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The map label for this gene is clcB [H]

Identifier: 209549727

GI number: 209549727

Start: 2194198

End: 2195988

Strand: Direct

Name: clcB [H]

Synonym: Rleg2_2134

Alternate gene names: 209549727

Gene position: 2194198-2195988 (Clockwise)

Preceding gene: 209549722

Following gene: 209549730

Centisome position: 48.35

GC content: 63.82

Gene sequence:

>1791_bases
ATGCTTATGAAATTGGATCGGCGCCGGTTCCGAGCGCTGCGTGTTTTCTTCGATCCGGGGCGGCTGCGGGCGCTGACCCG
CCGTAGCGAAGTCGGTCTGTCTCTGGCGGGCGCTGTCGTCGGCATTGCTTCGGGTCTTGCCGTGACCGGCATGAGCTTCG
TCTCCAATGAACTGCATCAGCTGGTCTTCGGTATCGCCGACAGCGAAAGGCTGAGCTCGTCGGTGATCGACGACAAGCTG
CTGCTGCTCACCGCCCCGGTCATCGGCGGCATGTTGCTCGGCCTGTTGCTCTTCATCTTGGCCAAGCGCCGCAAGAAGCC
GATGGTCGACCCGATCGAGGCCAATGCGCTGCATGGCGGCCGCCTGTCCTTGACCGACAGCATTATCGTCGCCGTGCAGA
ACCTGATCTCCAACGGTTTCGGCGCCTCCGTCGGCCTGGAGGCCGGCTATACCCAGCTTGCCGCAGGCCTCGCCTCGAAA
CTCGGCCTGAAGCTGCAGCTTCGCCGTTCGGATCTCCGCGTCCTCGTCGGCTGCGGCGCAGCCGGCGCCATCGCCGCTGC
CTTCAACGCGCCGCTGACCGGCGCCTTCTATGCCTTCGAGCTGATCATCGGCACCTATACGATCGTCTCGCTGACCCCTG
TAGTCGTCTCGGCCCTCGTTTCCACCCTGATCGCAAGGCTGCTCACCCATGGAGATTTCACCATCGATATCGGCGGCTTC
GGTGCCGTCGTGCCGGCCGATTATATCCCGGCGCTGCTGCTCGGCGTGGTCTCGGCCGGCGTCGGCATCCTGATCATGCA
GGGTGTCGCCTTCGTCGAGGAACTGGCGCGCAAGAGCGCGATCGCCCCGCCCTTCCGCCCGGCGCTCGGCGGCATCATCG
TCGGGCTGCTGGCGATGATCTCGCCGCAGGTGCTTTCGGCCGGCCACGGTGCATTGCATCTGAACCTTTCCCGCGATGTC
GCCATTCCGGCGCTGATCGGCCTCTTCCTGTTGAAATCCTTGGCTTCGGCGATCTCGATCGGCTCGGGCTTCAGGGGCGG
CCTGTTCTTCGCCTCGCTGTTCATGGGCGCCCTGCTCGGCAAGCTCTTTGCCTATTGCGGCCCCTATTTTGCCGATGCGA
CGCTGACGCCCGTCATTTATGCCGTGGTCGGCATGAGTTCGCTTGCCGTCGCCGTCATCGGCGGGCCGCTGACGATGACG
TTCCTGGCACTCGAAATCACTGGCGACTTCCCGATCACAGCGCTGGTGCTTGCCGCCGTCATCACCTCCTCGCTCGTCGT
GCGCTCGACCTTCGGATACTCCTTCGCCACATGGCGCTTCCATCTGCGCGGCGAAAGCATCCGCAGCGCCCATGACGTCG
GCTGGATCCGCAACCTGACGGTGGAAAAGCTGATGCGCGCCGACGTCAAGACGGCAAGGGCGGGCATCTCGCTCGAGGAA
TTCAAGAAGGCTTTCCCGATCGGCTCGACCCAGCGCGTTATCCTCGTCGAGGAGAGCGACAAATATGCCGGCCTCGTGCT
GGTGCCGGAGATCTACGCCAACCCGACCGACGCGCAGGACGAGGGCAAGACGCTCGCCGATTTCATCCACTACCGCAACG
ATTTCCTGCAGCCGCAGATGAATGCCCGGCAGGCGGCGGCGATCTTCGACAAGAGCGAAAGCGAAGCCCTCGCCGTCGTC
AACAACCTTATCGAACGCAAGGTGATCGGCCAGCTCAGCGAAAGCTATACGCTGCGCCGCTACAGCGAGGAACTTGACCG
CCGCCGCCGCGAGGTCTCCGGCGAAATTTGA

Upstream 100 bases:

>100_bases
TAAATATTTGACCTACGCGCCGGCTTTTCGCCGCAATTGCACTGCAAGCGGACTGCGCCATCGCCCTTGACCGGGCCTCT
TCCTGCCTAGTTGTCTTGCC

Downstream 100 bases:

>100_bases
AGGGGTGTTATGACGCGGCGTCGGCCAGCCGGAAGACGTCTGCCTTCTTCGACACGCCCCGCAATTCGAAAGAGCCGAGA
TACTCGCAGGCGACGGCTAA

Product: chloride channel core protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MLMKLDRRRFRALRVFFDPGRLRALTRRSEVGLSLAGAVVGIASGLAVTGMSFVSNELHQLVFGIADSERLSSSVIDDKL
LLLTAPVIGGMLLGLLLFILAKRRKKPMVDPIEANALHGGRLSLTDSIIVAVQNLISNGFGASVGLEAGYTQLAAGLASK
LGLKLQLRRSDLRVLVGCGAAGAIAAAFNAPLTGAFYAFELIIGTYTIVSLTPVVVSALVSTLIARLLTHGDFTIDIGGF
GAVVPADYIPALLLGVVSAGVGILIMQGVAFVEELARKSAIAPPFRPALGGIIVGLLAMISPQVLSAGHGALHLNLSRDV
AIPALIGLFLLKSLASAISIGSGFRGGLFFASLFMGALLGKLFAYCGPYFADATLTPVIYAVVGMSSLAVAVIGGPLTMT
FLALEITGDFPITALVLAAVITSSLVVRSTFGYSFATWRFHLRGESIRSAHDVGWIRNLTVEKLMRADVKTARAGISLEE
FKKAFPIGSTQRVILVEESDKYAGLVLVPEIYANPTDAQDEGKTLADFIHYRNDFLQPQMNARQAAAIFDKSESEALAVV
NNLIERKVIGQLSESYTLRRYSEELDRRRREVSGEI

Sequences:

>Translated_596_residues
MLMKLDRRRFRALRVFFDPGRLRALTRRSEVGLSLAGAVVGIASGLAVTGMSFVSNELHQLVFGIADSERLSSSVIDDKL
LLLTAPVIGGMLLGLLLFILAKRRKKPMVDPIEANALHGGRLSLTDSIIVAVQNLISNGFGASVGLEAGYTQLAAGLASK
LGLKLQLRRSDLRVLVGCGAAGAIAAAFNAPLTGAFYAFELIIGTYTIVSLTPVVVSALVSTLIARLLTHGDFTIDIGGF
GAVVPADYIPALLLGVVSAGVGILIMQGVAFVEELARKSAIAPPFRPALGGIIVGLLAMISPQVLSAGHGALHLNLSRDV
AIPALIGLFLLKSLASAISIGSGFRGGLFFASLFMGALLGKLFAYCGPYFADATLTPVIYAVVGMSSLAVAVIGGPLTMT
FLALEITGDFPITALVLAAVITSSLVVRSTFGYSFATWRFHLRGESIRSAHDVGWIRNLTVEKLMRADVKTARAGISLEE
FKKAFPIGSTQRVILVEESDKYAGLVLVPEIYANPTDAQDEGKTLADFIHYRNDFLQPQMNARQAAAIFDKSESEALAVV
NNLIERKVIGQLSESYTLRRYSEELDRRRREVSGEI
>Mature_596_residues
MLMKLDRRRFRALRVFFDPGRLRALTRRSEVGLSLAGAVVGIASGLAVTGMSFVSNELHQLVFGIADSERLSSSVIDDKL
LLLTAPVIGGMLLGLLLFILAKRRKKPMVDPIEANALHGGRLSLTDSIIVAVQNLISNGFGASVGLEAGYTQLAAGLASK
LGLKLQLRRSDLRVLVGCGAAGAIAAAFNAPLTGAFYAFELIIGTYTIVSLTPVVVSALVSTLIARLLTHGDFTIDIGGF
GAVVPADYIPALLLGVVSAGVGILIMQGVAFVEELARKSAIAPPFRPALGGIIVGLLAMISPQVLSAGHGALHLNLSRDV
AIPALIGLFLLKSLASAISIGSGFRGGLFFASLFMGALLGKLFAYCGPYFADATLTPVIYAVVGMSSLAVAVIGGPLTMT
FLALEITGDFPITALVLAAVITSSLVVRSTFGYSFATWRFHLRGESIRSAHDVGWIRNLTVEKLMRADVKTARAGISLEE
FKKAFPIGSTQRVILVEESDKYAGLVLVPEIYANPTDAQDEGKTLADFIHYRNDFLQPQMNARQAAAIFDKSESEALAVV
NNLIERKVIGQLSESYTLRRYSEELDRRRREVSGEI

