Click here to switch to the map view.

The map label for this gene is cynR [H]

Identifier: 209551773

GI number: 209551773

Start: 4377048

End: 4377956

Strand: Reverse

Name: cynR [H]

Synonym: Rleg2_4202

Alternate gene names: 209551773

Gene position: 4377956-4377048 (Counterclockwise)

Preceding gene: 209551774

Following gene: 209551772

Centisome position: 96.47

GC content: 62.05

Gene sequence:

>909_bases
ATGCAGATCCGGGCGCTGATGTATTTCGACGAGTTGGTCAGGACCAATTCGATGCGTCAGGCGGCCGAGAACCTCAATGT
CGCGCCGACGGCGATCAGCCGGCAGATCGAAAACCTCGAATCTCATTTCGGCGCACCGCTCGTCGAGCGCAGCTCGCGAG
GCGTCAAACTGACGGCCGCAGGCGAGCTGCTTGCCGCCCACGCCGGCCGCACGCTGCGCGAACTCGATCACGTGCAGCAG
CTGATCGAAGACCTGAAGGGTCTGCAACACGGCCATGTCAGCATCTATGCCAATGGCGCCACACTGACCAGTGTGCTGGC
GCCGGTGCTTGCGGAATTCAGCCTGAAATATCCAAAGCTGCGTTTTACGGTGACGATCAGCAGTGCGCGGCAGGCCGTCG
ACGCCGTCAGCAGCGCCGAGGCCGATATCGCCGTGACGCTGTTTGCGCCGGTCATGTCGGGCACCAAGGTCCGGCTGCGT
TCCGAGATCGCCTATGATCTTATCGTCGCGCCGCAGCATCCGGCCGCGGCGCAGCCCGATATCTCCTTGAGGAAACTTGC
CGACTACCCACTGGCGCTGCCGGAGCATTCCTTTGGCTTCCGTCAGGCCTTCGACGCGCTGATCGAAAAGGAGGGATTGA
ATCTCGATCCCGTTTTCGTCACGAGTTCGATCGAGATGCTGAAGGAGCTTGTGCTCAGCGGCGCTGCGGCGACGTTGCTG
CCCGCGCTTGCCGTTCGCCGCGAGATCGAAGCCGACCAGTTGCGCGCCATCCCGCTTGCCGGCAAGACCGGCATTCGCAC
CCATGTCGATCTCTGCGTTGCGCCGGACCGACAACTATCTTTTGCGGCGGCGACACTGGTCGGCTTCATCGAAAACTTCA
TGCGCCAACGCACGGGGATTAAAGGCTGA

Upstream 100 bases:

>100_bases
AATAGTCGCAAGCTGAAACGCGTTGTTTTCATGCATGTCGTTAACCCGCAACCGGGCGACATGCATGGGCAGGTCGAACA
GGAATGGCGGAGAGACGTGA

Downstream 100 bases:

>100_bases
CGCTTGCATTTGCAGCGGATATGCTGTGTAGCTATTTTGGCTACACGGATCCGTAATATTCGTCATTATGTGTGCGCCGC
GTAGCCATGGTCTGATAATG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MQIRALMYFDELVRTNSMRQAAENLNVAPTAISRQIENLESHFGAPLVERSSRGVKLTAAGELLAAHAGRTLRELDHVQQ
LIEDLKGLQHGHVSIYANGATLTSVLAPVLAEFSLKYPKLRFTVTISSARQAVDAVSSAEADIAVTLFAPVMSGTKVRLR
SEIAYDLIVAPQHPAAAQPDISLRKLADYPLALPEHSFGFRQAFDALIEKEGLNLDPVFVTSSIEMLKELVLSGAAATLL
PALAVRREIEADQLRAIPLAGKTGIRTHVDLCVAPDRQLSFAAATLVGFIENFMRQRTGIKG

Sequences:

>Translated_302_residues
MQIRALMYFDELVRTNSMRQAAENLNVAPTAISRQIENLESHFGAPLVERSSRGVKLTAAGELLAAHAGRTLRELDHVQQ
LIEDLKGLQHGHVSIYANGATLTSVLAPVLAEFSLKYPKLRFTVTISSARQAVDAVSSAEADIAVTLFAPVMSGTKVRLR
SEIAYDLIVAPQHPAAAQPDISLRKLADYPLALPEHSFGFRQAFDALIEKEGLNLDPVFVTSSIEMLKELVLSGAAATLL
PALAVRREIEADQLRAIPLAGKTGIRTHVDLCVAPDRQLSFAAATLVGFIENFMRQRTGIKG
>Mature_302_residues
MQIRALMYFDELVRTNSMRQAAENLNVAPTAISRQIENLESHFGAPLVERSSRGVKLTAAGELLAAHAGRTLRELDHVQQ
LIEDLKGLQHGHVSIYANGATLTSVLAPVLAEFSLKYPKLRFTVTISSARQAVDAVSSAEADIAVTLFAPVMSGTKVRLR
SEIAYDLIVAPQHPAAAQPDISLRKLADYPLALPEHSFGFRQAFDALIEKEGLNLDPVFVTSSIEMLKELVLSGAAATLL
PALAVRREIEADQLRAIPLAGKTGIRTHVDLCVAPDRQLSFAAATLVGFIENFMRQRTGIKG

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=262, Percent_Identity=32.824427480916, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI87081904, Length=291, Percent_Identity=25.085910652921, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787530, Length=260, Percent_Identity=26.5384615384615, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790399, Length=271, Percent_Identity=28.4132841328413, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787601, Length=213, Percent_Identity=27.6995305164319, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789506, Length=254, Percent_Identity=20.8661417322835, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790208, Length=260, Percent_Identity=24.6153846153846, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=258, Percent_Identity=26.7441860465116, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=21.7213114754098, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082132, Length=264, Percent_Identity=23.1060606060606, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787879, Length=282, Percent_Identity=23.758865248227, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788748, Length=251, Percent_Identity=22.7091633466135, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32769; Mature: 32769

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRALMYFDELVRTNSMRQAAENLNVAPTAISRQIENLESHFGAPLVERSSRGVKLTAA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEH
GELLAAHAGRTLRELDHVQQLIEDLKGLQHGHVSIYANGATLTSVLAPVLAEFSLKYPKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEE
RFTVTISSARQAVDAVSSAEADIAVTLFAPVMSGTKVRLRSEIAYDLIVAPQHPAAAQPD
EEEEEEHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCEEHHHHHCEEEEECCCCCCCCCCC
ISLRKLADYPLALPEHSFGFRQAFDALIEKEGLNLDPVFVTSSIEMLKELVLSGAAATLL
CHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCHHHHHH
PALAVRREIEADQLRAIPLAGKTGIRTHVDLCVAPDRQLSFAAATLVGFIENFMRQRTGI
HHHHHHHHCCHHHHEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
KG
CC
>Mature Secondary Structure
MQIRALMYFDELVRTNSMRQAAENLNVAPTAISRQIENLESHFGAPLVERSSRGVKLTAA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEH
GELLAAHAGRTLRELDHVQQLIEDLKGLQHGHVSIYANGATLTSVLAPVLAEFSLKYPKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEE
RFTVTISSARQAVDAVSSAEADIAVTLFAPVMSGTKVRLRSEIAYDLIVAPQHPAAAQPD
EEEEEEHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCEEHHHHHCEEEEECCCCCCCCCCC
ISLRKLADYPLALPEHSFGFRQAFDALIEKEGLNLDPVFVTSSIEMLKELVLSGAAATLL
CHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCHHHHHH
PALAVRREIEADQLRAIPLAGKTGIRTHVDLCVAPDRQLSFAAATLVGFIENFMRQRTGI
HHHHHHHHCCHHHHEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
KG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]