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The map label for this gene is xseA

Identifier: 209551852

GI number: 209551852

Start: 4455074

End: 4456657

Strand: Direct

Name: xseA

Synonym: Rleg2_4284

Alternate gene names: 209551852

Gene position: 4455074-4456657 (Clockwise)

Preceding gene: 209551850

Following gene: 209551854

Centisome position: 98.17

GC content: 64.84

Gene sequence:

>1584_bases
ATGAGCAACGTCTTCGACAGCGATTCGCCGACCAATCTTGCCGAATATTCGGTTTCGGAGCTTTCCGGCTCGATCAAGCG
CACCGTCGAAACCGCCTTCGACCAGGTTCGCGTGCGCGGCGAGATCTCCGGTTATCGCGGCCCCCACTCCTCGGGCCATG
CCTATTTCGCGCTGAAGGACGATCGCGCCCGCATCGACGCTGTCATCTGGAAGGGCACTTTCTCTCGGCTGAAGTTCCGT
CCGGAAGAGGGCATGGAGGTGATTGCCACCGGCAAGGTCACCACCTTTCCCGGCTCCTCGAAATATCAGATCGTCATCGA
GACGCTGGAGCCGGCCGGCGCCGGCGCGCTGATGGCGCTGATCGAGGAGCGCAAGCGCAAGCTCGGCGCCGAAGGCCTGT
TCGATGCCGCCCGCAAGAAGCGGCTGCCCTTCATGCCGCGAGTGATCGGCGTCGTCACCTCGCCGACCGGCGCCGTGATC
CGCGATATCCTTCATCGCATCTCCGATCGTTTTCCCGTACATGTCCTCGTCTGGCCGGTAAAGGTCCAGGGCGAGGGATC
CGGCGAGGAGGTGGCGAACGCCATTCGCGGCTTCAATGCGCTGGAACCGGCCGGCCTCATTCCGCGGCCTGATGTGCTGA
TTGTCGCGCGCGGCGGCGGCAGCCTGGAAGATCTCTGGAGTTTCAACGACGAAATCGTCGTGCGCGCTGCGGCCGAAAGC
CGGATACCGCTGATCTCGGCGGTCGGACACGAAACCGACTGGACGCTGATCGATTATGCCGCCGATGTCCGAGCGCCCAC
ACCGACCGGGGCGGCCGAAATGGCCGTGCCGGTCAAGGCGGAGCTTGAGGCCCAGGCCGCCGCCCTTGCCGCGCGGCTGC
AGGGCTGCATGAACCGGCAGATGGATCAGCGCCGTCAGTCCGTCCGTGCTCTGATGCGGGCATTGCCGTCGCTCGATCAG
CTCCTCGCTTTGCCGCGCCGTCGTTTCGACGAGGCGGCGGCCGGGCTTGGCCGTGGGCTGGAACTCAACACCATCAACAA
GCGTCGCGGCTTCGAACGTGTTGGCGCGCATCTGCGTCCCGATCTGCTCTCCGGCCGTATCGCCGAGCGCCGCCAGACCC
TGAATGAGCGCATTGTCCGGGCCGAACGCATGGTCGAACGGCTGATTGACCGCTCGAAATCCCGCATTGATCGCGCTGAG
GCAATCCTCGCCTCGCTGCCAGCCCGGTTCAAGACGCAAACCGATCGGAGCCGTGAGGCTCTCGCCAATCTTTCGCGCCA
CGGCGATACGGCGATCCGCCACCAATTGGCTCGCGCCCGCGCCGAGCTTTCCGCGCAGGATCGTGTGCTGCAGTCGCTGT
CCTATAAGAATGTGCTGAAGCGCGGCTACGCCGTCATTCGTGATGAGGATGACAGGCCGGTCTCGCAGGCTGCCGCTCTT
TCCGCAGGTTCCGCGGTCTCGATCGAATTTTCCGACGGCCGCATCGGCGCCGTGACCACCGAAGGCGGCGCACCGCCTGC
TTCGTTGAAGAAGCGGCCTGCCAGGGAAGCCGGCGATCCGCCGAAGCAGGGAAGCCTTTTTTAG

Upstream 100 bases:

>100_bases
CAGCGATCTCGACAGCCGGGAAAACCGGCTTCGGCGGCGGTCGCGACCTTCCCGTTTGCCGCTGATCGACATAGAAAGCC
GATCGACATAGAAAGAAGGG

Downstream 100 bases:

>100_bases
GGCAATTCCGGCGGGGAAATAAACAAAATCTTACGCTGTGGTAACGCGAACGCAGCGCTTGCGGTCATGGGTCCTCGGGT
CAAGCCCGAGGACGACGGAG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSNVFDSDSPTNLAEYSVSELSGSIKRTVETAFDQVRVRGEISGYRGPHSSGHAYFALKDDRARIDAVIWKGTFSRLKFR
PEEGMEVIATGKVTTFPGSSKYQIVIETLEPAGAGALMALIEERKRKLGAEGLFDAARKKRLPFMPRVIGVVTSPTGAVI
RDILHRISDRFPVHVLVWPVKVQGEGSGEEVANAIRGFNALEPAGLIPRPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
RIPLISAVGHETDWTLIDYAADVRAPTPTGAAEMAVPVKAELEAQAAALAARLQGCMNRQMDQRRQSVRALMRALPSLDQ
LLALPRRRFDEAAAGLGRGLELNTINKRRGFERVGAHLRPDLLSGRIAERRQTLNERIVRAERMVERLIDRSKSRIDRAE
AILASLPARFKTQTDRSREALANLSRHGDTAIRHQLARARAELSAQDRVLQSLSYKNVLKRGYAVIRDEDDRPVSQAAAL
SAGSAVSIEFSDGRIGAVTTEGGAPPASLKKRPAREAGDPPKQGSLF

Sequences:

>Translated_527_residues
MSNVFDSDSPTNLAEYSVSELSGSIKRTVETAFDQVRVRGEISGYRGPHSSGHAYFALKDDRARIDAVIWKGTFSRLKFR
PEEGMEVIATGKVTTFPGSSKYQIVIETLEPAGAGALMALIEERKRKLGAEGLFDAARKKRLPFMPRVIGVVTSPTGAVI
RDILHRISDRFPVHVLVWPVKVQGEGSGEEVANAIRGFNALEPAGLIPRPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
RIPLISAVGHETDWTLIDYAADVRAPTPTGAAEMAVPVKAELEAQAAALAARLQGCMNRQMDQRRQSVRALMRALPSLDQ
LLALPRRRFDEAAAGLGRGLELNTINKRRGFERVGAHLRPDLLSGRIAERRQTLNERIVRAERMVERLIDRSKSRIDRAE
AILASLPARFKTQTDRSREALANLSRHGDTAIRHQLARARAELSAQDRVLQSLSYKNVLKRGYAVIRDEDDRPVSQAAAL
SAGSAVSIEFSDGRIGAVTTEGGAPPASLKKRPAREAGDPPKQGSLF
>Mature_526_residues
SNVFDSDSPTNLAEYSVSELSGSIKRTVETAFDQVRVRGEISGYRGPHSSGHAYFALKDDRARIDAVIWKGTFSRLKFRP
EEGMEVIATGKVTTFPGSSKYQIVIETLEPAGAGALMALIEERKRKLGAEGLFDAARKKRLPFMPRVIGVVTSPTGAVIR
DILHRISDRFPVHVLVWPVKVQGEGSGEEVANAIRGFNALEPAGLIPRPDVLIVARGGGSLEDLWSFNDEIVVRAAAESR
IPLISAVGHETDWTLIDYAADVRAPTPTGAAEMAVPVKAELEAQAAALAARLQGCMNRQMDQRRQSVRALMRALPSLDQL
LALPRRRFDEAAAGLGRGLELNTINKRRGFERVGAHLRPDLLSGRIAERRQTLNERIVRAERMVERLIDRSKSRIDRAEA
ILASLPARFKTQTDRSREALANLSRHGDTAIRHQLARARAELSAQDRVLQSLSYKNVLKRGYAVIRDEDDRPVSQAAALS
AGSAVSIEFSDGRIGAVTTEGGAPPASLKKRPAREAGDPPKQGSLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=493, Percent_Identity=34.0770791075051, Blast_Score=243, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_RHILW (B5ZYC6)

Other databases:

- EMBL:   CP001191
- RefSeq:   YP_002283769.1
- GeneID:   6983058
- GenomeReviews:   CP001191_GR
- KEGG:   rlt:Rleg2_4284
- HOGENOM:   HBG634411
- OMA:   LVWPVKV
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 57604; Mature: 57473

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVFDSDSPTNLAEYSVSELSGSIKRTVETAFDQVRVRGEISGYRGPHSSGHAYFALKD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
DRARIDAVIWKGTFSRLKFRPEEGMEVIATGKVTTFPGSSKYQIVIETLEPAGAGALMAL
CCCCEEEEEECCHHHHHEECCCCCCEEEEECEEEECCCCCCEEEEEEECCCCCCHHHHHH
IEERKRKLGAEGLFDAARKKRLPFMPRVIGVVTSPTGAVIRDILHRISDRFPVHVLVWPV
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
KVQGEGSGEEVANAIRGFNALEPAGLIPRPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
EEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCEEEEECCCC
RIPLISAVGHETDWTLIDYAADVRAPTPTGAAEMAVPVKAELEAQAAALAARLQGCMNRQ
CCCEEEECCCCCCCEEEEEHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHH
MDQRRQSVRALMRALPSLDQLLALPRRRFDEAAAGLGRGLELNTINKRRGFERVGAHLRP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCHHHHCCCCCH
DLLSGRIAERRQTLNERIVRAERMVERLIDRSKSRIDRAEAILASLPARFKTQTDRSREA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
LANLSRHGDTAIRHQLARARAELSAQDRVLQSLSYKNVLKRGYAVIRDEDDRPVSQAAAL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHH
SAGSAVSIEFSDGRIGAVTTEGGAPPASLKKRPAREAGDPPKQGSLF
CCCCEEEEEECCCEEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNVFDSDSPTNLAEYSVSELSGSIKRTVETAFDQVRVRGEISGYRGPHSSGHAYFALKD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
DRARIDAVIWKGTFSRLKFRPEEGMEVIATGKVTTFPGSSKYQIVIETLEPAGAGALMAL
CCCCEEEEEECCHHHHHEECCCCCCEEEEECEEEECCCCCCEEEEEEECCCCCCHHHHHH
IEERKRKLGAEGLFDAARKKRLPFMPRVIGVVTSPTGAVIRDILHRISDRFPVHVLVWPV
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
KVQGEGSGEEVANAIRGFNALEPAGLIPRPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
EEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCEEEEECCCC
RIPLISAVGHETDWTLIDYAADVRAPTPTGAAEMAVPVKAELEAQAAALAARLQGCMNRQ
CCCEEEECCCCCCCEEEEEHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHH
MDQRRQSVRALMRALPSLDQLLALPRRRFDEAAAGLGRGLELNTINKRRGFERVGAHLRP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCHHHHCCCCCH
DLLSGRIAERRQTLNERIVRAERMVERLIDRSKSRIDRAEAILASLPARFKTQTDRSREA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
LANLSRHGDTAIRHQLARARAELSAQDRVLQSLSYKNVLKRGYAVIRDEDDRPVSQAAAL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHH
SAGSAVSIEFSDGRIGAVTTEGGAPPASLKKRPAREAGDPPKQGSLF
CCCCEEEEEECCCEEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA