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The map label for this gene is acsA [H]

Identifier: 209551491

GI number: 209551491

Start: 4067778

End: 4069733

Strand: Reverse

Name: acsA [H]

Synonym: Rleg2_3920

Alternate gene names: 209551491

Gene position: 4069733-4067778 (Counterclockwise)

Preceding gene: 209551493

Following gene: 209551489

Centisome position: 89.68

GC content: 59.97

Gene sequence:

>1956_bases
ATGTCGGAGAAGATCTATCCGGTCACGAAGCCGGTGAAGGCGCGCGCCCTGATCGATAAGGAAAAGTACCTGAAATGGTA
CGAGGAAAGCGTCGAGAATCCGGACAAATTCTGGGGCAAACACGGCAAGCGGATCGACTGGTTCAAGCCCTATACCAAGG
TCAAGAACACGTCCTTTACCGGTAAGGTTTCGATCAAGTGGTTCGAAGACGGTCAGACCAACGTCTCCTATAATTGCATC
GACCGCCATCTGAAAACCAACGGCGACCAGGTGGCGATCATCTGGGAGGGCGACAATCCCTATATCGACAAGAAGGTCAC
CTACAACGAGCTCTACGAACATGTCTGCCGGATGGCGAACGTGTTGAAAAAGCACGGCGTCAAGAAGGGTGATCGCGTTA
CCATCTATATGCCGATGATCCCGGAAGCGGCTTACGCGATGCTCGCCTGCGCCCGCATCGGCGCGGTGCATTCGGTGGTG
TTCGGCGGCTTTTCACCCGAGGCGCTGGCCGGGCGTATCGTCGACTGTGAATCCACTTTCGTCATCACCTGCGACGAAGG
TTTGCGCGGCGGCAAGCCGGTGCCGTTGAAGGACAATACCGATACGGCGATCCATATCGCCGCCCGCCAGCATGTGCATG
TCAGCAAGGTGCTGGTGGTGCGCCGCACCGGCGGCAAGACCGGCTGGGCGCCAGGCCGCGATCTCTGGCATCACCAGGAA
ATCGCCACGGTGAAGCCGGAATGCCCGCCGGTGAAGATGAAGGCGGAAGATCCACTCTTCATTCTTTATACCTCAGGCTC
GACCGGCAAACCGAAGGGTGTGCTGCACACGACCGGCGGTTATCTCGTCTATGCGGCGATGACGCATGAATATGTCTTCG
ACTACCATGACGGCGACGTCTATTGGTGCACCGCCGATGTCGGCTGGGTCACCGGTCACTCCTATATCGTCTACGGGCCG
CTCGCCAACTGCGCGACGACGTTAATGTTCGAGGGCGTGCCGAATTTCCCCGATCAGGGCCGCTTTTGGGAAGTCATCGA
CAAACACAAGGTCAATATCTTCTATACCGCGCCGACGGCGATCCGCTCGCTGATGGGGGCCGGCGACGATTTCGTCACCC
GCTCCTCGCGCTCGTCGCTGCGGCTGCTCGGCACTGTGGGCGAACCGATCAATCCGGAAGCCTGGGAATGGTATTACAAT
GTGGTTGGCGACAAGCGCTGCCCGGTCATCGATACCTGGTGGCAGACTGAAACCGGCGGCCACATGATCACGCCGCTGCC
CGGCGCCATCGATCTGAAACCCGGTTCTGCGACAGTGCCGTTCTTCGGCATCAAGCCTGAACTGGTCGACAATGAAGGCA
AGGTGCTGGAAGGGGCCGCCGACGGCAATCTCTGCATCACCGACAGCTGGCCGGGCCAGATGCGCACGGTCTATGGCGAT
CACGACCGCTTCATCCAGACCTATTTCTCCACCTACAAGGGGAAATATTTCACCGGCGACGGCTGCCGGCGCGATGCGGA
CGGCTATTACTGGATCACTGGCCGCGTCGACGACGTGCTTAACGTCTCCGGCCACCGGCTCGGCACCGCGGAGGTGGAAT
CCGCACTCGTCTCGCACAATCTGGTTTCGGAAGCCGCGGTCGTCGGTTACCCCCACCCGATCAAGGGCCAGGGCATCTAT
TGCTATGTGACGCTGATGGCCGGACACGAAGGAACGGACACGCTCCGCCAGGACCTGGTGAAACATGTCCGTGCCGAAAT
CGGCCCGATCGCTGCACCCGACAAGATCCAGTTTGCGCCCGGCCTGCCGAAGACCCGTTCCGGCAAGATCATGCGCCGGA
TCCTGCGCAAGATCGCCGAGGACGATTTCGGTGCTCTCGGCGATACCTCGACGCTCGCCGATCCTGCCGTTGTCGACGAT
CTGATCGCCAACCGGCAAAACAAGGCGACGGCCTGA

Upstream 100 bases:

>100_bases
TCTAATTGCCGCCACGATGCGAGCTGCTATGAATTGCCGTGTTTTGAATCCGGGCTCTAAATTCAGGCAGCCCGTCGCAT
GTCCCATGAGGAGGAGTTGC

Downstream 100 bases:

>100_bases
TATAGAGAGCCGCTCCGGCGCTACCGGGTTCTGGGGCGGCTCAATTTGCTTCCACATTTTGATGCGTGGGAGTGGCCGGC
GGTTCCCTCATCTTCCTGTA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSEKIYPVTKPVKARALIDKEKYLKWYEESVENPDKFWGKHGKRIDWFKPYTKVKNTSFTGKVSIKWFEDGQTNVSYNCI
DRHLKTNGDQVAIIWEGDNPYIDKKVTYNELYEHVCRMANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGLRGGKPVPLKDNTDTAIHIAARQHVHVSKVLVVRRTGGKTGWAPGRDLWHHQE
IATVKPECPPVKMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHEYVFDYHDGDVYWCTADVGWVTGHSYIVYGP
LANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTAIRSLMGAGDDFVTRSSRSSLRLLGTVGEPINPEAWEWYYN
VVGDKRCPVIDTWWQTETGGHMITPLPGAIDLKPGSATVPFFGIKPELVDNEGKVLEGAADGNLCITDSWPGQMRTVYGD
HDRFIQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVLNVSGHRLGTAEVESALVSHNLVSEAAVVGYPHPIKGQGIY
CYVTLMAGHEGTDTLRQDLVKHVRAEIGPIAAPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDD
LIANRQNKATA

Sequences:

>Translated_651_residues
MSEKIYPVTKPVKARALIDKEKYLKWYEESVENPDKFWGKHGKRIDWFKPYTKVKNTSFTGKVSIKWFEDGQTNVSYNCI
DRHLKTNGDQVAIIWEGDNPYIDKKVTYNELYEHVCRMANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGLRGGKPVPLKDNTDTAIHIAARQHVHVSKVLVVRRTGGKTGWAPGRDLWHHQE
IATVKPECPPVKMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHEYVFDYHDGDVYWCTADVGWVTGHSYIVYGP
LANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTAIRSLMGAGDDFVTRSSRSSLRLLGTVGEPINPEAWEWYYN
VVGDKRCPVIDTWWQTETGGHMITPLPGAIDLKPGSATVPFFGIKPELVDNEGKVLEGAADGNLCITDSWPGQMRTVYGD
HDRFIQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVLNVSGHRLGTAEVESALVSHNLVSEAAVVGYPHPIKGQGIY
CYVTLMAGHEGTDTLRQDLVKHVRAEIGPIAAPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDD
LIANRQNKATA
>Mature_650_residues
SEKIYPVTKPVKARALIDKEKYLKWYEESVENPDKFWGKHGKRIDWFKPYTKVKNTSFTGKVSIKWFEDGQTNVSYNCID
RHLKTNGDQVAIIWEGDNPYIDKKVTYNELYEHVCRMANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVF
GGFSPEALAGRIVDCESTFVITCDEGLRGGKPVPLKDNTDTAIHIAARQHVHVSKVLVVRRTGGKTGWAPGRDLWHHQEI
ATVKPECPPVKMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHEYVFDYHDGDVYWCTADVGWVTGHSYIVYGPL
ANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTAIRSLMGAGDDFVTRSSRSSLRLLGTVGEPINPEAWEWYYNV
VGDKRCPVIDTWWQTETGGHMITPLPGAIDLKPGSATVPFFGIKPELVDNEGKVLEGAADGNLCITDSWPGQMRTVYGDH
DRFIQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVLNVSGHRLGTAEVESALVSHNLVSEAAVVGYPHPIKGQGIYC
YVTLMAGHEGTDTLRQDLVKHVRAEIGPIAAPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDDL
IANRQNKATA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=653, Percent_Identity=54.8238897396631, Blast_Score=724, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=666, Percent_Identity=53.7537537537538, Blast_Score=719, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=625, Percent_Identity=51.52, Blast_Score=651, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=629, Percent_Identity=39.1096979332273, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI38505220, Length=521, Percent_Identity=31.2859884836852, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI42544132, Length=517, Percent_Identity=29.4003868471954, Blast_Score=193, Evalue=5e-49,
Organism=Homo sapiens, GI115511026, Length=524, Percent_Identity=29.1984732824427, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI122937307, Length=516, Percent_Identity=27.7131782945736, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI31982927, Length=636, Percent_Identity=25.314465408805, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI58082049, Length=514, Percent_Identity=27.0428015564202, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI157311624, Length=517, Percent_Identity=25.9187620889749, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI157311622, Length=517, Percent_Identity=25.9187620889749, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI187761345, Length=388, Percent_Identity=26.5463917525773, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=388, Percent_Identity=26.5463917525773, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI195947378, Length=438, Percent_Identity=24.8858447488584, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI42544134, Length=335, Percent_Identity=25.3731343283582, Blast_Score=95, Evalue=3e-19,
Organism=Escherichia coli, GI1790505, Length=636, Percent_Identity=65.4088050314465, Blast_Score=873, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=639, Percent_Identity=38.0281690140845, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI221142682, Length=531, Percent_Identity=21.2806026365348, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788107, Length=541, Percent_Identity=23.4750462107209, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=23.062381852552, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71983001, Length=643, Percent_Identity=50.0777604976672, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=664, Percent_Identity=49.2469879518072, Blast_Score=639, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=638, Percent_Identity=21.3166144200627, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=558, Percent_Identity=24.0143369175627, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=127, Percent_Identity=32.2834645669291, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=648, Percent_Identity=50, Blast_Score=641, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=659, Percent_Identity=47.3444613050076, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319699, Length=377, Percent_Identity=23.8726790450928, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24667955, Length=667, Percent_Identity=54.4227886056971, Blast_Score=724, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=566, Percent_Identity=57.9505300353357, Blast_Score=660, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=524, Percent_Identity=58.0152671755725, Blast_Score=613, Evalue=1e-175,
Organism=Drosophila melanogaster, GI21355225, Length=635, Percent_Identity=37.6377952755906, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21355181, Length=574, Percent_Identity=23.3449477351916, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859661, Length=543, Percent_Identity=22.8360957642726, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24581924, Length=575, Percent_Identity=22.0869565217391, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72396; Mature: 72265

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKIYPVTKPVKARALIDKEKYLKWYEESVENPDKFWGKHGKRIDWFKPYTKVKNTSFT
CCCCCCCCCCCCHHHHHHCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHCCCCEE
GKVSIKWFEDGQTNVSYNCIDRHLKTNGDQVAIIWEGDNPYIDKKVTYNELYEHVCRMAN
EEEEEEEEECCCCCEEHHHHHHHHCCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEECCCEE
VITCDEGLRGGKPVPLKDNTDTAIHIAARQHVHVSKVLVVRRTGGKTGWAPGRDLWHHQE
EEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCHHCCCC
IATVKPECPPVKMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHEYVFDYHDGDV
CCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEEECCCE
YWCTADVGWVTGHSYIVYGPLANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTA
EEEECCCCEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEECHHH
IRSLMGAGDDFVTRSSRSSLRLLGTVGEPINPEAWEWYYNVVGDKRCPVIDTWWQTETGG
HHHHHCCCCHHEECCCCCCEEEEEECCCCCCCCHHHHEEEECCCCCCCEEECCCCCCCCC
HMITPLPGAIDLKPGSATVPFFGIKPELVDNEGKVLEGAADGNLCITDSWPGQMRTVYGD
EEEECCCCCEEECCCCCCCCEECCCCCEECCCCCEEEECCCCCEEEECCCCCCEEEEECC
HDRFIQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVLNVSGHRLGTAEVESALVSHN
HHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
LVSEAAVVGYPHPIKGQGIYCYVTLMAGHEGTDTLRQDLVKHVRAEIGPIAAPDKIQFAP
HHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDDLIANRQNKATA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEKIYPVTKPVKARALIDKEKYLKWYEESVENPDKFWGKHGKRIDWFKPYTKVKNTSFT
CCCCCCCCCCCHHHHHHCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHCCCCEE
GKVSIKWFEDGQTNVSYNCIDRHLKTNGDQVAIIWEGDNPYIDKKVTYNELYEHVCRMAN
EEEEEEEEECCCCCEEHHHHHHHHCCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEECCCEE
VITCDEGLRGGKPVPLKDNTDTAIHIAARQHVHVSKVLVVRRTGGKTGWAPGRDLWHHQE
EEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCHHCCCC
IATVKPECPPVKMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHEYVFDYHDGDV
CCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEEECCCE
YWCTADVGWVTGHSYIVYGPLANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTA
EEEECCCCEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEECHHH
IRSLMGAGDDFVTRSSRSSLRLLGTVGEPINPEAWEWYYNVVGDKRCPVIDTWWQTETGG
HHHHHCCCCHHEECCCCCCEEEEEECCCCCCCCHHHHEEEECCCCCCCEEECCCCCCCCC
HMITPLPGAIDLKPGSATVPFFGIKPELVDNEGKVLEGAADGNLCITDSWPGQMRTVYGD
EEEECCCCCEEECCCCCCCCEECCCCCEECCCCCEEEECCCCCEEEECCCCCCEEEEECC
HDRFIQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVLNVSGHRLGTAEVESALVSHN
HHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
LVSEAAVVGYPHPIKGQGIYCYVTLMAGHEGTDTLRQDLVKHVRAEIGPIAAPDKIQFAP
HHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDDLIANRQNKATA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA