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The map label for this gene is hflC [H]

Identifier: 209550122

GI number: 209550122

Start: 2572138

End: 2573097

Strand: Reverse

Name: hflC [H]

Synonym: Rleg2_2540

Alternate gene names: 209550122

Gene position: 2573097-2572138 (Counterclockwise)

Preceding gene: 209550123

Following gene: 209550121

Centisome position: 56.7

GC content: 62.29

Gene sequence:

>960_bases
ATGACATCGAACAGACTTCCCATCATTCTCCTCATCCTCGCCATCGTGCTGGTCGGCCTCTATTCGTCGATCTTCGTGGT
GAATGCCCGCGAGCAGGCGATCGTCGTCCGCTTCGGCCAGATCCAGTCGGTCAAGACCGAACCCGGCATCTATTTCAAGC
TGCCCTTCGGCTTCATGGATGCCGACCGAGTCCAGCTTGTGGAAAAGCAGGCGCTGAGGCTCGATCTCGACAATATCCGC
GTTCAGGTTCAGGACGGCCAGACCTTCGACGTCGATGCCTTCGTGATCTATAACATCTCGGATGTTCGCCGCTTCCGCGA
AACGGTCTCGGGCGATCGCGAGGCCGCGGAAGCGCGGCTGAGAGCGCAGCTCGATTCATCGCTTCGCCGCGTCTACGGTC
TGCGCGACTACAATGCTGCGCTCTCGGAAGAGCGTGTCGCGATGATGCTGGAGATCCGGGACGACCTGCGCACGGATGCC
GAAAATCTCGGCCTGCATATCGACGACGTTCGCATCCGCCGTACCGACCTTTCTCCCGAGGTTGCGCCCAACACCTACAA
CGCCATGCGTTCGGAACGTCTGGCCGAAGCCGAGCGCATCCGCGCGGAGGGCAATGAAGAAGGTCAGCGGCGCCGGGCCG
TCGCCGACCGCCAGGTCGTCGAGTTCACCGCGGGCGCCCAGCGCGATGCGGAAATCCTGCGCGGTCAAGGCGATGCGGAA
CGCAACCGTGTCTTCGCCGACGCCTTCAACAAGGATCCGGCTTTCTTCGAGTTCTATCGCTCGATGGCGGCCTATTCCTC
GGCGCTTTCTTCACAGGACACGACGCTGGTGTTGTCGCCGAATACGGAATTCTTCCGCTATTTCGACAATGCCGCCGGCA
CCCTGAAGGCGCCGACAAACCCGGCTGCGGCAATTCCCGGCGCGGCTGCTCCGGCAGCACCCGCCCAGCCGGCGAACTGA

Upstream 100 bases:

>100_bases
GAAGAACTCGAAGAAGGTCATCATCGACGAGAAGCAGGGCGTGCTGCCCTATCTGCCGCTCAATGAGCTCGGCAAGCCGG
CGCAGCAGGGAGGTTGAACC

Downstream 100 bases:

>100_bases
CACCGAGGGATGCCACTTGCATCCTGACAATCTTGAAAGGGCCGGCCCGGGTGCCGGCCCTTTTTTCGTGGAAAGGTCGA
GATAATCAGGCTTTTGTGAG

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTSNRLPIILLILAIVLVGLYSSIFVVNAREQAIVVRFGQIQSVKTEPGIYFKLPFGFMDADRVQLVEKQALRLDLDNIR
VQVQDGQTFDVDAFVIYNISDVRRFRETVSGDREAAEARLRAQLDSSLRRVYGLRDYNAALSEERVAMMLEIRDDLRTDA
ENLGLHIDDVRIRRTDLSPEVAPNTYNAMRSERLAEAERIRAEGNEEGQRRRAVADRQVVEFTAGAQRDAEILRGQGDAE
RNRVFADAFNKDPAFFEFYRSMAAYSSALSSQDTTLVLSPNTEFFRYFDNAAGTLKAPTNPAAAIPGAAAPAAPAQPAN

Sequences:

>Translated_319_residues
MTSNRLPIILLILAIVLVGLYSSIFVVNAREQAIVVRFGQIQSVKTEPGIYFKLPFGFMDADRVQLVEKQALRLDLDNIR
VQVQDGQTFDVDAFVIYNISDVRRFRETVSGDREAAEARLRAQLDSSLRRVYGLRDYNAALSEERVAMMLEIRDDLRTDA
ENLGLHIDDVRIRRTDLSPEVAPNTYNAMRSERLAEAERIRAEGNEEGQRRRAVADRQVVEFTAGAQRDAEILRGQGDAE
RNRVFADAFNKDPAFFEFYRSMAAYSSALSSQDTTLVLSPNTEFFRYFDNAAGTLKAPTNPAAAIPGAAAPAAPAQPAN
>Mature_318_residues
TSNRLPIILLILAIVLVGLYSSIFVVNAREQAIVVRFGQIQSVKTEPGIYFKLPFGFMDADRVQLVEKQALRLDLDNIRV
QVQDGQTFDVDAFVIYNISDVRRFRETVSGDREAAEARLRAQLDSSLRRVYGLRDYNAALSEERVAMMLEIRDDLRTDAE
NLGLHIDDVRIRRTDLSPEVAPNTYNAMRSERLAEAERIRAEGNEEGQRRRAVADRQVVEFTAGAQRDAEILRGQGDAER
NRVFADAFNKDPAFFEFYRSMAAYSSALSSQDTTLVLSPNTEFFRYFDNAAGTLKAPTNPAAAIPGAAAPAAPAQPAN

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=330, Percent_Identity=33.6363636363636, Blast_Score=165, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 35656; Mature: 35524

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNRLPIILLILAIVLVGLYSSIFVVNAREQAIVVRFGQIQSVKTEPGIYFKLPFGFMD
CCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCEEEECCCCEEEEECCCCCC
ADRVQLVEKQALRLDLDNIRVQVQDGQTFDVDAFVIYNISDVRRFRETVSGDREAAEARL
HHHHHHHHHHHHHEEHHHEEEEEECCCEEEECEEEEECHHHHHHHHHHHCCCHHHHHHHH
RAQLDSSLRRVYGLRDYNAALSEERVAMMLEIRDDLRTDAENLGLHIDDVRIRRTDLSPE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEECEEEEECCCCCC
VAPNTYNAMRSERLAEAERIRAEGNEEGQRRRAVADRQVVEFTAGAQRDAEILRGQGDAE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
RNRVFADAFNKDPAFFEFYRSMAAYSSALSSQDTTLVLSPNTEFFRYFDNAAGTLKAPTN
HCEEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCEEECCCC
PAAAIPGAAAPAAPAQPAN
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSNRLPIILLILAIVLVGLYSSIFVVNAREQAIVVRFGQIQSVKTEPGIYFKLPFGFMD
CCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCEEEECCCCEEEEECCCCCC
ADRVQLVEKQALRLDLDNIRVQVQDGQTFDVDAFVIYNISDVRRFRETVSGDREAAEARL
HHHHHHHHHHHHHEEHHHEEEEEECCCEEEECEEEEECHHHHHHHHHHHCCCHHHHHHHH
RAQLDSSLRRVYGLRDYNAALSEERVAMMLEIRDDLRTDAENLGLHIDDVRIRRTDLSPE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEECEEEEECCCCCC
VAPNTYNAMRSERLAEAERIRAEGNEEGQRRRAVADRQVVEFTAGAQRDAEILRGQGDAE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
RNRVFADAFNKDPAFFEFYRSMAAYSSALSSQDTTLVLSPNTEFFRYFDNAAGTLKAPTN
HCEEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCEEECCCC
PAAAIPGAAAPAAPAQPAN
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]