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The map label for this gene is hom [H]

Identifier: 213157252

GI number: 213157252

Start: 2027283

End: 2028287

Strand: Direct

Name: hom [H]

Synonym: AB57_1939

Alternate gene names: 213157252

Gene position: 2027283-2028287 (Clockwise)

Preceding gene: 213157251

Following gene: 213157255

Centisome position: 50.05

GC content: 37.81

Gene sequence:

>1005_bases
ATGAAGCGAATTAATGTGGCAATTTGTGGTTTCGGACGGATTGGGCAACAAATTGCAGAGCTTCTTTTAAATCGATCGAC
ATACTATAAACAAAAATATCAAATTGATGCCCGTTTAGTGGGTGTCTGTAACTCATCATCAGGCTTAATTGATCAAGAAG
GTTTACAAGCTTCAAAGTGGCTAGATAAAACACAATATCAAGCAGGCCTAACAGAGCAAAAGTTTTTAGAAAAGGTTCAA
GCAGATGTCATTATTGAGACTGGACCAAGTGATTATGTGACAGGTGGGAAAGGCCTATTTTATTTAAATTATGCTTTAAC
CCATAGCATGCATGCGATTGCGGTATCTAAAGGTGCTTTAGTCGTAGAAGGTAAAAAACTAATTAACTTGGCGCATCAGC
ACAATAAAAAACTATTTTTTAGTGGTGCGACAGCAGCAGCTTTACCGACGGTTGATTTGTTTGAATATAACTTGGCTGGT
TGCCAAATTTTAGAAATAGAAGGTGTGTTTACAGGTACCACAAATTTTATTTTAAATGATATGTTGCAACATGAATGCGC
ATTTACAGAATCTCTTGAAAAAGCTCAAGCAAAAGGTATTGCGGAACCTGACAGCTCTTTTGATGTAGATGGATGGGATA
CTGCTGCAAAAATTACGATACTAGCCAATACTGTTTTGGGAGCTGATATAAAAATTCAAGATATTCCACGACAAGGAATT
AGTCATGTTACGGCTGAACATATTCGTGATTGGAAAAAAGAAAATGTAATTCCTCGTCTGGTTGGTTTTATTCATATTAA
AAATCTGCAAATTCAAACAGGTGTTGAATTAAGGTTAGTCCCAGCAAATCATCCGTTTGCTCATCTGCAAGGTTCTAATA
AATGTATTCGGGTGTTAACGCAAGAAATGGGGGAATTTGTTGTCAGTGGAGGGGCATCTGCGCCATTAGCCACAGCAGCC
GCGGCTTTAAAAGATTTTGAGTTGATGCTAAAAACGGGCTGCTAA

Upstream 100 bases:

>100_bases
TATTTTAACCTTCTCTATAAGTAGCAATTTTTCCAAGATGAGATATTAAAATTATCTTTGGAAAATTGATTTAAACCATT
TAAATTTTTGAGAAAGTGAA

Downstream 100 bases:

>100_bases
AATTAATTATGATTTATAAAAAAAGCAGGCTTTTATGCCTGCTTCTCACAATTTTTTTGACTGCTAAATAACTTCTTTCC
AATTTCAAACTTACTAAACA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKRINVAICGFGRIGQQIAELLLNRSTYYKQKYQIDARLVGVCNSSSGLIDQEGLQASKWLDKTQYQAGLTEQKFLEKVQ
ADVIIETGPSDYVTGGKGLFYLNYALTHSMHAIAVSKGALVVEGKKLINLAHQHNKKLFFSGATAAALPTVDLFEYNLAG
CQILEIEGVFTGTTNFILNDMLQHECAFTESLEKAQAKGIAEPDSSFDVDGWDTAAKITILANTVLGADIKIQDIPRQGI
SHVTAEHIRDWKKENVIPRLVGFIHIKNLQIQTGVELRLVPANHPFAHLQGSNKCIRVLTQEMGEFVVSGGASAPLATAA
AALKDFELMLKTGC

Sequences:

>Translated_334_residues
MKRINVAICGFGRIGQQIAELLLNRSTYYKQKYQIDARLVGVCNSSSGLIDQEGLQASKWLDKTQYQAGLTEQKFLEKVQ
ADVIIETGPSDYVTGGKGLFYLNYALTHSMHAIAVSKGALVVEGKKLINLAHQHNKKLFFSGATAAALPTVDLFEYNLAG
CQILEIEGVFTGTTNFILNDMLQHECAFTESLEKAQAKGIAEPDSSFDVDGWDTAAKITILANTVLGADIKIQDIPRQGI
SHVTAEHIRDWKKENVIPRLVGFIHIKNLQIQTGVELRLVPANHPFAHLQGSNKCIRVLTQEMGEFVVSGGASAPLATAA
AALKDFELMLKTGC
>Mature_334_residues
MKRINVAICGFGRIGQQIAELLLNRSTYYKQKYQIDARLVGVCNSSSGLIDQEGLQASKWLDKTQYQAGLTEQKFLEKVQ
ADVIIETGPSDYVTGGKGLFYLNYALTHSMHAIAVSKGALVVEGKKLINLAHQHNKKLFFSGATAAALPTVDLFEYNLAG
CQILEIEGVFTGTTNFILNDMLQHECAFTESLEKAQAKGIAEPDSSFDVDGWDTAAKITILANTVLGADIKIQDIPRQGI
SHVTAEHIRDWKKENVIPRLVGFIHIKNLQIQTGVELRLVPANHPFAHLQGSNKCIRVLTQEMGEFVVSGGASAPLATAA
AALKDFELMLKTGC

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=241, Percent_Identity=28.6307053941909, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786183, Length=226, Percent_Identity=25.2212389380531, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=347, Percent_Identity=23.6311239193084, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 36473; Mature: 36473

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRINVAICGFGRIGQQIAELLLNRSTYYKQKYQIDARLVGVCNSSSGLIDQEGLQASKW
CCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHEEEEEEEEEEECCCCCCCCCCCCCHHHH
LDKTQYQAGLTEQKFLEKVQADVIIETGPSDYVTGGKGLFYLNYALTHSMHAIAVSKGAL
HHHHHHHCCCCHHHHHHHHHHCEEEECCCCCCCCCCCEEEEEEEHHHHCHHEEEEECCEE
VVEGKKLINLAHQHNKKLFFSGATAAALPTVDLFEYNLAGCQILEIEGVFTGTTNFILND
EEECHHHHHHHHHCCCEEEEECCCHHHCCCHHHEEECCCCEEEEEEEEEEECCHHHHHHH
MLQHECAFTESLEKAQAKGIAEPDSSFDVDGWDTAAKITILANTVLGADIKIQDIPRQGI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEEECCCCCHH
SHVTAEHIRDWKKENVIPRLVGFIHIKNLQIQTGVELRLVPANHPFAHLQGSNKCIRVLT
HHHHHHHHHHHHHCCCHHHHHHEEEEECEEEECCCEEEEEECCCCEEEECCCCHHHHHHH
QEMGEFVVSGGASAPLATAAAALKDFELMLKTGC
HHHHHHEECCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRINVAICGFGRIGQQIAELLLNRSTYYKQKYQIDARLVGVCNSSSGLIDQEGLQASKW
CCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHEEEEEEEEEEECCCCCCCCCCCCCHHHH
LDKTQYQAGLTEQKFLEKVQADVIIETGPSDYVTGGKGLFYLNYALTHSMHAIAVSKGAL
HHHHHHHCCCCHHHHHHHHHHCEEEECCCCCCCCCCCEEEEEEEHHHHCHHEEEEECCEE
VVEGKKLINLAHQHNKKLFFSGATAAALPTVDLFEYNLAGCQILEIEGVFTGTTNFILND
EEECHHHHHHHHHCCCEEEEECCCHHHCCCHHHEEECCCCEEEEEEEEEEECCHHHHHHH
MLQHECAFTESLEKAQAKGIAEPDSSFDVDGWDTAAKITILANTVLGADIKIQDIPRQGI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEEECCCCCHH
SHVTAEHIRDWKKENVIPRLVGFIHIKNLQIQTGVELRLVPANHPFAHLQGSNKCIRVLT
HHHHHHHHHHHHHCCCHHHHHHEEEEECEEEECCCEEEEEECCCCEEEECCCCHHHHHHH
QEMGEFVVSGGASAPLATAAAALKDFELMLKTGC
HHHHHHEECCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]