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The map label for this gene is accD [C]

Identifier: 212223186

GI number: 212223186

Start: 35233

End: 36801

Strand: Reverse

Name: accD [C]

Synonym: TON_0041

Alternate gene names: 212223186

Gene position: 36801-35233 (Counterclockwise)

Preceding gene: 212223187

Following gene: 212223185

Centisome position: 1.99

GC content: 56.34

Gene sequence:

>1569_bases
ATGAGCATGGAGGAAAAGGTTAACGAGCTGTACGAACGGAGAAAAAAGATTCTTGAGATGGGCGGCGAAAAGGCCGTCGA
AAAGCAGCACGCTAAAGGCAAGCTCACAGCGCGCGAGAGGATCGAGAAGCTCCTCGACCCGGGAAGCTTCGTTGAGATCG
GCATGTTCGTCAAGCACAGAGGAACGGAGTTCGGTCTCGATAAGAAGGAACTGCCCGCGGATGGTGTCATCACCGGCTAT
GGAACCATCGATGGAAGGCTTGTCTTCGTCTATGCCCAGGACTTCACCGTCATGGGAGGTTCCCTCGGCGAGATGCACGC
TGCTAAGATAAAGCGCATAATGGAGCTCGCCCTTGAGGCGGGAGCACCTGTAATAGGCCTCAATGATTCCGGCGGTGCAA
GGATTCAGGAGGGTGTGGACTCCCTCAAGGGCTACGGTGAGATCTTCAAGATGAACACAATTCTCAGCGGTGTTGTGCCA
CAGATCACCGCAATTATGGGTCCCTGTGCCGGAGGAGCGGTTTACAGCCCGGCGATAGGAGACTTCATCCTCATGGTGGA
CAACCCGTCGAGCTTCATGTTCATCACAGGCCCACAGGTCGTTAAAGCTGTCACGGGCGTCGAGGTTACACCTGTTCAGC
TCGGTGGAGCCATGGTTCACGCCCAAAAGAGCGGACAGGCCCACCTCATAGGAAAGAGCGACGAAGAGGTTCTAGCGTTG
ATAAGACGTCTCATGAGCTACCTGCCGTCAAACAACATGGAGAAGCCGCCGCGTGTTAAGACAAGCGATTTGCCATTCAG
GAAGACCGAAAGCCTGTACTCCATAGTTCCGGACGACCCGAACAAGGGCTACGACGTCAGGCAGGTCATCTACGAGATAG
TTGACAGGGATGAGAACGGCAATCCGGACTTCCTGGAGATTCTGCCCTACTTCGCCCCAAACGCCGTCGTCGGCTTCGGA
AGGATGAACGGCCAGACGGTTGGTATAGTCGCCAACAACCCCAACTACTTCGCGGGCGTTCTTGACATAGACAGCTCCGA
CAAGATAGCACGCTTTGTGAGAACCTGCGACGCCTTCAACATACCCATCGTCACGCTTGTTGACGTCCCCGGCTACCTGC
CGGGCACCCAGCAGGAGTATGGTGGAATCATCAGGCACGGAGCCAAGGTCCTTTACGCCTACTCCGAGGCCACCGTCCCG
ATGGTGACCGTCATTCTCAGGAAGGCCTACGGTGGCGCTTACCTCGCAATGGGAAGCAAGCACCTCGGTGCCGACTTCGT
CTTCGCCTGGCCGACCGCAGAGATAGCCGTTATGGGTCCTGAGGGAGCGGCCAATATCATCTTCAGGAAAGAGATTGCAG
CGGCAGAGAACCCTGAGGAGGTCAGGCAGCAGAAGATACAGGAGTACAAGGACAGGTTTGCCAACCCGTACGTCGCTGCC
GCGAGGGGATACATCGACGATGTCATAGACCCTGCCGAGACAAGGGCAAAGATAATCCTTGCCCTCGAGGCCATGGAGAG
CAAGCGCGTCAAGCTCCCGCCGAAGAAGCACGGCAACATACCGCTGTGA

Upstream 100 bases:

>100_bases
AAGAATTTTATCAACTCCTCAACGGGCAGTGGAGCAAAAACCCTTTTAAACTTTACAAACTACAACCACCAGACACTCTC
AGCTGTTAGGGGGAGTTCTC

Downstream 100 bases:

>100_bases
GGTGTGAGACATGGTAACCATGGCCGAGTTCGTGGAGGGCCTCAACATAACCGCCCTCGGAGTGACGGTGGTCTTTGCCG
TCCTCACCATTTTAGCTTTA

Product: methylmalonyl-CoA decarboxylase, alpha subunit

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSMEEKVNELYERRKKILEMGGEKAVEKQHAKGKLTARERIEKLLDPGSFVEIGMFVKHRGTEFGLDKKELPADGVITGY
GTIDGRLVFVYAQDFTVMGGSLGEMHAAKIKRIMELALEAGAPVIGLNDSGGARIQEGVDSLKGYGEIFKMNTILSGVVP
QITAIMGPCAGGAVYSPAIGDFILMVDNPSSFMFITGPQVVKAVTGVEVTPVQLGGAMVHAQKSGQAHLIGKSDEEVLAL
IRRLMSYLPSNNMEKPPRVKTSDLPFRKTESLYSIVPDDPNKGYDVRQVIYEIVDRDENGNPDFLEILPYFAPNAVVGFG
RMNGQTVGIVANNPNYFAGVLDIDSSDKIARFVRTCDAFNIPIVTLVDVPGYLPGTQQEYGGIIRHGAKVLYAYSEATVP
MVTVILRKAYGGAYLAMGSKHLGADFVFAWPTAEIAVMGPEGAANIIFRKEIAAAENPEEVRQQKIQEYKDRFANPYVAA
ARGYIDDVIDPAETRAKIILALEAMESKRVKLPPKKHGNIPL

Sequences:

>Translated_522_residues
MSMEEKVNELYERRKKILEMGGEKAVEKQHAKGKLTARERIEKLLDPGSFVEIGMFVKHRGTEFGLDKKELPADGVITGY
GTIDGRLVFVYAQDFTVMGGSLGEMHAAKIKRIMELALEAGAPVIGLNDSGGARIQEGVDSLKGYGEIFKMNTILSGVVP
QITAIMGPCAGGAVYSPAIGDFILMVDNPSSFMFITGPQVVKAVTGVEVTPVQLGGAMVHAQKSGQAHLIGKSDEEVLAL
IRRLMSYLPSNNMEKPPRVKTSDLPFRKTESLYSIVPDDPNKGYDVRQVIYEIVDRDENGNPDFLEILPYFAPNAVVGFG
RMNGQTVGIVANNPNYFAGVLDIDSSDKIARFVRTCDAFNIPIVTLVDVPGYLPGTQQEYGGIIRHGAKVLYAYSEATVP
MVTVILRKAYGGAYLAMGSKHLGADFVFAWPTAEIAVMGPEGAANIIFRKEIAAAENPEEVRQQKIQEYKDRFANPYVAA
ARGYIDDVIDPAETRAKIILALEAMESKRVKLPPKKHGNIPL
>Mature_521_residues
SMEEKVNELYERRKKILEMGGEKAVEKQHAKGKLTARERIEKLLDPGSFVEIGMFVKHRGTEFGLDKKELPADGVITGYG
TIDGRLVFVYAQDFTVMGGSLGEMHAAKIKRIMELALEAGAPVIGLNDSGGARIQEGVDSLKGYGEIFKMNTILSGVVPQ
ITAIMGPCAGGAVYSPAIGDFILMVDNPSSFMFITGPQVVKAVTGVEVTPVQLGGAMVHAQKSGQAHLIGKSDEEVLALI
RRLMSYLPSNNMEKPPRVKTSDLPFRKTESLYSIVPDDPNKGYDVRQVIYEIVDRDENGNPDFLEILPYFAPNAVVGFGR
MNGQTVGIVANNPNYFAGVLDIDSSDKIARFVRTCDAFNIPIVTLVDVPGYLPGTQQEYGGIIRHGAKVLYAYSEATVPM
VTVILRKAYGGAYLAMGSKHLGADFVFAWPTAEIAVMGPEGAANIIFRKEIAAAENPEEVRQQKIQEYKDRFANPYVAAA
RGYIDDVIDPAETRAKIILALEAMESKRVKLPPKKHGNIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=525, Percent_Identity=55.6190476190476, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI295821216, Length=545, Percent_Identity=53.5779816513761, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI11545863, Length=518, Percent_Identity=35.1351351351351, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI134142062, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI310133460, Length=130, Percent_Identity=39.2307692307692, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1788655, Length=244, Percent_Identity=31.1475409836066, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25147362, Length=515, Percent_Identity=56.504854368932, Blast_Score=578, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=56.3953488372093, Blast_Score=577, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17552936, Length=531, Percent_Identity=35.5932203389831, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71997163, Length=351, Percent_Identity=24.7863247863248, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323863, Length=350, Percent_Identity=23.1428571428571, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586065, Length=532, Percent_Identity=34.7744360902256, Blast_Score=261, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56916; Mature: 56785

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMEEKVNELYERRKKILEMGGEKAVEKQHAKGKLTARERIEKLLDPGSFVEIGMFVKHR
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEHHHHCC
GTEFGLDKKELPADGVITGYGTIDGRLVFVYAQDFTVMGGSLGEMHAAKIKRIMELALEA
CCCCCCCHHHCCCCCEEEEECCCCCEEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHC
GAPVIGLNDSGGARIQEGVDSLKGYGEIFKMNTILSGVVPQITAIMGPCAGGAVYSPAIG
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
DFILMVDNPSSFMFITGPQVVKAVTGVEVTPVQLGGAMVHAQKSGQAHLIGKSDEEVLAL
CEEEEEECCCCEEEEECHHHHHHHCCCEEEEEECCCEEEEECCCCCEEEECCCCHHHHHH
IRRLMSYLPSNNMEKPPRVKTSDLPFRKTESLYSIVPDDPNKGYDVRQVIYEIVDRDENG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCHHHHHHHHHHCCCCCC
NPDFLEILPYFAPNAVVGFGRMNGQTVGIVANNPNYFAGVLDIDSSDKIARFVRTCDAFN
CCCHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCC
IPIVTLVDVPGYLPGTQQEYGGIIRHGAKVLYAYSEATVPMVTVILRKAYGGAYLAMGSK
CCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCC
HLGADFVFAWPTAEIAVMGPEGAANIIFRKEIAAAENPEEVRQQKIQEYKDRFANPYVAA
CCCCCEEEECCCCEEEEECCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHH
ARGYIDDVIDPAETRAKIILALEAMESKRVKLPPKKHGNIPL
HHHHHHHHCCCCHHHEEEEEEEEHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SMEEKVNELYERRKKILEMGGEKAVEKQHAKGKLTARERIEKLLDPGSFVEIGMFVKHR
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEHHHHCC
GTEFGLDKKELPADGVITGYGTIDGRLVFVYAQDFTVMGGSLGEMHAAKIKRIMELALEA
CCCCCCCHHHCCCCCEEEEECCCCCEEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHC
GAPVIGLNDSGGARIQEGVDSLKGYGEIFKMNTILSGVVPQITAIMGPCAGGAVYSPAIG
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
DFILMVDNPSSFMFITGPQVVKAVTGVEVTPVQLGGAMVHAQKSGQAHLIGKSDEEVLAL
CEEEEEECCCCEEEEECHHHHHHHCCCEEEEEECCCEEEEECCCCCEEEECCCCHHHHHH
IRRLMSYLPSNNMEKPPRVKTSDLPFRKTESLYSIVPDDPNKGYDVRQVIYEIVDRDENG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCHHHHHHHHHHCCCCCC
NPDFLEILPYFAPNAVVGFGRMNGQTVGIVANNPNYFAGVLDIDSSDKIARFVRTCDAFN
CCCHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCC
IPIVTLVDVPGYLPGTQQEYGGIIRHGAKVLYAYSEATVPMVTVILRKAYGGAYLAMGSK
CCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCC
HLGADFVFAWPTAEIAVMGPEGAANIIFRKEIAAAENPEEVRQQKIQEYKDRFANPYVAA
CCCCCEEEECCCCEEEEECCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHH
ARGYIDDVIDPAETRAKIILALEAMESKRVKLPPKKHGNIPL
HHHHHHHHCCCCHHHEEEEEEEEHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]