Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 212224914

GI number: 212224914

Start: 1626636

End: 1627862

Strand: Reverse

Name: pyrC [H]

Synonym: TON_1763

Alternate gene names: 212224914

Gene position: 1627862-1626636 (Counterclockwise)

Preceding gene: 212224923

Following gene: 212224913

Centisome position: 88.11

GC content: 48.33

Gene sequence:

>1227_bases
ATGTATGACCTAGTTCTAAAAGGAAAGCTTCTGAAAGATGGAAAACTGATAGAAGGAAACATAGGGATTCTCGATGGTAG
AATCTCCCGAATTTCCCGCAGTGACTTGAGGGGAGAAGAGGTGTTACAGATTGACCGGGGGAGGATTGTCCTTCCCGGAT
TGATAGATGTTCACGTCCACCTCAGGGACTTCAGGCAGAAATCAAAGGAGACCATCAGAACAGGAACAATGGCAGCCCTA
CACGGCGGGATAACCACAGTTTTTGACATGCCCAACACGGACCCACCGATAACTAACTCGGAGACCTTTGAGTTCCGCCA
GGCTACGCTCAGGGGAAAATCCTACGCGGACTATTTCCTAAGTTTCCTCATCGCCGGGAATTGCGAAGAGGCAAAAAAAG
TACAGGCAGGCTTCTACAAAATATTCATGGGCGCCTCTACAGGGGGCATATATTCTGAGGACTTTGAGAGTGACTACGCC
TGTGCGCCCGGTATAGTCAGCGTTCATGCCGAAGACGCAAGAATAATTCGGGAAAAACCAGAGAGACCACCGGAGGCTGA
AGTCAGGGCAATAAAAGAAGCTCTCGAAGCAGCGGAAAGGCTGAAGAAGCCTCTCAATATCTGCCACGTCTCGACAGCCG
ATGGCATGAAGCTAATCACGAAGAAAAACCTTCCGTGGGTAAGTTTTGAGGTGACACCTCATCACCTCTTTCTCACGAGA
AAGGACTACGAGAGGAACCCGCTTTTCAAAGTTTACCCTCCTCTGAGAAGGGAAAGTGACAGAGCGTTCATGTGGAAGAA
CTTCAGCAAGATCCCACTCATAGCAAGCGACCATGCACCCCACACCCAGGAGGATAAAGAAAACGGGGCAGCTGGAATTC
CAGGACTTGAAACCGAAGTTGCCTTACTTCTCGATGCTACGAACAGAGGGATGATCAGTCTTAAGGACATCGTCGAGAAG
ATGCACACTAATCCTATTAGAATATTTGGAATAAGAAACAAAGGCCTGGAGATTGGGAAGGACGCGGATTTCACTATCAT
TGATATGAAAGAGGAATGGGTCGTAAAGCCAGAGGAGTTCTACACCAAAGCAAGATGGAGTCCATGGGAGGGTAAAAAGC
TTAGAGGAAAGGTCGTGATGACCGTTCTCCGTGGTAGCGTTGTTATGGAGGAAGATGAAATCATAGGAAAGCCGCGGGGG
GTTAAGATCAATGCTGGAAAGGGTTAA

Upstream 100 bases:

>100_bases
AAACCCGAAAAAATCGTTAGCTACCTTTTAGACAGTCATGGAAATGGGCGATAGGGCAAAAAACTTAAAATCCTTAGGTC
TTCATCCCCGTGCGGGCACT

Downstream 100 bases:

>100_bases
GCTCAAAGAAGTTTGGAAAGTTGCTAGGGACGTGAAGGCATTTAGATTTGAGAGAGACTTTGATTTCAAAGCGGGCCAGT
TCATCATGGCGTGGCTTCCT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MYDLVLKGKLLKDGKLIEGNIGILDGRISRISRSDLRGEEVLQIDRGRIVLPGLIDVHVHLRDFRQKSKETIRTGTMAAL
HGGITTVFDMPNTDPPITNSETFEFRQATLRGKSYADYFLSFLIAGNCEEAKKVQAGFYKIFMGASTGGIYSEDFESDYA
CAPGIVSVHAEDARIIREKPERPPEAEVRAIKEALEAAERLKKPLNICHVSTADGMKLITKKNLPWVSFEVTPHHLFLTR
KDYERNPLFKVYPPLRRESDRAFMWKNFSKIPLIASDHAPHTQEDKENGAAGIPGLETEVALLLDATNRGMISLKDIVEK
MHTNPIRIFGIRNKGLEIGKDADFTIIDMKEEWVVKPEEFYTKARWSPWEGKKLRGKVVMTVLRGSVVMEEDEIIGKPRG
VKINAGKG

Sequences:

>Translated_408_residues
MYDLVLKGKLLKDGKLIEGNIGILDGRISRISRSDLRGEEVLQIDRGRIVLPGLIDVHVHLRDFRQKSKETIRTGTMAAL
HGGITTVFDMPNTDPPITNSETFEFRQATLRGKSYADYFLSFLIAGNCEEAKKVQAGFYKIFMGASTGGIYSEDFESDYA
CAPGIVSVHAEDARIIREKPERPPEAEVRAIKEALEAAERLKKPLNICHVSTADGMKLITKKNLPWVSFEVTPHHLFLTR
KDYERNPLFKVYPPLRRESDRAFMWKNFSKIPLIASDHAPHTQEDKENGAAGIPGLETEVALLLDATNRGMISLKDIVEK
MHTNPIRIFGIRNKGLEIGKDADFTIIDMKEEWVVKPEEFYTKARWSPWEGKKLRGKVVMTVLRGSVVMEEDEIIGKPRG
VKINAGKG
>Mature_408_residues
MYDLVLKGKLLKDGKLIEGNIGILDGRISRISRSDLRGEEVLQIDRGRIVLPGLIDVHVHLRDFRQKSKETIRTGTMAAL
HGGITTVFDMPNTDPPITNSETFEFRQATLRGKSYADYFLSFLIAGNCEEAKKVQAGFYKIFMGASTGGIYSEDFESDYA
CAPGIVSVHAEDARIIREKPERPPEAEVRAIKEALEAAERLKKPLNICHVSTADGMKLITKKNLPWVSFEVTPHHLFLTR
KDYERNPLFKVYPPLRRESDRAFMWKNFSKIPLIASDHAPHTQEDKENGAAGIPGLETEVALLLDATNRGMISLKDIVEK
MHTNPIRIFGIRNKGLEIGKDADFTIIDMKEEWVVKPEEFYTKARWSPWEGKKLRGKVVMTVLRGSVVMEEDEIIGKPRG
VKINAGKG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=367, Percent_Identity=33.5149863760218, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4503379, Length=445, Percent_Identity=23.8202247191011, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786722, Length=434, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082175, Length=406, Percent_Identity=26.3546798029557, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=363, Percent_Identity=31.129476584022, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322218, Length=383, Percent_Identity=30.5483028720627, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322331, Length=361, Percent_Identity=22.1606648199446, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24642586, Length=365, Percent_Identity=34.5205479452055, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18859883, Length=463, Percent_Identity=28.9416846652268, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45960; Mature: 45960

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLVLKGKLLKDGKLIEGNIGILDGRISRISRSDLRGEEVLQIDRGRIVLPGLIDVHVH
CCEEEEECEEECCCEEEECCCEEECCHHHHHHHHHCCCCCEEEECCCCEEECCEEEEEEH
LRDFRQKSKETIRTGTMAALHGGITTVFDMPNTDPPITNSETFEFRQATLRGKSYADYFL
HHHHHHHHHHHHHHCHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHH
SFLIAGNCEEAKKVQAGFYKIFMGASTGGIYSEDFESDYACAPGIVSVHAEDARIIREKP
HHHHCCCCHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCC
ERPPEAEVRAIKEALEAAERLKKPLNICHVSTADGMKLITKKNLPWVSFEVTPHHLFLTR
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCEEEEEECCCEEEEEE
KDYERNPLFKVYPPLRRESDRAFMWKNFSKIPLIASDHAPHTQEDKENGAAGIPGLETEV
CCCCCCCCEEECCCCCCCCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEE
ALLLDATNRGMISLKDIVEKMHTNPIRIFGIRNKGLEIGKDADFTIIDMKEEWVVKPEEF
EEEEECCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCHHHEECHHHH
YTKARWSPWEGKKLRGKVVMTVLRGSVVMEEDEIIGKPRGVKINAGKG
HHHCCCCCCCCCCCCHHEEEEEHHCCEEEECHHHCCCCCCEEEECCCC
>Mature Secondary Structure
MYDLVLKGKLLKDGKLIEGNIGILDGRISRISRSDLRGEEVLQIDRGRIVLPGLIDVHVH
CCEEEEECEEECCCEEEECCCEEECCHHHHHHHHHCCCCCEEEECCCCEEECCEEEEEEH
LRDFRQKSKETIRTGTMAALHGGITTVFDMPNTDPPITNSETFEFRQATLRGKSYADYFL
HHHHHHHHHHHHHHCHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHH
SFLIAGNCEEAKKVQAGFYKIFMGASTGGIYSEDFESDYACAPGIVSVHAEDARIIREKP
HHHHCCCCHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCC
ERPPEAEVRAIKEALEAAERLKKPLNICHVSTADGMKLITKKNLPWVSFEVTPHHLFLTR
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCEEEEEECCCEEEEEE
KDYERNPLFKVYPPLRRESDRAFMWKNFSKIPLIASDHAPHTQEDKENGAAGIPGLETEV
CCCCCCCCEEECCCCCCCCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEE
ALLLDATNRGMISLKDIVEKMHTNPIRIFGIRNKGLEIGKDADFTIIDMKEEWVVKPEEF
EEEEECCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCHHHEECHHHH
YTKARWSPWEGKKLRGKVVMTVLRGSVVMEEDEIIGKPRGVKINAGKG
HHHCCCCCCCCCCCCHHEEEEEHHCCEEEECHHHCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA