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The map label for this gene is penA [H]

Identifier: 209550180

GI number: 209550180

Start: 2641567

End: 2643327

Strand: Reverse

Name: penA [H]

Synonym: Rleg2_2600

Alternate gene names: 209550180

Gene position: 2643327-2641567 (Counterclockwise)

Preceding gene: 209550181

Following gene: 209550179

Centisome position: 58.25

GC content: 61.44

Gene sequence:

>1761_bases
ATGTCGTTTCTTTCCCGCATCATGGTCTTGAAGAGCCAGGCGCATTTCTCCGCTGGTGTTTATAACCGGTTCGGCGGCCC
GTCCCCCGCCGGCCTGGCGATCGAGGGATCCCGCAAGAAGAAATCAGGACAGGCAAAAAGCCGCGTCGGCCTGCTGATCC
TCGGCTTCATGGGTGTCTATGTCGTCATCGGCGGCCGTCTCGTCGAATATGCGATGAAGGATCAGGAGGTCGTCTCCAGC
ATCCTGCCGCCCGACCGGCTGATGGCCTCGCGCCCCGACATTCTCGACCGCAACGGCGAAGTGCTGGCGACCGACATCCG
CACCGTCTCGCTGTTTGCCGAACCCAACAAGATCGTCGATGCCGACGAGGCGGTCGAGAAGCTTGCGACTGTTCTGCCGG
AGCTCGACGTCCGGGATACCTATAAGAAGCTCTCGGTCAAAACCTCGCATTTCGCCTGGCTGCGCCGGCAGCTGACGCCG
AAGCAGCAGAGCCAGATCCTGGCGCTCGGCATTCCCGGCATCGGCTTCCGGCCGGAAAAGCGCCGCTTCTACCCGGGCGG
CTCGACCGCCGCGCATATCCTCGGTTACGTCAACATCGACAACCGCGGTGTCGCCGGCATGGAGAAATATATCGACGACC
AGGGGCTTGCCGATCTTGCCTCGGTCGGCATGACCAGCGACCAGCCGCTGGAGCCGGTGCGGCTGTCGATCGACCTGCGT
GTGCAGAACATCGTCCGGGATGCGGTCGTCAACGCCGTCAACAACTTCCAGTCCAAGGGGGCGGGTGCTGCCGTCATCGA
CGTGCATACCGGGGAAGTGCTGGCCATGGCCTCGGCGCCGGATTTCGATCCGAACGATCCGCAGGAAGGCGCCAAGGAGG
GTTGGCTCAACCGGATGACCAACGGCACCTTCGAAATGGGATCGACGTTCAAGACCTTTTCGCTGGCGATGGCGCTCGAC
ACCGGCAAGGTGAAGATGACCGACACGTTCGATGCCAGCAAGTCGATCTATATCGGCGGCTTCACCATTCACGATTTCCA
CGGCCAGCGCCGCTGGCTGACCGTGCCAGAGATTTTCCAGTATTCGTCGAATATCGGCACCGCGCGCGTCATCGATATCG
TCGGCATCGACGCGCAGAAGGACTATCTGACCAAGTTCGGCCTCTTGACCAAGATGCAGACCGAACTGCCTGAAGTGAAG
ATGCCGAGCCAGCCGAGGGTGTGGAAGAAGATCAATTCGATCACGATTTCCTTCGGCCACGGCGTCTCGACGACGGCGCT
GCAGACCGGGGTGGCAGCCGCCGCTCTCGTCAATGGCGGCAAGCTGATCGAGCCGACATTCCTGCCGCGCAGCCGCGAAC
AGGCCGATGAAATCGCCACGCAGGTCATCAAGAAGACGACCAGCGACGAAATCCGCTATCTGCTCGATTTCAACGGATAC
AAGGGATCGGGCCGCGTCGCCCGCGTGCCGGGCTTTGCCGTCGGCAGCAAGACCGGGACGGCCGACAAGGTAGTGAACGG
CCGTTATTCCGCGACCTTGAACTTCAACTCCTTCATTGCCGCCTTCCCGATCAACGACCCAAAATATGCGGTGATCACCT
TCTGCGACGAGCCGAAGACCGGCGAGAAGCAATATGGCGGAACGATCTCTGCCGGTACCGCTGGCCCGATCGCCCGCGAG
ATCATCAGCCGCGCAGCTCCCATTCTCGGCATCGAGCCGAAATTCGGGGAGGGCGGATCGGCCTTGCTGGTGTCTTATTG
A

Upstream 100 bases:

>100_bases
GCGCGACGGTTACGACGAAGGCGCAGCCTGTTCCCAAGCCCGCGCCGCGCGCCGCGGAGGAGGATGAAGCAGACGAGATC
GAAACGGGGTCGGTGGAATA

Downstream 100 bases:

>100_bases
GTGTGAATGAATATCGACGCCGATTCGCGAGGGGTGGACCGGCTTCAAGAGAGAAAAGTGCATTCGATGAAATTGCGAGA
CCTGGCCGGAGATCAGTTTC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MSFLSRIMVLKSQAHFSAGVYNRFGGPSPAGLAIEGSRKKKSGQAKSRVGLLILGFMGVYVVIGGRLVEYAMKDQEVVSS
ILPPDRLMASRPDILDRNGEVLATDIRTVSLFAEPNKIVDADEAVEKLATVLPELDVRDTYKKLSVKTSHFAWLRRQLTP
KQQSQILALGIPGIGFRPEKRRFYPGGSTAAHILGYVNIDNRGVAGMEKYIDDQGLADLASVGMTSDQPLEPVRLSIDLR
VQNIVRDAVVNAVNNFQSKGAGAAVIDVHTGEVLAMASAPDFDPNDPQEGAKEGWLNRMTNGTFEMGSTFKTFSLAMALD
TGKVKMTDTFDASKSIYIGGFTIHDFHGQRRWLTVPEIFQYSSNIGTARVIDIVGIDAQKDYLTKFGLLTKMQTELPEVK
MPSQPRVWKKINSITISFGHGVSTTALQTGVAAAALVNGGKLIEPTFLPRSREQADEIATQVIKKTTSDEIRYLLDFNGY
KGSGRVARVPGFAVGSKTGTADKVVNGRYSATLNFNSFIAAFPINDPKYAVITFCDEPKTGEKQYGGTISAGTAGPIARE
IISRAAPILGIEPKFGEGGSALLVSY

Sequences:

>Translated_586_residues
MSFLSRIMVLKSQAHFSAGVYNRFGGPSPAGLAIEGSRKKKSGQAKSRVGLLILGFMGVYVVIGGRLVEYAMKDQEVVSS
ILPPDRLMASRPDILDRNGEVLATDIRTVSLFAEPNKIVDADEAVEKLATVLPELDVRDTYKKLSVKTSHFAWLRRQLTP
KQQSQILALGIPGIGFRPEKRRFYPGGSTAAHILGYVNIDNRGVAGMEKYIDDQGLADLASVGMTSDQPLEPVRLSIDLR
VQNIVRDAVVNAVNNFQSKGAGAAVIDVHTGEVLAMASAPDFDPNDPQEGAKEGWLNRMTNGTFEMGSTFKTFSLAMALD
TGKVKMTDTFDASKSIYIGGFTIHDFHGQRRWLTVPEIFQYSSNIGTARVIDIVGIDAQKDYLTKFGLLTKMQTELPEVK
MPSQPRVWKKINSITISFGHGVSTTALQTGVAAAALVNGGKLIEPTFLPRSREQADEIATQVIKKTTSDEIRYLLDFNGY
KGSGRVARVPGFAVGSKTGTADKVVNGRYSATLNFNSFIAAFPINDPKYAVITFCDEPKTGEKQYGGTISAGTAGPIARE
IISRAAPILGIEPKFGEGGSALLVSY
>Mature_585_residues
SFLSRIMVLKSQAHFSAGVYNRFGGPSPAGLAIEGSRKKKSGQAKSRVGLLILGFMGVYVVIGGRLVEYAMKDQEVVSSI
LPPDRLMASRPDILDRNGEVLATDIRTVSLFAEPNKIVDADEAVEKLATVLPELDVRDTYKKLSVKTSHFAWLRRQLTPK
QQSQILALGIPGIGFRPEKRRFYPGGSTAAHILGYVNIDNRGVAGMEKYIDDQGLADLASVGMTSDQPLEPVRLSIDLRV
QNIVRDAVVNAVNNFQSKGAGAAVIDVHTGEVLAMASAPDFDPNDPQEGAKEGWLNRMTNGTFEMGSTFKTFSLAMALDT
GKVKMTDTFDASKSIYIGGFTIHDFHGQRRWLTVPEIFQYSSNIGTARVIDIVGIDAQKDYLTKFGLLTKMQTELPEVKM
PSQPRVWKKINSITISFGHGVSTTALQTGVAAAALVNGGKLIEPTFLPRSREQADEIATQVIKKTTSDEIRYLLDFNGYK
GSGRVARVPGFAVGSKTGTADKVVNGRYSATLNFNSFIAAFPINDPKYAVITFCDEPKTGEKQYGGTISAGTAGPIAREI
ISRAAPILGIEPKFGEGGSALLVSY

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=515, Percent_Identity=29.3203883495146, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786854, Length=480, Percent_Identity=23.5416666666667, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63456; Mature: 63325

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLSRIMVLKSQAHFSAGVYNRFGGPSPAGLAIEGSRKKKSGQAKSRVGLLILGFMGVY
CCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHH
VVIGGRLVEYAMKDQEVVSSILPPDRLMASRPDILDRNGEVLATDIRTVSLFAEPNKIVD
HHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCC
ADEAVEKLATVLPELDVRDTYKKLSVKTSHFAWLRRQLTPKQQSQILALGIPGIGFRPEK
HHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCC
RRFYPGGSTAAHILGYVNIDNRGVAGMEKYIDDQGLADLASVGMTSDQPLEPVRLSIDLR
CEECCCCCCCEEEEEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEEEH
VQNIVRDAVVNAVNNFQSKGAGAAVIDVHTGEVLAMASAPDFDPNDPQEGAKEGWLNRMT
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHC
NGTFEMGSTFKTFSLAMALDTGKVKMTDTFDASKSIYIGGFTIHDFHGQRRWLTVPEIFQ
CCCEECCCCEEEEEEEEEEECCCEEEEECCCCCCEEEEEEEEEEECCCCCEEEEHHHHHH
YSSNIGTARVIDIVGIDAQKDYLTKFGLLTKMQTELPEVKMPSQPRVWKKINSITISFGH
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCEEEEEECC
GVSTTALQTGVAAAALVNGGKLIEPTFLPRSREQADEIATQVIKKTTSDEIRYLLDFNGY
CCCHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
KGSGRVARVPGFAVGSKTGTADKVVNGRYSATLNFNSFIAAFPINDPKYAVITFCDEPKT
CCCCCEEECCCEEECCCCCCHHHHCCCEEEEEEECCCEEEEECCCCCCEEEEEEECCCCC
GEKQYGGTISAGTAGPIAREIISRAAPILGIEPKFGEGGSALLVSY
CCHHCCCEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SFLSRIMVLKSQAHFSAGVYNRFGGPSPAGLAIEGSRKKKSGQAKSRVGLLILGFMGVY
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHH
VVIGGRLVEYAMKDQEVVSSILPPDRLMASRPDILDRNGEVLATDIRTVSLFAEPNKIVD
HHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCC
ADEAVEKLATVLPELDVRDTYKKLSVKTSHFAWLRRQLTPKQQSQILALGIPGIGFRPEK
HHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCC
RRFYPGGSTAAHILGYVNIDNRGVAGMEKYIDDQGLADLASVGMTSDQPLEPVRLSIDLR
CEECCCCCCCEEEEEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEEEH
VQNIVRDAVVNAVNNFQSKGAGAAVIDVHTGEVLAMASAPDFDPNDPQEGAKEGWLNRMT
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHC
NGTFEMGSTFKTFSLAMALDTGKVKMTDTFDASKSIYIGGFTIHDFHGQRRWLTVPEIFQ
CCCEECCCCEEEEEEEEEEECCCEEEEECCCCCCEEEEEEEEEEECCCCCEEEEHHHHHH
YSSNIGTARVIDIVGIDAQKDYLTKFGLLTKMQTELPEVKMPSQPRVWKKINSITISFGH
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCEEEEEECC
GVSTTALQTGVAAAALVNGGKLIEPTFLPRSREQADEIATQVIKKTTSDEIRYLLDFNGY
CCCHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
KGSGRVARVPGFAVGSKTGTADKVVNGRYSATLNFNSFIAAFPINDPKYAVITFCDEPKT
CCCCCEEECCCEEECCCCCCHHHHCCCEEEEEEECCCEEEEECCCCCCEEEEEEECCCCC
GEKQYGGTISAGTAGPIAREIISRAAPILGIEPKFGEGGSALLVSY
CCHHCCCEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]