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The map label for this gene is pyrD [H]

Identifier: 212224413

GI number: 212224413

Start: 1149064

End: 1149966

Strand: Reverse

Name: pyrD [H]

Synonym: TON_1264

Alternate gene names: 212224413

Gene position: 1149966-1149064 (Counterclockwise)

Preceding gene: 212224428

Following gene: 212224412

Centisome position: 62.24

GC content: 55.7

Gene sequence:

>903_bases
GTGGTGAGGCTTTTCGTTGAGGTCGCCGGTCTTAAGCTTGAAAATCCACTTATTCTCGCCTCGGGAGTAAACGATAAGAC
CCCTGAACAGTGGATACGCGCTCATGAGGAAGGTGCTGGCGGCGTCGTTACCAAGTCCATCGGAATCGAGCCGAGAAATG
GCTACGACAACCCCACTATCGTGGAGCTCCCCTATGGACTGATAAACGCGATGGGCCTTCCGAATCCCGGCTGGAAGGGC
TTTCTGGAGATGGTTGAAGGCTACACCTTTGACTTTCCGCTGATAGTATCGATATTCGGCGGAACGCCGGAGGAGTTTGC
CTTTCTCGCTGAAAAGCTGAGCGAAGTGGCCAATGCCTTCGAGCTCAACCTCAGCTGTCCCCATGCGAAGGGCTACGGCA
TGGAGATAGGCCAGAGACCGGAGATGGTCTACGAGGTCGTCAAAGCCGTTAAGGATGTGACGGACAAGCCCGTTATAGCG
AAGCTCACGCCAAACATAGACGACATAACGAAGCTCGGTCTGGCCGCTGAAAAGGCCGGTGCAGATGCGGTCGCAGCCAT
AAACACGCTGAAGGCGATAGCGATAGACGTCTACGCGAGGAGGCCGATACTGAGCAACAGAGTCGGCGGCTACTCTGGTC
CTGGGGTCAAGCCCGTTGCCTTGAGGGCGGTCTACGATTTGGCCAAGGCCCTTAATATCCCGGTCATCGGGATAGGCGGC
ATAACTACGTGGCGGGATGCCCTGGAGTTTTTCCTCGCTGGAGCAAGAGCGCTCCAGATAGGAACTGCAGTGGCTCTACG
GGGCTGGAAGGTCTTCAGGGAGATAAACGAGGGAATAGCGAGGTATCTCGAGGAGGAAGGCTTTGAGAGTATTGAGGAAA
TAGTTGGGCTGGCGCTGGAGTAG

Upstream 100 bases:

>100_bases
GACGGTGGAGGGTTCCCACCCCCGGGCGCGCCCGCCGCCGTTAAAATTCTGGCAAAAACCTTAATAGCAAACCACCTCTT
TTGCCTCCGGGGTGTTAAAT

Downstream 100 bases:

>100_bases
ATTTTTAACCTTCAGTCCTCCTTTTAATCTAAGCGAGGTGATAACATGAAGCGCGCAGTTGTGTTATTTTCCGGGGGGCT
CGACTCGACGGCCTGCCTCT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MVRLFVEVAGLKLENPLILASGVNDKTPEQWIRAHEEGAGGVVTKSIGIEPRNGYDNPTIVELPYGLINAMGLPNPGWKG
FLEMVEGYTFDFPLIVSIFGGTPEEFAFLAEKLSEVANAFELNLSCPHAKGYGMEIGQRPEMVYEVVKAVKDVTDKPVIA
KLTPNIDDITKLGLAAEKAGADAVAAINTLKAIAIDVYARRPILSNRVGGYSGPGVKPVALRAVYDLAKALNIPVIGIGG
ITTWRDALEFFLAGARALQIGTAVALRGWKVFREINEGIARYLEEEGFESIEEIVGLALE

Sequences:

>Translated_300_residues
MVRLFVEVAGLKLENPLILASGVNDKTPEQWIRAHEEGAGGVVTKSIGIEPRNGYDNPTIVELPYGLINAMGLPNPGWKG
FLEMVEGYTFDFPLIVSIFGGTPEEFAFLAEKLSEVANAFELNLSCPHAKGYGMEIGQRPEMVYEVVKAVKDVTDKPVIA
KLTPNIDDITKLGLAAEKAGADAVAAINTLKAIAIDVYARRPILSNRVGGYSGPGVKPVALRAVYDLAKALNIPVIGIGG
ITTWRDALEFFLAGARALQIGTAVALRGWKVFREINEGIARYLEEEGFESIEEIVGLALE
>Mature_300_residues
MVRLFVEVAGLKLENPLILASGVNDKTPEQWIRAHEEGAGGVVTKSIGIEPRNGYDNPTIVELPYGLINAMGLPNPGWKG
FLEMVEGYTFDFPLIVSIFGGTPEEFAFLAEKLSEVANAFELNLSCPHAKGYGMEIGQRPEMVYEVVKAVKDVTDKPVIA
KLTPNIDDITKLGLAAEKAGADAVAAINTLKAIAIDVYARRPILSNRVGGYSGPGVKPVALRAVYDLAKALNIPVIGIGG
ITTWRDALEFFLAGARALQIGTAVALRGWKVFREINEGIARYLEEEGFESIEEIVGLALE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=331, Percent_Identity=31.1178247734139, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI45006951, Length=318, Percent_Identity=25.1572327044025, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082059, Length=316, Percent_Identity=35.7594936708861, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1787177, Length=292, Percent_Identity=26.027397260274, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71984108, Length=317, Percent_Identity=30.9148264984227, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322633, Length=298, Percent_Identity=32.8859060402685, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640763, Length=301, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18858217, Length=301, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=24.1379310344828, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=24.1379310344828, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32353; Mature: 32353

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLFVEVAGLKLENPLILASGVNDKTPEQWIRAHEEGAGGVVTKSIGIEPRNGYDNPTI
CEEEEEEEECEEECCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEE
VELPYGLINAMGLPNPGWKGFLEMVEGYTFDFPLIVSIFGGTPEEFAFLAEKLSEVANAF
EEECHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ELNLSCPHAKGYGMEIGQRPEMVYEVVKAVKDVTDKPVIAKLTPNIDDITKLGLAAEKAG
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCC
ADAVAAINTLKAIAIDVYARRPILSNRVGGYSGPGVKPVALRAVYDLAKALNIPVIGIGG
CHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECC
ITTWRDALEFFLAGARALQIGTAVALRGWKVFREINEGIARYLEEEGFESIEEIVGLALE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVRLFVEVAGLKLENPLILASGVNDKTPEQWIRAHEEGAGGVVTKSIGIEPRNGYDNPTI
CEEEEEEEECEEECCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEE
VELPYGLINAMGLPNPGWKGFLEMVEGYTFDFPLIVSIFGGTPEEFAFLAEKLSEVANAF
EEECHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ELNLSCPHAKGYGMEIGQRPEMVYEVVKAVKDVTDKPVIAKLTPNIDDITKLGLAAEKAG
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCC
ADAVAAINTLKAIAIDVYARRPILSNRVGGYSGPGVKPVALRAVYDLAKALNIPVIGIGG
CHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECC
ITTWRDALEFFLAGARALQIGTAVALRGWKVFREINEGIARYLEEEGFESIEEIVGLALE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA