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The map label for this gene is gyaR [H]

Identifier: 209550956

GI number: 209550956

Start: 3492822

End: 3493778

Strand: Reverse

Name: gyaR [H]

Synonym: Rleg2_3380

Alternate gene names: 209550956

Gene position: 3493778-3492822 (Counterclockwise)

Preceding gene: 209550957

Following gene: 209550955

Centisome position: 76.99

GC content: 63.85

Gene sequence:

>957_bases
ATGTCCCGCATCGCCATTCTCGTTCCAGGGAAGATACACGAGCGCGTTCTCGAAAGGCTGAAGGATCGCTTCGAGATTAT
CGCCGTGGCGCGCGAGGAGAGGCTTGCGCTCGACGCCGAAACGGCCGGCCGCATTCGCGGCGTCGCCGTCTCCGGTGCTT
TCCCGGGTGTTTGGATGGATCAGCTGCCGCATGCCGAGGTGATTGCCAGTTTTGGCGTCGGTTATGACGGCATGGATGTG
AAGCGCGCCGCCGAAAAGGGCATCGTCGTCACCAATACGCCTGAGGTTCTGAACGACGAAGTCGCCGATACGGCGATCGG
CCTGCTCCTGAACACGATCCGCGAATTGCCGCGGGCCGAGGCCTGGCTGCGGGAGGGCAACTGGAAGCCGGGGACGACCT
ATCGGCTGTCGCGCTTCTCGCTCAAGGGTCGCCATATCGGGCTCTACGGCCTTGGCCGCATCGGGCTCGAAATCGCCAAG
CGGCTGGAGCCGTTCAAGGTGAAGATCAGCTATCACACGCGCTCGCGTCATGCCGATGCACCCTATGATTATCACCCGAC
GCTGAAGGGGCTGGCGGAAGCGGTGGATACGCTGATCGCCATTGTTCCGAAGACGCCGCAGACGCATAAGACGATCGATG
CCGATATTCTGGCAGCCCTTGGTCCTGAGGGCATTCTCGTCAATGTCGGCCGCGGCTGGACGGTGGACGAGGAGGCGCTG
AGTGCAGCCCTTGCTTCCGGTGCGCTCGGCGCCGCCGGTCTCGATGTCTTCTATGACGAGCCGACCGTGCCGGCCGGCCT
GCTGGAACCGGCCAATGCGGTGCTCCTGCCGCACGTCGCCTCCGCCTCGGTGCCGACCCGCAACGCCATGGCCGATCTCG
TCGCCGACAATCTCATTGCCTGGTTCGAAAAGGGGACCGCCCTGACGCCGGTGCCGGAGACACCGCAAAAGAGCTAG

Upstream 100 bases:

>100_bases
ACGGCATGCATCTGATCAAACCGGAAATGCGCATTCGCCAGTCCACCAGTCCCCATCGGCCGCGCGCCTGAACCAAGTTC
GCCATCCAAGAGGAAAAGCC

Downstream 100 bases:

>100_bases
GCGCGCCGCATAGAAGTTGATTTTTGCGAAATGCGCCAGGTCCCCGGCCTCTATGCCGGCGCTGTCAATCGACTGCTGTT
CCTGGACGATATGTTGCCCA

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSRIAILVPGKIHERVLERLKDRFEIIAVAREERLALDAETAGRIRGVAVSGAFPGVWMDQLPHAEVIASFGVGYDGMDV
KRAAEKGIVVTNTPEVLNDEVADTAIGLLLNTIRELPRAEAWLREGNWKPGTTYRLSRFSLKGRHIGLYGLGRIGLEIAK
RLEPFKVKISYHTRSRHADAPYDYHPTLKGLAEAVDTLIAIVPKTPQTHKTIDADILAALGPEGILVNVGRGWTVDEEAL
SAALASGALGAAGLDVFYDEPTVPAGLLEPANAVLLPHVASASVPTRNAMADLVADNLIAWFEKGTALTPVPETPQKS

Sequences:

>Translated_318_residues
MSRIAILVPGKIHERVLERLKDRFEIIAVAREERLALDAETAGRIRGVAVSGAFPGVWMDQLPHAEVIASFGVGYDGMDV
KRAAEKGIVVTNTPEVLNDEVADTAIGLLLNTIRELPRAEAWLREGNWKPGTTYRLSRFSLKGRHIGLYGLGRIGLEIAK
RLEPFKVKISYHTRSRHADAPYDYHPTLKGLAEAVDTLIAIVPKTPQTHKTIDADILAALGPEGILVNVGRGWTVDEEAL
SAALASGALGAAGLDVFYDEPTVPAGLLEPANAVLLPHVASASVPTRNAMADLVADNLIAWFEKGTALTPVPETPQKS
>Mature_317_residues
SRIAILVPGKIHERVLERLKDRFEIIAVAREERLALDAETAGRIRGVAVSGAFPGVWMDQLPHAEVIASFGVGYDGMDVK
RAAEKGIVVTNTPEVLNDEVADTAIGLLLNTIRELPRAEAWLREGNWKPGTTYRLSRFSLKGRHIGLYGLGRIGLEIAKR
LEPFKVKISYHTRSRHADAPYDYHPTLKGLAEAVDTLIAIVPKTPQTHKTIDADILAALGPEGILVNVGRGWTVDEEALS
AALASGALGAAGLDVFYDEPTVPAGLLEPANAVLLPHVASASVPTRNAMADLVADNLIAWFEKGTALTPVPETPQKS

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=241, Percent_Identity=36.0995850622407, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=30.1204819277108, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI145580578, Length=252, Percent_Identity=30.1587301587302, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557499, Length=252, Percent_Identity=30.1587301587302, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI145580575, Length=244, Percent_Identity=31.1475409836066, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI87082289, Length=297, Percent_Identity=32.996632996633, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789279, Length=252, Percent_Identity=29.3650793650794, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081824, Length=250, Percent_Identity=26.4, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787645, Length=202, Percent_Identity=26.7326732673267, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=246, Percent_Identity=28.8617886178862, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=276, Percent_Identity=34.0579710144928, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=27.1739130434783, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=25.3623188405797, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=25.8992805755396, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=32.8859060402685, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571528, Length=243, Percent_Identity=37.8600823045267, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24585516, Length=249, Percent_Identity=31.3253012048193, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=31.1023622047244, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=31.1023622047244, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=31.1023622047244, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=31.1023622047244, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=31.1023622047244, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28574286, Length=255, Percent_Identity=30.5882352941176, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646446, Length=253, Percent_Identity=30.8300395256917, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646448, Length=253, Percent_Identity=30.8300395256917, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646452, Length=253, Percent_Identity=30.8300395256917, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646450, Length=253, Percent_Identity=30.8300395256917, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=30.8880308880309, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19921140, Length=241, Percent_Identity=28.6307053941909, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34277; Mature: 34146

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIAILVPGKIHERVLERLKDRFEIIAVAREERLALDAETAGRIRGVAVSGAFPGVWMD
CCEEEEEECCHHHHHHHHHHHHHHHEEHEEHHHHHEECCHHCCCEEEEEEECCCCCCHHH
QLPHAEVIASFGVGYDGMDVKRAAEKGIVVTNTPEVLNDEVADTAIGLLLNTIRELPRAE
HCCHHHHHHHHCCCCCCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHH
AWLREGNWKPGTTYRLSRFSLKGRHIGLYGLGRIGLEIAKRLEPFKVKISYHTRSRHADA
HHHHCCCCCCCCCEEEEEEEECCCEEEEEEHHHHHHHHHHCCCCEEEEEEEEECCCCCCC
PYDYHPTLKGLAEAVDTLIAIVPKTPQTHKTIDADILAALGPEGILVNVGRGWTVDEEAL
CCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCCCCHHHH
SAALASGALGAAGLDVFYDEPTVPAGLLEPANAVLLPHVASASVPTRNAMADLVADNLIA
HHHHHHCCCCCCCCEEEECCCCCCHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
WFEKGTALTPVPETPQKS
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRIAILVPGKIHERVLERLKDRFEIIAVAREERLALDAETAGRIRGVAVSGAFPGVWMD
CEEEEEECCHHHHHHHHHHHHHHHEEHEEHHHHHEECCHHCCCEEEEEEECCCCCCHHH
QLPHAEVIASFGVGYDGMDVKRAAEKGIVVTNTPEVLNDEVADTAIGLLLNTIRELPRAE
HCCHHHHHHHHCCCCCCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHH
AWLREGNWKPGTTYRLSRFSLKGRHIGLYGLGRIGLEIAKRLEPFKVKISYHTRSRHADA
HHHHCCCCCCCCCEEEEEEEECCCEEEEEEHHHHHHHHHHCCCCEEEEEEEEECCCCCCC
PYDYHPTLKGLAEAVDTLIAIVPKTPQTHKTIDADILAALGPEGILVNVGRGWTVDEEAL
CCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCCCCHHHH
SAALASGALGAAGLDVFYDEPTVPAGLLEPANAVLLPHVASASVPTRNAMADLVADNLIA
HHHHHHCCCCCCCCEEEECCCCCCHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
WFEKGTALTPVPETPQKS
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA