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The map label for this gene is upp [H]

Identifier: 209551750

GI number: 209551750

Start: 4354608

End: 4355237

Strand: Reverse

Name: upp [H]

Synonym: Rleg2_4179

Alternate gene names: 209551750

Gene position: 4355237-4354608 (Counterclockwise)

Preceding gene: 209551751

Following gene: 209551749

Centisome position: 95.97

GC content: 61.11

Gene sequence:

>630_bases
ATGGACGGCGTCACGGTCATCGATCATCCGCTTGTGCAGCACAAGCTCACCATCATGCGGCGCAAGGAGACATCGACGGG
AAGTTTCCGGCGATTGCTGCGCGAAATCTCCACACTGCTCTGTTACGAGGTGACCCGCGATCTCGAACTGACGATGGAAA
CGATCGAGACGCCGCTGCAGACGATGGAATCGCCGATCCTCGAGGGCAAGAAGCTGGTCTTCGCCTCGATCCTGCGCGCC
GGCAACGGGCTGCTCGAGGGCATGCTCGATCTCGTACCCTCAGCCCGCGTCTCGCATATCGGCGTCTACCGCGACCACGA
GACGCTGCAGCCGGTCGAATATTACTTCAAGGCGCCTGAAGATGTGGCCGAGCGCCTGATCATCGTCGTCGATCCGATGC
TGGCGACCGGCAATTCCTCGATCGCCGCAATCGACAAGCTCAAGGAACGCGGCGCCCACAATATCCGCTTCCTCTGCCTG
CTCGCCGCCCCGGAAGGCATCCAGAACTTCCGCGCCGCCCATCCAGACGTTCCTGTTTTCACCGCCTCGATCGACAGTCA
TCTCAACGAGAAGGGCTATATCGTGCCCGGCCTCGGCGATGCCGGCGACCGCATGTACGGCACCAAATAA

Upstream 100 bases:

>100_bases
AGCGAGGCTGGGGAAGATCGGCGCAAATTTACCGCCACTCTTGCGGTCGGGCCGATTTCCGTGAAAGAAACATTCGATAG
AAAGAATGAAAGGCTTCCCC

Downstream 100 bases:

>100_bases
TTTCAGCCTTCCTTTACCAAATCGAAAGACTTAAGGCCCGGACGGTTCGTTCCGGGCCTTTTCATTGTCGATATTAGCAA
CTTATCAGGATTTGAGGCTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MDGVTVIDHPLVQHKLTIMRRKETSTGSFRRLLREISTLLCYEVTRDLELTMETIETPLQTMESPILEGKKLVFASILRA
GNGLLEGMLDLVPSARVSHIGVYRDHETLQPVEYYFKAPEDVAERLIIVVDPMLATGNSSIAAIDKLKERGAHNIRFLCL
LAAPEGIQNFRAAHPDVPVFTASIDSHLNEKGYIVPGLGDAGDRMYGTK

Sequences:

>Translated_209_residues
MDGVTVIDHPLVQHKLTIMRRKETSTGSFRRLLREISTLLCYEVTRDLELTMETIETPLQTMESPILEGKKLVFASILRA
GNGLLEGMLDLVPSARVSHIGVYRDHETLQPVEYYFKAPEDVAERLIIVVDPMLATGNSSIAAIDKLKERGAHNIRFLCL
LAAPEGIQNFRAAHPDVPVFTASIDSHLNEKGYIVPGLGDAGDRMYGTK
>Mature_209_residues
MDGVTVIDHPLVQHKLTIMRRKETSTGSFRRLLREISTLLCYEVTRDLELTMETIETPLQTMESPILEGKKLVFASILRA
GNGLLEGMLDLVPSARVSHIGVYRDHETLQPVEYYFKAPEDVAERLIIVVDPMLATGNSSIAAIDKLKERGAHNIRFLCL
LAAPEGIQNFRAAHPDVPVFTASIDSHLNEKGYIVPGLGDAGDRMYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.7128712871287, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.7128712871287, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI21450816, Length=183, Percent_Identity=27.3224043715847, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=53.2019704433498, Blast_Score=221, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=25.2427184466019, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=25.2427184466019, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.0625, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=30.0970873786408, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=30.0970873786408, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=30.0970873786408, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=30.0970873786408, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358379, Length=188, Percent_Identity=26.5957446808511, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23212; Mature: 23212

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVTVIDHPLVQHKLTIMRRKETSTGSFRRLLREISTLLCYEVTRDLELTMETIETPLQ
CCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMESPILEGKKLVFASILRAGNGLLEGMLDLVPSARVSHIGVYRDHETLQPVEYYFKAPE
HHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHEEEECCCCCCCHHHHHHCCCH
DVAERLIIVVDPMLATGNSSIAAIDKLKERGAHNIRFLCLLAAPEGIQNFRAAHPDVPVF
HHHHCEEEEECCCEECCCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCCCCEE
TASIDSHLNEKGYIVPGLGDAGDRMYGTK
EECHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MDGVTVIDHPLVQHKLTIMRRKETSTGSFRRLLREISTLLCYEVTRDLELTMETIETPLQ
CCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMESPILEGKKLVFASILRAGNGLLEGMLDLVPSARVSHIGVYRDHETLQPVEYYFKAPE
HHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHEEEECCCCCCCHHHHHHCCCH
DVAERLIIVVDPMLATGNSSIAAIDKLKERGAHNIRFLCLLAAPEGIQNFRAAHPDVPVF
HHHHCEEEEECCCEECCCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCCCCEE
TASIDSHLNEKGYIVPGLGDAGDRMYGTK
EECHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA