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The map label for this gene is ksgA [H]

Identifier: 209554601

GI number: 209554601

Start: 871796

End: 872641

Strand: Reverse

Name: ksgA [H]

Synonym: UUR10_0706

Alternate gene names: 209554601

Gene position: 872641-871796 (Counterclockwise)

Preceding gene: 209554229

Following gene: 209554027

Centisome position: 99.79

GC content: 24.94

Gene sequence:

>846_bases
TTGAATAAAACAGTCATTAAAAATAAACTCAAGCAAGAAAGTTTTGTTCCATCAAAAAAAATGGGGCAAAACTTCTTGTT
GTCTAATGAGATAAAAAACAAAATTGTAAATGTGGCAAATATTAGTAAAGATGATTTAATTTTAGAAATTGGTCCAGGAT
GAGGAGCAATTACTGAGCTTCTTGTTCAAAAAACAGATACCTTAGTGGCTATTGAATTAGATAAAAGATTATATGCGCAC
TTAAAAACATACATAAAAGCACCTAATTTTCATATAATAAATAATGATGTGTTATGTGTAGATTTAGATAAATTAATCTT
AGATTACACCAACACTAAAAAAAATCAAAAAATTAAAGTTGTTGCAAACCTTCCTTATGCAATTTCTTCAAAAATAGTTT
TGAAAATTATTCAATCAAAATTAATTAATGATGCTTATATTATGGTTCAAAAAGAGATGGCTGAACGTATTGGTGCTAAA
GTAAATACACGTGGTTATAATGCTTTTACTGTTTTAGTTCAACTATTTTGTAAGACAAAGATTCTTTTTCAAGTAAATGC
AAAGGAATTTCATCCACAACCAAAAGTACAAAGTGCTGTTATTCATCTTGAAAACCTTCATAATAAAGTTGATTTTGATA
TTGAACAAGTAAGTAAATTTTTACGGATTTGTTTTTTAAACAAACGTAAGAAGTTAAAAAATAATTTGTCTAATATTTAT
GATATAAAACTCGTTAATGAAATGTTTATTGATTATAATTTAGATATGAATTTACGAGCTGAGAATATTGAACCAAAAAT
GTTTTTAGAACTCTTTAATTATTTGAATAAATCAAATAATGAATAA

Upstream 100 bases:

>100_bases
ATTTTACAATCATATATTATTCACGTTATTATTATGAAACGTCGTTCAAATAGTGCCACAAGAATTGAATCAAAACTTGC
CAAATTAGGAATTAGCTAAC

Downstream 100 bases:

>100_bases
AATTAAGCTGTAGGTCAAATTATGAAAGTAAAATCATTCGCAAAAATTGATTTAGGATATAGTGTTTACAAAAAACGAAA
AAACATTACAAAACACGATT

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNKTVIKNKLKQESFVPSKKMGQNFLLSNEIKNKIVNVANISKDDLILEIGPGWGAITELLVQKTDTLVAIELDKRLYAH
LKTYIKAPNFHIINNDVLCVDLDKLILDYTNTKKNQKIKVVANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAK
VNTRGYNAFTVLVQLFCKTKILFQVNAKEFHPQPKVQSAVIHLENLHNKVDFDIEQVSKFLRICFLNKRKKLKNNLSNIY
DIKLVNEMFIDYNLDMNLRAENIEPKMFLELFNYLNKSNNE

Sequences:

>Translated_281_residues
MNKTVIKNKLKQESFVPSKKMGQNFLLSNEIKNKIVNVANISKDDLILEIGPG*GAITELLVQKTDTLVAIELDKRLYAH
LKTYIKAPNFHIINNDVLCVDLDKLILDYTNTKKNQKIKVVANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAK
VNTRGYNAFTVLVQLFCKTKILFQVNAKEFHPQPKVQSAVIHLENLHNKVDFDIEQVSKFLRICFLNKRKKLKNNLSNIY
DIKLVNEMFIDYNLDMNLRAENIEPKMFLELFNYLNKSNNE
>Mature_281_residues
MNKTVIKNKLKQESFVPSKKMGQNFLLSNEIKNKIVNVANISKDDLILEIGPG*GAITELLVQKTDTLVAIELDKRLYAH
LKTYIKAPNFHIINNDVLCVDLDKLILDYTNTKKNQKIKVVANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAK
VNTRGYNAFTVLVQLFCKTKILFQVNAKEFHPQPKVQSAVIHLENLHNKVDFDIEQVSKFLRICFLNKRKKLKNNLSNIY
DIKLVNEMFIDYNLDMNLRAENIEPKMFLELFNYLNKSNNE

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=217, Percent_Identity=32.7188940092166, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI156415992, Length=286, Percent_Identity=24.4755244755245, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786236, Length=262, Percent_Identity=32.0610687022901, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25146882, Length=228, Percent_Identity=31.140350877193, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25141369, Length=284, Percent_Identity=22.1830985915493, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324989, Length=225, Percent_Identity=27.5555555555556, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21358017, Length=268, Percent_Identity=29.8507462686567, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357273, Length=238, Percent_Identity=27.7310924369748, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 32313; Mature: 32313

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTVIKNKLKQESFVPSKKMGQNFLLSNEIKNKIVNVANISKDDLILEIGPGGAITELL
CCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
VQKTDTLVAIELDKRLYAHLKTYIKAPNFHIINNDVLCVDLDKLILDYTNTKKNQKIKVV
HHCCCCEEEEEHHHHHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHHCCCCCCCEEEEE
ANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAKVNTRGYNAFTVLVQLFCKTKI
EECCHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHEE
LFQVNAKEFHPQPKVQSAVIHLENLHNKVDFDIEQVSKFLRICFLNKRKKLKNNLSNIYD
EEEECHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKLVNEMFIDYNLDMNLRAENIEPKMFLELFNYLNKSNNE
HEEHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKTVIKNKLKQESFVPSKKMGQNFLLSNEIKNKIVNVANISKDDLILEIGPGGAITELL
CCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
VQKTDTLVAIELDKRLYAHLKTYIKAPNFHIINNDVLCVDLDKLILDYTNTKKNQKIKVV
HHCCCCEEEEEHHHHHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHHCCCCCCCEEEEE
ANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAKVNTRGYNAFTVLVQLFCKTKI
EECCHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHEE
LFQVNAKEFHPQPKVQSAVIHLENLHNKVDFDIEQVSKFLRICFLNKRKKLKNNLSNIYD
EEEECHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKLVNEMFIDYNLDMNLRAENIEPKMFLELFNYLNKSNNE
HEEHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA