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The map label for this gene is tetA [H]

Identifier: 209550289

GI number: 209550289

Start: 2750255

End: 2751499

Strand: Reverse

Name: tetA [H]

Synonym: Rleg2_2709

Alternate gene names: 209550289

Gene position: 2751499-2750255 (Counterclockwise)

Preceding gene: 209550291

Following gene: 209550288

Centisome position: 60.63

GC content: 64.34

Gene sequence:

>1245_bases
ATGCTTGACCCCAAATTCGTCCGTCGCGGCCTTTTCCTGGTCTTCATCATCCTCTTCCTCGACATTATCGGCATCGCCAT
CATCATGCCGGTGCTGCCCGCCTATCTGGAGCAGTTGACCGGCGGCGGCGTGAGCGATGCGGCGATCGACGGCGGCTGGC
TGATGCTCGTCTATGCCGGCATGCAATTCCTGTTCGCGCCGCTGCTCGGAAACCTGTCCGACCGGTTCGGCCGCCGGCCG
ATCCTTCTGCTGTCGGTGTTGACCTTTGCGATCGACAATTTCATCTGCGGCATCGCCACCAGCTTCTGGATGCTGTTCGT
CGGCCGCGTGCTTGCCGGCATCAGCGGCGGCAGCTTTGCCACGTGCTCGGCCTATATCGCTGATATCAGCACCGAGGAGA
ACCGGGCGAAGAATTTCGGGCTGATCGGCATCGCCTTCGGCGTCGGCTTCACGATCGGCCCCGTCATCGGCGGTGTCCTC
GGCGAATTCGGCCCGCGTGTGCCGTTTCTCGGTGCGGCCGCACTCTCGTTCGTCAATTTCATCGCCGCCTGCTTCCTGCT
GCCGGAAACGCTGGAGGCCAGGAATCGCCGCCGCTTCGAGTGGAAGCGTGCCAATCCGCTCGGCGCGTTGCGGCAGATGC
GTCACTACCCGGGCATCGGTTGGGTCAGCCTCGTCATGTTCCTGTTTTTCCTGGCGCATGCCGTCTATCCCTCGGTCTGG
TCCTTCGTCTCGACTTATCGCTACGGCTGGAGCGAGGGACAGATCGGCCTGTCGCTCGGGATCTACGGCATCGGCGCGGC
ACTGGTGATGGGATTGGTATTGCCGCGCGTCGTACCTCTGCTCGGCGAATGGAAGACGGCGCTTCTCGGCCTCTGTTTTT
CGGCTGCGGGGCTGACCGGCTATGCCTTCGCCTGGGAGGGCTGGGTGGTCTATGTGGTGATCGTTGCGACCGTCATGGAA
AACGTCGCCGATCCGCCGTTGCGCAGCATCGCCGCCGGCAAGGTGCCGCCCTCGGCGCAGGGCGAGCTGCAGGGCGCGCT
GACCAGTCTCAGCAGCATCACCACCATCGTCGGGCCGCTGATCTTCACCCAGTTGTTCAGCTATTTCACCCGGCCAGAGG
CGCCCGTCACCTTTGCCGGGGCGCCCTATCTGACTGCTGCCCTGTTCATCCTGGTGGCCGCCGGCGTGTTCCTCGTGCGG
GTCCGGGTGCGTCAGCCGGCCGAAGCGCTGGAGGCGGCGGGTTGA

Upstream 100 bases:

>100_bases
TTTGAAATGTTCACGGATTGTTTCGGTTTCTTTTCTGGGCTATGTCAGTTTCTCGGCGACGAAATCGTCTTTTCAGAAGC
AACCGCTGTAGAGATGCCTC

Downstream 100 bases:

>100_bases
TCGATCAGAAACGGTGATACGATGATGAATTTTTCATCATCTGCCTGTTTAGGGTGGTTCTTTGCTGGGGTTTGATCTAA
ATCCCGATGATATTTCTCCG

Product: major facilitator superfamily protein

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLDPKFVRRGLFLVFIILFLDIIGIAIIMPVLPAYLEQLTGGGVSDAAIDGGWLMLVYAGMQFLFAPLLGNLSDRFGRRP
ILLLSVLTFAIDNFICGIATSFWMLFVGRVLAGISGGSFATCSAYIADISTEENRAKNFGLIGIAFGVGFTIGPVIGGVL
GEFGPRVPFLGAAALSFVNFIAACFLLPETLEARNRRRFEWKRANPLGALRQMRHYPGIGWVSLVMFLFFLAHAVYPSVW
SFVSTYRYGWSEGQIGLSLGIYGIGAALVMGLVLPRVVPLLGEWKTALLGLCFSAAGLTGYAFAWEGWVVYVVIVATVME
NVADPPLRSIAAGKVPPSAQGELQGALTSLSSITTIVGPLIFTQLFSYFTRPEAPVTFAGAPYLTAALFILVAAGVFLVR
VRVRQPAEALEAAG

Sequences:

>Translated_414_residues
MLDPKFVRRGLFLVFIILFLDIIGIAIIMPVLPAYLEQLTGGGVSDAAIDGGWLMLVYAGMQFLFAPLLGNLSDRFGRRP
ILLLSVLTFAIDNFICGIATSFWMLFVGRVLAGISGGSFATCSAYIADISTEENRAKNFGLIGIAFGVGFTIGPVIGGVL
GEFGPRVPFLGAAALSFVNFIAACFLLPETLEARNRRRFEWKRANPLGALRQMRHYPGIGWVSLVMFLFFLAHAVYPSVW
SFVSTYRYGWSEGQIGLSLGIYGIGAALVMGLVLPRVVPLLGEWKTALLGLCFSAAGLTGYAFAWEGWVVYVVIVATVME
NVADPPLRSIAAGKVPPSAQGELQGALTSLSSITTIVGPLIFTQLFSYFTRPEAPVTFAGAPYLTAALFILVAAGVFLVR
VRVRQPAEALEAAG
>Mature_414_residues
MLDPKFVRRGLFLVFIILFLDIIGIAIIMPVLPAYLEQLTGGGVSDAAIDGGWLMLVYAGMQFLFAPLLGNLSDRFGRRP
ILLLSVLTFAIDNFICGIATSFWMLFVGRVLAGISGGSFATCSAYIADISTEENRAKNFGLIGIAFGVGFTIGPVIGGVL
GEFGPRVPFLGAAALSFVNFIAACFLLPETLEARNRRRFEWKRANPLGALRQMRHYPGIGWVSLVMFLFFLAHAVYPSVW
SFVSTYRYGWSEGQIGLSLGIYGIGAALVMGLVLPRVVPLLGEWKTALLGLCFSAAGLTGYAFAWEGWVVYVVIVATVME
NVADPPLRSIAAGKVPPSAQGELQGALTSLSSITTIVGPLIFTQLFSYFTRPEAPVTFAGAPYLTAALFILVAAGVFLVR
VRVRQPAEALEAAG

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=332, Percent_Identity=26.2048192771084, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI94721311, Length=378, Percent_Identity=24.3386243386243, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI225703104, Length=370, Percent_Identity=28.1081081081081, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI225703102, Length=370, Percent_Identity=28.1081081081081, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI217416366, Length=156, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI87081738, Length=158, Percent_Identity=34.1772151898734, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996331, Length=320, Percent_Identity=26.25, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551570, Length=357, Percent_Identity=25.7703081232493, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221513297, Length=321, Percent_Identity=27.7258566978193, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357569, Length=326, Percent_Identity=24.8466257668712, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24656463, Length=326, Percent_Identity=24.8466257668712, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656468, Length=326, Percent_Identity=24.8466257668712, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161080926, Length=326, Percent_Identity=24.8466257668712, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161080924, Length=326, Percent_Identity=24.8466257668712, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17738085, Length=249, Percent_Identity=25.3012048192771, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24667561, Length=201, Percent_Identity=24.8756218905473, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24667557, Length=166, Percent_Identity=27.710843373494, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44485; Mature: 44485

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00213 LIPOCALIN ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MLDPKFVRRGLFLVFIILFLDIIGIAIIMPVLPAYLEQLTGGGVSDAAIDGGWLMLVYAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHH
MQFLFAPLLGNLSDRFGRRPILLLSVLTFAIDNFICGIATSFWMLFVGRVLAGISGGSFA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TCSAYIADISTEENRAKNFGLIGIAFGVGFTIGPVIGGVLGEFGPRVPFLGAAALSFVNF
HHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
IAACFLLPETLEARNRRRFEWKRANPLGALRQMRHYPGIGWVSLVMFLFFLAHAVYPSVW
HHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SFVSTYRYGWSEGQIGLSLGIYGIGAALVMGLVLPRVVPLLGEWKTALLGLCFSAAGLTG
HHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
YAFAWEGWVVYVVIVATVMENVADPPLRSIAAGKVPPSAQGELQGALTSLSSITTIVGPL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFTQLFSYFTRPEAPVTFAGAPYLTAALFILVAAGVFLVRVRVRQPAEALEAAG
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]