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The map label for this gene is nuoI [H]

Identifier: 212223633

GI number: 212223633

Start: 446875

End: 447573

Strand: Reverse

Name: nuoI [H]

Synonym: TON_0486

Alternate gene names: 212223633

Gene position: 447573-446875 (Counterclockwise)

Preceding gene: 212223634

Following gene: 212223632

Centisome position: 24.22

GC content: 50.79

Gene sequence:

>699_bases
ATGGAGGTTGATTTTAAGGTCGCCCCAGAGGAGAAAGTCAGGAAGAAGCCATCATTCATCAAGCCCTGGATGGGCCTCAA
GTACCTCTTCAAGAAGCCCGTTACTATCAAGATACCCTACGAGAGGGTACAGATAGCTAAGGACTACAGGGGATTCCACA
CCCTAGACTGGAAGAAGTGTGTCGGCTGTAACTTCTGCGGCCAGATATGTCCGGCGAGGGCAATAGAGATGACCTGGATA
GAAGTGGATGGCAAGATGGAGAAGAGGCCACATCCAAAGATAGACTATGGCAGGTGTACCTTCTGTGAGTTCTGTGTCGA
CGTCTGTCCACCTGGAGCGCTGGGCTTCATCGAGAACTACATCCTCACCACCGAGTGGAAGGACGAGGAGCTGGAGCTCT
TTGACTGGGTTCCAATCCATCCAGACAAGTTCAGGGAGATAAACGAGAAGTTCCCCGACTACAGATTCCCGGTGGAGAAG
ATAGAGTTCAACAAGGAAACGAAGGAGGTCACCTACTACCTGAGAGACGGAGAGGTCATGAAGTTCAAGATACTCGGCTA
CGGCATCAGACCGCCGAAGCCACCGACAAAGCCTGCTCAGAAGGCAGCCGCAAAAGCAGCGGAAAAGAATGATACCAAGC
CTGTTGAAAAGCCCACTGAGAAGAAGGAAGCTGGGAAGATAGAAGAAAAGAAAGAATGA

Upstream 100 bases:

>100_bases
GGGTTCTCGAGCAGCTCTTGGTTGGAGCAAGAATAGCCGACGTCCCCGTGATATTGATGAGCCTTGACAACTGTCCACCA
GACATTGACAGGTGATGAAA

Downstream 100 bases:

>100_bases
ACCTCTTTTTCCCATTAATTTCTTGCCATTTTTTCGAAATGATTTTAAGAAGTTCGTGAGTTATTAATTTGGTGGAATTC
TATGGCAATAGACGTCAGAA

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MEVDFKVAPEEKVRKKPSFIKPWMGLKYLFKKPVTIKIPYERVQIAKDYRGFHTLDWKKCVGCNFCGQICPARAIEMTWI
EVDGKMEKRPHPKIDYGRCTFCEFCVDVCPPGALGFIENYILTTEWKDEELELFDWVPIHPDKFREINEKFPDYRFPVEK
IEFNKETKEVTYYLRDGEVMKFKILGYGIRPPKPPTKPAQKAAAKAAEKNDTKPVEKPTEKKEAGKIEEKKE

Sequences:

>Translated_232_residues
MEVDFKVAPEEKVRKKPSFIKPWMGLKYLFKKPVTIKIPYERVQIAKDYRGFHTLDWKKCVGCNFCGQICPARAIEMTWI
EVDGKMEKRPHPKIDYGRCTFCEFCVDVCPPGALGFIENYILTTEWKDEELELFDWVPIHPDKFREINEKFPDYRFPVEK
IEFNKETKEVTYYLRDGEVMKFKILGYGIRPPKPPTKPAQKAAAKAAEKNDTKPVEKPTEKKEAGKIEEKKE
>Mature_232_residues
MEVDFKVAPEEKVRKKPSFIKPWMGLKYLFKKPVTIKIPYERVQIAKDYRGFHTLDWKKCVGCNFCGQICPARAIEMTWI
EVDGKMEKRPHPKIDYGRCTFCEFCVDVCPPGALGFIENYILTTEWKDEELELFDWVPIHPDKFREINEKFPDYRFPVEK
IEFNKETKEVTYYLRDGEVMKFKILGYGIRPPKPPTKPAQKAAAKAAEKNDTKPVEKPTEKKEAGKIEEKKE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=138, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17864306, Length=111, Percent_Identity=32.4324324324324, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 27234; Mature: 27234

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVDFKVAPEEKVRKKPSFIKPWMGLKYLFKKPVTIKIPYERVQIAKDYRGFHTLDWKKC
CCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCCHHHH
VGCNFCGQICPARAIEMTWIEVDGKMEKRPHPKIDYGRCTFCEFCVDVCPPGALGFIENY
CCCCCHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHC
ILTTEWKDEELELFDWVPIHPDKFREINEKFPDYRFPVEKIEFNKETKEVTYYLRDGEVM
EEECCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEEEECCCEE
KFKILGYGIRPPKPPTKPAQKAAAKAAEKNDTKPVEKPTEKKEAGKIEEKKE
EEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MEVDFKVAPEEKVRKKPSFIKPWMGLKYLFKKPVTIKIPYERVQIAKDYRGFHTLDWKKC
CCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCCHHHH
VGCNFCGQICPARAIEMTWIEVDGKMEKRPHPKIDYGRCTFCEFCVDVCPPGALGFIENY
CCCCCHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHC
ILTTEWKDEELELFDWVPIHPDKFREINEKFPDYRFPVEKIEFNKETKEVTYYLRDGEVM
EEECCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEEEECCCEE
KFKILGYGIRPPKPPTKPAQKAAAKAAEKNDTKPVEKPTEKKEAGKIEEKKE
EEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA