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The map label for this gene is murC [H]

Identifier: 209550173

GI number: 209550173

Start: 2632371

End: 2633786

Strand: Reverse

Name: murC [H]

Synonym: Rleg2_2593

Alternate gene names: 209550173

Gene position: 2633786-2632371 (Counterclockwise)

Preceding gene: 209550174

Following gene: 209550172

Centisome position: 58.04

GC content: 63.06

Gene sequence:

>1416_bases
ATGAAACTGCCGAAGGCGATCGGCCTCGTTCATTTCATCGGCATCGGCGGCATCGGCATGAGCGGCATTGCCGAAGTGCT
GCACAATCTCGGCCACAAGGTGCAGGGGTCCGACCAGGCCGACAGCGCCAATGTCCAGCGCCTGCGCGACAAGGGTATCG
AAGTGTTCGTCGGCCACCGGGCCGAGAACCTGGGTGATGCCGAAGTCGTCGTCGTTTCGACGGCGATCAAGAAGAGCAAT
CCGGAACTGATCGCCGCGCGCGAAAAGCTGCTGCCGGTGGTGCGCCGTGCCGAAATGCTTGCCGAGCTGATGCGCTTCCG
CAATGCGATTGCGATTGGCGGCACGCATGGCAAGACGACGACCACGTCGCTGGTCGCCACGCTGCTCGAAGCCGGCGGGC
TCGACCCGACCGTCATCAACGGCGGCATTATCAATGCGTACGGCACCAATGCCCGTATGGGCGAGGGCGAGTGGATGGTG
GTCGAGGCCGACGAATCCGACGGCACCTTCCTGAAGCTTCCTGCCGATGTCGCCGTCATCACCAATATCGACCCCGAGCA
TCTCGACCATTACGGCAATTTCGACGCCGTGCGCGCCGCCTTTAGGCAGTTCGTCGAGAACGTGCCGTTTTACGGTTTCG
GCGTCATGTGCCTCGATCATCCCGAAGTGCAGTCGCTGGTCGGCCGCATCGAGGATCGCAAGATCATCACCTATGGCGAG
AACCCGCAGGCCGACGTACGCTTCAAGAATGTGCGCATCGATGGCACACGCTCGATCTTCGACGTCGAAATCCGCCGCCG
CCGCACCGGCCAGGTGATCGAGCTCAAGGGGCTGGTCATGCCGATGCCGGGGCGGCATAATATCTCCAACGCGACGGCGG
CGATCGCCGTTGCCAACCGGCTCGGCATATCGAGCGCCGATATCGCCAAGGGACTTGCCTCCTTCGGCGGCGTCAAGCGC
CGTTTCACGCTGACCGGCGAATGGAACGGGGTGCAGATCTTCGACGATTACGGCCACCATCCGGTCGAGATCAAGGCGGT
GCTGCGCGCTGCCCGCGAAGCCTGCAAGGGGCGCATCATCGCGGTCCACCAGCCGCACCGCCACAGCCGCCTGGCAAGCC
TCTTCGAGGAATTCGCCGCCTGCTTCAACGATGCCGACAGCATTTTCCTGGCGCCGGTCTATGCGGCAGGCGAAGATCCG
ATCGCGGGGATCGATTCCGTGTCGCTGGTCTCGCGGATAAAATCCGGCGGCCATCGCGACGCCCGCTTTCTGAACTCGGC
GGAGCTTCTGCCGCAGATGGTTGCGGAGGTTGCAAAGCCTGGCGATTTCGTGGTTCTGTTGGGGGCTGGGAGCATCACAT
CCTGGGCGGCGGCGCTGCCCAAGCAACTGGAAGGCCTATCGGGAAAGTCCGTATGA

Upstream 100 bases:

>100_bases
CGAAACTCGCCGGGAAACCCGATGCCGCGAACTTGCTTGCCGACATGGTTGAGGCTATTGCCGCCGGACGGACAATTGCG
GAATTGAAGAGGACACGCGC

Downstream 100 bases:

>100_bases
AACAGGTGAATGGGGAAAAGCTTCTCGCGTCTCTCGGAGACGGTGTAAAGGATATCCGCGGTCGCATCACGCCGGATGCC
CCCATGGACCGCGTCACCTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKLPKAIGLVHFIGIGGIGMSGIAEVLHNLGHKVQGSDQADSANVQRLRDKGIEVFVGHRAENLGDAEVVVVSTAIKKSN
PELIAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSLVATLLEAGGLDPTVINGGIINAYGTNARMGEGEWMV
VEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQSLVGRIEDRKIITYGE
NPQADVRFKNVRIDGTRSIFDVEIRRRRTGQVIELKGLVMPMPGRHNISNATAAIAVANRLGISSADIAKGLASFGGVKR
RFTLTGEWNGVQIFDDYGHHPVEIKAVLRAAREACKGRIIAVHQPHRHSRLASLFEEFAACFNDADSIFLAPVYAAGEDP
IAGIDSVSLVSRIKSGGHRDARFLNSAELLPQMVAEVAKPGDFVVLLGAGSITSWAAALPKQLEGLSGKSV

Sequences:

>Translated_471_residues
MKLPKAIGLVHFIGIGGIGMSGIAEVLHNLGHKVQGSDQADSANVQRLRDKGIEVFVGHRAENLGDAEVVVVSTAIKKSN
PELIAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSLVATLLEAGGLDPTVINGGIINAYGTNARMGEGEWMV
VEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQSLVGRIEDRKIITYGE
NPQADVRFKNVRIDGTRSIFDVEIRRRRTGQVIELKGLVMPMPGRHNISNATAAIAVANRLGISSADIAKGLASFGGVKR
RFTLTGEWNGVQIFDDYGHHPVEIKAVLRAAREACKGRIIAVHQPHRHSRLASLFEEFAACFNDADSIFLAPVYAAGEDP
IAGIDSVSLVSRIKSGGHRDARFLNSAELLPQMVAEVAKPGDFVVLLGAGSITSWAAALPKQLEGLSGKSV
>Mature_471_residues
MKLPKAIGLVHFIGIGGIGMSGIAEVLHNLGHKVQGSDQADSANVQRLRDKGIEVFVGHRAENLGDAEVVVVSTAIKKSN
PELIAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSLVATLLEAGGLDPTVINGGIINAYGTNARMGEGEWMV
VEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQSLVGRIEDRKIITYGE
NPQADVRFKNVRIDGTRSIFDVEIRRRRTGQVIELKGLVMPMPGRHNISNATAAIAVANRLGISSADIAKGLASFGGVKR
RFTLTGEWNGVQIFDDYGHHPVEIKAVLRAAREACKGRIIAVHQPHRHSRLASLFEEFAACFNDADSIFLAPVYAAGEDP
IAGIDSVSLVSRIKSGGHRDARFLNSAELLPQMVAEVAKPGDFVVLLGAGSITSWAAALPKQLEGLSGKSV

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=43.6008676789588, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1790680, Length=477, Percent_Identity=28.7211740041929, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786276, Length=280, Percent_Identity=27.1428571428571, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50713; Mature: 50713

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPKAIGLVHFIGIGGIGMSGIAEVLHNLGHKVQGSDQADSANVQRLRDKGIEVFVGHR
CCCCHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEECC
AENLGDAEVVVVSTAIKKSNPELIAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTT
CCCCCCCEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCH
TTSLVATLLEAGGLDPTVINGGIINAYGTNARMGEGEWMVVEADESDGTFLKLPADVAVI
HHHHHHHHHHHCCCCCEEECCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQSLVGRIEDRKIITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECC
NPQADVRFKNVRIDGTRSIFDVEIRRRRTGQVIELKGLVMPMPGRHNISNATAAIAVANR
CCCCCEEEEEEEECCCCCEEEHHHHHCCCCCEEEECCEEECCCCCCCCCCHHHHHHHHHH
LGISSADIAKGLASFGGVKRRFTLTGEWNGVQIFDDYGHHPVEIKAVLRAAREACKGRII
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEE
AVHQPHRHSRLASLFEEFAACFNDADSIFLAPVYAAGEDPIAGIDSVSLVSRIKSGGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCHH
ARFLNSAELLPQMVAEVAKPGDFVVLLGAGSITSWAAALPKQLEGLSGKSV
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLPKAIGLVHFIGIGGIGMSGIAEVLHNLGHKVQGSDQADSANVQRLRDKGIEVFVGHR
CCCCHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEECC
AENLGDAEVVVVSTAIKKSNPELIAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTT
CCCCCCCEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCH
TTSLVATLLEAGGLDPTVINGGIINAYGTNARMGEGEWMVVEADESDGTFLKLPADVAVI
HHHHHHHHHHHCCCCCEEECCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQSLVGRIEDRKIITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECC
NPQADVRFKNVRIDGTRSIFDVEIRRRRTGQVIELKGLVMPMPGRHNISNATAAIAVANR
CCCCCEEEEEEEECCCCCEEEHHHHHCCCCCEEEECCEEECCCCCCCCCCHHHHHHHHHH
LGISSADIAKGLASFGGVKRRFTLTGEWNGVQIFDDYGHHPVEIKAVLRAAREACKGRII
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEE
AVHQPHRHSRLASLFEEFAACFNDADSIFLAPVYAAGEDPIAGIDSVSLVSRIKSGGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCHH
ARFLNSAELLPQMVAEVAKPGDFVVLLGAGSITSWAAALPKQLEGLSGKSV
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA