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The map label for this gene is lip2 [H]

Identifier: 209550423

GI number: 209550423

Start: 2894445

End: 2895458

Strand: Reverse

Name: lip2 [H]

Synonym: Rleg2_2844

Alternate gene names: 209550423

Gene position: 2895458-2894445 (Counterclockwise)

Preceding gene: 209550425

Following gene: 209550420

Centisome position: 63.81

GC content: 63.51

Gene sequence:

>1014_bases
ATGTCGACCATCAAGACCGCCGTTTCCGCCGCAGCACTCCTCGCAGCCTCCGCCGCCGGTGCGCTTGCCGACCCGGTACT
CGAGCCGACAACGCAGACATTCATCGACGGCCTTGCCGGGGGAAAGCCGATCTACACGCTGTCGCCGGTCGATGCCCGCA
ATGTTCTGGCCCGCGCACAGAAGGGCGAGGTGAAGAAGCTTGCTGCCCAGGTGGAGGATAAGGTCATCAAGGCTGGCCCG
ACGGACAGCATCAAACTGCGCATTGTCCGCCCGGAACATGCCAAGGGCACGCTGCCGGTCATTCTCTACTTTCATGGCGG
CGGCTGGGTACTGGGCGATGCGGATACGCATGACCGGCTGGTGCGCGAGATCGCCAACGGCGCCAACGCTGCCGTCGTCT
TCGTCGATTACGAACGCTCGCCAGAAGCCCGTTATCCCGTCGCCATCGAGCAGGCCTATGCGGCGACCAAATATGTCGCA
GAGCATGCCAAGGAGTTCAACGTCGACGCCGGCAGGCTGGCGGTCGCGGGCGACAGCGTCGGCGGGAATATGGCGGCGGT
GGTGACGCTGCTCGCCAAGGAGCGCGGAGGTCCCGCCATCGATCAGCAGGTGCTGTTCTACCCGGTCACCGACGCCAATT
TCGACAATGGTTCTTATAATGAGTTCGCCAATGGTCCGTGGCTGACCAAGGAAGCGATGAAGTGGTTCTGGAACGCCTAC
CTGCCCGACGAAGCCAAGCGCAAGGAGCCGACGGCTTCACCGCTGCAGGCCTCGCTGGAGCAACTGAACGGCCTGCCGCC
GGCACTGGTCATCGTCGATGAGAACGACGTGCTGCGCGACGAAGGCGAGGCCTATGCCCGCAAGCTCAGCCAGGCCGGCG
TTCGCGTCGCGTCGATGCGCTACAACGGCACGATCCACGACTTTGTGCTCTTGAACGCCATTGCCGAAACGCCTGCGGCG
CGTAGCGCGATCGCCGTCGCGAACGACACGCTTCGCAACGCTTTGCATAAGTAG

Upstream 100 bases:

>100_bases
CTGCATGGCAGGCATGCGGAGATTTAAGTTGTCCAATAAATAATCGTGCGCGATATAAATGTTGTGTTCACGACGAACAC
CAAACCGAGAGGACAAGACA

Downstream 100 bases:

>100_bases
GGGCGATTGAAGCTCTTTGTTTTCACGCAATTCCCGGCAAAAGCGCTTTGCCTGGCAAAGCCGCTTCACACTTTTGCTGG
AATTGCTTTAATCTGCGGAG

Product: alpha/beta hydrolase fold-3 domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSTIKTAVSAAALLAASAAGALADPVLEPTTQTFIDGLAGGKPIYTLSPVDARNVLARAQKGEVKKLAAQVEDKVIKAGP
TDSIKLRIVRPEHAKGTLPVILYFHGGGWVLGDADTHDRLVREIANGANAAVVFVDYERSPEARYPVAIEQAYAATKYVA
EHAKEFNVDAGRLAVAGDSVGGNMAAVVTLLAKERGGPAIDQQVLFYPVTDANFDNGSYNEFANGPWLTKEAMKWFWNAY
LPDEAKRKEPTASPLQASLEQLNGLPPALVIVDENDVLRDEGEAYARKLSQAGVRVASMRYNGTIHDFVLLNAIAETPAA
RSAIAVANDTLRNALHK

Sequences:

>Translated_337_residues
MSTIKTAVSAAALLAASAAGALADPVLEPTTQTFIDGLAGGKPIYTLSPVDARNVLARAQKGEVKKLAAQVEDKVIKAGP
TDSIKLRIVRPEHAKGTLPVILYFHGGGWVLGDADTHDRLVREIANGANAAVVFVDYERSPEARYPVAIEQAYAATKYVA
EHAKEFNVDAGRLAVAGDSVGGNMAAVVTLLAKERGGPAIDQQVLFYPVTDANFDNGSYNEFANGPWLTKEAMKWFWNAY
LPDEAKRKEPTASPLQASLEQLNGLPPALVIVDENDVLRDEGEAYARKLSQAGVRVASMRYNGTIHDFVLLNAIAETPAA
RSAIAVANDTLRNALHK
>Mature_336_residues
STIKTAVSAAALLAASAAGALADPVLEPTTQTFIDGLAGGKPIYTLSPVDARNVLARAQKGEVKKLAAQVEDKVIKAGPT
DSIKLRIVRPEHAKGTLPVILYFHGGGWVLGDADTHDRLVREIANGANAAVVFVDYERSPEARYPVAIEQAYAATKYVAE
HAKEFNVDAGRLAVAGDSVGGNMAAVVTLLAKERGGPAIDQQVLFYPVTDANFDNGSYNEFANGPWLTKEAMKWFWNAYL
PDEAKRKEPTASPLQASLEQLNGLPPALVIVDENDVLRDEGEAYARKLSQAGVRVASMRYNGTIHDFVLLNAIAETPAAR
SAIAVANDTLRNALHK

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=267, Percent_Identity=29.2134831460674, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI68299767, Length=288, Percent_Identity=27.7777777777778, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI157041239, Length=282, Percent_Identity=24.822695035461, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI68051721, Length=148, Percent_Identity=33.7837837837838, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI61966717, Length=327, Percent_Identity=25.3822629969419, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI21328446, Length=121, Percent_Identity=32.2314049586777, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI226423947, Length=156, Percent_Identity=31.4102564102564, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786682, Length=222, Percent_Identity=29.2792792792793, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71996133, Length=304, Percent_Identity=25.9868421052632, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17567059, Length=289, Percent_Identity=25.6055363321799, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72001146, Length=125, Percent_Identity=33.6, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540028, Length=151, Percent_Identity=31.7880794701987, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656084, Length=115, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656076, Length=115, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130169, Length=115, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 36028; Mature: 35897

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIKTAVSAAALLAASAAGALADPVLEPTTQTFIDGLAGGKPIYTLSPVDARNVLARAQ
CCHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
KGEVKKLAAQVEDKVIKAGPTDSIKLRIVRPEHAKGTLPVILYFHGGGWVLGDADTHDRL
CCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEECCCCHHHHH
VREIANGANAAVVFVDYERSPEARYPVAIEQAYAATKYVAEHAKEFNVDAGRLAVAGDSV
HHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
GGNMAAVVTLLAKERGGPAIDQQVLFYPVTDANFDNGSYNEFANGPWLTKEAMKWFWNAY
CCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LPDEAKRKEPTASPLQASLEQLNGLPPALVIVDENDVLRDEGEAYARKLSQAGVRVASMR
CCCHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEE
YNGTIHDFVLLNAIAETPAARSAIAVANDTLRNALHK
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STIKTAVSAAALLAASAAGALADPVLEPTTQTFIDGLAGGKPIYTLSPVDARNVLARAQ
CHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
KGEVKKLAAQVEDKVIKAGPTDSIKLRIVRPEHAKGTLPVILYFHGGGWVLGDADTHDRL
CCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEECCCCHHHHH
VREIANGANAAVVFVDYERSPEARYPVAIEQAYAATKYVAEHAKEFNVDAGRLAVAGDSV
HHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
GGNMAAVVTLLAKERGGPAIDQQVLFYPVTDANFDNGSYNEFANGPWLTKEAMKWFWNAY
CCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LPDEAKRKEPTASPLQASLEQLNGLPPALVIVDENDVLRDEGEAYARKLSQAGVRVASMR
CCCHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEE
YNGTIHDFVLLNAIAETPAARSAIAVANDTLRNALHK
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]