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The map label for this gene is galE [C]

Identifier: 212224987

GI number: 212224987

Start: 1720565

End: 1721518

Strand: Reverse

Name: galE [C]

Synonym: TON_1836

Alternate gene names: 212224987

Gene position: 1721518-1720565 (Counterclockwise)

Preceding gene: 212225006

Following gene: 212224984

Centisome position: 93.18

GC content: 56.29

Gene sequence:

>954_bases
ATGAAGGTTCTGGTCACGGGCGGTGCAGGCTTCATAGGCTCCCATCTTGTGGACAGGCTCATGGAGCTCGGATACGAGGT
CAGGGTTCTGGACGATTTAAGCGCCGGCAGTCTGGACAACCTTAAACGCTGGCTCAAGCATGAGAGGTTCGAGTTCATAG
AGGGAGACATGAGAAATCGGGAAATCGTGGAGAAGGCCGTTGAAGACGTAGAGGTGGTCTTCCATCTCGCCGCCAATCCG
GAGGTTAGGATCGGCTCTCAGAGCCCGGAGCTGCTCTACGAGACCAACGTCGTTATAACCTACAACCTCCTTGAAGCAAT
GAGGAAATCCGGGGTCAAATACCTCGTTTTCACCTCGTCATCGACGGTCTACGGCGACGCCGAGGTCATCCCCACTCCAG
AGGACTACGCCCCGCTCGAGCCGATAAGCGTCTACGGCGGGGCGAAGCTCGCGGCTGAAGCCCTGATAAGCGGCTACGCC
CACACCTTCGACTTCAAAGCTCTCGTCTTCAGGCTGGCCAACATAATAGGCGAGCGCTCCAACCACGGCGTCATCTACGA
CTTCATCAACAAGCTCAGGAAGAACCCCAATGAACTGGAAATTCTGGGCGACGGAACCCAGAGGAAGAGCTACCTCCACG
TGAGCGACACCGTTGATGGGATGCTCCACATCTTCGAGCACTTCAGGAAGGAAGGCAAAACCTACGACGCTTACAACCTC
GGAAACGACGACTGGATAACCGTCAGGGAAATCGCCGAGATAGTCAGCGAGGAGATGGGGCTGAATCCAGCCTTCAGGTT
CACAGGTGGAGTCGACGGTGGCCGCGGCTGGAAGGGCGACGTCAAGTTCATGCGCCTGAGCATAGAGAAAGCGAAGAAAA
CCGGCTGGGAGCCGAAGCTCAACAGCTACGAAGCCGTAAGGAGGACGGTTAGGGAGCTTCTCTCAACCATCTGA

Upstream 100 bases:

>100_bases
TCAGAACCTTCATGGCGCTCACCGTTCCAACGTACTTCAACCACAGGGTTTACCCCTAACATATTTAAATAATTTCGCTT
CATCATGGGTGGTGGTATGA

Downstream 100 bases:

>100_bases
CTTATTTTATCACTTCATACACTTTTCTTGCCACTATGAAGGCGAAGGCGAGAAGGAGCAGATAGGCGGAGAGTTTCAGA
GAGCTTTTGACGTCCCTCGG

Product: galE-2 UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKVLVTGGAGFIGSHLVDRLMELGYEVRVLDDLSAGSLDNLKRWLKHERFEFIEGDMRNREIVEKAVEDVEVVFHLAANP
EVRIGSQSPELLYETNVVITYNLLEAMRKSGVKYLVFTSSSTVYGDAEVIPTPEDYAPLEPISVYGGAKLAAEALISGYA
HTFDFKALVFRLANIIGERSNHGVIYDFINKLRKNPNELEILGDGTQRKSYLHVSDTVDGMLHIFEHFRKEGKTYDAYNL
GNDDWITVREIAEIVSEEMGLNPAFRFTGGVDGGRGWKGDVKFMRLSIEKAKKTGWEPKLNSYEAVRRTVRELLSTI

Sequences:

>Translated_317_residues
MKVLVTGGAGFIGSHLVDRLMELGYEVRVLDDLSAGSLDNLKRWLKHERFEFIEGDMRNREIVEKAVEDVEVVFHLAANP
EVRIGSQSPELLYETNVVITYNLLEAMRKSGVKYLVFTSSSTVYGDAEVIPTPEDYAPLEPISVYGGAKLAAEALISGYA
HTFDFKALVFRLANIIGERSNHGVIYDFINKLRKNPNELEILGDGTQRKSYLHVSDTVDGMLHIFEHFRKEGKTYDAYNL
GNDDWITVREIAEIVSEEMGLNPAFRFTGGVDGGRGWKGDVKFMRLSIEKAKKTGWEPKLNSYEAVRRTVRELLSTI
>Mature_317_residues
MKVLVTGGAGFIGSHLVDRLMELGYEVRVLDDLSAGSLDNLKRWLKHERFEFIEGDMRNREIVEKAVEDVEVVFHLAANP
EVRIGSQSPELLYETNVVITYNLLEAMRKSGVKYLVFTSSSTVYGDAEVIPTPEDYAPLEPISVYGGAKLAAEALISGYA
HTFDFKALVFRLANIIGERSNHGVIYDFINKLRKNPNELEILGDGTQRKSYLHVSDTVDGMLHIFEHFRKEGKTYDAYNL
GNDDWITVREIAEIVSEEMGLNPAFRFTGGVDGGRGWKGDVKFMRLSIEKAKKTGWEPKLNSYEAVRRTVRELLSTI

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=318, Percent_Identity=31.7610062893082, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI7657641, Length=320, Percent_Identity=29.0625, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI56237023, Length=287, Percent_Identity=29.616724738676, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI56118217, Length=287, Percent_Identity=29.616724738676, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI189083684, Length=287, Percent_Identity=29.616724738676, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI193211614, Length=346, Percent_Identity=23.6994219653179, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI8393516, Length=346, Percent_Identity=23.6994219653179, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4504031, Length=355, Percent_Identity=25.9154929577465, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786974, Length=290, Percent_Identity=30.3448275862069, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI48994969, Length=351, Percent_Identity=27.0655270655271, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788589, Length=352, Percent_Identity=26.1363636363636, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788353, Length=358, Percent_Identity=26.8156424581006, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539532, Length=319, Percent_Identity=31.6614420062696, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17568069, Length=270, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=332, Percent_Identity=27.4096385542169, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982035, Length=329, Percent_Identity=28.2674772036474, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=331, Percent_Identity=28.0966767371601, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=25.2941176470588, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=339, Percent_Identity=25.3687315634218, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=339, Percent_Identity=25.3687315634218, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=339, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=339, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=25.3687315634218, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=336, Percent_Identity=30.0595238095238, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321437, Length=188, Percent_Identity=27.1276595744681, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356223, Length=317, Percent_Identity=32.807570977918, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI19923002, Length=269, Percent_Identity=28.6245353159851, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35729; Mature: 35729

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVTGGAGFIGSHLVDRLMELGYEVRVLDDLSAGSLDNLKRWLKHERFEFIEGDMRNR
CEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
EIVEKAVEDVEVVFHLAANPEVRIGSQSPELLYETNVVITYNLLEAMRKSGVKYLVFTSS
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCEEEEHHHHHHHHHCCCEEEEEECC
STVYGDAEVIPTPEDYAPLEPISVYGGAKLAAEALISGYAHTFDFKALVFRLANIIGERS
CEEECCCEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NHGVIYDFINKLRKNPNELEILGDGTQRKSYLHVSDTVDGMLHIFEHFRKEGKTYDAYNL
CCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEC
GNDDWITVREIAEIVSEEMGLNPAFRFTGGVDGGRGWKGDVKFMRLSIEKAKKTGWEPKL
CCCCEEEHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHEEHHHHHHHHCCCCCCC
NSYEAVRRTVRELLSTI
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVLVTGGAGFIGSHLVDRLMELGYEVRVLDDLSAGSLDNLKRWLKHERFEFIEGDMRNR
CEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
EIVEKAVEDVEVVFHLAANPEVRIGSQSPELLYETNVVITYNLLEAMRKSGVKYLVFTSS
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCEEEEHHHHHHHHHCCCEEEEEECC
STVYGDAEVIPTPEDYAPLEPISVYGGAKLAAEALISGYAHTFDFKALVFRLANIIGERS
CEEECCCEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NHGVIYDFINKLRKNPNELEILGDGTQRKSYLHVSDTVDGMLHIFEHFRKEGKTYDAYNL
CCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEC
GNDDWITVREIAEIVSEEMGLNPAFRFTGGVDGGRGWKGDVKFMRLSIEKAKKTGWEPKL
CCCCEEEHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHEEHHHHHHHHCCCCCCC
NSYEAVRRTVRELLSTI
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]