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The map label for this gene is licA [H]

Identifier: 209551591

GI number: 209551591

Start: 4190588

End: 4191463

Strand: Direct

Name: licA [H]

Synonym: Rleg2_4020

Alternate gene names: 209551591

Gene position: 4190588-4191463 (Clockwise)

Preceding gene: 209551590

Following gene: 209551592

Centisome position: 92.35

GC content: 61.53

Gene sequence:

>876_bases
ATGACGCCTGAAGATAGGATTCATGCGCTCGGCATCTGGCAGGGCCCGATCGAAATTGCGCCGATCTCAGGCGGCATCAC
CAATCGGAATTATCTGGTCAGCGATGCCGTCGCGCGTTGTGTGGTGAGGCTCGGCACCGATATCCCGATCCATCACATCA
GCAGGCAGAACGAGCTTGCCGCCAGCCGTGCGGCCCATGCCGCCGGCATATCGCCTGCCGTCATCCACCATTCGCCCGGT
GTTCTGGTGCTCGACTATATCGAGGCGAAGGCGCTTTGCCCGGAGGATATCAGGGCGCCTGATATGCTCGCCCGGGTCTT
GTCCCTGGTGCGCGCCTGCCACCATGATATCGCCCGGCATTTCCGCGGCCAGGCGATGATCTTCTGGGTCTTCCACGTCA
TCCGTGACTATGCCGCCAGCCTGAAGGAGGCGGGCAGCCCCTATCTGCCGCTGTTGCCGGCGCTGATCGCCAAGGCCGAG
GCGCTGGAGCAGGCGGCAGGGCCGTTCGAGATCGCCTTCGGCCACAACGATCTTCTCGCCGCCAACTTTCTCGACGACGG
CAAGCGGCTCTGGCTGATCGACTGGGACTATGCCGGCTTCAACACGCCGCTGTTCGATCTCGGCGGATTGGCCTCCAACA
ACGAGTTTTCGCAAGCCGCCGAGCAGATGATGCTGGAGAGCTATTTCGACCGGCCGTTGACCGATGATCTCAGCCGCCGT
TACGCCGCGATGAAATGCGCCTCGCTGTTGCGCGAGACGCTCTGGAGCATGATTTCGGAAATCCACTCCACCATCCAATT
CGACTACGCCGCCTATACGGCCGAAAACCTCGCGCGTTTCGAGCGCGCCTACCAAGCCTTTGAACGGAAACGATAA

Upstream 100 bases:

>100_bases
GGCTCCGGCAAGACCATCTAATCCCGCCGCAGCGCTGTAACCGCTGCTTGACAGCCGATCCTCCTCTGCCTCATCATTTC
GAGAAGGCGAGGGGGATGGC

Downstream 100 bases:

>100_bases
ATGACGAGACAATTACCGAAGACGGCGAAAGCCGTTGTCATCGGCGGTGGCATCATCGGCTGCTCGACAGCCTATCATCT
CGGCAAGCTCGGCTGGACCG

Product: Choline/ethanolamine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTPEDRIHALGIWQGPIEIAPISGGITNRNYLVSDAVARCVVRLGTDIPIHHISRQNELAASRAAHAAGISPAVIHHSPG
VLVLDYIEAKALCPEDIRAPDMLARVLSLVRACHHDIARHFRGQAMIFWVFHVIRDYAASLKEAGSPYLPLLPALIAKAE
ALEQAAGPFEIAFGHNDLLAANFLDDGKRLWLIDWDYAGFNTPLFDLGGLASNNEFSQAAEQMMLESYFDRPLTDDLSRR
YAAMKCASLLRETLWSMISEIHSTIQFDYAAYTAENLARFERAYQAFERKR

Sequences:

>Translated_291_residues
MTPEDRIHALGIWQGPIEIAPISGGITNRNYLVSDAVARCVVRLGTDIPIHHISRQNELAASRAAHAAGISPAVIHHSPG
VLVLDYIEAKALCPEDIRAPDMLARVLSLVRACHHDIARHFRGQAMIFWVFHVIRDYAASLKEAGSPYLPLLPALIAKAE
ALEQAAGPFEIAFGHNDLLAANFLDDGKRLWLIDWDYAGFNTPLFDLGGLASNNEFSQAAEQMMLESYFDRPLTDDLSRR
YAAMKCASLLRETLWSMISEIHSTIQFDYAAYTAENLARFERAYQAFERKR
>Mature_290_residues
TPEDRIHALGIWQGPIEIAPISGGITNRNYLVSDAVARCVVRLGTDIPIHHISRQNELAASRAAHAAGISPAVIHHSPGV
LVLDYIEAKALCPEDIRAPDMLARVLSLVRACHHDIARHFRGQAMIFWVFHVIRDYAASLKEAGSPYLPLLPALIAKAEA
LEQAAGPFEIAFGHNDLLAANFLDDGKRLWLIDWDYAGFNTPLFDLGGLASNNEFSQAAEQMMLESYFDRPLTDDLSRRY
AAMKCASLLRETLWSMISEIHSTIQFDYAAYTAENLARFERAYQAFERKR

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Homo sapiens, GI186659525, Length=301, Percent_Identity=26.2458471760797, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 32487; Mature: 32356

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEDRIHALGIWQGPIEIAPISGGITNRNYLVSDAVARCVVRLGTDIPIHHISRQNELA
CCCCHHEEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHH
ASRAAHAAGISPAVIHHSPGVLVLDYIEAKALCPEDIRAPDMLARVLSLVRACHHDIARH
HHHHHHHCCCCCCEEECCCCEEEEEEHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHH
FRGQAMIFWVFHVIRDYAASLKEAGSPYLPLLPALIAKAEALEQAAGPFEIAFGHNDLLA
HCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
ANFLDDGKRLWLIDWDYAGFNTPLFDLGGLASNNEFSQAAEQMMLESYFDRPLTDDLSRR
EHCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
YAAMKCASLLRETLWSMISEIHSTIQFDYAAYTAENLARFERAYQAFERKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPEDRIHALGIWQGPIEIAPISGGITNRNYLVSDAVARCVVRLGTDIPIHHISRQNELA
CCCHHEEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHH
ASRAAHAAGISPAVIHHSPGVLVLDYIEAKALCPEDIRAPDMLARVLSLVRACHHDIARH
HHHHHHHCCCCCCEEECCCCEEEEEEHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHH
FRGQAMIFWVFHVIRDYAASLKEAGSPYLPLLPALIAKAEALEQAAGPFEIAFGHNDLLA
HCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
ANFLDDGKRLWLIDWDYAGFNTPLFDLGGLASNNEFSQAAEQMMLESYFDRPLTDDLSRR
EHCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
YAAMKCASLLRETLWSMISEIHSTIQFDYAAYTAENLARFERAYQAFERKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]