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The map label for this gene is hemA [H]

Identifier: 209551198

GI number: 209551198

Start: 3746407

End: 3747621

Strand: Reverse

Name: hemA [H]

Synonym: Rleg2_3624

Alternate gene names: 209551198

Gene position: 3747621-3746407 (Counterclockwise)

Preceding gene: 209551202

Following gene: 209551197

Centisome position: 82.58

GC content: 61.56

Gene sequence:

>1215_bases
ATGGATTTCGAAGCGTTTTTCAAAAACGAGTTGGACGGGCTTCATGCCGAGGGCCGTTACCGCGTTTTTGCCGATCTCGA
GCGTCACCGCGGCAATTTTCCGCGCGCGACGCGCCATACGGCCGATGGCGAAAAGGAAGTCACGGTCTGGTGCTCCAACG
ACTATCTCGGCATGGGCCAGAACCCGAAGGTGATCGAGGCGATGAAAAACGCCATCGACCACTGTGGCGCGGGTGCGGGA
GGCACCCGGAATATTTCTGGCACCAACCACTACCACGTCATGCTCGAGCGTGAGCTTGCCGATCTGCACGCCAAGGAAGC
AGCGCTGATCTTCACCTCGGGCTATGTGTCCAACTGGGCAGCGCTCGGCACGCTTGGCGCCAAGATCCCCGGCCTGATCA
TCTTCTCCGACGCGCTGAACCATGCCTCGATGATCGAGGGCATCCGCCATGCCAAATGCGACAAGGTGATCTGGAAGCAC
AATGACGTCGCCGATCTCGAAGCCAAGCTTAAGGCCGCCGATCCGAAGGCGCCGAAGCTGATCGCCTTCGAAAGCGTCTA
TTCGATGGACGGCGATATCGCCCCGATCAAGGAAATCTGCGACCTCGCCGATAAATACGGCGCGATGACCTATCTCGACG
AAGTGCATGCGGTCGGCATGTACGGCCCGCGCGGCGGCGGCATAGCCGAACGCGAGGGGCTGATGGACCGGCTGACTGTC
ATCGAGGGCACGCTCGGCAAGGCTTTCGGGGTGATGGGCGGTTATATCGCCGCGTCTTCAGCGCTTTGCGATTTCATCCG
TTCCTTCGCCTCCGGCTTCATCTTCACTACGGCGCTGCCGCCGGCGCTTGCCGCCGGTGCCGTCGCCTCGATCCAGCATC
TGAAGGTCAGCCAGTTCGAGCGCGCCCGCCATCAGGACCGGGTGCGCAAACTCCGGATGCTGCTCGATCAGAGCGGCATT
CCGCATGTGCCCAATCCGAGCCATATCGTGCCGGTGCTTGTCGGCGATGCCGCCAAATGCAAGTGGATTTCCGACCTGCT
GCTCGACAATTGCGGCGTCTACGTCCAGCCGATCAACTATCCCACCGTGCCGAAGAAGACCGAACGCTTGCGCATCACGC
CGACGCCGCTGCATTCCGATGCCGACATCGCCCATCTGGTCGAGGCGCTGCATTCGCTCTGGTCGCGCTGCGCGCTGGCA
AGACACGTCGCCTGA

Upstream 100 bases:

>100_bases
AAACTGGGCCTTTTGCCGCAGTTGATGTTAAAGCAAAGGGTAAGCATTGACGCGCGGACGTCCGGTCGGCAAGAACGGCC
GCGCGATACTGGAGCAGATG

Downstream 100 bases:

>100_bases
TTTTTCGATGATCGCGCCGTTCAGGACCTCCCTTGGAGGTCCTGACGGTGATCGGCTGTGCGCCTCTGCGGCCGGCCAAC
CTTCCCTATCCTGACCCAGA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDFEAFFKNELDGLHAEGRYRVFADLERHRGNFPRATRHTADGEKEVTVWCSNDYLGMGQNPKVIEAMKNAIDHCGAGAG
GTRNISGTNHYHVMLERELADLHAKEAALIFTSGYVSNWAALGTLGAKIPGLIIFSDALNHASMIEGIRHAKCDKVIWKH
NDVADLEAKLKAADPKAPKLIAFESVYSMDGDIAPIKEICDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTV
IEGTLGKAFGVMGGYIAASSALCDFIRSFASGFIFTTALPPALAAGAVASIQHLKVSQFERARHQDRVRKLRMLLDQSGI
PHVPNPSHIVPVLVGDAAKCKWISDLLLDNCGVYVQPINYPTVPKKTERLRITPTPLHSDADIAHLVEALHSLWSRCALA
RHVA

Sequences:

>Translated_404_residues
MDFEAFFKNELDGLHAEGRYRVFADLERHRGNFPRATRHTADGEKEVTVWCSNDYLGMGQNPKVIEAMKNAIDHCGAGAG
GTRNISGTNHYHVMLERELADLHAKEAALIFTSGYVSNWAALGTLGAKIPGLIIFSDALNHASMIEGIRHAKCDKVIWKH
NDVADLEAKLKAADPKAPKLIAFESVYSMDGDIAPIKEICDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTV
IEGTLGKAFGVMGGYIAASSALCDFIRSFASGFIFTTALPPALAAGAVASIQHLKVSQFERARHQDRVRKLRMLLDQSGI
PHVPNPSHIVPVLVGDAAKCKWISDLLLDNCGVYVQPINYPTVPKKTERLRITPTPLHSDADIAHLVEALHSLWSRCALA
RHVA
>Mature_404_residues
MDFEAFFKNELDGLHAEGRYRVFADLERHRGNFPRATRHTADGEKEVTVWCSNDYLGMGQNPKVIEAMKNAIDHCGAGAG
GTRNISGTNHYHVMLERELADLHAKEAALIFTSGYVSNWAALGTLGAKIPGLIIFSDALNHASMIEGIRHAKCDKVIWKH
NDVADLEAKLKAADPKAPKLIAFESVYSMDGDIAPIKEICDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTV
IEGTLGKAFGVMGGYIAASSALCDFIRSFASGFIFTTALPPALAAGAVASIQHLKVSQFERARHQDRVRKLRMLLDQSGI
PHVPNPSHIVPVLVGDAAKCKWISDLLLDNCGVYVQPINYPTVPKKTERLRITPTPLHSDADIAHLVEALHSLWSRCALA
RHVA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=48.3870967741936, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=48.3870967741936, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=48.3870967741936, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.6277915632754, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.6277915632754, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI7657118, Length=392, Percent_Identity=35.969387755102, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI284448556, Length=343, Percent_Identity=38.7755102040816, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI4758668, Length=373, Percent_Identity=30.8310991957105, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI119220554, Length=391, Percent_Identity=28.9002557544757, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI5454084, Length=259, Percent_Identity=30.1158301158301, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=35.3689567430025, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786993, Length=363, Percent_Identity=32.7823691460055, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=34.7607052896725, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI32566772, Length=386, Percent_Identity=29.7927461139896, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=363, Percent_Identity=29.2011019283747, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=29.2011019283747, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=263, Percent_Identity=26.615969581749, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=263, Percent_Identity=26.615969581749, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=424, Percent_Identity=49.2924528301887, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320267, Length=354, Percent_Identity=27.4011299435028, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=285, Percent_Identity=25.9649122807018, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137420, Length=405, Percent_Identity=47.1604938271605, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=34.9162011173184, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI17136286, Length=330, Percent_Identity=28.1818181818182, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653280, Length=261, Percent_Identity=26.8199233716475, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653276, Length=261, Percent_Identity=26.8199233716475, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653278, Length=261, Percent_Identity=26.8199233716475, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44099; Mature: 44099

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEAFFKNELDGLHAEGRYRVFADLERHRGNFPRATRHTADGEKEVTVWCSNDYLGMGQ
CCHHHHHHHHCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
NPKVIEAMKNAIDHCGAGAGGTRNISGTNHYHVMLERELADLHAKEAALIFTSGYVSNWA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHCCEEEEEECCHHHHHH
ALGTLGAKIPGLIIFSDALNHASMIEGIRHAKCDKVIWKHNDVADLEAKLKAADPKAPKL
HHHHHCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCE
IAFESVYSMDGDIAPIKEICDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTV
EEEHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IEGTLGKAFGVMGGYIAASSALCDFIRSFASGFIFTTALPPALAAGAVASIQHLKVSQFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RARHQDRVRKLRMLLDQSGIPHVPNPSHIVPVLVGDAAKCKWISDLLLDNCGVYVQPINY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCC
PTVPKKTERLRITPTPLHSDADIAHLVEALHSLWSRCALARHVA
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFEAFFKNELDGLHAEGRYRVFADLERHRGNFPRATRHTADGEKEVTVWCSNDYLGMGQ
CCHHHHHHHHCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
NPKVIEAMKNAIDHCGAGAGGTRNISGTNHYHVMLERELADLHAKEAALIFTSGYVSNWA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHCCEEEEEECCHHHHHH
ALGTLGAKIPGLIIFSDALNHASMIEGIRHAKCDKVIWKHNDVADLEAKLKAADPKAPKL
HHHHHCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCE
IAFESVYSMDGDIAPIKEICDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTV
EEEHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IEGTLGKAFGVMGGYIAASSALCDFIRSFASGFIFTTALPPALAAGAVASIQHLKVSQFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RARHQDRVRKLRMLLDQSGIPHVPNPSHIVPVLVGDAAKCKWISDLLLDNCGVYVQPINY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCC
PTVPKKTERLRITPTPLHSDADIAHLVEALHSLWSRCALARHVA
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]