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The map label for this gene is cysK [H]

Identifier: 209551907

GI number: 209551907

Start: 4506135

End: 4507097

Strand: Reverse

Name: cysK [H]

Synonym: Rleg2_4340

Alternate gene names: 209551907

Gene position: 4507097-4506135 (Counterclockwise)

Preceding gene: 209551908

Following gene: 209551900

Centisome position: 99.32

GC content: 63.14

Gene sequence:

>963_bases
ATGTCGCACAAGCCCGGCCGCGGCCGCATCTATTCCTCGATCACCGAGACCATCGGCAACACGCCGCTCGTGCGCTTCGA
CAAGCTGGCGCGGGAAAAGGGCGTGGTAGCAAATCTGATCGGCAAACTCGAATTCTTCAACCCGATCGCCTCCGTCAAGG
ACCGCATCGGCGTGGCGATGATCGAAGGCCTGGAAGCACAGGGCAAGATCACGCCAGGGAAGACGGTGCTGATCGAGCCG
ACCTCCGGCAACACCGGCATCGCGCTCGCCTTTGCCGCCGCCGCCAAGGGCTATCGGCTGATCCTGACCATGCCGGAAAC
CATGTCGGTCGAGCGCCGCAAGATGCTGGCGCTGCTCGGCGCCGAGCTGGTGCTGACCGAAGGCCCGAAGGGCATGAAGG
GCGCCATTGCCAAGGCCGAGGAACTGGCAGGGTCGCTTCCCGACGCCATCATTCCGCAGCAGTTCGAAAATCCGGATAAT
CCCGAGATCCACCGCAAGACGACGGCCGAGGAAATCTGGAACGACACCGAAGGCGCCGTCGACATCGTCATATCAGGCAT
CGGCACCGGCGGCACGATCACCGGCGTCGGCCAGGTGCTGAAGAGCCGCAAACCCGAAATCCAGATCATCGCCGTCGAGC
CCGCCGATTCCCCGATCCTCTCCGGCGGCAATCCCGGCCCGCACAAAATCCAGGGCATCGGCGCCGGCTTCGCCCCAAAA
ATCCTCGATACCGGCATTTATGACGAGGTGGTGACCGTCACCAACGACGAGGCCTTCGAACAGGCGCGGCTGGTCGCAAG
GCTCGAAGGCGTGCCGGTCGGCATCTCCTCGGGTGCAGCGCTGGCGGCTGCGATCAAGGTCGGCAGCAGACCGGAGAATG
CGGGCAAGAACATTGTGGTGATCATTCCGTCCTTTGCGGAGCGTTATCTTTCGACGGCGTTGTTTGAAGGGCTGGGCAGC
TAA

Upstream 100 bases:

>100_bases
CGCGTCCCGCTCTCCCTATACGAACGCGGTCTGGTCTCTTCAGCCCTTTGACCCTATTCTCCTCCTGATTTCAGGAACAG
GATTTCAAAGGGAGGCACTC

Downstream 100 bases:

>100_bases
AGTTAGCTGTGGCCCGCTCTTTCCTCCGGCAATTTCTTGCAAAATATCGGGGCGCTTCGGCGCCCCTTCTTTTGTGCCGT
CACCTGCATCCCAATCGAAG

Product: cysteine synthase A

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSHKPGRGRIYSSITETIGNTPLVRFDKLAREKGVVANLIGKLEFFNPIASVKDRIGVAMIEGLEAQGKITPGKTVLIEP
TSGNTGIALAFAAAAKGYRLILTMPETMSVERRKMLALLGAELVLTEGPKGMKGAIAKAEELAGSLPDAIIPQQFENPDN
PEIHRKTTAEEIWNDTEGAVDIVISGIGTGGTITGVGQVLKSRKPEIQIIAVEPADSPILSGGNPGPHKIQGIGAGFAPK
ILDTGIYDEVVTVTNDEAFEQARLVARLEGVPVGISSGAALAAAIKVGSRPENAGKNIVVIIPSFAERYLSTALFEGLGS

Sequences:

>Translated_320_residues
MSHKPGRGRIYSSITETIGNTPLVRFDKLAREKGVVANLIGKLEFFNPIASVKDRIGVAMIEGLEAQGKITPGKTVLIEP
TSGNTGIALAFAAAAKGYRLILTMPETMSVERRKMLALLGAELVLTEGPKGMKGAIAKAEELAGSLPDAIIPQQFENPDN
PEIHRKTTAEEIWNDTEGAVDIVISGIGTGGTITGVGQVLKSRKPEIQIIAVEPADSPILSGGNPGPHKIQGIGAGFAPK
ILDTGIYDEVVTVTNDEAFEQARLVARLEGVPVGISSGAALAAAIKVGSRPENAGKNIVVIIPSFAERYLSTALFEGLGS
>Mature_319_residues
SHKPGRGRIYSSITETIGNTPLVRFDKLAREKGVVANLIGKLEFFNPIASVKDRIGVAMIEGLEAQGKITPGKTVLIEPT
SGNTGIALAFAAAAKGYRLILTMPETMSVERRKMLALLGAELVLTEGPKGMKGAIAKAEELAGSLPDAIIPQQFENPDNP
EIHRKTTAEEIWNDTEGAVDIVISGIGTGGTITGVGQVLKSRKPEIQIIAVEPADSPILSGGNPGPHKIQGIGAGFAPKI
LDTGIYDEVVTVTNDEAFEQARLVARLEGVPVGISSGAALAAAIKVGSRPENAGKNIVVIIPSFAERYLSTALFEGLGS

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=39.4321766561514, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=39.4321766561514, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=39.4321766561514, Blast_Score=220, Evalue=1e-57,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=54.858934169279, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=40.7894736842105, Blast_Score=204, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=51.4851485148515, Blast_Score=312, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=54.0453074433657, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=50.6666666666667, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=51.1864406779661, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=48.8524590163934, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=50.4716981132076, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17534315, Length=325, Percent_Identity=39.3846153846154, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=37.2670807453416, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=123, Percent_Identity=45.5284552845528, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=37.8548895899054, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=32.9268292682927, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=37.0253164556962, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=37.0253164556962, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33507; Mature: 33376

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHKPGRGRIYSSITETIGNTPLVRFDKLAREKGVVANLIGKLEFFNPIASVKDRIGVAM
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHH
IEGLEAQGKITPGKTVLIEPTSGNTGIALAFAAAAKGYRLILTMPETMSVERRKMLALLG
HHCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHC
AELVLTEGPKGMKGAIAKAEELAGSLPDAIIPQQFENPDNPEIHRKTTAEEIWNDTEGAV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCEE
DIVISGIGTGGTITGVGQVLKSRKPEIQIIAVEPADSPILSGGNPGPHKIQGIGAGFAPK
EEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHH
ILDTGIYDEVVTVTNDEAFEQARLVARLEGVPVGISSGAALAAAIKVGSRPENAGKNIVV
HHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEE
IIPSFAERYLSTALFEGLGS
EECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHKPGRGRIYSSITETIGNTPLVRFDKLAREKGVVANLIGKLEFFNPIASVKDRIGVAM
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHH
IEGLEAQGKITPGKTVLIEPTSGNTGIALAFAAAAKGYRLILTMPETMSVERRKMLALLG
HHCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHC
AELVLTEGPKGMKGAIAKAEELAGSLPDAIIPQQFENPDNPEIHRKTTAEEIWNDTEGAV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCEE
DIVISGIGTGGTITGVGQVLKSRKPEIQIIAVEPADSPILSGGNPGPHKIQGIGAGFAPK
EEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHH
ILDTGIYDEVVTVTNDEAFEQARLVARLEGVPVGISSGAALAAAIKVGSRPENAGKNIVV
HHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEE
IIPSFAERYLSTALFEGLGS
EECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]