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The map label for this gene is ubiB [H]

Identifier: 209551933

GI number: 209551933

Start: 4533012

End: 4534586

Strand: Reverse

Name: ubiB [H]

Synonym: Rleg2_4366

Alternate gene names: 209551933

Gene position: 4534586-4533012 (Counterclockwise)

Preceding gene: 209551934

Following gene: 209551932

Centisome position: 99.93

GC content: 63.87

Gene sequence:

>1575_bases
ATGAGCACGTTCGGGGCCTATTTCCGCCTTTGGCGCGTCGGCTGGGTGCTTGTGCGTGAGGGCGTCGTCTCAGCTCTGCC
GTCCGAAGGCCTGCCGCCTCCGGTGGCGCTCGCCAAATCCTTCGTGACGATTTTCGAGCGCAGCAAGGCGCGCCATCAAA
AGCGCAGCGACCGGTTGGCGCACGCCGTCGAGCGGCTCGGCCCCTCCTATGTAAAAATCGGGCAGTTCCTGGCGACGCGG
CCGGATGTCGTCGGCGTCGAATTCGCCAACGACCTGTCGCAGTTGCAGGATCGGATGGCCTTCTTCCACTCGGCTGCGGC
CAAGGCCAATATCGAAGGCTCGCTCGGGCGGCCGATCGACGAGCTCTATGCGAGCTTCGGCGAGCCGATCGCCGCTGCCT
CGATCGCCCAGGTGCATCCTGCCGAAGTCGAAACATCGGAGGGCCGCAAGAAGGTCGCCGTCAAGATCGTGCGGCCCGGC
GTGCGCCAGCGCTTTGCCCACGACATCGAGGCGATGTATCTCGTCTCCCGTATGCAGGAGCGTTTCCTGGCCTCCAGCCG
GCGGCTGCGGCCGGTCGAGGTGACGAAGACGCTGGAGCAGACGACGAAGGTGGAGATGGATCTTCGCCTGGAGGCGGCCG
CCCTCTCCGAAATCGCCGAGAATACCGAAAGGGATCCCGGTTTCCGCGTGCCGAAGGTCGACTGGGAGCGCACCGGGCGC
GACGTCATCACCATGGAATGGATCGACGGCACCCGCATGTCCGACGTCGAGGGGCTGCGCGCGGCCGGCCACGATCTCAA
CCTGCTCGCCGACACGCTGATCCAGTCCTTCCTGCGCCACACGCTGCGCGACGGCTTCTTCCATGCCGACATGCATCCGG
GCAATCTCTTCGTCGATGCGGACGGCATGATCGTTGCGGTCGACATGGGCATTGTCGGGCGGCTCGGCAAAAAGGAACGG
CGGTTCCTCGCCGAAATTCTCTATGGCTTCATCACCCGCGACTATATCCGCGTCGCCGAGGTGCATTTCGAGGCGGGCTA
TGTGCCGGGCCACCACAATGTCGAGAGTTTCGCCCAGGCGATCCGGGCGATCGGCGAGCCGATCCATGGACAGCCGGCGG
AGACGATCTCGATGGGCAAGCTGTTGACGCTGCTGTTCGAAGTGACTGAACTCTTCGACATGGCGACACGGCCGGAACTG
GTGATGCTGCAGAAGACCATGGTGGTGGTCGAGGGCGTGTCGCGCATGCTCAATCCGCGCTTCAACATGTGGAAGGCCTC
CGAGCCGGTCGTCGGCGACTGGATCCGCACCAATCTCGGCCCGAAGCGGATCGCCACCGATCTCAAGGATGGGCTGAAGG
CGGCGGTGAAGCTTGCCGAAGCCGTGCCGGAAATTGCGGCGAAGACCGAAAAATTCCACCACCAGCTTCTGCATATGAGC
GAACACGGCTTACGCTTCGACGCTGAGACGGCGGATGCGATCGGCAAGGCCGAGGCGCGGCACAACCGCTCCGCCCGGAT
CGCCCTCTGGGTGATCGCATTGACGCTTCTCTATATTGCCTGGATGGTGAGTTGA

Upstream 100 bases:

>100_bases
CACCAATTACACCGGCGGCATCGCCGCGCTGCATTCCGGCTGGAAGCTCTGAGGGCATGAGGGAAGAAAACACCAACCTC
GGCCGGCGGGGCAGTGCAGC

Downstream 100 bases:

>100_bases
TCCGCCTGTCAAAAACATGCTGTGTTCGGCATTTAGGATATCCCATGTGACGGAGGGGCCGCTTAATCTCATAATCTAGG
AGATATGGCACATGCAGCAC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSTFGAYFRLWRVGWVLVREGVVSALPSEGLPPPVALAKSFVTIFERSKARHQKRSDRLAHAVERLGPSYVKIGQFLATR
PDVVGVEFANDLSQLQDRMAFFHSAAAKANIEGSLGRPIDELYASFGEPIAAASIAQVHPAEVETSEGRKKVAVKIVRPG
VRQRFAHDIEAMYLVSRMQERFLASSRRLRPVEVTKTLEQTTKVEMDLRLEAAALSEIAENTERDPGFRVPKVDWERTGR
DVITMEWIDGTRMSDVEGLRAAGHDLNLLADTLIQSFLRHTLRDGFFHADMHPGNLFVDADGMIVAVDMGIVGRLGKKER
RFLAEILYGFITRDYIRVAEVHFEAGYVPGHHNVESFAQAIRAIGEPIHGQPAETISMGKLLTLLFEVTELFDMATRPEL
VMLQKTMVVVEGVSRMLNPRFNMWKASEPVVGDWIRTNLGPKRIATDLKDGLKAAVKLAEAVPEIAAKTEKFHHQLLHMS
EHGLRFDAETADAIGKAEARHNRSARIALWVIALTLLYIAWMVS

Sequences:

>Translated_524_residues
MSTFGAYFRLWRVGWVLVREGVVSALPSEGLPPPVALAKSFVTIFERSKARHQKRSDRLAHAVERLGPSYVKIGQFLATR
PDVVGVEFANDLSQLQDRMAFFHSAAAKANIEGSLGRPIDELYASFGEPIAAASIAQVHPAEVETSEGRKKVAVKIVRPG
VRQRFAHDIEAMYLVSRMQERFLASSRRLRPVEVTKTLEQTTKVEMDLRLEAAALSEIAENTERDPGFRVPKVDWERTGR
DVITMEWIDGTRMSDVEGLRAAGHDLNLLADTLIQSFLRHTLRDGFFHADMHPGNLFVDADGMIVAVDMGIVGRLGKKER
RFLAEILYGFITRDYIRVAEVHFEAGYVPGHHNVESFAQAIRAIGEPIHGQPAETISMGKLLTLLFEVTELFDMATRPEL
VMLQKTMVVVEGVSRMLNPRFNMWKASEPVVGDWIRTNLGPKRIATDLKDGLKAAVKLAEAVPEIAAKTEKFHHQLLHMS
EHGLRFDAETADAIGKAEARHNRSARIALWVIALTLLYIAWMVS
>Mature_523_residues
STFGAYFRLWRVGWVLVREGVVSALPSEGLPPPVALAKSFVTIFERSKARHQKRSDRLAHAVERLGPSYVKIGQFLATRP
DVVGVEFANDLSQLQDRMAFFHSAAAKANIEGSLGRPIDELYASFGEPIAAASIAQVHPAEVETSEGRKKVAVKIVRPGV
RQRFAHDIEAMYLVSRMQERFLASSRRLRPVEVTKTLEQTTKVEMDLRLEAAALSEIAENTERDPGFRVPKVDWERTGRD
VITMEWIDGTRMSDVEGLRAAGHDLNLLADTLIQSFLRHTLRDGFFHADMHPGNLFVDADGMIVAVDMGIVGRLGKKERR
FLAEILYGFITRDYIRVAEVHFEAGYVPGHHNVESFAQAIRAIGEPIHGQPAETISMGKLLTLLFEVTELFDMATRPELV
MLQKTMVVVEGVSRMLNPRFNMWKASEPVVGDWIRTNLGPKRIATDLKDGLKAAVKLAEAVPEIAAKTEKFHHQLLHMSE
HGLRFDAETADAIGKAEARHNRSARIALWVIALTLLYIAWMVS

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=300, Percent_Identity=30.6666666666667, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI40254938, Length=304, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI217035081, Length=232, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI27363457, Length=323, Percent_Identity=24.7678018575851, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI217416386, Length=267, Percent_Identity=27.7153558052434, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI34147522, Length=302, Percent_Identity=23.841059602649, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367309, Length=436, Percent_Identity=37.1559633027523, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17559152, Length=323, Percent_Identity=24.4582043343653, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=443, Percent_Identity=22.7990970654628, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=320, Percent_Identity=24.6875, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=327, Percent_Identity=24.7706422018349, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24662575, Length=319, Percent_Identity=28.8401253918495, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI22024280, Length=289, Percent_Identity=27.3356401384083, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58628; Mature: 58497

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFGAYFRLWRVGWVLVREGVVSALPSEGLPPPVALAKSFVTIFERSKARHQKRSDRLA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAVERLGPSYVKIGQFLATRPDVVGVEFANDLSQLQDRMAFFHSAAAKANIEGSLGRPID
HHHHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ELYASFGEPIAAASIAQVHPAEVETSEGRKKVAVKIVRPGVRQRFAHDIEAMYLVSRMQE
HHHHHHCCCHHHHHHHHCCCCCCCCCCCHHEEEHHHHCCHHHHHHHHHHHHHHHHHHHHH
RFLASSRRLRPVEVTKTLEQTTKVEMDLRLEAAALSEIAENTERDPGFRVPKVDWERTGR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
DVITMEWIDGTRMSDVEGLRAAGHDLNLLADTLIQSFLRHTLRDGFFHADMHPGNLFVDA
CEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
DGMIVAVDMGIVGRLGKKERRFLAEILYGFITRDYIRVAEVHFEAGYVPGHHNVESFAQA
CCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IRAIGEPIHGQPAETISMGKLLTLLFEVTELFDMATRPELVMLQKTMVVVEGVSRMLNPR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
FNMWKASEPVVGDWIRTNLGPKRIATDLKDGLKAAVKLAEAVPEIAAKTEKFHHQLLHMS
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHGLRFDAETADAIGKAEARHNRSARIALWVIALTLLYIAWMVS
HCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STFGAYFRLWRVGWVLVREGVVSALPSEGLPPPVALAKSFVTIFERSKARHQKRSDRLA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAVERLGPSYVKIGQFLATRPDVVGVEFANDLSQLQDRMAFFHSAAAKANIEGSLGRPID
HHHHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ELYASFGEPIAAASIAQVHPAEVETSEGRKKVAVKIVRPGVRQRFAHDIEAMYLVSRMQE
HHHHHHCCCHHHHHHHHCCCCCCCCCCCHHEEEHHHHCCHHHHHHHHHHHHHHHHHHHHH
RFLASSRRLRPVEVTKTLEQTTKVEMDLRLEAAALSEIAENTERDPGFRVPKVDWERTGR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
DVITMEWIDGTRMSDVEGLRAAGHDLNLLADTLIQSFLRHTLRDGFFHADMHPGNLFVDA
CEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
DGMIVAVDMGIVGRLGKKERRFLAEILYGFITRDYIRVAEVHFEAGYVPGHHNVESFAQA
CCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IRAIGEPIHGQPAETISMGKLLTLLFEVTELFDMATRPELVMLQKTMVVVEGVSRMLNPR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
FNMWKASEPVVGDWIRTNLGPKRIATDLKDGLKAAVKLAEAVPEIAAKTEKFHHQLLHMS
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHGLRFDAETADAIGKAEARHNRSARIALWVIALTLLYIAWMVS
HCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA