Click here to switch to the map view.

The map label for this gene is eif2b [H]

Identifier: 212223187

GI number: 212223187

Start: 36951

End: 37382

Strand: Reverse

Name: eif2b [H]

Synonym: TON_0042

Alternate gene names: 212223187

Gene position: 37382-36951 (Counterclockwise)

Preceding gene: 212223188

Following gene: 212223186

Centisome position: 2.02

GC content: 52.55

Gene sequence:

>432_bases
GTGAGCGAGAAGAAGGTTGACTTTTACGATTTCGAAGGCTTACTCGATAAGGCTTACGAGGAGCTCCCAGAGAACGTTAA
GCATCACATCTCGAGGTTTGAGGTTCCCGCCGCCGTAGTCACGATAGCCGGAAACAGGACTATAATCGAGAACTTCATGG
ACATAGCCGAGGCCATGAACCGCGACCCGAACCATCTTCTCAAGTTCATCTTGAGAGAGGTGGCAACGGCCGGAACACTC
GAGGGAAGGAGAGTTGTCCTCCAAGGACGCTTCACACCCTACCTGATAGCCAACAAGATGAAGAAGTACCTCAAGGACTA
CGTTATCTGCCCGGTCTGCGGCTCACCAGATACCAAGATCATCAAGAGGGGACGCTTCCACTTCCTCAAGTGCGAGGCCT
GTGGTGCAGAAACTCCGATTGCACACCTCTGA

Upstream 100 bases:

>100_bases
AACCGAGAGCCGGCTTCTACAGGGTGCTTTGATTTTCTCGATTTTCCCCACGCCAAAAGGTTATAAACGGCTCTGCATAC
CTTAAGTGGAGGTGAGGAAA

Downstream 100 bases:

>100_bases
ATCCGTTCTACCTTTTTCTACTTCACCCCTTTTGCTGCTTTCAACATCTAAGAATTTTATCAACTCCTCAACGGGCAGTG
GAGCAAAAACCCTTTTAAAC

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MSEKKVDFYDFEGLLDKAYEELPENVKHHISRFEVPAAVVTIAGNRTIIENFMDIAEAMNRDPNHLLKFILREVATAGTL
EGRRVVLQGRFTPYLIANKMKKYLKDYVICPVCGSPDTKIIKRGRFHFLKCEACGAETPIAHL

Sequences:

>Translated_143_residues
MSEKKVDFYDFEGLLDKAYEELPENVKHHISRFEVPAAVVTIAGNRTIIENFMDIAEAMNRDPNHLLKFILREVATAGTL
EGRRVVLQGRFTPYLIANKMKKYLKDYVICPVCGSPDTKIIKRGRFHFLKCEACGAETPIAHL
>Mature_142_residues
SEKKVDFYDFEGLLDKAYEELPENVKHHISRFEVPAAVVTIAGNRTIIENFMDIAEAMNRDPNHLLKFILREVATAGTLE
GRRVVLQGRFTPYLIANKMKKYLKDYVICPVCGSPDTKIIKRGRFHFLKCEACGAETPIAHL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family [H]

Homologues:

Organism=Homo sapiens, GI29826335, Length=141, Percent_Identity=36.1702127659575, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17508049, Length=114, Percent_Identity=32.4561403508772, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6325018, Length=115, Percent_Identity=31.304347826087, Blast_Score=86, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647377, Length=135, Percent_Identity=37.7777777777778, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190 [H]

Pfam domain/function: PF01873 eIF-5_eIF-2B [H]

EC number: NA

Molecular weight: Translated: 16298; Mature: 16167

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKKVDFYDFEGLLDKAYEELPENVKHHISRFEVPAAVVTIAGNRTIIENFMDIAEAMN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHC
RDPNHLLKFILREVATAGTLEGRRVVLQGRFTPYLIANKMKKYLKDYVICPVCGSPDTKI
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCEECCCCCCCCHHH
IKRGRFHFLKCEACGAETPIAHL
HHCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SEKKVDFYDFEGLLDKAYEELPENVKHHISRFEVPAAVVTIAGNRTIIENFMDIAEAMN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHC
RDPNHLLKFILREVATAGTLEGRRVVLQGRFTPYLIANKMKKYLKDYVICPVCGSPDTKI
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCEECCCCCCCCHHH
IKRGRFHFLKCEACGAETPIAHL
HHCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA