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The map label for this gene is cobQ [H]

Identifier: 209549729

GI number: 209549729

Start: 2198202

End: 2199656

Strand: Reverse

Name: cobQ [H]

Synonym: Rleg2_2137

Alternate gene names: 209549729

Gene position: 2199656-2198202 (Counterclockwise)

Preceding gene: 209549732

Following gene: 209549728

Centisome position: 48.47

GC content: 65.43

Gene sequence:

>1455_bases
ATGGCAAGAGCGATCATGCTGCAGGGAACCGGCTCGGATGTCGGCAAGACGGTGCTGGTCGCGGGCCTTTGCCGGCTGGC
GGCCAATCGCGGGCTTGCCGTGCGGCCGTTCAAGCCGCAGAACATGTCGAACAATGCGGCAGTTGCCGATGACGGCGGCG
AGATCGGCCGGGCGCAGTGGCTGCAATCGTTGGCTGCACGCGCGCCATCCTCGGTGCACATGAACCCTGTGCTGCTCAAG
CCGCAATCGGAAAACGGCAGCCAGATCATCGTGCAGGGCAGGGTGTTCGGCCAGTCGAAGGGGCGCGACTATCAGCGGCT
GAAGCCGCAACTCCTCGGCGCGGTGCTCGAAAGCTTCGAAAAAGTCGCTGCGGGCGCCGATCTCGTCATCGTCGAGGGCG
CCGGATCGCCGGCCGAAATCAATCTGAGGGCCGGCGATATCGCCAATATGGGTTTTGCGACCCGGGCCGGCGTGCCTGTC
GTGCTCGTCGGCGATATCGACCGCGGCGGTGTCATCGCCTCGCTGGTCGGCACGCATGCGATCCTCGATGATGGCGACCG
GGCGATGATCGCCGGCTATATCATCAACAAGTTTCGCGGCGACATCTCGCTGTTCGACGACGGCATCCGCGCCATCGAAG
GCTTTACCGGCTGGCCGTGTTTCGGCGTGGTGCCGTGGCTGCCGGGTGCGGCGCGACTGCCGGCCGAAGATTCGGTCGTG
CTCGAACGGCTGGCGAAGGGCAGGGCGGGCGCGCTGAAGATCGCCGTGCCGGTGCTGCCGCGCATCGCCAATTTCGACGA
TCTCGACCCGCTGCGGGCAGAGCCGGACGTCGAACTGGTCTTCGTGCGATCAGGCGAACGGCTGCCTGCCGATGCGAGCC
TCGTCATTCTTCCCGGCTCGAAATCGACGATATCGGATCTCGCCGATTTCAGGGCTGAAGGCTGGGACCGCGATCTTCAC
ATGCATGTCAGACGCGGCGGCCGGGTGATCGGCATTTGCGGCGGCTACCAGATGCTCGGCCGCACGGTGCGCGATCGGCT
CGGTATCGAGGGCGGGACACTTGAGACGCCGGGGCTGGCACTTCTCGACGTCGAGACCGAAATGGCGCCTGAAAAAACCG
TGCGCAACAGCCATGCTCGCTCGACCGAATACGACGTGCCGCTTGCCGGCTACCAGATCCACCTCGGCATCACCCACGGC
CCGGATTGCGACCGGCCTTCGGCAATCGTCGATGGCGTGCCCGACGGGGCGCTTTCCGCCGACGGCCGAATCGTGGGCAC
CTACCTGCACGGGCTCTTCGGCAGCGACGCCTATCGCACCCGGCTGCTTCAAAGCTTCGGTCTTTCGGGCGAGCGGCGGA
ACTATCGTGAGAGTGTCGAGCAGGCGCTTGATGAGATCGCCGGAGAACTCGAGCGTTACCTCGATCCGCGCTGGTTGGCC
GGGCTGCTCGGTTAG

Upstream 100 bases:

>100_bases
GGGGTCAAGTCCTGCCGCCAGAGCAAGTCTTGACCGGGGGCACGCCTTGACCCGGTGTCGTTGCCCATTGTAGGCCTCGC
CTCAGCGAAAGGCGGCCACC

Downstream 100 bases:

>100_bases
GCTGCCCCTCTTTGTACTCTTGCCAAATTAGTTGACTGAGTCCATTAAATCTCGCGGCGAGACCGGTTGAGAGCGATGAA
ACCATGAGCATATCGGATAG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MARAIMLQGTGSDVGKTVLVAGLCRLAANRGLAVRPFKPQNMSNNAAVADDGGEIGRAQWLQSLAARAPSSVHMNPVLLK
PQSENGSQIIVQGRVFGQSKGRDYQRLKPQLLGAVLESFEKVAAGADLVIVEGAGSPAEINLRAGDIANMGFATRAGVPV
VLVGDIDRGGVIASLVGTHAILDDGDRAMIAGYIINKFRGDISLFDDGIRAIEGFTGWPCFGVVPWLPGAARLPAEDSVV
LERLAKGRAGALKIAVPVLPRIANFDDLDPLRAEPDVELVFVRSGERLPADASLVILPGSKSTISDLADFRAEGWDRDLH
MHVRRGGRVIGICGGYQMLGRTVRDRLGIEGGTLETPGLALLDVETEMAPEKTVRNSHARSTEYDVPLAGYQIHLGITHG
PDCDRPSAIVDGVPDGALSADGRIVGTYLHGLFGSDAYRTRLLQSFGLSGERRNYRESVEQALDEIAGELERYLDPRWLA
GLLG

Sequences:

>Translated_484_residues
MARAIMLQGTGSDVGKTVLVAGLCRLAANRGLAVRPFKPQNMSNNAAVADDGGEIGRAQWLQSLAARAPSSVHMNPVLLK
PQSENGSQIIVQGRVFGQSKGRDYQRLKPQLLGAVLESFEKVAAGADLVIVEGAGSPAEINLRAGDIANMGFATRAGVPV
VLVGDIDRGGVIASLVGTHAILDDGDRAMIAGYIINKFRGDISLFDDGIRAIEGFTGWPCFGVVPWLPGAARLPAEDSVV
LERLAKGRAGALKIAVPVLPRIANFDDLDPLRAEPDVELVFVRSGERLPADASLVILPGSKSTISDLADFRAEGWDRDLH
MHVRRGGRVIGICGGYQMLGRTVRDRLGIEGGTLETPGLALLDVETEMAPEKTVRNSHARSTEYDVPLAGYQIHLGITHG
PDCDRPSAIVDGVPDGALSADGRIVGTYLHGLFGSDAYRTRLLQSFGLSGERRNYRESVEQALDEIAGELERYLDPRWLA
GLLG
>Mature_483_residues
ARAIMLQGTGSDVGKTVLVAGLCRLAANRGLAVRPFKPQNMSNNAAVADDGGEIGRAQWLQSLAARAPSSVHMNPVLLKP
QSENGSQIIVQGRVFGQSKGRDYQRLKPQLLGAVLESFEKVAAGADLVIVEGAGSPAEINLRAGDIANMGFATRAGVPVV
LVGDIDRGGVIASLVGTHAILDDGDRAMIAGYIINKFRGDISLFDDGIRAIEGFTGWPCFGVVPWLPGAARLPAEDSVVL
ERLAKGRAGALKIAVPVLPRIANFDDLDPLRAEPDVELVFVRSGERLPADASLVILPGSKSTISDLADFRAEGWDRDLHM
HVRRGGRVIGICGGYQMLGRTVRDRLGIEGGTLETPGLALLDVETEMAPEKTVRNSHARSTEYDVPLAGYQIHLGITHGP
DCDRPSAIVDGVPDGALSADGRIVGTYLHGLFGSDAYRTRLLQSFGLSGERRNYRESVEQALDEIAGELERYLDPRWLAG
LLG

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 51615; Mature: 51483

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAIMLQGTGSDVGKTVLVAGLCRLAANRGLAVRPFKPQNMSNNAAVADDGGEIGRAQW
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCCCHHHHHH
LQSLAARAPSSVHMNPVLLKPQSENGSQIIVQGRVFGQSKGRDYQRLKPQLLGAVLESFE
HHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
KVAAGADLVIVEGAGSPAEINLRAGDIANMGFATRAGVPVVLVGDIDRGGVIASLVGTHA
HHHCCCCEEEEECCCCCCEEEEECCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHH
ILDDGDRAMIAGYIINKFRGDISLFDDGIRAIEGFTGWPCFGVVPWLPGAARLPAEDSVV
EECCCCCEEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHH
LERLAKGRAGALKIAVPVLPRIANFDDLDPLRAEPDVELVFVRSGERLPADASLVILPGS
HHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCC
KSTISDLADFRAEGWDRDLHMHVRRGGRVIGICGGYQMLGRTVRDRLGIEGGTLETPGLA
CHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEE
LLDVETEMAPEKTVRNSHARSTEYDVPLAGYQIHLGITHGPDCDRPSAIVDGVPDGALSA
EEEECHHCCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCC
DGRIVGTYLHGLFGSDAYRTRLLQSFGLSGERRNYRESVEQALDEIAGELERYLDPRWLA
CCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GLLG
HHCC
>Mature Secondary Structure 
ARAIMLQGTGSDVGKTVLVAGLCRLAANRGLAVRPFKPQNMSNNAAVADDGGEIGRAQW
CCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCCCHHHHHH
LQSLAARAPSSVHMNPVLLKPQSENGSQIIVQGRVFGQSKGRDYQRLKPQLLGAVLESFE
HHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
KVAAGADLVIVEGAGSPAEINLRAGDIANMGFATRAGVPVVLVGDIDRGGVIASLVGTHA
HHHCCCCEEEEECCCCCCEEEEECCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHH
ILDDGDRAMIAGYIINKFRGDISLFDDGIRAIEGFTGWPCFGVVPWLPGAARLPAEDSVV
EECCCCCEEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHH
LERLAKGRAGALKIAVPVLPRIANFDDLDPLRAEPDVELVFVRSGERLPADASLVILPGS
HHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCC
KSTISDLADFRAEGWDRDLHMHVRRGGRVIGICGGYQMLGRTVRDRLGIEGGTLETPGLA
CHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEE
LLDVETEMAPEKTVRNSHARSTEYDVPLAGYQIHLGITHGPDCDRPSAIVDGVPDGALSA
EEEECHHCCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCC
DGRIVGTYLHGLFGSDAYRTRLLQSFGLSGERRNYRESVEQALDEIAGELERYLDPRWLA
CCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GLLG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA