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The map label for this gene is top6B

Identifier: 212223913

GI number: 212223913

Start: 710933

End: 712624

Strand: Reverse

Name: top6B

Synonym: TON_0764

Alternate gene names: 212223913

Gene position: 712624-710933 (Counterclockwise)

Preceding gene: 212223914

Following gene: 212223912

Centisome position: 38.57

GC content: 55.26

Gene sequence:

>1692_bases
ATGGCCGAGGCAAGTCAGCTGTTTAAGGAGTTCAAGATTCAGAGCGTCAGCGAGTTCTTCAGAAGAAACGCTGCAATGCT
CGGTTACACGGGCAAGATACGCTCCCTCACGACCGTCGTCCACGAGGCAGTCACCAATTCCCTCGACGCCTGTGAGGAGG
CCGGTATTCTGCCGTACGTCCGCGTTGAGATTGAAGAGCTAGGGAGGGAGCACTACAAGGTTATAGTCGAGGACAACGGT
CCCGGAATCCCTGAGAAGTTCATAACCCACGTCTTTGGAAAGATGCTCGCTGGAACCAAGGCTCACAGGAACATACAGAG
CCGCGGTCAGCAGGGTATAGGTATATCCGGTGCGGTAATGTTCGCCCAGATAACGAGCGGAAAGGCCACGCGCGTAATCA
CCTCAACCGGAGGCGACATAATCGAGGCCTGGGTCAAGATCGACGTCGACAAGAACGAAGGTAAGATAGTCAAGAAGGAA
AGGCACCCGAATCCAAAGGGCTGGCGGGGCACTAGGATAGAGCTTGAGGTTAAAAACGTCCGCTACGTCCGTTCCAAGCA
GGGTGTCTACTGGTACCTCAAGCTCACGGCCATAGCCAATCCGCACGCCCACATAGAGCTTATCGAGCCGGACGGGAAGC
TCATAGTCTTCCCGCGTTCGAGTGAGGAAGTTCCAAAGCCGCCCGTCGAGATGAAGCCCCACCCGAAGGGAGTTCTCACG
GATGACGTTTACAGAATGGCCAAGAAGACGAGGAGAAACACCGTCAGGCGCTTCCTAATAGGCGAGTTCTCGAGGATAAG
TGACAAGAAGGTCGATGAGTTGATAAAGTACATCGCCGCCCTCAGGCTCATTAAGACGGAGAAGGACAAAGCGGTTCAGG
ATCAGCTCTACGAAAGGCTGATGAATGGTGAGGTCGATAAGGTTCTGCGTTCCTTCAAGGGCTACACCAAGGTCGTCAAG
CAGGTGGCAAAGCTCATGGAGAAGCCGCCAGAGAAGCTCAGCTGGCACGAGGCTGAGGAGATAGTCGAGGCATTCAAGTA
TATGAAGTTCCTCGCTCCACCAACCCACGGCCTCAGACCGATAGGCGAGGAGAACATCGAGAAGGGTCTCAAGGGAATCC
TCAAACCTGAGTTCGTCACGGCGGTCACGAGGCCTCCGAAGGTCTACAGCGGTGGAATTCCTTTCCAGGTTGAGGTCGGC
CTGGCCTACGGCGGGGAGATAAGCAGCGGCTTTGATCTTCTCCGCTATGCCAACCGCGTCCCGCTCCTCTTCGATGCGGG
CTCGTGTGTGACCACTTTGGCGGCTCGTTCCATCGACTGGAAGCGCTACAAGGTTGACGACCTCGAGCGTGCCCCGGTAG
TGCTCATGATAAACGTCATCAGCGTCCACGTTCCCTATACCGGAACCGGAAAGCAGAGCATAGCCAACGTTGATGAGATA
CACAACGAGATCAGGCTGGCGATAATGGACGCCGCGAGGAGGCTCCAGACATACCTGAGTGGCAAGCACAGAAGGCTCTA
CCAGGTGAAGAGGAAGAAGACCTTCGAGAAGTACGTGCCCGAGATAGCTAAGGCCCTGAGTATATTAACGGGCGAGCCCG
AGGAGGAGGTTAAGAACTACTTCCTGAGGTTCATCGAGGAAAGGTTCGCCCAGAGCGAGGTTGAGGCAGAGGAGGTGGCT
GAGAATGCCTAA

Upstream 100 bases:

>100_bases
ATCTTGAGAGGCGCAAGAAAGATTTGGAACTTGAAAGCGTCACCTACTACGAGGCCCTTGGCGGCTCTGAAAACTTTGAA
GGCTTTGAGGAGGAGTGAAA

Downstream 100 bases:

>100_bases
ATCCAAGGCCGTCAAGAGGAGCCAGCCAAGGGAGCGCTTCTCCTATGACCCCACTAAGGTGCTCAACAAGCTGGAGGAGT
ACGGAAGGCGTGTGCTGGAG

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MAEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYVRVEIEELGREHYKVIVEDNG
PGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKE
RHPNPKGWRGTRIELEVKNVRYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLT
DDVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERLMNGEVDKVLRSFKGYTKVVK
QVAKLMEKPPEKLSWHEAEEIVEAFKYMKFLAPPTHGLRPIGEENIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVG
LAYGGEISSGFDLLRYANRVPLLFDAGSCVTTLAARSIDWKRYKVDDLERAPVVLMINVISVHVPYTGTGKQSIANVDEI
HNEIRLAIMDAARRLQTYLSGKHRRLYQVKRKKTFEKYVPEIAKALSILTGEPEEEVKNYFLRFIEERFAQSEVEAEEVA
ENA

Sequences:

>Translated_563_residues
MAEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYVRVEIEELGREHYKVIVEDNG
PGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKE
RHPNPKGWRGTRIELEVKNVRYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLT
DDVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERLMNGEVDKVLRSFKGYTKVVK
QVAKLMEKPPEKLSWHEAEEIVEAFKYMKFLAPPTHGLRPIGEENIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVG
LAYGGEISSGFDLLRYANRVPLLFDAGSCVTTLAARSIDWKRYKVDDLERAPVVLMINVISVHVPYTGTGKQSIANVDEI
HNEIRLAIMDAARRLQTYLSGKHRRLYQVKRKKTFEKYVPEIAKALSILTGEPEEEVKNYFLRFIEERFAQSEVEAEEVA
ENA
>Mature_562_residues
AEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYVRVEIEELGREHYKVIVEDNGP
GIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKER
HPNPKGWRGTRIELEVKNVRYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLTD
DVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERLMNGEVDKVLRSFKGYTKVVKQ
VAKLMEKPPEKLSWHEAEEIVEAFKYMKFLAPPTHGLRPIGEENIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVGL
AYGGEISSGFDLLRYANRVPLLFDAGSCVTTLAARSIDWKRYKVDDLERAPVVLMINVISVHVPYTGTGKQSIANVDEIH
NEIRLAIMDAARRLQTYLSGKHRRLYQVKRKKTFEKYVPEIAKALSILTGEPEEEVKNYFLRFIEERFAQSEVEAEEVAE
NA

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TOP6B_THEON (B6YVS9)

Other databases:

- EMBL:   CP000855
- RefSeq:   YP_002307149.1
- GeneID:   7017067
- GenomeReviews:   CP000855_GR
- KEGG:   ton:TON_0764
- HOGENOM:   HBG733142
- OMA:   YTSAGKQ
- ProtClustDB:   PRK04184
- GO:   GO:0005694
- HAMAP:   MF_00322
- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF006553
- ProDom:   PD013790
- SMART:   SM00387
- TIGRFAMs:   TIGR01052

Pfam domain/function: PF02518 HATPase_c; PF09239 Topo-VIb_trans; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =5.99.1.3

Molecular weight: Translated: 63805; Mature: 63673

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYV
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
RVEIEELGREHYKVIVEDNGPGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVM
EHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHEE
FAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKERHPNPKGWRGTRIELEVKNV
EEEECCCCCEEEEECCCCHHEEEHHEEEEECCCCCEEECCCCCCCCCCCCCEEEEEECCH
RYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLT
HHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
DDVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MNGEVDKVLRSFKGYTKVVKQVAKLMEKPPEKLSWHEAEEIVEAFKYMKFLAPPTHGLRP
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IGEENIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVGLAYGGEISSGFDLLRYANRV
CCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCC
PLLFDAGSCVTTLAARSIDWKRYKVDDLERAPVVLMINVISVHVPYTGTGKQSIANVDEI
CEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEHEEECCCCCCCHHHHHHHHHH
HNEIRLAIMDAARRLQTYLSGKHRRLYQVKRKKTFEKYVPEIAKALSILTGEPEEEVKNY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FLRFIEERFAQSEVEAEEVAENA
HHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
AEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYV
CCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
RVEIEELGREHYKVIVEDNGPGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVM
EHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHEE
FAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKERHPNPKGWRGTRIELEVKNV
EEEECCCCCEEEEECCCCHHEEEHHEEEEECCCCCEEECCCCCCCCCCCCCEEEEEECCH
RYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLT
HHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
DDVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MNGEVDKVLRSFKGYTKVVKQVAKLMEKPPEKLSWHEAEEIVEAFKYMKFLAPPTHGLRP
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IGEENIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVGLAYGGEISSGFDLLRYANRV
CCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCC
PLLFDAGSCVTTLAARSIDWKRYKVDDLERAPVVLMINVISVHVPYTGTGKQSIANVDEI
CEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEHEEECCCCCCCHHHHHHHHHH
HNEIRLAIMDAARRLQTYLSGKHRRLYQVKRKKTFEKYVPEIAKALSILTGEPEEEVKNY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FLRFIEERFAQSEVEAEEVAENA
HHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA