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The map label for this gene is rppH [H]

Identifier: 209551458

GI number: 209551458

Start: 4028407

End: 4028940

Strand: Direct

Name: rppH [H]

Synonym: Rleg2_3887

Alternate gene names: 209551458

Gene position: 4028407-4028940 (Clockwise)

Preceding gene: 209551457

Following gene: 209551464

Centisome position: 88.77

GC content: 62.92

Gene sequence:

>534_bases
ATGAGCCAGGCGACCGTAAAAGCCGAGGACCTGCCCTACCGCCCCTGCGTCGGCGTGATGATCCTGAACCGCGACGGCCT
CGTCTGGGCCGGGCGGCGCATTCCCGACGGCAATTCGGAATATGACGGCTCGCCGCAGCTCTGGCAGATGCCCCAGGGCG
GCATCGACAAGGGCGAGGATCCATTGGACGCCGCCTATCGCGAACTCTACGAGGAGACCGGCATCAAGACGGTGACCTTG
CTGGCCGAAGCGGGAGACTGGATCAATTACGATCTGCCGCCGGCACTGATCGGTATCGGATTGAAGGGAAAGTTCCGCGG
CCAGACGCAACGCTGGTTCGCCTTCCGCTTCGACGGTGACGACAGCGAGATCGCCATCAACCCGCCGCCCGGCGGCCACG
AGCCGGAATTCGATGCGTGGGAATGGAAGCCGATGCAGGAACTGCCCAGCCTGATCGTCCCCTTCAAGCGCGGCGTCTAC
GATCAGGTCATTGCCGAATTCCAGCATCTGGCGACATTGCAATCGGAAGACTGA

Upstream 100 bases:

>100_bases
CGATGCGCGGCATCGAGATCGTCGGCGTCGCCGCCCTTTCCAACGACCCACGGAACCCTTGAGAGCAGTCTCTTGAGGAG
ATCCCTGAACGGAGAAGAAG

Downstream 100 bases:

>100_bases
TCATGCCGGAGTGACGCCTCCGTTTGCGCTCGGCAAGCGGGAGGAGTTCCGGCCGCCCAAAGGCGGCCGGCATCTCGTGA
GAGCTTATTCTGCCTCGTTG

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSQATVKAEDLPYRPCVGVMILNRDGLVWAGRRIPDGNSEYDGSPQLWQMPQGGIDKGEDPLDAAYRELYEETGIKTVTL
LAEAGDWINYDLPPALIGIGLKGKFRGQTQRWFAFRFDGDDSEIAINPPPGGHEPEFDAWEWKPMQELPSLIVPFKRGVY
DQVIAEFQHLATLQSED

Sequences:

>Translated_177_residues
MSQATVKAEDLPYRPCVGVMILNRDGLVWAGRRIPDGNSEYDGSPQLWQMPQGGIDKGEDPLDAAYRELYEETGIKTVTL
LAEAGDWINYDLPPALIGIGLKGKFRGQTQRWFAFRFDGDDSEIAINPPPGGHEPEFDAWEWKPMQELPSLIVPFKRGVY
DQVIAEFQHLATLQSED
>Mature_176_residues
SQATVKAEDLPYRPCVGVMILNRDGLVWAGRRIPDGNSEYDGSPQLWQMPQGGIDKGEDPLDAAYRELYEETGIKTVTLL
AEAGDWINYDLPPALIGIGLKGKFRGQTQRWFAFRFDGDDSEIAINPPPGGHEPEFDAWEWKPMQELPSLIVPFKRGVYD
QVIAEFQHLATLQSED

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=171, Percent_Identity=37.4269005847953, Blast_Score=107, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19894; Mature: 19762

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQATVKAEDLPYRPCVGVMILNRDGLVWAGRRIPDGNSEYDGSPQLWQMPQGGIDKGED
CCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PLDAAYRELYEETGIKTVTLLAEAGDWINYDLPPALIGIGLKGKFRGQTQRWFAFRFDGD
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHEECCCCCCCCCCCCEEEEEEECCC
DSEIAINPPPGGHEPEFDAWEWKPMQELPSLIVPFKRGVYDQVIAEFQHLATLQSED
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQATVKAEDLPYRPCVGVMILNRDGLVWAGRRIPDGNSEYDGSPQLWQMPQGGIDKGED
CCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PLDAAYRELYEETGIKTVTLLAEAGDWINYDLPPALIGIGLKGKFRGQTQRWFAFRFDGD
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHEECCCCCCCCCCCCEEEEEEECCC
DSEIAINPPPGGHEPEFDAWEWKPMQELPSLIVPFKRGVYDQVIAEFQHLATLQSED
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]