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The map label for this gene is nuoD [H]

Identifier: 212223634

GI number: 212223634

Start: 447579

End: 448754

Strand: Reverse

Name: nuoD [H]

Synonym: TON_0487

Alternate gene names: 212223634

Gene position: 448754-447579 (Counterclockwise)

Preceding gene: 212223635

Following gene: 212223633

Centisome position: 24.29

GC content: 54.93

Gene sequence:

>1176_bases
ATGGTTTCACAGAATGAGCTCATTCGGGAAGCGAGAGAAAATGGGATGGATCTGCTCCCAATCGATAAGGACACTTACGA
GTTGTTCTTTGGCCCACAGCACATGGCTACTGAGAACTTCAGCATAATCCTCAAGATGGACGGTCACAGGGTTGTGAAGG
CTATAGCCAACCCCGGCTTCCTCCACAGGGGCTTTGAGAAGCTCGCCGAGTACAGGCCGTGGCACACGAACATAGCGCTC
CTCCTTAGAATCTGTGTTCCAGAGCCAGACGTCCCCGAGGCAATATACTCAATGGCCGTTGATGAGATAATCGGCTGGGA
GGTTCCAGAGAGGGCTCAGTGGATTAGAACAACCGTCCTCGAAATGGCGAGGGTTTCCGCATATCTGTTCTGGATAATGG
GTCTCAGCTTCAAGCTCGGTGTCTACACTGCCGGTCAGTGGGCTGCTGCCTACAGGGAGAGGCTGATGGCCCTCTTCGAG
CAACTGACCGGTGCCAGGGTCTATCACATATACACCATCCCCGGCGGTGTCAGGAGGGACATTCCGGGCGACAAGTGGCT
TCGCCAGCTCAAGGACACCGTCGAGTACATCAGGAGCAAGTTATCAGACTTCGACAACCTTGTCTTCGAGAACTACGTTG
CCCACAGGAGGCTTGAGGGAATTGGAGTGATGGACAAGAAGTTTGCCCTCGCCGAAGGCGTCACTGGGCCAAACCTCAGA
GCCACCGGCGTTCCCTACGACGTGAGGAGGGCAGATCCATACCTGCTCTATCCAGAGCTCGACTTCGAGGTTCCCGTCCT
GAAGGAGGGCGATGCCCTCGCGAGGGCTTTGATAAGGCGCTTCGAGCTTGAGCAGGATCTTTACATCCTCGACCAGCTCC
TCGAGATGGGACCGCCGAGCGGACCGTATAAGGTTGAAGATCCCAAGCTCAAGAATCTCCCGAGGTTTAAGGTTCCGGCT
GGAGATGCATTTGCCCACGTGGAATCAACGAAGGGCGACTTTGGTGCCTATGTCGTCAGTGATGGAAAGCACAAGCCGTA
CAGAGTGCAGATAAGGGGCCCAAGTATAGCCCACGGAGTCAGGGTTCTCGAGCAGCTCTTGGTTGGAGCAAGAATAGCCG
ACGTCCCCGTGATATTGATGAGCCTTGACAACTGTCCACCAGACATTGACAGGTGA

Upstream 100 bases:

>100_bases
AGAAAGGACTTCGACATGCTGACCTACGTGAAGAAGAAGTACAAGCTGCTCGACAGGTTCGATGAGGATAAGGACAACTA
CGTGATTTGAGGTGAGAGTT

Downstream 100 bases:

>100_bases
TGAAAATGGAGGTTGATTTTAAGGTCGCCCCAGAGGAGAAAGTCAGGAAGAAGCCATCATTCATCAAGCCCTGGATGGGC
CTCAAGTACCTCTTCAAGAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MVSQNELIREARENGMDLLPIDKDTYELFFGPQHMATENFSIILKMDGHRVVKAIANPGFLHRGFEKLAEYRPWHTNIAL
LLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTTVLEMARVSAYLFWIMGLSFKLGVYTAGQWAAAYRERLMALFE
QLTGARVYHIYTIPGGVRRDIPGDKWLRQLKDTVEYIRSKLSDFDNLVFENYVAHRRLEGIGVMDKKFALAEGVTGPNLR
ATGVPYDVRRADPYLLYPELDFEVPVLKEGDALARALIRRFELEQDLYILDQLLEMGPPSGPYKVEDPKLKNLPRFKVPA
GDAFAHVESTKGDFGAYVVSDGKHKPYRVQIRGPSIAHGVRVLEQLLVGARIADVPVILMSLDNCPPDIDR

Sequences:

>Translated_391_residues
MVSQNELIREARENGMDLLPIDKDTYELFFGPQHMATENFSIILKMDGHRVVKAIANPGFLHRGFEKLAEYRPWHTNIAL
LLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTTVLEMARVSAYLFWIMGLSFKLGVYTAGQWAAAYRERLMALFE
QLTGARVYHIYTIPGGVRRDIPGDKWLRQLKDTVEYIRSKLSDFDNLVFENYVAHRRLEGIGVMDKKFALAEGVTGPNLR
ATGVPYDVRRADPYLLYPELDFEVPVLKEGDALARALIRRFELEQDLYILDQLLEMGPPSGPYKVEDPKLKNLPRFKVPA
GDAFAHVESTKGDFGAYVVSDGKHKPYRVQIRGPSIAHGVRVLEQLLVGARIADVPVILMSLDNCPPDIDR
>Mature_391_residues
MVSQNELIREARENGMDLLPIDKDTYELFFGPQHMATENFSIILKMDGHRVVKAIANPGFLHRGFEKLAEYRPWHTNIAL
LLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTTVLEMARVSAYLFWIMGLSFKLGVYTAGQWAAAYRERLMALFE
QLTGARVYHIYTIPGGVRRDIPGDKWLRQLKDTVEYIRSKLSDFDNLVFENYVAHRRLEGIGVMDKKFALAEGVTGPNLR
ATGVPYDVRRADPYLLYPELDFEVPVLKEGDALARALIRRFELEQDLYILDQLLEMGPPSGPYKVEDPKLKNLPRFKVPA
GDAFAHVESTKGDFGAYVVSDGKHKPYRVQIRGPSIAHGVRVLEQLLVGARIADVPVILMSLDNCPPDIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=388, Percent_Identity=32.2164948453608, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI260898743, Length=376, Percent_Identity=32.4468085106383, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI145693162, Length=407, Percent_Identity=31.6953316953317, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1789076, Length=389, Percent_Identity=28.7917737789203, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788832, Length=364, Percent_Identity=28.8461538461538, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=385, Percent_Identity=31.1688311688312, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17555284, Length=404, Percent_Identity=30.1980198019802, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI221459469, Length=400, Percent_Identity=34.75, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24638644, Length=398, Percent_Identity=32.1608040201005, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44467; Mature: 44467

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSQNELIREARENGMDLLPIDKDTYELFFGPQHMATENFSIILKMDGHRVVKAIANPGF
CCCHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHCCCCCEEEEEECCHHHHHHHCCCCH
LHRGFEKLAEYRPWHTNIALLLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTTVL
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EMARVSAYLFWIMGLSFKLGVYTAGQWAAAYRERLMALFEQLTGARVYHIYTIPGGVRRD
HHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
IPGDKWLRQLKDTVEYIRSKLSDFDNLVFENYVAHRRLEGIGVMDKKFALAEGVTGPNLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCE
ATGVPYDVRRADPYLLYPELDFEVPVLKEGDALARALIRRFELEQDLYILDQLLEMGPPS
ECCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GPYKVEDPKLKNLPRFKVPAGDAFAHVESTKGDFGAYVVSDGKHKPYRVQIRGPSIAHGV
CCCCCCCCCCCCCCCEECCCCCHHHEEECCCCCCCEEEEECCCCCCEEEEECCCCHHHHH
RVLEQLLVGARIADVPVILMSLDNCPPDIDR
HHHHHHHHCCHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure
MVSQNELIREARENGMDLLPIDKDTYELFFGPQHMATENFSIILKMDGHRVVKAIANPGF
CCCHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHCCCCCEEEEEECCHHHHHHHCCCCH
LHRGFEKLAEYRPWHTNIALLLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTTVL
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EMARVSAYLFWIMGLSFKLGVYTAGQWAAAYRERLMALFEQLTGARVYHIYTIPGGVRRD
HHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
IPGDKWLRQLKDTVEYIRSKLSDFDNLVFENYVAHRRLEGIGVMDKKFALAEGVTGPNLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCE
ATGVPYDVRRADPYLLYPELDFEVPVLKEGDALARALIRRFELEQDLYILDQLLEMGPPS
ECCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GPYKVEDPKLKNLPRFKVPAGDAFAHVESTKGDFGAYVVSDGKHKPYRVQIRGPSIAHGV
CCCCCCCCCCCCCCCEECCCCCHHHEEECCCCCCCEEEEECCCCCCEEEEECCCCHHHHH
RVLEQLLVGARIADVPVILMSLDNCPPDIDR
HHHHHHHHCCHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA