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The map label for this gene is gcvT [H]

Identifier: 209551592

GI number: 209551592

Start: 4191464

End: 4193914

Strand: Direct

Name: gcvT [H]

Synonym: Rleg2_4021

Alternate gene names: 209551592

Gene position: 4191464-4193914 (Clockwise)

Preceding gene: 209551591

Following gene: 209551595

Centisome position: 92.36

GC content: 61.93

Gene sequence:

>2451_bases
ATGACGAGACAATTACCGAAGACGGCGAAAGCCGTTGTCATCGGCGGTGGCATCATCGGCTGCTCGACAGCCTATCATCT
CGGCAAGCTCGGCTGGACCGATACCGTGCTGCTCGAGCGCAAGAAGCTCACATCCGGGACCACCTTCCATGCCGCCGGCC
TTGTCGGCCAGCTGCGCACCAGCGCTAATATCACCCAGCTGCTCGGCTATTCCGTTGATCTCTATAAGCGCCTTGAAGAG
GAAACCGGCCTCGGCACCGGCTGGAAAATGAATGGCGGCCTGCGCCTTGCCTGCAACGAGGAGCGCTGGACGGAGGTCAG
GCGCCAGGCGACCACCGCGCAGTCCTTCGGCCTCGAAATGCAGTTGCTGACGCCGCAGGAGGCCTTCGATCTCTGGCCGC
TGATGACGACAGACGATCTCGTCGGCGCCGCCTTCCTTCCCACAGACGGCCAGGCCAACCCCTCCGACATCACCCAGGCG
CTGGCAAAGGGCGCCCGTTTGTCCGGCGTTTCGATCTTCGAGGATACCGAAGTTCTCGATCTCGAGATCGACAAGGGACG
AATCCGCGCCGTCGTCACGGCTGAAGGCCGCATCGAATGCGAGCGGGTTGTCGTCTGCGCCGGCCAGTGGACGCGCGCCT
TCGCTGCCCGCTTCGGCGTCAACGTACCTTTGGTCTCGGTCGAGCATCAATATATCATCACCGAATCCTTCGGCGTCCCC
TCGAACCTGCCGACGCTGCGCGATCCCGATCGCCTGACCTATTACAAGGAGGAGGTCGGCGGCATCGTCATGGGCGGCTA
TGAGCCGAACCCCATCGCCTGGGCGGAGAAAGGCATCCCCGAGGGTTTCCACTACACACTGCTCGACAGCAATTTCGATC
ATTTCGAGCAGATCATGGAACAGGCGCTTGGCCGCGTTCCGGCGCTGGAGAATGTCGGCGTCAAACAGCTGCTGAACGGC
CCGGAAAGTTTCACGCCGGATGGCAATTTCATTCTCGGCGAGGCGCCGGAACTGAAGAATTTCTTCGTCGGCGCCGGTTT
CAACGCCTTCGGCATCGCCTCGGCCGGCGGTGCCGGCATGGCGCTTGCCGAATGGGTGACGAAGGGAGAGCCGCCCTACG
ATCTCTGGCCGGTCGATATTCGCCGTTTCGGCCGGCCGCATTTCGATACCGACTGGGTGCGGACCCGCACGCTCGAAGCC
TATGGCAAACACTACACCATGGCTTGGCCGTTCGAGGAGCATTCGAGCGGCCGCCCCTGCCGCAAGTCGCCGCTCTATGA
CCGGCTGAAGGCGCAGGGGGCCTGTTTCGGCGAAAAGCTCGGCTGGGAGCGGCCGAACTGGTTTGCCGATCTCTTCGCCA
ACGAGGAGCCGCGGGATGTCTACAGCTATACCAGACAGAACTGGTTTGACGCCGTCGGCCGCGAGCATAAGGCGGTGCGC
GAGGCGGCGGTCATCTTCGACCAGACCTCATTCGCCAAATTCGTGCTGAAGGGCAGGGACGCCGAGGCGGCACTCTCCTG
GATTGCTTCCAACGATGTCGCAAGACCCGTGGGATCGCTCATCTACACGCAGATGCTGAACGACAAGGGTGGCATCGAAT
GCGACCTGACCGTCGCCCGCATCGCCGAGGACGAATATTACATCGTCACCGGCACTGGTTTCGCCACCCACGACTTCAAC
TGGATCGCCCGCAATATTCCGGCGGAGATGCATGCCGAACTGGTCGATGTGACCTCATCCTATTGCGTGCTGTCACTAAT
GGGGCCGAATGCGCGCGCTGTGCTGGAAAAGGTGACCGGCAGCGACGTCTCCAATGCCGCCTTCCCCTTCGGCCAGGTCA
GAACCATCGGCATATCGGGCTGCCCGGTACGGGCGCTACGCATCACCTATGTCGGCGAGCTCGGTTATGAACTGCATGTT
CCCATCGAATATGCGACCACGGTCTATGATCTGCTGATGGCATCAGGCGGCAAGCTCGGTCTCGTCAATGCCGGCTACCG
CGCCATCGAAAGCTGCCGCCTGGAAAAAGGGTATCGCGCCTGGGGCTCCGATATCGGCCCCGACCATACGCCTGTTGAAG
CCGGCCTCGGCTGGGCGGTGAAGATCAGGAAGAGCATTCCCTTCCGCGGGCGCGAAGCGATTGAGCGCCAGCTCAAGGAG
GGTGTGAAGAAGCGCCTCGCCTGCTTCGTTCCCGAGGATCCCGATACCGTGCTGCTCGGCCGCGAAACCATCTATCGCAA
CGGCAAACGTGTCGGCTGGCTATCGAGCGGCGGCTTCGGCTATACGCTCGGCAAGCCAATCGGCTACGGCTACATCCGCA
ATGCCGACGGCGTGACGGAAGATTTCATCCTCTCCGGCACCTATGAACTCGATGTCGCCAGGGAGCGCATCCCTTGCAAG
GTGTCGCTGGCGCCGCTTTACGATCCTGGTATGGTGCGGGTGAAGGCTTGA

Upstream 100 bases:

>100_bases
GGAAATCCACTCCACCATCCAATTCGACTACGCCGCCTATACGGCCGAAAACCTCGCGCGTTTCGAGCGCGCCTACCAAG
CCTTTGAACGGAAACGATAA

Downstream 100 bases:

>100_bases
CGGGTTGCTTTTACGGCGCGTTCGAGCGCTCCGAGGATATAGGTTTAGGAGGAGAGGGTGTGCCGGGCCGCCCCCCCCTG
CCCTGCCGGGCATCTCTCCC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MTRQLPKTAKAVVIGGGIIGCSTAYHLGKLGWTDTVLLERKKLTSGTTFHAAGLVGQLRTSANITQLLGYSVDLYKRLEE
ETGLGTGWKMNGGLRLACNEERWTEVRRQATTAQSFGLEMQLLTPQEAFDLWPLMTTDDLVGAAFLPTDGQANPSDITQA
LAKGARLSGVSIFEDTEVLDLEIDKGRIRAVVTAEGRIECERVVVCAGQWTRAFAARFGVNVPLVSVEHQYIITESFGVP
SNLPTLRDPDRLTYYKEEVGGIVMGGYEPNPIAWAEKGIPEGFHYTLLDSNFDHFEQIMEQALGRVPALENVGVKQLLNG
PESFTPDGNFILGEAPELKNFFVGAGFNAFGIASAGGAGMALAEWVTKGEPPYDLWPVDIRRFGRPHFDTDWVRTRTLEA
YGKHYTMAWPFEEHSSGRPCRKSPLYDRLKAQGACFGEKLGWERPNWFADLFANEEPRDVYSYTRQNWFDAVGREHKAVR
EAAVIFDQTSFAKFVLKGRDAEAALSWIASNDVARPVGSLIYTQMLNDKGGIECDLTVARIAEDEYYIVTGTGFATHDFN
WIARNIPAEMHAELVDVTSSYCVLSLMGPNARAVLEKVTGSDVSNAAFPFGQVRTIGISGCPVRALRITYVGELGYELHV
PIEYATTVYDLLMASGGKLGLVNAGYRAIESCRLEKGYRAWGSDIGPDHTPVEAGLGWAVKIRKSIPFRGREAIERQLKE
GVKKRLACFVPEDPDTVLLGRETIYRNGKRVGWLSSGGFGYTLGKPIGYGYIRNADGVTEDFILSGTYELDVARERIPCK
VSLAPLYDPGMVRVKA

Sequences:

>Translated_816_residues
MTRQLPKTAKAVVIGGGIIGCSTAYHLGKLGWTDTVLLERKKLTSGTTFHAAGLVGQLRTSANITQLLGYSVDLYKRLEE
ETGLGTGWKMNGGLRLACNEERWTEVRRQATTAQSFGLEMQLLTPQEAFDLWPLMTTDDLVGAAFLPTDGQANPSDITQA
LAKGARLSGVSIFEDTEVLDLEIDKGRIRAVVTAEGRIECERVVVCAGQWTRAFAARFGVNVPLVSVEHQYIITESFGVP
SNLPTLRDPDRLTYYKEEVGGIVMGGYEPNPIAWAEKGIPEGFHYTLLDSNFDHFEQIMEQALGRVPALENVGVKQLLNG
PESFTPDGNFILGEAPELKNFFVGAGFNAFGIASAGGAGMALAEWVTKGEPPYDLWPVDIRRFGRPHFDTDWVRTRTLEA
YGKHYTMAWPFEEHSSGRPCRKSPLYDRLKAQGACFGEKLGWERPNWFADLFANEEPRDVYSYTRQNWFDAVGREHKAVR
EAAVIFDQTSFAKFVLKGRDAEAALSWIASNDVARPVGSLIYTQMLNDKGGIECDLTVARIAEDEYYIVTGTGFATHDFN
WIARNIPAEMHAELVDVTSSYCVLSLMGPNARAVLEKVTGSDVSNAAFPFGQVRTIGISGCPVRALRITYVGELGYELHV
PIEYATTVYDLLMASGGKLGLVNAGYRAIESCRLEKGYRAWGSDIGPDHTPVEAGLGWAVKIRKSIPFRGREAIERQLKE
GVKKRLACFVPEDPDTVLLGRETIYRNGKRVGWLSSGGFGYTLGKPIGYGYIRNADGVTEDFILSGTYELDVARERIPCK
VSLAPLYDPGMVRVKA
>Mature_815_residues
TRQLPKTAKAVVIGGGIIGCSTAYHLGKLGWTDTVLLERKKLTSGTTFHAAGLVGQLRTSANITQLLGYSVDLYKRLEEE
TGLGTGWKMNGGLRLACNEERWTEVRRQATTAQSFGLEMQLLTPQEAFDLWPLMTTDDLVGAAFLPTDGQANPSDITQAL
AKGARLSGVSIFEDTEVLDLEIDKGRIRAVVTAEGRIECERVVVCAGQWTRAFAARFGVNVPLVSVEHQYIITESFGVPS
NLPTLRDPDRLTYYKEEVGGIVMGGYEPNPIAWAEKGIPEGFHYTLLDSNFDHFEQIMEQALGRVPALENVGVKQLLNGP
ESFTPDGNFILGEAPELKNFFVGAGFNAFGIASAGGAGMALAEWVTKGEPPYDLWPVDIRRFGRPHFDTDWVRTRTLEAY
GKHYTMAWPFEEHSSGRPCRKSPLYDRLKAQGACFGEKLGWERPNWFADLFANEEPRDVYSYTRQNWFDAVGREHKAVRE
AAVIFDQTSFAKFVLKGRDAEAALSWIASNDVARPVGSLIYTQMLNDKGGIECDLTVARIAEDEYYIVTGTGFATHDFNW
IARNIPAEMHAELVDVTSSYCVLSLMGPNARAVLEKVTGSDVSNAAFPFGQVRTIGISGCPVRALRITYVGELGYELHVP
IEYATTVYDLLMASGGKLGLVNAGYRAIESCRLEKGYRAWGSDIGPDHTPVEAGLGWAVKIRKSIPFRGREAIERQLKEG
VKKRLACFVPEDPDTVLLGRETIYRNGKRVGWLSSGGFGYTLGKPIGYGYIRNADGVTEDFILSGTYELDVARERIPCKV
SLAPLYDPGMVRVKA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI197927446, Length=861, Percent_Identity=41.3472706155633, Blast_Score=652, Evalue=0.0,
Organism=Homo sapiens, GI21361378, Length=861, Percent_Identity=41.3472706155633, Blast_Score=652, Evalue=0.0,
Organism=Homo sapiens, GI194306651, Length=825, Percent_Identity=37.2121212121212, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI24797151, Length=775, Percent_Identity=34.9677419354839, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI257796258, Length=366, Percent_Identity=28.6885245901639, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=28.6885245901639, Blast_Score=103, Evalue=8e-22,
Organism=Homo sapiens, GI257796256, Length=298, Percent_Identity=30.5369127516779, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI60499001, Length=407, Percent_Identity=25.3071253071253, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI257796254, Length=198, Percent_Identity=32.8282828282828, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789272, Length=388, Percent_Identity=26.2886597938144, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1787438, Length=330, Percent_Identity=22.1212121212121, Blast_Score=63, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI32563613, Length=830, Percent_Identity=30, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71994045, Length=802, Percent_Identity=30.6733167082294, Blast_Score=323, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71994052, Length=809, Percent_Identity=30.4079110012361, Blast_Score=320, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17560118, Length=367, Percent_Identity=27.7929155313352, Blast_Score=108, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320222, Length=266, Percent_Identity=29.6992481203008, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20130091, Length=855, Percent_Identity=37.3099415204678, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI28571104, Length=827, Percent_Identity=37.2430471584039, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI20129441, Length=350, Percent_Identity=29.4285714285714, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 89994; Mature: 89863

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQLPKTAKAVVIGGGIIGCSTAYHLGKLGWTDTVLLERKKLTSGTTFHAAGLVGQLRT
CCCCCCCCCCEEEEECCEEECCHHHHHCCCCCCHHHEEEHHHCCCCCEEEHHHHHHHHHC
SANITQLLGYSVDLYKRLEEETGLGTGWKMNGGLRLACNEERWTEVRRQATTAQSFGLEM
CCCHHHHHCCCHHHHHHHHHHCCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHCCEE
QLLTPQEAFDLWPLMTTDDLVGAAFLPTDGQANPSDITQALAKGARLSGVSIFEDTEVLD
EEECCHHHHHCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCEEEECCCEEEE
LEIDKGRIRAVVTAEGRIECERVVVCAGQWTRAFAARFGVNVPLVSVEHQYIITESFGVP
EEECCCEEEEEEEECCCEEEEEEEEECCCHHHHHHHHHCCCCCEEEECCEEEEEECCCCC
SNLPTLRDPDRLTYYKEEVGGIVMGGYEPNPIAWAEKGIPEGFHYTLLDSNFDHFEQIME
CCCCCCCCCCHHHHHHHHHCEEEECCCCCCCCCHHHCCCCCCCEEEEECCCHHHHHHHHH
QALGRVPALENVGVKQLLNGPESFTPDGNFILGEAPELKNFFVGAGFNAFGIASAGGAGM
HHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCCCCEEEECCCCCEEECCCCCCCH
ALAEWVTKGEPPYDLWPVDIRRFGRPHFDTDWVRTRTLEAYGKHYTMAWPFEEHSSGRPC
HHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEECCHHHCCCCCCC
RKSPLYDRLKAQGACFGEKLGWERPNWFADLFANEEPRDVYSYTRQNWFDAVGREHKAVR
CCCCHHHHHHHCCCCCHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHH
EAAVIFDQTSFAKFVLKGRDAEAALSWIASNDVARPVGSLIYTQMLNDKGGIECDLTVAR
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEE
IAEDEYYIVTGTGFATHDFNWIARNIPAEMHAELVDVTSSYCVLSLMGPNARAVLEKVTG
ECCCCEEEEECCCCEECCCHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCC
SDVSNAAFPFGQVRTIGISGCPVRALRITYVGELGYELHVPIEYATTVYDLLMASGGKLG
CCCCCCCCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCEE
LVNAGYRAIESCRLEKGYRAWGSDIGPDHTPVEAGLGWAVKIRKSIPFRGREAIERQLKE
EECCCHHHHHHHHHHCCHHHCCCCCCCCCCCHHHCCCEEEEEECCCCCCCHHHHHHHHHH
GVKKRLACFVPEDPDTVLLGRETIYRNGKRVGWLSSGGFGYTLGKPIGYGYIRNADGVTE
HHHHHEEEECCCCCCEEEEECHHHHHCCCEEEEEECCCCCEECCCCCCCCEEECCCCCCC
DFILSGTYELDVARERIPCKVSLAPLYDPGMVRVKA
CEEEECCEEEEEHHCCCCEEEEECCCCCCCCEEEEC
>Mature Secondary Structure 
TRQLPKTAKAVVIGGGIIGCSTAYHLGKLGWTDTVLLERKKLTSGTTFHAAGLVGQLRT
CCCCCCCCCEEEEECCEEECCHHHHHCCCCCCHHHEEEHHHCCCCCEEEHHHHHHHHHC
SANITQLLGYSVDLYKRLEEETGLGTGWKMNGGLRLACNEERWTEVRRQATTAQSFGLEM
CCCHHHHHCCCHHHHHHHHHHCCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHCCEE
QLLTPQEAFDLWPLMTTDDLVGAAFLPTDGQANPSDITQALAKGARLSGVSIFEDTEVLD
EEECCHHHHHCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCEEEECCCEEEE
LEIDKGRIRAVVTAEGRIECERVVVCAGQWTRAFAARFGVNVPLVSVEHQYIITESFGVP
EEECCCEEEEEEEECCCEEEEEEEEECCCHHHHHHHHHCCCCCEEEECCEEEEEECCCCC
SNLPTLRDPDRLTYYKEEVGGIVMGGYEPNPIAWAEKGIPEGFHYTLLDSNFDHFEQIME
CCCCCCCCCCHHHHHHHHHCEEEECCCCCCCCCHHHCCCCCCCEEEEECCCHHHHHHHHH
QALGRVPALENVGVKQLLNGPESFTPDGNFILGEAPELKNFFVGAGFNAFGIASAGGAGM
HHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCCCCEEEECCCCCEEECCCCCCCH
ALAEWVTKGEPPYDLWPVDIRRFGRPHFDTDWVRTRTLEAYGKHYTMAWPFEEHSSGRPC
HHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEECCHHHCCCCCCC
RKSPLYDRLKAQGACFGEKLGWERPNWFADLFANEEPRDVYSYTRQNWFDAVGREHKAVR
CCCCHHHHHHHCCCCCHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHH
EAAVIFDQTSFAKFVLKGRDAEAALSWIASNDVARPVGSLIYTQMLNDKGGIECDLTVAR
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEE
IAEDEYYIVTGTGFATHDFNWIARNIPAEMHAELVDVTSSYCVLSLMGPNARAVLEKVTG
ECCCCEEEEECCCCEECCCHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCC
SDVSNAAFPFGQVRTIGISGCPVRALRITYVGELGYELHVPIEYATTVYDLLMASGGKLG
CCCCCCCCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCEE
LVNAGYRAIESCRLEKGYRAWGSDIGPDHTPVEAGLGWAVKIRKSIPFRGREAIERQLKE
EECCCHHHHHHHHHHCCHHHCCCCCCCCCCCHHHCCCEEEEEECCCCCCCHHHHHHHHHH
GVKKRLACFVPEDPDTVLLGRETIYRNGKRVGWLSSGGFGYTLGKPIGYGYIRNADGVTE
HHHHHEEEECCCCCCEEEEECHHHHHCCCEEEEEECCCCCEECCCCCCCCEEECCCCCCC
DFILSGTYELDVARERIPCKVSLAPLYDPGMVRVKA
CEEEECCEEEEEHHCCCCEEEEECCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA