARRAAVAVEL
IHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDEQGQGTDAAIVLKQIQILATASSK
MVCGQVLDLQAEAKQISQDELENIHRNKTGALIQAAIMMGAVTIFSGTDQAIPKLRQYGQAIGLAFQVQDDILDITSSTE
TLGKTAGKDEQVQKSTYPALMGLEQAQIYAKELHDQAFEALAHFGENAKELVEISQFLLARTN

Sequences:

>Translated_303_residues
MSSLSQVNADVLKQAQQRIQQDLLTTLAAFSIPEPLKSAVHHAVMLGGKRVRPALCYATASLQDNPNFAAARRAAVAVEL
IHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDEQGQGTDAAIVLKQIQILATASSK
MVCGQVLDLQAEAKQISQDELENIHRNKTGALIQAAIMMGAVTIFSGTDQAIPKLRQYGQAIGLAFQVQDDILDITSSTE
TLGKTAGKDEQVQKSTYPALMGLEQAQIYAKELHDQAFEALAHFGENAKELVEISQFLLARTN
>Mature_302_residues
SSLSQVNADVLKQAQQRIQQDLLTTLAAFSIPEPLKSAVHHAVMLGGKRVRPALCYATASLQDNPNFAAARRAAVAVELI
HCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDEQGQGTDAAIVLKQIQILATASSKM
VCGQVLDLQAEAKQISQDELENIHRNKTGALIQAAIMMGAVTIFSGTDQAIPKLRQYGQAIGLAFQVQDDILDITSSTET
LGKTAGKDEQVQKSTYPALMGLEQAQIYAKELHDQAFEALAHFGENAKELVEISQFLLARTN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=227, Percent_Identity=32.15859030837, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786623, Length=260, Percent_Identity=48.4615384615385, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1789578, Length=272, Percent_Identity=30.1470588235294, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=322, Percent_Identity=23.6024844720497, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24651612, Length=232, Percent_Identity=32.7586206896552, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32818; Mature: 32687

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLSQVNADVLKQAQQRIQQDLLTTLAAFSIPEPLKSAVHHAVMLGGKRVRPALCYATA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHEEC
SLQDNPNFAAARRAAVAVELIHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHH
ILQSMAFEVLGSRLFDEQGQGTDAAIVLKQIQILATASSKMVCGQVLDLQAEAKQISQDE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHH
LENIHRNKTGALIQAAIMMGAVTIFSGTDQAIPKLRQYGQAIGLAFQVQDDILDITSSTE
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHH
TLGKTAGKDEQVQKSTYPALMGLEQAQIYAKELHDQAFEALAHFGENAKELVEISQFLLA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RTN
CCC
>Mature Secondary Structure 
SSLSQVNADVLKQAQQRIQQDLLTTLAAFSIPEPLKSAVHHAVMLGGKRVRPALCYATA
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHEEC
SLQDNPNFAAARRAAVAVELIHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHH
ILQSMAFEVLGSRLFDEQGQGTDAAIVLKQIQILATASSKMVCGQVLDLQAEAKQISQDE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHH
LENIHRNKTGALIQAAIMMGAVTIFSGTDQAIPKLRQYGQAIGLAFQVQDDILDITSSTE
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHH
TLGKTAGKDEQVQKSTYPALMGLEQAQIYAKELHDQAFEALAHFGENAKELVEISQFLLA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RTN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]