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=401, Percent_Identity=28.6783042394015, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786350, Length=242, Percent_Identity=26.4462809917355, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 63475; Mature: 63475

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMKLDRRRFRALRVFFDPGRLRALTRRSEVGLSLAGAVVGIASGLAVTGMSFVSNELHQ
CCCCHHHHHHHHHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVFGIADSERLSSSVIDDKLLLLTAPVIGGMLLGLLLFILAKRRKKPMVDPIEANALHGG
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RLSLTDSIIVAVQNLISNGFGASVGLEAGYTQLAAGLASKLGLKLQLRRSDLRVLVGCGA
CEEHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEECCC
AGAIAAAFNAPLTGAFYAFELIIGTYTIVSLTPVVVSALVSTLIARLLTHGDFTIDIGGF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GAVVPADYIPALLLGVVSAGVGILIMQGVAFVEELARKSAIAPPFRPALGGIIVGLLAMI
CCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
SPQVLSAGHGALHLNLSRDVAIPALIGLFLLKSLASAISIGSGFRGGLFFASLFMGALLG
CHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KLFAYCGPYFADATLTPVIYAVVGMSSLAVAVIGGPLTMTFLALEITGDFPITALVLAAV
HHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEEECCCCHHHHHHHHH
ITSSLVVRSTFGYSFATWRFHLRGESIRSAHDVGWIRNLTVEKLMRADVKTARAGISLEE
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FKKAFPIGSTQRVILVEESDKYAGLVLVPEIYANPTDAQDEGKTLADFIHYRNDFLQPQM
HHHHCCCCCCCEEEEEECCCCCCCEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
NARQAAAIFDKSESEALAVVNNLIERKVIGQLSESYTLRRYSEELDRRRREVSGEI
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLMKLDRRRFRALRVFFDPGRLRALTRRSEVGLSLAGAVVGIASGLAVTGMSFVSNELHQ
CCCCHHHHHHHHHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVFGIADSERLSSSVIDDKLLLLTAPVIGGMLLGLLLFILAKRRKKPMVDPIEANALHGG
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RLSLTDSIIVAVQNLISNGFGASVGLEAGYTQLAAGLASKLGLKLQLRRSDLRVLVGCGA
CEEHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEECCC
AGAIAAAFNAPLTGAFYAFELIIGTYTIVSLTPVVVSALVSTLIARLLTHGDFTIDIGGF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GAVVPADYIPALLLGVVSAGVGILIMQGVAFVEELARKSAIAPPFRPALGGIIVGLLAMI
CCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
SPQVLSAGHGALHLNLSRDVAIPALIGLFLLKSLASAISIGSGFRGGLFFASLFMGALLG
CHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KLFAYCGPYFADATLTPVIYAVVGMSSLAVAVIGGPLTMTFLALEITGDFPITALVLAAV
HHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEEECCCCHHHHHHHHH
ITSSLVVRSTFGYSFATWRFHLRGESIRSAHDVGWIRNLTVEKLMRADVKTARAGISLEE
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FKKAFPIGSTQRVILVEESDKYAGLVLVPEIYANPTDAQDEGKTLADFIHYRNDFLQPQM
HHHHCCCCCCCEEEEEECCCCCCCEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
NARQAAAIFDKSESEALAVVNNLIERKVIGQLSESYTLRRYSEELDRRRREVSGEI
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA