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The map label for this gene is clpP3 [H]

Identifier: 209550385

GI number: 209550385

Start: 2851779

End: 2852363

Strand: Reverse

Name: clpP3 [H]

Synonym: Rleg2_2806

Alternate gene names: 209550385

Gene position: 2852363-2851779 (Counterclockwise)

Preceding gene: 209550387

Following gene: 209550384

Centisome position: 62.86

GC content: 59.83

Gene sequence:

>585_bases
ATGAACGACGAAGACCAGGACGACAAGACGAAGGAACTGCCGCTCGGCAAGGAAACGGAGGCGAATCTTTTCAAGTCGCG
TTCGATCTTCATCTACGGACCGATCAATCAGGAATTGGCGCAGAAGGTCTGCTCGCAGCTCGTGGCGCTTGCCGCGGCCA
GCGACGAAGACATCCGCATCTATGTGAATTCGCCCGGCGGCCACGTCGAATCCGGCGATTCCATTCATGACATGATCAAG
TTCATCAAACCGAAGGTCTGGATGATCGGCACGGGCTGGGTCGCCTCCGCCGGGGCGCTGATCTATGTCGCCGCTCCGAA
AGAGCAGCGCCTGTGCCTGCCGAACACCCGCTTCCTGCTGCACCAGCCCTCGGGCGGCACGCGCGGCATGGCATCGGACA
TCGAAATCCAGGCACGCGAGATCATCAAGATGAACGAGCGCCTGAACAAGATCATGGCGGCAGCCACCGGCCAGCCGCTC
GACAAGATCGCCAAGGATACCGATCGCGATTACTGGCTGTCGGCCGAAGAGGCGAAGGACTATGGTCTTGTCTCGCGGAT
CGTGACGTCACAGGCCGATATCTGA

Upstream 100 bases:

>100_bases
ATATCTCCATCGCTTCGGTGCCTTGTGTTTTTCCCACATTGTTTTAGGCATTGAGTCGCACTATGTGCGGGGAAGCCGAA
TTCATCTCCAAGAGGTTCGA

Downstream 100 bases:

>100_bases
GTTTTCTCATGTAATGCTATTGAACGCCCTCGCCTGCAGCATCAGGCGAGGGCGTTTTGTTTCTGCCGGAAGACGCGGGT
GCTGAACGGAAAGAGCTGAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 3 [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MNDEDQDDKTKELPLGKETEANLFKSRSIFIYGPINQELAQKVCSQLVALAAASDEDIRIYVNSPGGHVESGDSIHDMIK
FIKPKVWMIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNKIMAAATGQPL
DKIAKDTDRDYWLSAEEAKDYGLVSRIVTSQADI

Sequences:

>Translated_194_residues
MNDEDQDDKTKELPLGKETEANLFKSRSIFIYGPINQELAQKVCSQLVALAAASDEDIRIYVNSPGGHVESGDSIHDMIK
FIKPKVWMIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNKIMAAATGQPL
DKIAKDTDRDYWLSAEEAKDYGLVSRIVTSQADI
>Mature_194_residues
MNDEDQDDKTKELPLGKETEANLFKSRSIFIYGPINQELAQKVCSQLVALAAASDEDIRIYVNSPGGHVESGDSIHDMIK
FIKPKVWMIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNKIMAAATGQPL
DKIAKDTDRDYWLSAEEAKDYGLVSRIVTSQADI

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=170, Percent_Identity=37.6470588235294, Blast_Score=126, Evalue=1e-29,
Organism=Escherichia coli, GI1786641, Length=172, Percent_Identity=47.6744186046512, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17538017, Length=177, Percent_Identity=39.5480225988701, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI20129427, Length=169, Percent_Identity=34.3195266272189, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21451; Mature: 21451

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDEDQDDKTKELPLGKETEANLFKSRSIFIYGPINQELAQKVCSQLVALAAASDEDIRI
CCCCCCCCCHHCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEE
YVNSPGGHVESGDSIHDMIKFIKPKVWMIGTGWVASAGALIYVAAPKEQRLCLPNTRFLL
EEECCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHCCCEEEEEECCCCCCEECCCCEEEE
HQPSGGTRGMASDIEIQAREIIKMNERLNKIMAAATGQPLDKIAKDTDRDYWLSAEEAKD
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECHHHHHH
YGLVSRIVTSQADI
HHHHHHHHHHCCCC
>Mature Secondary Structure
MNDEDQDDKTKELPLGKETEANLFKSRSIFIYGPINQELAQKVCSQLVALAAASDEDIRI
CCCCCCCCCHHCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEE
YVNSPGGHVESGDSIHDMIKFIKPKVWMIGTGWVASAGALIYVAAPKEQRLCLPNTRFLL
EEECCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHCCCEEEEEECCCCCCEECCCCEEEE
HQPSGGTRGMASDIEIQAREIIKMNERLNKIMAAATGQPLDKIAKDTDRDYWLSAEEAKD
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECHHHHHH
YGLVSRIVTSQADI
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA