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The map label for this gene is ubiE [H]

Identifier: 209551934

GI number: 209551934

Start: 4534635

End: 4535411

Strand: Reverse

Name: ubiE [H]

Synonym: Rleg2_4367

Alternate gene names: 209551934

Gene position: 4535411-4534635 (Counterclockwise)

Preceding gene: NA

Following gene: 209551933

Centisome position: 99.94

GC content: 62.81

Gene sequence:

>777_bases
ATGCCTGAAAGCCGCACTTCCGCCGATGGCGGCATGGAGACCTCCTACGGCTTCCGCGAGGTGCCGGGCGGCGAGAAGCA
GGACCTGGTCAACCAGGTGTTCCACAAGGTCGCCAAGCGCTACGACATCATGAACGACGTGATGTCGATGGGCATGCACC
GCGCCTGGAAAGACGCGATGATTTCGGCGCTGAACCCGCGCAAGGAGCCGGGCTACAGGGTGCTCGACGTTGCCGGCGGC
ACCGGCGACATCGCCTTCCGCATCGTCGAGGCCTCGGGCCGGCAGGCGCATGCGACCGTGCTCGACATCAACGGCTCGAT
GCTCGGCGTCGGCGCCGAGCGGGCGGAAAAGAAGAAGCTTTCCGGCAATCTCACCTTCGTCGAGGCGAATGCCGAGGAAC
TGCCTTTCGAGCCGGCGAGCTTCGACGCCTATACGATCGCCTTCGGCATCCGCAACGTACCGCGGATCGATGCCGCACTG
TCGGAGGCCTATCGCGTGCTGAAGCGCGGTGGACGACTGCTGGTCTTGGAATTTTCCGAAGTCGACATGCCGCTGCTCGA
CAGGATCTACGACGCCTGGTCGTTCAATGCCATTCCGCAATTCGGCAAGGCGATCACCGGCGATGCCGAACCCTACCAGT
ATCTGGTGGAATCTATCCGCAAGTTCCCGAACCAGGAGAATTTCGCGGCGATGATCCGCCAGGCCGGCTTTTCGCGAGTC
ACCTACACCAATTACACCGGCGGCATCGCCGCGCTGCATTCCGGCTGGAAGCTCTGA

Upstream 100 bases:

>100_bases
TAGCGCCAGTGGTCCGCGGAGAGCGCGGCCCAGTGATAACGTCGCGCGCGGTCTTTCGCTATGGCCTGCGCGGCTGAATA
TCGAGGAACGGAGCAGTCTG

Downstream 100 bases:

>100_bases
GGGCATGAGGGAAGAAAACACCAACCTCGGCCGGCGGGGCAGTGCAGCATGAGCACGTTCGGGGCCTATTTCCGCCTTTG
GCGCGTCGGCTGGGTGCTTG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPESRTSADGGMETSYGFREVPGGEKQDLVNQVFHKVAKRYDIMNDVMSMGMHRAWKDAMISALNPRKEPGYRVLDVAGG
TGDIAFRIVEASGRQAHATVLDINGSMLGVGAERAEKKKLSGNLTFVEANAEELPFEPASFDAYTIAFGIRNVPRIDAAL
SEAYRVLKRGGRLLVLEFSEVDMPLLDRIYDAWSFNAIPQFGKAITGDAEPYQYLVESIRKFPNQENFAAMIRQAGFSRV
TYTNYTGGIAALHSGWKL

Sequences:

>Translated_258_residues
MPESRTSADGGMETSYGFREVPGGEKQDLVNQVFHKVAKRYDIMNDVMSMGMHRAWKDAMISALNPRKEPGYRVLDVAGG
TGDIAFRIVEASGRQAHATVLDINGSMLGVGAERAEKKKLSGNLTFVEANAEELPFEPASFDAYTIAFGIRNVPRIDAAL
SEAYRVLKRGGRLLVLEFSEVDMPLLDRIYDAWSFNAIPQFGKAITGDAEPYQYLVESIRKFPNQENFAAMIRQAGFSRV
TYTNYTGGIAALHSGWKL
>Mature_257_residues
PESRTSADGGMETSYGFREVPGGEKQDLVNQVFHKVAKRYDIMNDVMSMGMHRAWKDAMISALNPRKEPGYRVLDVAGGT
GDIAFRIVEASGRQAHATVLDINGSMLGVGAERAEKKKLSGNLTFVEANAEELPFEPASFDAYTIAFGIRNVPRIDAALS
EAYRVLKRGGRLLVLEFSEVDMPLLDRIYDAWSFNAIPQFGKAITGDAEPYQYLVESIRKFPNQENFAAMIRQAGFSRVT
YTNYTGGIAALHSGWKL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=279, Percent_Identity=49.4623655913978, Blast_Score=260, Evalue=8e-70,
Organism=Escherichia coli, GI48994983, Length=245, Percent_Identity=47.3469387755102, Blast_Score=234, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17557039, Length=252, Percent_Identity=50.3968253968254, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6323526, Length=258, Percent_Identity=43.4108527131783, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24641702, Length=258, Percent_Identity=50, Blast_Score=254, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28542; Mature: 28411

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESRTSADGGMETSYGFREVPGGEKQDLVNQVFHKVAKRYDIMNDVMSMGMHRAWKDAM
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISALNPRKEPGYRVLDVAGGTGDIAFRIVEASGRQAHATVLDINGSMLGVGAERAEKKKL
HHHCCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEEEEECCCEEECCHHHHHHHHH
SGNLTFVEANAEELPFEPASFDAYTIAFGIRNVPRIDAALSEAYRVLKRGGRLLVLEFSE
CCCEEEEECCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
VDMPLLDRIYDAWSFNAIPQFGKAITGDAEPYQYLVESIRKFPNQENFAAMIRQAGFSRV
CCHHHHHHHHHHHCCCCCHHHCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEE
TYTNYTGGIAALHSGWKL
EEECCCCCHHHHHCCCCC
>Mature Secondary Structure 
PESRTSADGGMETSYGFREVPGGEKQDLVNQVFHKVAKRYDIMNDVMSMGMHRAWKDAM
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISALNPRKEPGYRVLDVAGGTGDIAFRIVEASGRQAHATVLDINGSMLGVGAERAEKKKL
HHHCCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEEEEECCCEEECCHHHHHHHHH
SGNLTFVEANAEELPFEPASFDAYTIAFGIRNVPRIDAALSEAYRVLKRGGRLLVLEFSE
CCCEEEEECCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
VDMPLLDRIYDAWSFNAIPQFGKAITGDAEPYQYLVESIRKFPNQENFAAMIRQAGFSRV
CCHHHHHHHHHHHCCCCCHHHCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEE
TYTNYTGGIAALHSGWKL
EEECCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA