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The map label for this gene is cytR [H]

Identifier: 209550957

GI number: 209550957

Start: 3493808

End: 3494830

Strand: Reverse

Name: cytR [H]

Synonym: Rleg2_3381

Alternate gene names: 209550957

Gene position: 3494830-3493808 (Counterclockwise)

Preceding gene: 209550958

Following gene: 209550956

Centisome position: 77.01

GC content: 64.03

Gene sequence:

>1023_bases
GTGGTCCAGAAGATCAAGCTTTCGACAATTGCCGAAACACTCGGCATTTCAACGGCTACGGTATCGCTTGCGTTACGCGA
CAGTCCGCTCGTCGCCGGCAATACCCGGGAAAAGATCAAGGAACAGGCGCGTGCGCTCGGTTACATCTACAATCGCCGCG
CCGCCAGCCTTCGCACCTCACGCTCGGGCATCATCGGCGTCGTCGTGCACGACATCATGAACCCGTTCTACGGGGAAATC
CTGAAGGCGATCGAAAGCGAGCTCGATCGCAGCCGCCACACCTTCATCCTTTCCAACCATTACGACAATGTCGAAAAGCA
GCGCACCTTCATCGAGACGCTTCTGCAGCTCGGCGGCGACGGCGTCATCATGTCGCCGGCGATCGGCACGCCGCCTGAGG
ATGTACAACTGGCGGAAGAGAACGGCATGCCGGCGATCCTGGTTGCCCGCTCGATGGAAGGCCAGGACCTGCCGACCTAT
CGCGGCGACGACAGCTACGGCATCTCGCTCGCCACCAACCATCTGATCGGCCTCGGCCACCGCTCGATCGCCATGATCGG
CGGCACGGACCAGACATCCACCGGCCGCGATCGCTACCAGGGTTATGTCAACGCGCTGCGCAAGGCCGGCATCGAGGTCG
ATCCGAACCTGCGCATCCCCGGCCCGCGCTCGAAACAGGGCGGCTTCGAGGCGGCGGTGCATTTCCTGTCGCTGCCGCAG
AAGCCGACGGCGGCCGTCTGCTGGAACGATCTCGTCGCGATCGGGTTGATGAACGGTATCGCGCGTGCCGGCCTGGTGCC
GGGACGCGATATTTCCGTCACCGGTTACGACGATCTCGAGGAGGCGTCGATCGCAACGCCGGCGCTGACGACCGTCTGGA
ACGGCCAGACCGAGGTCGGGCGCCTGGCGGCCCGGGCGCTGCTCGATCGCCTTGCCGGCAGTCACGAGCCTGACGGCATG
CATCTGATCAAACCGGAAATGCGCATTCGCCAGTCCACCAGTCCCCATCGGCCGCGCGCCTGA

Upstream 100 bases:

>100_bases
TGCTTCCGCCGGTTAAATCTTTTAATTAAACATTTTAAGGGGACCGCGCCGGTTAGCCGGCGTGGTCTTGCTGTCTTGCG
TGCTGCCTGGAGGAGGACAC

Downstream 100 bases:

>100_bases
ACCAAGTTCGCCATCCAAGAGGAAAAGCCATGTCCCGCATCGCCATTCTCGTTCCAGGGAAGATACACGAGCGCGTTCTC
GAAAGGCTGAAGGATCGCTT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MVQKIKLSTIAETLGISTATVSLALRDSPLVAGNTREKIKEQARALGYIYNRRAASLRTSRSGIIGVVVHDIMNPFYGEI
LKAIESELDRSRHTFILSNHYDNVEKQRTFIETLLQLGGDGVIMSPAIGTPPEDVQLAEENGMPAILVARSMEGQDLPTY
RGDDSYGISLATNHLIGLGHRSIAMIGGTDQTSTGRDRYQGYVNALRKAGIEVDPNLRIPGPRSKQGGFEAAVHFLSLPQ
KPTAAVCWNDLVAIGLMNGIARAGLVPGRDISVTGYDDLEEASIATPALTTVWNGQTEVGRLAARALLDRLAGSHEPDGM
HLIKPEMRIRQSTSPHRPRA

Sequences:

>Translated_340_residues
MVQKIKLSTIAETLGISTATVSLALRDSPLVAGNTREKIKEQARALGYIYNRRAASLRTSRSGIIGVVVHDIMNPFYGEI
LKAIESELDRSRHTFILSNHYDNVEKQRTFIETLLQLGGDGVIMSPAIGTPPEDVQLAEENGMPAILVARSMEGQDLPTY
RGDDSYGISLATNHLIGLGHRSIAMIGGTDQTSTGRDRYQGYVNALRKAGIEVDPNLRIPGPRSKQGGFEAAVHFLSLPQ
KPTAAVCWNDLVAIGLMNGIARAGLVPGRDISVTGYDDLEEASIATPALTTVWNGQTEVGRLAARALLDRLAGSHEPDGM
HLIKPEMRIRQSTSPHRPRA
>Mature_340_residues
MVQKIKLSTIAETLGISTATVSLALRDSPLVAGNTREKIKEQARALGYIYNRRAASLRTSRSGIIGVVVHDIMNPFYGEI
LKAIESELDRSRHTFILSNHYDNVEKQRTFIETLLQLGGDGVIMSPAIGTPPEDVQLAEENGMPAILVARSMEGQDLPTY
RGDDSYGISLATNHLIGLGHRSIAMIGGTDQTSTGRDRYQGYVNALRKAGIEVDPNLRIPGPRSKQGGFEAAVHFLSLPQ
KPTAAVCWNDLVAIGLMNGIARAGLVPGRDISVTGYDDLEEASIATPALTTVWNGQTEVGRLAARALLDRLAGSHEPDGM
HLIKPEMRIRQSTSPHRPRA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=329, Percent_Identity=31.9148936170213, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1787948, Length=329, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790194, Length=305, Percent_Identity=29.1803278688525, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1787906, Length=289, Percent_Identity=31.1418685121107, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789202, Length=288, Percent_Identity=31.25, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788474, Length=332, Percent_Identity=28.9156626506024, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786540, Length=310, Percent_Identity=31.9354838709677, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789068, Length=300, Percent_Identity=26.3333333333333, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=26.8608414239482, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790715, Length=318, Percent_Identity=26.4150943396226, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787580, Length=320, Percent_Identity=25, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786268, Length=282, Percent_Identity=23.0496453900709, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790689, Length=338, Percent_Identity=24.5562130177515, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36850; Mature: 36850

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQKIKLSTIAETLGISTATVSLALRDSPLVAGNTREKIKEQARALGYIYNRRAASLRTS
CCCEEHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RSGIIGVVVHDIMNPFYGEILKAIESELDRSRHTFILSNHYDNVEKQRTFIETLLQLGGD
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIMSPAIGTPPEDVQLAEENGMPAILVARSMEGQDLPTYRGDDSYGISLATNHLIGLGH
CEEECCCCCCCCCCCEEHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEHHHEEECCC
RSIAMIGGTDQTSTGRDRYQGYVNALRKAGIEVDPNLRIPGPRSKQGGFEAAVHFLSLPQ
CEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
KPTAAVCWNDLVAIGLMNGIARAGLVPGRDISVTGYDDLEEASIATPALTTVWNGQTEVG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCCCHHEEECCCHHHH
RLAARALLDRLAGSHEPDGMHLIKPEMRIRQSTSPHRPRA
HHHHHHHHHHHCCCCCCCCEEEECCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVQKIKLSTIAETLGISTATVSLALRDSPLVAGNTREKIKEQARALGYIYNRRAASLRTS
CCCEEHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RSGIIGVVVHDIMNPFYGEILKAIESELDRSRHTFILSNHYDNVEKQRTFIETLLQLGGD
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIMSPAIGTPPEDVQLAEENGMPAILVARSMEGQDLPTYRGDDSYGISLATNHLIGLGH
CEEECCCCCCCCCCCEEHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEHHHEEECCC
RSIAMIGGTDQTSTGRDRYQGYVNALRKAGIEVDPNLRIPGPRSKQGGFEAAVHFLSLPQ
CEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
KPTAAVCWNDLVAIGLMNGIARAGLVPGRDISVTGYDDLEEASIATPALTTVWNGQTEVG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCCCHHEEECCCHHHH
RLAARALLDRLAGSHEPDGMHLIKPEMRIRQSTSPHRPRA
HHHHHHHHHHHCCCCCCCCEEEECCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]