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The map label for this gene is deoA [H]

Identifier: 209551748

GI number: 209551748

Start: 4352599

End: 4353906

Strand: Direct

Name: deoA [H]

Synonym: Rleg2_4177

Alternate gene names: 209551748

Gene position: 4352599-4353906 (Clockwise)

Preceding gene: 209551747

Following gene: 209551756

Centisome position: 95.92

GC content: 64.91

Gene sequence:

>1308_bases
ATGATCCCGCAGGAGATCATCCGGCGCAAACGCGATGGCGACGAACTCGACCCCGCCGATATCCGGTCTTTCATCGCAGC
CCTCGCGGCCGGCCAGCTGTCGGAAGGCCAGATCGGCGCCTTCGCCATGGCCGTCTGGTTCAAGGGCATGTCACGCGAGG
AAATCGTTGCTCTGACGCTGGCGATGGCCGATTCCGGCGATCGGCTGCAATGGACGGATATCGACCGCCCGATCGCCGAC
AAACATTCGACCGGCGGTGTCGGCGACAATGTTTCGCTGATGCTGGCGCCGATTGCTGCCGCCTGCGGCCTCGCCGTTCC
GATGATATCGGGGCGCGGCCTCGGTCATACCGGCGGCACGCTCGATAAGCTCGAATCCATTCCCGGCTATAGGATCACCC
CGGATGCCGACCTGTTCCACACAGTCGTGAAGCAGGTGGGATGCGCCATTATCGGTCAGACCGGCGCCCTGGCGCCGGCC
GATGGGAGGCTCTATGCCGTGCGCGATGTGACCGCAACCGTCGATTCCATTCCGCTCATCACCGCCTCCATCCTGTCGAA
GAAACTTGCGGCCGGGCTTCAGACGCTGGTGCTCGACGTCAAGGTCGGCAACGGCGCCTTCATGGCCGACCGTGCCCAGG
CGGAGATCCTGGCGCAGTCGCTGGTCGAGGTTGCCAATGGGGCAGGGGTGAAGACCTCGGCGCTGATCACCGACATGAAC
CAGCCGCTCGCCGATGCGGCCGGCAATGCCGTTGAAATGCGCAATTGCCTGGATTTCCTGGCGGGTGGGAAGGCGGACAC
GCGGCTCGAGGCTGTCGTTCTTGCCTTTGCCGCCGAGATGCTGGTGAAGTCGGGTATTGCCGCGTCCTCTGAAGAAGGCG
AGGGGATGGCGCGTCGAGCGCTGTCATCGGGAAAGGCAGCTGAGGTTTTCGCGCGCATGGTATCCATGCTTGGCGGCCCG
GCCGATCTCATGGAAAACCCCGACAGGTATCTCGCCAGGGCGGCTGTGGAAAAACCTGTCCTTGCCGCCCGGTCAGGCTG
GCTTGCCGCATGCGACGCGCGCGGCATCGGCGTCAGCGTCATCGATCTTGGCGGCGGCAGACGCCATCCAGCTGACCGGA
TCGATCACCGCGTCGGCTTCTCAGAATTGCTGCCGCTTGGCAGCCGGGTCAGTGCGGGCGAGCCGATCGCGCTGGTTCAT
GCCGCCGACGACGCGGCCGCGGAAAGGGCAGCGGCCGCCCTTGCCGCGCACTACCGTATCACCGAAGACAGTCCGAAGCT
GACGCCGGTGATTTCGAGCCGGATCTGA

Upstream 100 bases:

>100_bases
CCGTCGACCTTCCGCTTCGGCGCTTCCGGCCTGCTCGACGATATCCTGGCGGTTCTGAGCGGAACACAATCCGCACCCGC
TGCGGCGTCGAGCTATTGAA

Downstream 100 bases:

>100_bases
CGCGGTTATTGCTTGAGGCTGAGTGAACCGTCGGCGACGGAATAGGAGGCGAGCTTCTGCAGGAAGCTCATGCCGACCAG
CGTCGTTGTCAGCGCATCGT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIPQEIIRRKRDGDELDPADIRSFIAALAAGQLSEGQIGAFAMAVWFKGMSREEIVALTLAMADSGDRLQWTDIDRPIAD
KHSTGGVGDNVSLMLAPIAAACGLAVPMISGRGLGHTGGTLDKLESIPGYRITPDADLFHTVVKQVGCAIIGQTGALAPA
DGRLYAVRDVTATVDSIPLITASILSKKLAAGLQTLVLDVKVGNGAFMADRAQAEILAQSLVEVANGAGVKTSALITDMN
QPLADAAGNAVEMRNCLDFLAGGKADTRLEAVVLAFAAEMLVKSGIAASSEEGEGMARRALSSGKAAEVFARMVSMLGGP
ADLMENPDRYLARAAVEKPVLAARSGWLAACDARGIGVSVIDLGGGRRHPADRIDHRVGFSELLPLGSRVSAGEPIALVH
AADDAAAERAAAALAAHYRITEDSPKLTPVISSRI

Sequences:

>Translated_435_residues
MIPQEIIRRKRDGDELDPADIRSFIAALAAGQLSEGQIGAFAMAVWFKGMSREEIVALTLAMADSGDRLQWTDIDRPIAD
KHSTGGVGDNVSLMLAPIAAACGLAVPMISGRGLGHTGGTLDKLESIPGYRITPDADLFHTVVKQVGCAIIGQTGALAPA
DGRLYAVRDVTATVDSIPLITASILSKKLAAGLQTLVLDVKVGNGAFMADRAQAEILAQSLVEVANGAGVKTSALITDMN
QPLADAAGNAVEMRNCLDFLAGGKADTRLEAVVLAFAAEMLVKSGIAASSEEGEGMARRALSSGKAAEVFARMVSMLGGP
ADLMENPDRYLARAAVEKPVLAARSGWLAACDARGIGVSVIDLGGGRRHPADRIDHRVGFSELLPLGSRVSAGEPIALVH
AADDAAAERAAAALAAHYRITEDSPKLTPVISSRI
>Mature_435_residues
MIPQEIIRRKRDGDELDPADIRSFIAALAAGQLSEGQIGAFAMAVWFKGMSREEIVALTLAMADSGDRLQWTDIDRPIAD
KHSTGGVGDNVSLMLAPIAAACGLAVPMISGRGLGHTGGTLDKLESIPGYRITPDADLFHTVVKQVGCAIIGQTGALAPA
DGRLYAVRDVTATVDSIPLITASILSKKLAAGLQTLVLDVKVGNGAFMADRAQAEILAQSLVEVANGAGVKTSALITDMN
QPLADAAGNAVEMRNCLDFLAGGKADTRLEAVVLAFAAEMLVKSGIAASSEEGEGMARRALSSGKAAEVFARMVSMLGGP
ADLMENPDRYLARAAVEKPVLAARSGWLAACDARGIGVSVIDLGGGRRHPADRIDHRVGFSELLPLGSRVSAGEPIALVH
AADDAAAERAAAALAAHYRITEDSPKLTPVISSRI

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=439, Percent_Identity=42.1412300683371, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI4503445, Length=439, Percent_Identity=42.1412300683371, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI166158922, Length=439, Percent_Identity=42.1412300683371, Blast_Score=285, Evalue=6e-77,
Organism=Escherichia coli, GI1790842, Length=437, Percent_Identity=52.4027459954233, Blast_Score=438, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 45156; Mature: 45156

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPQEIIRRKRDGDELDPADIRSFIAALAAGQLSEGQIGAFAMAVWFKGMSREEIVALTL
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHEEEEEE
AMADSGDRLQWTDIDRPIADKHSTGGVGDNVSLMLAPIAAACGLAVPMISGRGLGHTGGT
EECCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKLESIPGYRITPDADLFHTVVKQVGCAIIGQTGALAPADGRLYAVRDVTATVDSIPLI
HHHHHCCCCCEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHH
TASILSKKLAAGLQTLVLDVKVGNGAFMADRAQAEILAQSLVEVANGAGVKTSALITDMN
HHHHHHHHHHHHHHEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
QPLADAAGNAVEMRNCLDFLAGGKADTRLEAVVLAFAAEMLVKSGIAASSEEGEGMARRA
CCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LSSGKAAEVFARMVSMLGGPADLMENPDRYLARAAVEKPVLAARSGWLAACDARGIGVSV
HHCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCHHHHCCCCEEEECCCCCCEEE
IDLGGGRRHPADRIDHRVGFSELLPLGSRVSAGEPIALVHAADDAAAERAAAALAAHYRI
EECCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEE
TEDSPKLTPVISSRI
CCCCCCCCCHHCCCC
>Mature Secondary Structure
MIPQEIIRRKRDGDELDPADIRSFIAALAAGQLSEGQIGAFAMAVWFKGMSREEIVALTL
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHEEEEEE
AMADSGDRLQWTDIDRPIADKHSTGGVGDNVSLMLAPIAAACGLAVPMISGRGLGHTGGT
EECCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKLESIPGYRITPDADLFHTVVKQVGCAIIGQTGALAPADGRLYAVRDVTATVDSIPLI
HHHHHCCCCCEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHH
TASILSKKLAAGLQTLVLDVKVGNGAFMADRAQAEILAQSLVEVANGAGVKTSALITDMN
HHHHHHHHHHHHHHEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
QPLADAAGNAVEMRNCLDFLAGGKADTRLEAVVLAFAAEMLVKSGIAASSEEGEGMARRA
CCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LSSGKAAEVFARMVSMLGGPADLMENPDRYLARAAVEKPVLAARSGWLAACDARGIGVSV
HHCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCHHHHCCCCEEEECCCCCCEEE
IDLGGGRRHPADRIDHRVGFSELLPLGSRVSAGEPIALVHAADDAAAERAAAALAAHYRI
EECCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEE
TEDSPKLTPVISSRI
CCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]