Click here to switch to the map view.

The map label for this gene is add [H]

Identifier: 209551751

GI number: 209551751

Start: 4355350

End: 4356318

Strand: Reverse

Name: add [H]

Synonym: Rleg2_4180

Alternate gene names: 209551751

Gene position: 4356318-4355350 (Counterclockwise)

Preceding gene: 209551752

Following gene: 209551750

Centisome position: 96.0

GC content: 63.26

Gene sequence:

>969_bases
GTGACGTTGCATTTGAAGAAGGTCGAATTGCACTGCCATCTGGAGGGTGCAGCTCCTCCTGAACTGACCGCGGCGCAGGC
GCGCAAATACGGCGTCGACATCAGCGGCGAGCTTCGCGGCGGAGCCTATGTCTGGCATGACTTCGCAAGTTTCCTCGAAT
GTTACGATAAGGTTTCCGAGGTCTACAGGACCGAGGAGGACTATGCGCGTCTGACTGAGACCTATCTCGACGAACTCGCC
GGCATCAATACGATCTACAGCGAACTCATCGTTTCGCCCGACCACGGCAAACGCATCGGCCTCGGCGCCGACGCCTATAT
CTCAGGCATCTGCGAAGGCATCCGGCGGGCCAGGGAAAAGAGCGGCATCGAAGCCCGGCTGATCGTCACCGGCGAGCGGC
ATTTCGGTCCGGAGAGCGTCATCGGCGCGGCCGAATACGCGGCAAAGGCCGGCAATCCTTTGATAACCGGCTTCAACCTT
GCCGGCGAGGAGCGCATGGGGCGCGTTGCCGACTATGCCAGGGCCTTCGATATCGCCCGCGATGCCGGCCTGGGGCTCAC
CATCCATGCCGGCGAGGTCTGCGGCGCCTTCAGCGTCGCCGACGCGCTCGATGCGGTACACCCCTCGCGCATCGGCCATG
GCGTGCGCGCCGTCGAGGATGTCGATCTGGTGAAGCGGCTTGCCGATCTCGGCACCGTGCTCGAGGTCTGCCCGGGCTCC
AATATCGCGCTCGGGGTCTTTCCCGATTTCGCTTCGCATCCGCTGCGCCGGCTGAAGGAAGCCGGCGTGCGGGTGACCAT
CAGCTCGGACGATCCGCCTTTCTTTCATACTTCGCTTGCGCGGGAATACGAACTTGCCGCCGAGGCTTTCGGCTTCAGCG
ACGCCGAGATCGATGCCATGACGCGAACGGCGATCGAAGCGGCCTTCGTCGACGAAGAGACACGCAAGGCGCTGCTCGCC
CGGCTTTGA

Upstream 100 bases:

>100_bases
GGTCGCGTTCAATCGGCGTGCGCCGCAGCTATGCCGATATCGGCGAGAGCATTGCGCGCCATCTCGGCATTCCGGCCGGA
CCGCATGGAAGGAGTTTTCT

Downstream 100 bases:

>100_bases
GGCCAAATGTGGAGCGAGGCTGGGGAAGATCGGCGCAAATTTACCGCCACTCTTGCGGTCGGGCCGATTTCCGTGAAAGA
AACATTCGATAGAAAGAATG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTLHLKKVELHCHLEGAAPPELTAAQARKYGVDISGELRGGAYVWHDFASFLECYDKVSEVYRTEEDYARLTETYLDELA
GINTIYSELIVSPDHGKRIGLGADAYISGICEGIRRAREKSGIEARLIVTGERHFGPESVIGAAEYAAKAGNPLITGFNL
AGEERMGRVADYARAFDIARDAGLGLTIHAGEVCGAFSVADALDAVHPSRIGHGVRAVEDVDLVKRLADLGTVLEVCPGS
NIALGVFPDFASHPLRRLKEAGVRVTISSDDPPFFHTSLAREYELAAEAFGFSDAEIDAMTRTAIEAAFVDEETRKALLA
RL

Sequences:

>Translated_322_residues
MTLHLKKVELHCHLEGAAPPELTAAQARKYGVDISGELRGGAYVWHDFASFLECYDKVSEVYRTEEDYARLTETYLDELA
GINTIYSELIVSPDHGKRIGLGADAYISGICEGIRRAREKSGIEARLIVTGERHFGPESVIGAAEYAAKAGNPLITGFNL
AGEERMGRVADYARAFDIARDAGLGLTIHAGEVCGAFSVADALDAVHPSRIGHGVRAVEDVDLVKRLADLGTVLEVCPGS
NIALGVFPDFASHPLRRLKEAGVRVTISSDDPPFFHTSLAREYELAAEAFGFSDAEIDAMTRTAIEAAFVDEETRKALLA
RL
>Mature_321_residues
TLHLKKVELHCHLEGAAPPELTAAQARKYGVDISGELRGGAYVWHDFASFLECYDKVSEVYRTEEDYARLTETYLDELAG
INTIYSELIVSPDHGKRIGLGADAYISGICEGIRRAREKSGIEARLIVTGERHFGPESVIGAAEYAAKAGNPLITGFNLA
GEERMGRVADYARAFDIARDAGLGLTIHAGEVCGAFSVADALDAVHPSRIGHGVRAVEDVDLVKRLADLGTVLEVCPGSN
IALGVFPDFASHPLRRLKEAGVRVTISSDDPPFFHTSLAREYELAAEAFGFSDAEIDAMTRTAIEAAFVDEETRKALLAR
L

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=340, Percent_Identity=25, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI226693318, Length=328, Percent_Identity=23.1707317073171, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI61175224, Length=221, Percent_Identity=25.3393665158371, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787910, Length=326, Percent_Identity=30.0613496932515, Blast_Score=127, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32565969, Length=344, Percent_Identity=25.2906976744186, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538512, Length=345, Percent_Identity=25.5072463768116, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115537133, Length=327, Percent_Identity=25.0764525993884, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324188, Length=333, Percent_Identity=27.9279279279279, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645260, Length=328, Percent_Identity=29.5731707317073, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24666073, Length=214, Percent_Identity=31.7757009345794, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45553183, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737615, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 34850; Mature: 34718

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHLKKVELHCHLEGAAPPELTAAQARKYGVDISGELRGGAYVWHDFASFLECYDKVSE
CCEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VYRTEEDYARLTETYLDELAGINTIYSELIVSPDHGKRIGLGADAYISGICEGIRRAREK
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
SGIEARLIVTGERHFGPESVIGAAEYAAKAGNPLITGFNLAGEERMGRVADYARAFDIAR
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
DAGLGLTIHAGEVCGAFSVADALDAVHPSRIGHGVRAVEDVDLVKRLADLGTVLEVCPGS
HCCCEEEEECCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
NIALGVFPDFASHPLRRLKEAGVRVTISSDDPPFFHTSLAREYELAAEAFGFSDAEIDAM
CEEEEECCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
TRTAIEAAFVDEETRKALLARL
HHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TLHLKKVELHCHLEGAAPPELTAAQARKYGVDISGELRGGAYVWHDFASFLECYDKVSE
CEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VYRTEEDYARLTETYLDELAGINTIYSELIVSPDHGKRIGLGADAYISGICEGIRRAREK
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
SGIEARLIVTGERHFGPESVIGAAEYAAKAGNPLITGFNLAGEERMGRVADYARAFDIAR
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
DAGLGLTIHAGEVCGAFSVADALDAVHPSRIGHGVRAVEDVDLVKRLADLGTVLEVCPGS
HCCCEEEEECCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
NIALGVFPDFASHPLRRLKEAGVRVTISSDDPPFFHTSLAREYELAAEAFGFSDAEIDAM
CEEEEECCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
TRTAIEAAFVDEETRKALLARL
HHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA