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The map label for this gene is bhbA [H]

Identifier: 212224259

GI number: 212224259

Start: 1025722

End: 1027410

Strand: Reverse

Name: bhbA [H]

Synonym: TON_1110

Alternate gene names: 212224259

Gene position: 1027410-1025722 (Counterclockwise)

Preceding gene: 212224266

Following gene: 212224258

Centisome position: 55.61

GC content: 55.18

Gene sequence:

>1689_bases
ATGACTTTCGATAAGGAGAAACTCAAAGCCATTAAGCAGGCTGAGGAGGAATGGGAGGAGAAAGTTGTCAAGCCTCTCAT
AGCGAAGAGGCCGGAAAGAAAGGAAAAGTTCATGACGGATGATGGCTTTGAGATAAAGCGCGTTTACACCCCCGCCGATC
TCGGAGAGGACTGGGACTACCTTGAGAAGCTTGGCTTCCCTGGGCAGTATCCGTTCACGAGGGGCGTTTACGGAACCATG
TACCGCGGCCGTTTCTGGACGATGAGGCAGTACGCAGGTTTTGGAACGGCGGAGGAGAGCAACAAGCGCTACAAGTATCT
CCTCGGCCAGGGACAGACGGGTTTGAGCGTCGCCTTTGATCTGCCCACTCAGATAGGATATGACTCCGACCACCCGATGA
GCGAGGGTGAGGTCGGAAAGGTCGGTGTTGCCATCGATTCTCTCTGGGATATGCGCATACTCTTCGATGGAATCCCGCTC
GATAAGGTCTCAACATCGATGACCATCAACTCGACCGCTGCCAACCTTCTTGCCATGTACATCCTCGTTGCCGAGGAGCA
GGGCGTTAAGCCCGAACAGCTCCGCGGAACCGTCCAGAACGACATCCTCAAGGAGTACATCGCTCGCGGTACCTATATCT
TCCCGCCTCAACCGAGCATGAGGCTCACCACCGATATCATCATGTACTGCGCTGAGCACGTGCCGAAGTGGAACCCGATT
TCGATAAGCGGCTACCACATAAGGGAGGCTGGAGCGAACGCCGTCCAGGAGGTCGCCTTCACCCTCGCCGACGGTATTGA
GTATGTTAAGGCTGTCATTGAGCGTGGAATGGACGTTGATAAGTTCGCCGGAAGGCTGAGCTTCTTCTTCAACGCCCACA
ACAACTTCCTCGAGGAGATAGCCAAATTCAGAGCTGCCAGAAGGCTCTGGGCCTACATAATGAAGGAGTGGTTCAACGCC
AAGAACCCGAAGTCGATGCTCCTGCGCTTCCATACCCAGACGGCAGGTTCAACCTTAACCGCCCAGCAGCCCGAGAACAA
CATTGTTAGAGTTGCGATTCAGGCCCTGGCAGCGGTTCTTGGTGGAACTCAGTCCCTGCACACCAACTCCTACGATGAAG
CTCTGAGCCTTCCGACGGAGAAGAGCGTTAGGATAGCCCTCAGAACCCAGCAGATTATCGCCTACGAGAGCGGCGTTGTT
GATACGATAGACCCGCTCGGCGGAGCCTACTACATCGAATGGCTCACCGACCACATCTACGAGGAGGCCCTCAAGTACAT
CGAGAAGATTCAGAAGATGGGCGGCATGATGAGGGCCATCGAGAGGGGCTACATCCAGAAGGAGATAGCAGAGAGCGCCT
ACAAGTTCCAGAAGGAGGTCGAGGAGAAAAAGCGCATCATCGTCGGTGTCAACGAGTTCATCGTCGACGAGCCGCTTGAT
GTCGAGATACTCAAGGTCGACCCGAGCATCAGGGAGAAGCAAATCGAGAGGCTCAAGAAGCTCAGGAGTGAGAGGGATAA
CAAGAAGGTCGAGGAGGCCCTCGATAAGCTCAGGAACGCCGCCGAGAAGGAAGACGAGAACCTCATTCCCTACATTATCG
AGGCCCACAGGCACCTCGCGACCCTTGGAGAGGTCACTGACGTCCTCCGTGAGGTCTGGGGCGAGTACAGAGCGCCGCTG
ATATTCTGA

Upstream 100 bases:

>100_bases
CTCAGCGCATGGCTGGACAATATATCCAACATCAAGTTTGACCTTTCGTTATGTAAAAGCTTTTTATAGTCGCTCGCCCA
AATATGGGCAGGTGATAGGC

Downstream 100 bases:

>100_bases
TTTTCGTCTTTCCTTTTTCTCATCCTTCCCTTTAGAAAACCTTAAAACCCCACGAAAAAGCTTAAAAAAGGATAGGTCAA
GCAACGTTAGACATCACGAT

Product: methylmalonyl-CoA mutase, N-terminus of large subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTFDKEKLKAIKQAEEEWEEKVVKPLIAKRPERKEKFMTDDGFEIKRVYTPADLGEDWDYLEKLGFPGQYPFTRGVYGTM
YRGRFWTMRQYAGFGTAEESNKRYKYLLGQGQTGLSVAFDLPTQIGYDSDHPMSEGEVGKVGVAIDSLWDMRILFDGIPL
DKVSTSMTINSTAANLLAMYILVAEEQGVKPEQLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAEHVPKWNPI
SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAGRLSFFFNAHNNFLEEIAKFRAARRLWAYIMKEWFNA
KNPKSMLLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVV
DTIDPLGGAYYIEWLTDHIYEEALKYIEKIQKMGGMMRAIERGYIQKEIAESAYKFQKEVEEKKRIIVGVNEFIVDEPLD
VEILKVDPSIREKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLIPYIIEAHRHLATLGEVTDVLREVWGEYRAPL
IF

Sequences:

>Translated_562_residues
MTFDKEKLKAIKQAEEEWEEKVVKPLIAKRPERKEKFMTDDGFEIKRVYTPADLGEDWDYLEKLGFPGQYPFTRGVYGTM
YRGRFWTMRQYAGFGTAEESNKRYKYLLGQGQTGLSVAFDLPTQIGYDSDHPMSEGEVGKVGVAIDSLWDMRILFDGIPL
DKVSTSMTINSTAANLLAMYILVAEEQGVKPEQLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAEHVPKWNPI
SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAGRLSFFFNAHNNFLEEIAKFRAARRLWAYIMKEWFNA
KNPKSMLLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVV
DTIDPLGGAYYIEWLTDHIYEEALKYIEKIQKMGGMMRAIERGYIQKEIAESAYKFQKEVEEKKRIIVGVNEFIVDEPLD
VEILKVDPSIREKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLIPYIIEAHRHLATLGEVTDVLREVWGEYRAPL
IF
>Mature_561_residues
TFDKEKLKAIKQAEEEWEEKVVKPLIAKRPERKEKFMTDDGFEIKRVYTPADLGEDWDYLEKLGFPGQYPFTRGVYGTMY
RGRFWTMRQYAGFGTAEESNKRYKYLLGQGQTGLSVAFDLPTQIGYDSDHPMSEGEVGKVGVAIDSLWDMRILFDGIPLD
KVSTSMTINSTAANLLAMYILVAEEQGVKPEQLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAEHVPKWNPIS
ISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAGRLSFFFNAHNNFLEEIAKFRAARRLWAYIMKEWFNAK
NPKSMLLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVD
TIDPLGGAYYIEWLTDHIYEEALKYIEKIQKMGGMMRAIERGYIQKEIAESAYKFQKEVEEKKRIIVGVNEFIVDEPLDV
EILKVDPSIREKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLIPYIIEAHRHLATLGEVTDVLREVWGEYRAPLI
F

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=543, Percent_Identity=51.9337016574586, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1789284, Length=552, Percent_Identity=50.7246376811594, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25144500, Length=521, Percent_Identity=52.2072936660269, Blast_Score=541, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 64339; Mature: 64208

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDKEKLKAIKQAEEEWEEKVVKPLIAKRPERKEKFMTDDGFEIKRVYTPADLGEDWDY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCCCHHH
LEKLGFPGQYPFTRGVYGTMYRGRFWTMRQYAGFGTAEESNKRYKYLLGQGQTGLSVAFD
HHHCCCCCCCCCCCCCHHHHHCCCCEEHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEE
LPTQIGYDSDHPMSEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINSTAANLLAMY
CCHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHCCCEEEHHHHHHHHHHH
ILVAEEQGVKPEQLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAEHVPKWNPI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCE
SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAGRLSFFFNAHNNFLEEI
EECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AKFRAARRLWAYIMKEWFNAKNPKSMLLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTIDPLGGAYYIEWLTDHIY
CCCCCCCCCCHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
EEALKYIEKIQKMGGMMRAIERGYIQKEIAESAYKFQKEVEEKKRIIVGVNEFIVDEPLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCCC
VEILKVDPSIREKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLIPYIIEAHRHLA
EEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TLGEVTDVLREVWGEYRAPLIF
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TFDKEKLKAIKQAEEEWEEKVVKPLIAKRPERKEKFMTDDGFEIKRVYTPADLGEDWDY
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCCCHHH
LEKLGFPGQYPFTRGVYGTMYRGRFWTMRQYAGFGTAEESNKRYKYLLGQGQTGLSVAFD
HHHCCCCCCCCCCCCCHHHHHCCCCEEHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEE
LPTQIGYDSDHPMSEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINSTAANLLAMY
CCHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHCCCEEEHHHHHHHHHHH
ILVAEEQGVKPEQLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAEHVPKWNPI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCE
SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAGRLSFFFNAHNNFLEEI
EECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AKFRAARRLWAYIMKEWFNAKNPKSMLLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTIDPLGGAYYIEWLTDHIY
CCCCCCCCCCHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
EEALKYIEKIQKMGGMMRAIERGYIQKEIAESAYKFQKEVEEKKRIIVGVNEFIVDEPLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCCC
VEILKVDPSIREKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLIPYIIEAHRHLA
EEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TLGEVTDVLREVWGEYRAPLIF
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]