Click here to switch to the map view.

The map label for this gene is top6A [H]

Identifier: 212223912

GI number: 212223912

Start: 709780

End: 710940

Strand: Reverse

Name: top6A [H]

Synonym: TON_0763

Alternate gene names: 212223912

Gene position: 710940-709780 (Counterclockwise)

Preceding gene: 212223913

Following gene: 212223911

Centisome position: 38.48

GC content: 55.38

Gene sequence:

>1161_bases
ATGCCTAAATCCAAGGCCGTCAAGAGGAGCCAGCCAAGGGAGCGCTTCTCCTATGACCCCACTAAGGTGCTCAACAAGCT
GGAGGAGTACGGAAGGCGTGTGCTGGAGGACATAAAGAGCGGTAAGAATCCCTACTTCGACATACCCATGCGCGGGCTGA
GCAACGTCTACTTCGATGAGAAGAGAAGAGTCATCAAGATGGGCGACAAGCTCTCCAGAAGGTACTTCCTCAACGTCGCC
CACGCGAGAAAGTTCATGCAGACGCTGCTCATAATGGCCTACGTCAAAAGGCTCGTCAGCGAAGGGAAGCACGCGAGCCT
CCGTGAAGCCTACTACGCCAACAAGCACACCATTCCGGGAACGAAGGAGAACACCTTCGAGGACCAGCGCGAGAGTGACC
CGATTATCGAGGATCTTGAGAGAATGCTCGGCGTTCTTCGTGAGGAGATGCATCTCACAGCCGACAGGCGCGGCTACATA
TACGGCGACATCGTCATACGCGACGGCGAGGACGAGTTCAACACCAGCAAGCTCGGTATGGGTGGCTGGGCAGTCCCAGG
AACGGTTGAGCACCTCCAGTTCGTCGAGGTCAACGTAGATTACGCTTTGGTCGTCGAGACGGCAGCTATGGCCGACCGTC
TCATCGAGGAAAAGTTCCCGAAGAAGGAGAACGCCCTAATCATAGCAACGCAGGGACAGGCCTCTCGTGGAGTCAGGAGG
CTCATCCACAGGCTCCACTACGAGGAAGGACTGCCCATCATAGTCTTCACCGATGGAGACCCCTACGGTTGGTACATCTA
CTCCACTATAAAGCAGGGCTCCATTAACCTCGCATACCTCAGCGAGAAGCTGGCAACCCCTGAGGCCAAGTTCGTGGGCA
TGACCATGGACGATATAGAGCGCTATGGCCTCAAGAACGTTACCGAAAAGCTCAAGGGCATACCACCAAACAAGAAGGGC
GGTCCAACGGGCGACTACAAGAGGATCATCGAGGAGATGAACTACCCATGGTTCCAGAACAAGGAGTGGCAGAGGCAGCT
CCAGCTGGCCCTCAAGATGGGCGTCAGGATTGAGCAGCAGGCTCTGGCCAACAAGAGCCTTGAGTTCGTGGCGAAGAAGT
ACTTGCCTGAAAAGATAAACAACGGTGAGCTCCTGCCATGA

Upstream 100 bases:

>100_bases
TTAACGGGCGAGCCCGAGGAGGAGGTTAAGAACTACTTCCTGAGGTTCATCGAGGAAAGGTTCGCCCAGAGCGAGGTTGA
GGCAGAGGAGGTGGCTGAGA

Downstream 100 bases:

>100_bases
CGACGACGGAAGAGCTCGTCGCGCAGGTGAACAAGATACTTGACGACATCGGAATAGACATGGACGGGTTATTCGAGACT
TTCGACGTCCCGTCCATTTC

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPKSKAVKRSQPRERFSYDPTKVLNKLEEYGRRVLEDIKSGKNPYFDIPMRGLSNVYFDEKRRVIKMGDKLSRRYFLNVA
HARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPGTKENTFEDQRESDPIIEDLERMLGVLREEMHLTADRRGYI
YGDIVIRDGEDEFNTSKLGMGGWAVPGTVEHLQFVEVNVDYALVVETAAMADRLIEEKFPKKENALIIATQGQASRGVRR
LIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPEAKFVGMTMDDIERYGLKNVTEKLKGIPPNKKG
GPTGDYKRIIEEMNYPWFQNKEWQRQLQLALKMGVRIEQQALANKSLEFVAKKYLPEKINNGELLP

Sequences:

>Translated_386_residues
MPKSKAVKRSQPRERFSYDPTKVLNKLEEYGRRVLEDIKSGKNPYFDIPMRGLSNVYFDEKRRVIKMGDKLSRRYFLNVA
HARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPGTKENTFEDQRESDPIIEDLERMLGVLREEMHLTADRRGYI
YGDIVIRDGEDEFNTSKLGMGGWAVPGTVEHLQFVEVNVDYALVVETAAMADRLIEEKFPKKENALIIATQGQASRGVRR
LIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPEAKFVGMTMDDIERYGLKNVTEKLKGIPPNKKG
GPTGDYKRIIEEMNYPWFQNKEWQRQLQLALKMGVRIEQQALANKSLEFVAKKYLPEKINNGELLP
>Mature_385_residues
PKSKAVKRSQPRERFSYDPTKVLNKLEEYGRRVLEDIKSGKNPYFDIPMRGLSNVYFDEKRRVIKMGDKLSRRYFLNVAH
ARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPGTKENTFEDQRESDPIIEDLERMLGVLREEMHLTADRRGYIY
GDIVIRDGEDEFNTSKLGMGGWAVPGTVEHLQFVEVNVDYALVVETAAMADRLIEEKFPKKENALIIATQGQASRGVRRL
IHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPEAKFVGMTMDDIERYGLKNVTEKLKGIPPNKKGG
PTGDYKRIIEEMNYPWFQNKEWQRQLQLALKMGVRIEQQALANKSLEFVAKKYLPEKINNGELLP

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=366, Percent_Identity=23.224043715847, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI38201680, Length=303, Percent_Identity=24.7524752475248, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552753, Length=365, Percent_Identity=22.7397260273973, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 44622; Mature: 44491

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSKAVKRSQPRERFSYDPTKVLNKLEEYGRRVLEDIKSGKNPYFDIPMRGLSNVYFDE
CCCCCCCHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
KRRVIKMGDKLSRRYFLNVAHARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
TKENTFEDQRESDPIIEDLERMLGVLREEMHLTADRRGYIYGDIVIRDGEDEFNTSKLGM
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCC
GGWAVPGTVEHLQFVEVNVDYALVVETAAMADRLIEEKFPKKENALIIATQGQASRGVRR
CCCCCCCHHHHEEEEEECCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
LIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPEAKFVGMTMDDIE
HHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCEEHHHHHHHHCCCCHHEECCCHHHHH
RYGLKNVTEKLKGIPPNKKGGPTGDYKRIIEEMNYPWFQNKEWQRQLQLALKMGVRIEQQ
HHCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHH
ALANKSLEFVAKKYLPEKINNGELLP
HHHHHHHHHHHHHHCHHHCCCCCCCC
>Mature Secondary Structure 
PKSKAVKRSQPRERFSYDPTKVLNKLEEYGRRVLEDIKSGKNPYFDIPMRGLSNVYFDE
CCCCCCHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
KRRVIKMGDKLSRRYFLNVAHARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
TKENTFEDQRESDPIIEDLERMLGVLREEMHLTADRRGYIYGDIVIRDGEDEFNTSKLGM
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCC
GGWAVPGTVEHLQFVEVNVDYALVVETAAMADRLIEEKFPKKENALIIATQGQASRGVRR
CCCCCCCHHHHEEEEEECCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
LIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPEAKFVGMTMDDIE
HHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCEEHHHHHHHHCCCCHHEECCCHHHHH
RYGLKNVTEKLKGIPPNKKGGPTGDYKRIIEEMNYPWFQNKEWQRQLQLALKMGVRIEQQ
HHCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHH
ALANKSLEFVAKKYLPEKINNGELLP
HHHHHHHHHHHHHHCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA