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The map label for this gene is fabB [H]

Identifier: 209551628

GI number: 209551628

Start: 4231965

End: 4233197

Strand: Direct

Name: fabB [H]

Synonym: Rleg2_4057

Alternate gene names: 209551628

Gene position: 4231965-4233197 (Clockwise)

Preceding gene: 209551627

Following gene: 209551629

Centisome position: 93.26

GC content: 63.34

Gene sequence:

>1233_bases
ATGAGACGGGTAGTTGTCACGGGTCTGGGTATCGTGTCCTCGATCGGAAACGACGCCGCCGAAGTCACCGAATCCTTGCG
GCAGGCAAAGTCGGGTATCTCCTTCTCCAGCGATTTCGCAGAGCACGGCTTCAAGTGCCAGGTTTGGGGCAGCCCCAAGC
TCGGCGCTGCGGAGCTTGCCGAACTGGTCGATCGCCGTGCCATGCGCTTCCTGTCGCAGGGCGGCGCCTGGAACCATGTC
GCCATGAAACAGGCACTGGCCGATTCCGGGCTGGAAGAGAAGGACTACGCTCAGAACGAGCGCACCGGCATCATCATGGG
CTCCGGCGGCCCGTCCACCCGCACTCTGATCGAGGCGGCCGACATCACCGTCAAGAACAACAGCCCGAAGCGCATCGGCC
CCTTCGCCGTGCCGAAGGCCATGTCCTCGACCGCATCGGCCACACTCGCCACCTGGTTCAAGATCCACGGTGTCAATTAC
TCGATCTCGTCGGCCTGCTCGACATCGGCGCATTGCATCGGCAACGCCGCCGAGATGATCCAGTGGGGCAAGCAGGACGT
GATGTTCGCCGGCGGCCACGAAGATCTCGACTGGACGATGTCCAACCTCTTCGACGCCATGGGCGCCATGTCCTCCAAGT
ACAACGATACGCCGGACAGCGCCTCGCGCGCCTATGACGTCAACCGCGACGGTTTCGTCATCGCCGGCGGCGCCGGTGTG
CTGGTGCTCGAGGAACTCGAGCGCGCCAAGGCCCGCGGTGCCAAGATCTATGCCGAAATCGTCGGCTACGGCGCAACCTC
GGACGGCTACGACATGGTCGCCCCCTCGGGCGAGGGCGCCATCCGCTGCATGCGCCAGGCGCTCGCCACCGTCAAAGGCG
ACGTCGACTACGTCAACACCCACGGCACCTCGACCCCGGTCGGCGACAGCAAGGAAATCGGCGCCATCCGCGAGGTATTC
GGCGCCAAGATCCCGCATATCCAGTCGACCAAGTCGCTGACCGGCCATTCGCTGGGTGCGGCCGGCGTGCAGGAATCGAT
CTATTCGCTGCTGATGATGCAGCAAGGCTTCATCGGCGAAAGCGCCCATATCACCGAGCTCGATCCTGAATTCGAAGGCG
TGCCGATCGTGCGCAAGCGTATCGACGATGCGAAGATCGATATCGCCCTCTCCAACTCCTTCGGCTTCGGCGGGACGAAC
GCCACGCTCGTCTTCCAGCGCTATAACGGATAA

Upstream 100 bases:

>100_bases
ACCATATATCAGGCGGCCGATCTTCGCGTCGGTCTCTCGAAAGACAAGACGGCCTGAACCGCATCTCGAGCGGCTCACGA
AACAAAAAAGGTTTGATCAG

Downstream 100 bases:

>100_bases
CAAAATGACTGGAATCATGCAGGGTAAGCGCGGCCTCATCATGGGCGTCGCAAACAACCACTCGATCGCCTGGGGAATTT
CAAAAGCTCTTGCCGCACAG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRRVVVTGLGIVSSIGNDAAEVTESLRQAKSGISFSSDFAEHGFKCQVWGSPKLGAAELAELVDRRAMRFLSQGGAWNHV
AMKQALADSGLEEKDYAQNERTGIIMGSGGPSTRTLIEAADITVKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNY
SISSACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPDSASRAYDVNRDGFVIAGGAGV
LVLEELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDVDYVNTHGTSTPVGDSKEIGAIREVF
GAKIPHIQSTKSLTGHSLGAAGVQESIYSLLMMQQGFIGESAHITELDPEFEGVPIVRKRIDDAKIDIALSNSFGFGGTN
ATLVFQRYNG

Sequences:

>Translated_410_residues
MRRVVVTGLGIVSSIGNDAAEVTESLRQAKSGISFSSDFAEHGFKCQVWGSPKLGAAELAELVDRRAMRFLSQGGAWNHV
AMKQALADSGLEEKDYAQNERTGIIMGSGGPSTRTLIEAADITVKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNY
SISSACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPDSASRAYDVNRDGFVIAGGAGV
LVLEELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDVDYVNTHGTSTPVGDSKEIGAIREVF
GAKIPHIQSTKSLTGHSLGAAGVQESIYSLLMMQQGFIGESAHITELDPEFEGVPIVRKRIDDAKIDIALSNSFGFGGTN
ATLVFQRYNG
>Mature_410_residues
MRRVVVTGLGIVSSIGNDAAEVTESLRQAKSGISFSSDFAEHGFKCQVWGSPKLGAAELAELVDRRAMRFLSQGGAWNHV
AMKQALADSGLEEKDYAQNERTGIIMGSGGPSTRTLIEAADITVKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNY
SISSACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPDSASRAYDVNRDGFVIAGGAGV
LVLEELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDVDYVNTHGTSTPVGDSKEIGAIREVF
GAKIPHIQSTKSLTGHSLGAAGVQESIYSLLMMQQGFIGESAHITELDPEFEGVPIVRKRIDDAKIDIALSNSFGFGGTN
ATLVFQRYNG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=35.6459330143541, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI41872631, Length=337, Percent_Identity=24.9258160237389, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=42.7536231884058, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788663, Length=407, Percent_Identity=59.95085995086, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=38.4615384615385, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=32.6241134751773, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=38.996138996139, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=339, Percent_Identity=25.9587020648968, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=366, Percent_Identity=28.9617486338798, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=30.9417040358744, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=37.4117647058824, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=28.9940828402367, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=28.9940828402367, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24581345, Length=364, Percent_Identity=23.9010989010989, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43527; Mature: 43527

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGNDAAEVTESLRQAKSGISFSSDFAEHGFKCQVWGSPKLGAAELA
CCEEEEECHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHCCCEEEECCCCCCCHHHHH
ELVDRRAMRFLSQGGAWNHVAMKQALADSGLEEKDYAQNERTGIIMGSGGPSTRTLIEAA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCHHEEEEEE
DITVKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNAAEMI
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEHHHHCCCCHHHHCCHHHHH
QWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPDSASRAYDVNRDGFVIAGGAGV
HCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCEECCCCCEEEECCCCE
LVLEELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDVDYVNT
EHHHHHHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEC
HGTSTPVGDSKEIGAIREVFGAKIPHIQSTKSLTGHSLGAAGVQESIYSLLMMQQGFIGE
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
SAHITELDPEFEGVPIVRKRIDDAKIDIALSNSFGFGGTNATLVFQRYNG
CCCEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGNDAAEVTESLRQAKSGISFSSDFAEHGFKCQVWGSPKLGAAELA
CCEEEEECHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHCCCEEEECCCCCCCHHHHH
ELVDRRAMRFLSQGGAWNHVAMKQALADSGLEEKDYAQNERTGIIMGSGGPSTRTLIEAA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCHHEEEEEE
DITVKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNAAEMI
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEHHHHCCCCHHHHCCHHHHH
QWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPDSASRAYDVNRDGFVIAGGAGV
HCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCEECCCCCEEEECCCCE
LVLEELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDVDYVNT
EHHHHHHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEC
HGTSTPVGDSKEIGAIREVFGAKIPHIQSTKSLTGHSLGAAGVQESIYSLLMMQQGFIGE
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
SAHITELDPEFEGVPIVRKRIDDAKIDIALSNSFGFGGTNATLVFQRYNG
CCCEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]